Combined shear/compression structural testing of asymmetric sandwich structures

Asymmetric sandwich technology can be applied in the design of lightweight, non-pressurized aeronautical structures such as those of helicopters. A test rig of asymmetric sandwich structures subjected to compression/shear loads was designed, validated, and set up. It conforms to the standard certification procedure for composite aeronautical structures set out in the “test pyramid”, a multiscale approach. The static tests until failure showed asymmetric sandwich structures to be extremely resistant, which, in the case of the tested specimen shape, were characterized by the absence of buckling and failure compressive strains up to 10,000 μ strains. Specimens impacted with perforation damage were also tested, enabling the original phenomenon of crack propagation to be observed step-by-step. The results of the completed tests thus enable the concept to be validated, and justify the possibility of creating a much larger machine to overcome the drawbacks linked to the use of small specimens

Pilot study investigating the prevalence of oral Human Papilloma Viral (HPV) infection in young adults

The rates of HPV related Head and neck squamous cell carcinomas (HNSCC) within the UK have been steadily increasing, particular in young white men. The reasons behind this increase have not been elucidated, but maybe linked to higher prevalence of oral HPV infection in men. This pilot study aimed to establish a reproducible HPV oral screening method to investigate the rate of oral HPV infection in young healthy adults. The study found that 4% (3 men and 2 women)of the study cohort (N = 124) had a detectable oral HPV infection, which was found to be comparable with US based investigations. An interesting finding of this pilot study was that 80% of the HPV infected individuals smoked, and one of the HPV infected females had received the HPV vaccination. This preliminary data highlights the need for further investigation into the rates of oral HPV infection in the healthy community and to determine what particular lifestyle choices could be risk factors for infection and how the HPV vaccination programme will affect HPV infectivity levels in both women and men

Mitochondrial function and oxygen supply in normal and in chronically ischemic muscle: A combined 31P magnetic resonance spectroscopy and near infrared spectroscopy study in vivo

AbstractPurpose: We used 31P magnetic resonance spectroscopy (MRS) and near-infrared spectroscopy (NIRS) as a means of quantifying abnormalities in calf muscle oxygenation and adenosine triphosphate (ATP) turnover in peripheral vascular disease (PVD). Methods: Eleven male patients with PVD (mean age, 65 years; range, 55-76 years) and nine male control subjects of similar age were observed in a case-control study in vascular outpatients. Inclusion criteria were more than 6 months' calf claudication (median, 1.5 years; range, 0.6-18 years); proven femoropopliteal or iliofemoral occlusive or stenotic disease; maximum treadmill walking distance (2 km/h, 10° gradient) of 50 to 230 m (mean, 112 m); ankle-brachial pressure index of 0.8 or less during exercise (mean, 0.47; range, 0.29-0.60). Exclusion criteria included diabetes mellitus, anemia, and magnet contraindications. Simultaneous 31P MRS and NIRS of lateral gastrocnemius was conducted during 2 to 4 minutes of voluntary 0.5 Hz isometric plantarflexion at 50% and 75% maximum voluntary contraction force (MVC), followed by 5 minutes recovery. Each subject was studied three times, and the results were combined. Results: Compared with control subjects, patients with PVD showed (1) normal muscle cross-sectional area, MVC, ATP turnover, and contractile efficiency (ATP turnover per force/area); (2) larger phosphocreatine (PCr) changes during exercise (ie, increased shortfall of oxidative ATP synthesis) and slower PCr recovery (47% ± 7% [mean ± SEM] decrease in functional capacity for oxidative ATP synthesis, P =.001); (3) faster deoxygenation during exercise and slower postexercise reoxygenation (59% ± 7% decrease in rate constant, P =.0009), despite reduced oxidative ATP synthesis; (4) correlation between PCr and NIRS recovery rate constants (P <.02); and (5) correlations between smaller walking distance, slower PCr recovery, and reduced MVC (P <.001). The precision of the key measurements (rate constants and contractile efficiency) was 12% to 18% interstudy and 30% to 40% intersubject. Conclusion: The primary lesion in oxygen supply dominates muscle metabolism. Reduced force-generation in patients who are affected more may protect muscle from metabolic stress. (J Vasc Surg 2001;34:1103-10.

A meta-analysis of protein binding of flucloxacillin in healthy volunteers and hospitalized patients

Objectives: The aim of this study was to develop a mechanistic protein-binding model to predict the unbound flucloxacillin concentrations in different patient populations. Methods: A mechanistic protein-binding model was fitted to the data using non-linear mixed-effects modelling. Data were obtained from four datasets, containing 710 paired total and unbound flucloxacillin concentrations from healthy volunteers, non-critically ill and critically ill patients. A fifth dataset with data from hospitalized patients was used for evaluation of our model. The predictive performance of the mechanistic model was evaluated and compared with the calculation of the unbound concentration with a fixed unbound fraction of 5%. Finally, we performed a fit-for-use evaluation, verifying whether the model-predicted unbound flucloxacillin concentrations would lead to clinically incorrect dose adjustments. Results: The mechanistic protein-binding model predicted the unbound flucloxacillin concentrations more accurately than assuming an unbound fraction of 5%. The mean prediction error varied between -26.2% to 27.8% for the mechanistic model and between -30.8% to 83% for calculation with a fixed factor of 5%. The normalized root mean squared error varied between 36.8% and 69% respectively between 57.1% and 134%. Predicting the unbound concentration with the use of the mechanistic model resulted in 6.1% incorrect dose adjustments versus 19.4% if calculated with a fixed unbound fraction of 5%. Conclusions: Estimating the unbound concentration with a mechanistic protein-binding model outperforms the calculation with the use of a fixed protein binding factor of 5%, but neither demonstrates acceptable performance. When performing dose individualization of flucloxacillin, this should be done based on measured unbound concentrations rather than on estimated unbound concentrations from the measured total concentrations. In the absence of an assay for unbound concentrations, the mechanistic binding model should be preferred over assuming a fixed unbound fraction of 5%

