Iron deficiency in pulmonary hypertension: from observation to intervention

Vonk Noordegraaf, A. [Promotor]Laarse, W.J. van der [Copromotor]Handoko-Man, F.S. de [Copromotor

The LISA Gravitational Wave Foreground: A Study of Double White Dwarfs

Double white dwarfs are expected to be a source of confusion-limited noise for the future gravitational wave observatory LISA. In a specific frequency range, this 'foreground noise' is predicted to rise above the instrumental noise and hinder the detection of other types of signals, e.g., gravitational waves arising from stellar mass objects inspiraling into massive black holes. In many previous studies only detached populations of compact object binaries have been considered in estimating the LISA gravitational wave foreground signal. Here, we investigate the influence of compact object detached and Roche-Lobe Overflow Galactic binaries on the shape and strength of the LISA signal. Since >99% of remnant binaries which have orbital periods within the LISA sensitivity range are white dwarf binaries, we consider only these binaries when calculating the LISA signal. We find that the contribution of RLOF binaries to the foreground noise is negligible at low frequencies, but becomes significant at higher frequencies, pushing the frequency at which the foreground noise drops below the instrumental noise to >6 mHz. We find that it is important to consider the population of mass transferring binaries in order to obtain an accurate assessment of the foreground noise on the LISA data stream. However, we estimate that there still exists a sizeable number (~11300) of Galactic double white dwarf binaries which will have a signal-to-noise ratio >5, and thus will be potentially resolvable with LISA. We present the LISA gravitational wave signal from the Galactic population of white dwarf binaries, show the most important formation channels contributing to the LISA disc and bulge populations and discuss the implications of these new findings.Comment: ApJ accepted. 28 pages, 11 figures (low resolution), 5 tables, some new references and changed content since last astro-ph versio

Progenitors of Supernovae Type Ia

Despite the significance of Type Ia supernovae (SNeIa) in many fields in astrophysics, SNeIa lack a theoretical explanation. The standard scenarios involve thermonuclear explosions of carbon/oxygen white dwarfs approaching the Chandrasekhar mass; either by accretion from a companion or by a merger of two white dwarfs. We investigate the contribution from both channels to the SNIa rate with the binary population synthesis (BPS) code SeBa in order to constrain binary processes such as the mass retention efficiency of WD accretion and common envelope evolution. We determine the theoretical rates and delay time distribution of SNIa progenitors and in particular study how assumptions affect the predicted rates.Comment: 6 pages, 6 figures, appeared in proceedings for "The 18th European White Dwarf Workshop

The ATESP 5 GHz radio survey. II. Physical properties of the faint radio population

One of the most debated issues about sub-mJy radio sources, which are responsible for the steepening of the 1.4 GHz source counts, is the origin of their radio emission. Particularly interesting is the possibility of combining radio spectral index information with other observational properties to assess whether the sources are triggered by star formation or nuclear activity. The aim of this work is to study the optical and near infrared properties of a complete sample of 131 radio sources with S>0.4 mJy, observed at both 1.4 and 5 GHz as part of the ATESP radio survey. We use deep multi-colour (UBVRIJK) images, mostly taken in the framework of the ESO Deep Public Survey, to optically identify and derive photometric redshifts for the ATESP radio sources. Deep optical coverage and extensive colour information are available for 3/4 of the region covered by the radio sample. Typical depths of the images are U~25, B~26, V~25.4, R~25.5, I~24.3, 19.5<K_s<20.2, J<22.2. Optical/near infrared counterparts are found for ~78% (66/85) of the radio sources in the region covered by the deep multi-colour imaging, and for 56 of these reliable estimates of the redshift and type are derived. We find that many of the sources with flat radio spectra are characterised by high radio-to-optical ratios (R>1000), typical of classical powerful radio galaxies and quasars. Flat-spectrum sources with low R values are preferentially identified with early type galaxies, where the radio emission is most probably triggered by low-luminosity active galactic nuclei. Considering both early type galaxies and quasars as sources with an active nucleus, such sources largely dominate our sample (78%). Flat-spectrum sources associated with early type galaxies are quite compact (d<10-30 kpc), suggesting core-dominated radio emission.Comment: 15 pages, 13 figures, accepted for pubblication in A&

