Short chain fatty acids in human large intestine, portal, hepatic and venous blood.

Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within four hours of death. Total SCFA concentration (mmol/kg) was low in the terminal ileum at 13 +/- 6 but high in all regions of the colon ranging from 131 +/- 9 in the caecum to 80 +/- 11 in the descending colon. The presence of branched chain fatty acids was also noted. A significant trend from high to low concentrations was found on passing distally from caecum to descending colon. pH also changed with region from 5.6 +/- 0.2 in the caecum to 6.6 +/- 0.1 in the descending colon. pH and SCFA concentrations were inversely related. Total SCFA (mumol/l) in blood was, portal 375 +/- 70, hepatic 148 +/- 42 and peripheral 79 +/- 22. In all samples acetate was the principal anion but molar ratios of the three principal SCFA changed on going from colonic contents to portal blood to hepatic vein indicating greater uptake of butyrate by the colonic epithelium and propionate by the liver. These data indicate that substantial carbohydrate, and possibly protein, fermentation is occurring in the human large intestine, principally in the caecum and ascending colon and that the large bowel may have a greater role to play in digestion than has previously been ascribed to it

Neutral strange particle production in deep inelastic scattering at HERA

This paper presents measurements of \k\ and \lam\ production in neutral current, deep inelastic scattering of 26.7 GeV electrons and 820 GeV protons in the kinematic range $10 0.04$. Average multiplicities for \k\ and \lam\ production are determined for transverse momenta \ \ptr\ $> 0.5$ GeV and pseudorapidities $\left| \eta \right| < 1.3$. The multiplicities favour a stronger strange to light quark suppression in the fragmentation chain than found in $e^+ e^-$ experiments. The production properties of \k's in events with and without a large rapidity gap with respect to the proton direction are compared. The ratio of neutral \k's to charged particles per event in the measured kinematic range is, within the present statistics, the same in both samples.Comment: 27 pages, latex 8 figures appended as uuencoded fil