Verbal working memory and functional large-scale networks in schizophrenia

The aim of this study was to test whether bilinear and nonlinear effective connectivity (EC) measures of working memory fMRI data can differentiate between patients with schizophrenia (SZ) and healthy controls (HC). We applied bilinear and nonlinear Dynamic Causal Modeling (DCM) for the analysis of verbal working memory in 16 SZ and 21 HC. The connection strengths with nonlinear modulation between the dorsolateral prefrontal cortex (DLPFC) and the ventral tegmental area/substantia nigra (VTA/SN) were evaluated. We used Bayesian Model Selection at the group and family levels to compare the optimal bilinear and nonlinear models. Bayesian Model Averaging was used to assess the connection strengths with nonlinear modulation. The DCM analyses revealed that SZ and HC used different bilinear networks despite comparable behavioral performance. In addition, the connection strengths with nonlinear modulation between the DLPFC and the VTA/SN area showed differences between SZ and HC. The adoption of different functional networks in SZ and HC indicated neurobiological alterations underlying working memory performance, including different connection strengths with nonlinear modulation between the DLPFC and the VTA/SN area. These novel findings may increase our understanding of connectivity in working memory in schizophrenia

SO(10) unified models and soft leptogenesis

Motivated by the fact that, in some realistic models combining SO(10) GUTs and flavour symmetries, it is not possible to achieve the required baryon asymmetry through the CP asymmetry generated in the decay of right-handed neutrinos, we take a fresh look on how deep this connection is in SO(10). The common characteristics of these models are that they use the see-saw with right-handed neutrinos, predict a normal hierarchy of masses for the neutrinos observed in oscillating experiments and in the basis where the right-handed Majorana mass is diagonal, the charged lepton mixings are tiny. In addition these models link the up-quark Yukawa matrix to the neutrino Yukawa matrix Y^\nu with the special feature of Y^\nu_{11}-> 0 Using this condition, we find that the required baryon asymmetry of the Universe can be explained by the soft leptogenesis using the soft B parameter of the second lightest right-handed neutrino whose mass turns out to be around 10^8 GeV. It is pointed out that a natural way to do so is to use no-scale supergravity where the value of B ~1 GeV is set through gauge-loop corrections.Comment: 26 pages, 2 figures. Added references, new appendix of a relevant fit and improved comment

Gluino Production in Electron-Positron Annihilation

We discuss the pair production of gluinos in electron-positron annihilation at LEP, in a model with soft supersymmetry breaking, allowing for mixing between the squarks. In much of the parameter space of the Minimal Supersymmetric Model (MSSM) the cross section corresponds to a $Z$ branching ratio above $10^{-5}$, even up to $10^{-4}$. A non-observation of gluinos at this level restricts the allowed MSSM parameter space. In particular, it leads to lower bounds on the soft mass parameters in the squark sector.Comment: 24 pages LATEX plus 10 pages of figures (not included, available on request). Full postscript version available by anonymous ftp at node VSFYS1.FI.UIB.NO in subdirectory OSLAND, file BERGEN94-10.PS), Bergen Scientific/Technical Report No. 1994-1

Vacuum Fluctuations, Geometric Modular Action and Relativistic Quantum Information Theory

A summary of some lines of ideas leading to model-independent frameworks of relativistic quantum field theory is given. It is followed by a discussion of the Reeh-Schlieder theorem and geometric modular action of Tomita-Takesaki modular objects associated with the quantum field vacuum state and certain algebras of observables. The distillability concept, which is significant in specifying useful entanglement in quantum information theory, is discussed within the setting of general relativistic quantum field theory.Comment: 26 pages. Contribution for the Proceedings of a Conference on Special Relativity held at Potsdam, 200

Oscillations and waves in solar spicules

Since their discovery, spicules have attracted increased attention as energy/mass bridges between the dense and dynamic photosphere and the tenuous hot solar corona. Mechanical energy of photospheric random and coherent motions can be guided by magnetic field lines, spanning from the interior to the upper parts of the solar atmosphere, in the form of waves and oscillations. Since spicules are one of the most pronounced features of the chromosphere, the energy transport they participate in can be traced by the observations of their oscillatory motions. Oscillations in spicules have been observed for a long time. However the recent high-resolutions and high-cadence space and ground based facilities with superb spatial, temporal and spectral capacities brought new aspects in the research of spicule dynamics. Here we review the progress made in imaging and spectroscopic observations of waves and oscillations in spicules. The observations are accompanied by a discussion on theoretical modelling and interpretations of these oscillations. Finally, we embark on the recent developments made on the presence and role of Alfven and kink waves in spicules. We also address the extensive debate made on the Alfven versus kink waves in the context of the explanation of the observed transverse oscillations of spicule axes

Statistics of the gravitational force in various dimensions of space: from Gaussian to Levy laws

We discuss the distribution of the gravitational force created by a Poissonian distribution of field sources (stars, galaxies,...) in different dimensions of space d. In d=3, it is given by a Levy law called the Holtsmark distribution. It presents an algebraic tail for large fluctuations due to the contribution of the nearest neighbor. In d=2, it is given by a marginal Gaussian distribution intermediate between Gaussian and Levy laws. In d=1, it is exactly given by the Bernouilli distribution (for any particle number N) which becomes Gaussian for N>>1. Therefore, the dimension d=2 is critical regarding the statistics of the gravitational force. We generalize these results for inhomogeneous systems with arbitrary power-law density profile and arbitrary power-law force in a d-dimensional universe