The ATESP Radio Survey II. The Source Catalogue

This paper is part of a series reporting the results of the Australia Telescope ESO Slice Project (ATESP) radio survey obtained at 1400 MHz with the Australia Telescope Compact Array (ATCA) over the region covered by the ESO Slice Project (ESP) galaxy redshift survey. The survey consists of 16 radio mosaics with ~8"x14" resolution and uniform sensitivity (1sigma noise level ~79 microJy) over the whole area of the ESP redshift survey (~26 sq. degrees at decl. -40 degr). Here we present the catalogue derived from the ATESP survey. We detected 2960 distinct radio sources down to a flux density limit of ~0.5 mJy (6sigma), 1402 being sub-mJy sources. We describe in detail the procedure followed for the source extraction and parameterization. The internal accuracy of the source parameters was tested with Monte Carlo simulations and possible systematic effects (e.g. bandwidth smearing) have been quantified.Comment: 14 pages, 14 Postscript figures, Accepted for publication in A&A Suppl. Corrected typos and added Journal Referenc

Comparison of LISA and Atom Interferometry for Gravitational Wave Astronomy in Space

One of the atom interferometer gravitational wave missions proposed by Dimopoulos et al.1 in 2008 was called AGIS-Sat. 2. It had a suggested gravitational wave sensitivity set by the atom state detection shot noise level that started at 1 mHz, was comparable to LISA sensitivity from 1 to about 20 mHz, and had better sensitivity from 20 to 500 mHz. The separation between the spacecraft was 1,000 km, with atom interferometers 200 m long and shades from sunlight used at each end. A careful analysis of many error sources was included, but requirements on the time-stability of both the laser wavefront aberrations and the atom temperatures in the atom clouds were not investigated. After including these considerations, the laser wavefront aberration stability requirement to meet the quoted sensitivity level is about 1\times10-8 wavelengths, and is far tighter than for LISA. Also, the temperature fluctuations between atom clouds have to be less than 1 pK. An alternate atom interferometer GW mission in Earth orbit called AGIS-LEO with 30 km satellite separation has been suggested recently. The reduction of wavefront aberration noise by sending the laser beam through a high-finesse mode-scrubbing optical cavity is discussed briefly, but the requirements on such a cavity are not given. Unfortunately, such an Earth-orbiting mission seems to be considerably more difficult to design than a non-geocentric mission and does not appear to have comparably attractive scientific goals.Comment: Submitted to Proc. 46th Rencontres de Moriond: Gravitational Waves and Experimental Gravity, March 20 - 27, 2011, La Thuile, Ital

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression

Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of postsynaptic serotonin-1A (5-HT1A) receptors, both in receptor binding and in mRNA levels, in the aggressive line. The aim of this experiment was to study whether similar differences in 5-HT1A receptors exist in individuals from a random-bred rat strain, varying in aggressiveness. In addition, because little is known about the functional consequences of these receptor differences, a response mediated via postsynaptic 5-HT1A receptors (i.e., hypothermia) was studied both in the selection lines of mice and in the randomly bred rats. The difference in receptor binding, as demonstrated in mice previously, could not be shown in rats. However, both in rats and mice, the hypothermic response to the 5-HT1A agonist alnespirone was larger in aggressive individuals. So, in the rat strain as well as in the mouse lines, there is, to a greater or lesser extent, an enhanced sensitivity of postsynaptic 5-HT1A receptors in aggressive individuals. This could be a compensatory up-regulation induced by a lower basal 5-HT neurotransmission, which is in agreement with the serotonin deficiency hypothesis of aggression.