The influence of first generation fertility and economic status on second generation fertility

This paper examines the impact of parental economic status and family size on the actual and expected fertility of adult children using longitudinal data from two generations of families participating in the Panel Study of Income Dynamics. There was a modest positive relationship between first generation family size and second generation fertility. More importantly, the ideal family size of the parental family was more closely related to fertility behavior and plans in the second generation than was actual parental family size. In addition, the data revealed the hypothesized negative correlation between parental financial status and second generation fertility behavior and plans. Several mechanisms which could produce the correlation between parental characteristics and the fertility of their children are explored.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43511/1/11111_2005_Article_BF01253070.pd

Timeline Localization

International audienceThe research findings provide evidence that time-oriented data visualizations can contribute to faster information processing, bet-ter understanding and improved recall. Thus, they are used in many application domains – medicine, law enforcement, traffic and navigation control to name but a few. Simultaneously, human's time perception varies depending inter alia on culture, language, personal experience and situational factors. Although, the differences caused by the aforemen-tioned aspects were acknowledged and addressed in the Human Com-puter Interaction (HCI) field for decades their impact on time-oriented data visualizations was largely neglected. To fill this gap, we investigate the influence of time spatializations (or-ganization of time along axes) on the response time and accuracy of inferences based on time-oriented data visualizations. Moreover, we ex-amine users' preferences toward different time arrangements. Our find-ings show that user-adapted organization of time along axes can speed up the decision-making process and increase the user experience

Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study

Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder caused by somatic genetic alterations in hematopoietic precursor cells differentiating into CD1a+/CD207+ histiocytes. LCH clinical manifestation is highly heterogeneous. BRAF and MAP2K1 mutations account for ~80% of genetic driver alterations in neoplastic LCH cells. However, their clinical associations remain incompletely understood. Here, we present an international clinicogenomic study of childhood LCH, investigating 377 patients genotyped for at least BRAFV600E. MAPK pathway gene alterations were detected in 300 (79.6%) patients, including 191 (50.7%) with BRAFV600E, 54 with MAP2K1 mutations, 39 with BRAF exon 12 mutations, 13 with rare BRAF alterations, and 3 with ARAF or KRAS mutations. Our results confirm that BRAFV600E associates with lower age at diagnosis and higher prevalence of multisystem LCH, high-risk disease, and skin involvement. Furthermore, BRAFV600E appeared to correlate with a higher prevalence of central nervous system (CNS)–risk bone lesions. In contrast, MAP2K1 mutations associated with a higher prevalence of single-system (SS)-bone LCH, and BRAF exon 12 deletions seemed to correlate with more lung involvement. Although BRAFV600E correlated with reduced event-free survival in the overall cohort, neither BRAF nor MAP2K1 mutations associated with event-free survival when patients were stratified by disease extent. Thus, the correlation of BRAFV600E with inferior clinical outcome is (primarily) driven by its association with disease extents known for high rates of progression or relapse, including multisystem LCH. These findings advance our understanding of factors underlying the remarkable clinical heterogeneity of LCH but also question the independent prognostic value of lesional BRAFV600E status