10 research outputs found
Pathomorphosis of tick-borne encephalitis in patients receiving Immunoprophylaxis
With account taken of the regional tick-borne encephalitis (TBE) vaccination program implementation (reaching the 86% population coverage by the year of 2016), clinical effectiveness of vaccination and emergency seroprevention was assessed in 795 patients with the ascertained TBE diagnosis in MA 'New Hospital' from 2006 to 2016. Predominance of febrile TBE forms (15.0%), decrease in the percentage of meningeal TBE forms to 12.5% and that of focal TBE forms to 1.7% in the vaccines compared with the relative proportions of these forms in the unvaccinated individuals reaching 44.6%; 65.2%; and 67.6% respectively was established. Development of febrile (27.2%), meningeal (21.4%) and focal forms (29.5%) in the TBE patients who received only emergency seroprevention was recorded more frequently than in the vaccination group, but reliably more rarely than in the non-vaccination group. It was detected that in the vaccinees given additional immunoglobulin injections after tick bites, meningeal TBE forms developed reliably more rarely (0.9%) than in the vaccinees who did not receive any emergency seroprevention (12.5%). Vaccination is a single-option method of active specific TBE prevention, yet there is a need for a personalized approach to preventive measures and determination of revaccination intervals based on TBE antibody titration in the vaccinees.Π‘ ΡΡΠ΅ΡΠΎΠΌ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΠΈ ΠΏΡΠΎΡΠΈΠ² ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΈΡΠ° (ΠΠΠ) (Ρ 86% ΠΎΡ
Π²Π°ΡΠΎΠΌ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΊ 2016 Π³ΠΎΠ΄Ρ) Π±ΡΠ» ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ ΠΈΠΌΠΌΡΠ½Π½ΡΠΉ ΡΡΠ°ΡΡΡ Ρ 3 Π³ΡΡΠΏΠΏ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ (ΡΠ΅ΠΏΡΠ΅Π·Π΅Π½ΡΠ°ΡΠΈΠ²Π½Π°Ρ Π²ΡΠ±ΠΎΡΠΊΠ°, ΠΏ=200) ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΠΈ ΠΈ ΡΠΊΡΡΡΠ΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠΎΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΠΠΠ (ΠΏ=795) Π½Π° Π±Π°Π·Π΅ ΠΠ Β«ΠΠΎΠ²Π°Ρ Π±ΠΎΠ»ΡΠ½ΠΈΡΠ°Β» Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ 2006-2016 Π³.Π³. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΎΡΠ½ΡΡ
- 15,0%, ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ Π΄ΠΎΠ»ΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³Π΅Π°Π»ΡΠ½ΡΡ
Π΄ΠΎ 12,5% ΠΈ ΠΎΡΠ°Π³ΠΎΠ²ΡΡ
ΡΠΎΡΠΌ ΠΠΠ Π΄ΠΎ 1,7% Ρ ΠΏΡΠΈΠ²ΠΈΡΡΡ
ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΡΠ΄Π΅Π»ΡΠ½ΡΠΌ Π²Π΅ΡΠΎΠΌ ΡΡΠΈΡ
ΡΠΎΡΠΌ Ρ Π½Π΅ ΠΏΡΠΈΠ²ΠΈΡΡΡ
, ΡΠΎΡΡΠ°Π²ΠΈΠ²ΡΠΈΡ
44,6%; 65,2%; 67,6% ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. Π‘ΡΠ΅Π΄ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΠΠ, ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΡ
ΡΠΎΠ»ΡΠΊΠΎ ΡΠΊΡΡΡΠ΅Π½Π½ΡΡ ΡΠ΅ΡΠΎΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΡ, ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΎΡΠ½ΡΡ
(27,2%), ΠΌΠ΅Π½ΠΈΠ½Π³Π΅Π°Π»ΡΠ½ΡΡ
(21,4%) ΠΈ ΠΎΡΠ°Π³ΠΎΠ²ΡΡ
ΡΠΎΡΠΌ (29,5%) ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ ΡΠ°ΡΠ΅, ΡΠ΅ΠΌ Π² Π³ΡΡΠΏΠΏΠ΅ ΠΏΡΠΈΠ²ΠΈΡΡΡ
, Π½ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ΅ΠΆΠ΅, ΡΠ΅ΠΌ Ρ Π½Π΅ ΠΏΡΠΈΠ²ΠΈΡΡΡ
. ΠΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Ρ Π²Π°ΠΊΡΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΡ
ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ ΠΏΠΎΡΠ»Π΅ ΡΠΊΡΡΠ° ΠΊΠ»Π΅ΡΠ°, ΠΌΠ΅Π½ΠΈΠ½Π³Π΅Π°Π»ΡΠ½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΠΠ ΡΠ°Π·Π²ΠΈΠ²Π°Π»ΠΈΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ΅ΠΆΠ΅ (0,9%), ΡΠ΅ΠΌ Ρ Π²Π°ΠΊΡΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π»ΠΈΡ Π±Π΅Π· ΡΠΊΡΡΡΠ΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠΎΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ (12,5%). ΠΠ°ΠΊΡΠΈΠ½Π°ΡΠΈΡ β Π±Π΅Π·Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΡΠΉ ΡΠΏΠΎΡΠΎΠ± Π°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΠΠ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΡΠ΅Π±ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΊ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡΠΌ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠΎΠΊΠ° ΡΠ΅Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΠΈ ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΡΠΈΡΡΠ° Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π²ΠΈΡΡΡΡ ΠΠΠ Ρ ΠΏΡΠΈΠ²ΠΈΡΡΡ
Dependence of atomic parity-violation effects on neutron skins and new physics
We estimate the relative contribution of nuclear structure and new physics
couplings to the parity non-conserving spin-independent effects in atomic
systems, for both single isotopes and isotopic ratios. General expressions are
presented to assess the sensitivity of isotopic ratios to neutron skins and to
couplings beyond standard model at tree level. The specific coefficients for
these contributions are calculated assuming Fermi distribution for proton and
neutron nuclear densities for isotopes of Cs, Ba, Sm, Dy, Yb, Pb, Fr, and Ra.
The present work aims to provide a guide to the choice of the best isotopes and
pairs of isotopes for conducting atomic PNC measurements.Comment: 11 pages, 2 figures, 3 table
A composite dislocation cell model to describe strain path change effects in BCC metals
Sheet metal forming processes are within the core of many modern manufacturing technologies, as applied in, e.g., automotive and packaging industries. Initially flat sheet material is forced to transform plastically into a three-dimensional shape through complex loading modes. Deviation from a proportional strain path is associated with hardening or softening of the material due to the induced plastic anisotropy resulting from the prior deformation. The main cause of these transient anisotropic effects at moderate strains is attributed to the evolving underlying dislocation microstructures. In this paper, a composite dislocation cell model, which explicitly describes the dislocation structure evolution, is combined with a BCC crystal plasticity framework to bridge the microstructure evolution and its macroscopic anisotropic effects. Monotonic and multi-stage loading simulations are conducted for a single crystal and polycrystal BCC metal, and the obtained macroscopic results and dislocation substructure evolution are compared qualitatively with the published experimental observations.Mechanical, Maritime and Materials Engineerin