Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization (WHO) the number of adults living with diabetes is expected to increase. Since type 2 diabetes mellitus (T2DM) is suffered by the majority of diabetic patients (around 90-95%) and often the mono-target therapy fails in managing blood glucose levels and the other comorbidities, this review focuses on the potential drugs acting on multi-targets involved in the treatment of this type of diabetes. In particular, the review considers the main systems directly involved in T2DM or involved in diabetes comorbidities. Agonists acting on incretin, glucagon systems, as well as on peroxisome proliferation activated receptors are considered. Inhibitors which target either aldose reductase and tyrosine phosphatase 1B or sodium glucose transporters 1 and 2 are taken into account. Moreover, with a view at the multi-target approaches for T2DM some phytocomplexes are also discussed

Torrefaction of residues and by-products from sunflower chain

The high heterogeneity of some residual biomasses makes rather difficult their energy use and standardisation is a key aspect for these fuel products. Torrefaction is an interesting process used to improve the quality of ligno-cellulosic biomasses and to achieve standardisation. In the present study torrefaction has been employed on residues and by-products deriving from sunflower production chain, in particular sunflower stalks and oil press cake. The thermal behaviour of materials has been studied at first by thermo-gravimetric analysis in order to identify torrefaction temperatures range. Different residence time and torrefaction temperatures have been employed in a bench top torrefaction reactor afterwards. Analyses of raw and torrefied materials have been carried out to assess the influence of the process. As a consequence of torrefaction, the carbon and ash contents increase while the volatilisation range is reduced making the material more stable and standardised. Mass yield, energy yield and energy densification reach values of about 60 %, 80 % and 1.33 for sunflower stalks and 64 %, 85 % and 1.33 for sunflower oil press cake respectively. As highlighted by results, torrefaction is more interesting for sunflower stalks than oil cake and husks because of the different starting characteristics. Untreated oil cake and husks already show a good high heating value and the eventual torrefaction should be mild. On the contrary for sunflower stalks the process is more useful and could be more severe

Variations in some of the body fluid hormone levels currently used for endocrine monitoring during the third trimester of pregnancy

Peer Reviewe

Combining molecular dynamics and docking simulations to develop targeted protocols for performing optimized virtual screening campaigns on the HTRPM8 channel

Background: There is an increasing interest in TRPM8 ligands of medicinal interest, the rational design of which can be nowadays supported by structure-based in silico studies based on the recently resolved TRPM8 structures. Methods: The study involves the generation of a reliable hTRPM8 homology model, the reliability of which was assessed by a 1.0 \u3bcs MD simulation which was also used to generate multiple receptor conformations for the following structure-based virtual screening (VS) campaigns; docking simulations utilized different programs and involved all monomers of the selected frames; the so computed docking scores were combined by consensus approaches based on the EFO algorithm. Results: The obtained models revealed very satisfactory performances; LiGen\u2122 provided the best results among the tested docking programs; the combination of docking results from the four monomers elicited a markedly beneficial effect on the computed consensus models. Conclusions: The generated hTRPM8 model appears to be amenable for successful structure-based VS studies; cross-talk modulating effects between interacting monomers on the binding sites can be accounted for by combining docking simulations as performed on all the monomers; this strategy can have general applicability for docking simulations involving quaternary protein structures with multiple identical binding pockets

Life cycle assessment of protected strawberry productions in central Italy

Agricultural activities in Europe cover half of the total area of the continent and are simultaneously a cause of environmental impact and victims of the same impact. Horticultural or fruit crops are considered highly intensive and often employ many crop inputs such as fertilizers, pesticides, and various materials. Strawberry falls into this group, and it has grown in acreage and production more than others globally. The aim of this study is to compare the environmental impact of two strawberry cultivation systems in central Italy, a mulched soil tunnel and a soilless tunnel system. The method used to assess the impact is LCA, widely applied in agriculture and supported by international standards. The data used are mainly primary, related to 2018, and representative of the cultivation systems of central Italy. For impact assessment, the method selected was the CML_IA baseline version. From the results obtained, the two systems show a similar impact per kg of strawberries produced (e.g., for global warming: 0.785 kg CO2 eq for soilless, 0.778 kg CO2 eq for mulched soil tunnel). Reduced differences can be observed for the use of crop inputs (greater for the tunnel) and the use of materials and technology (greater for soilless). The mitigation measures considered concern the replacement of the packaging (excluding plastic) and the growing medium of the soilless using perlite and compost from insect breeding

[Measuring change in rehabilitative cardiology: reliability of a short questionnaire to assess an outcome].

The present Italian health planning demands the use of tools, care and treatments useful for the National Health Service, but with empirical effectiveness scientifically sustained. Aim of the present paper is to verify the validity, the reliability and the responsiveness of the factor "Perception of positive change" (named Schedule C) in cardiovascular rehabilitation. Method. The reliability of the Schedule C of the CBA VE has been examined comparing the mean scores obtained from each item at the entry and just before the discharge through the t-Student for paired sample. To assess the concurrent validity we used the AD Short Scale to measure anxiety and depression. 100 patients who underwent cardiac surgery were enrolled during hospitalization for a Cardiac Rehabilitation Programme. Cronbach's alpha was used to assess internal consistency of each item. Results. Each item of the Schedule C demonstrated good internal consistency (Cronbach Alpha >.88) and elevated correlations item-total for each item. The strong correlation of anxiety and depression scores with the Schedule C points out appropriate concurrent validation. Conclusions. We believe that the Schedule C of the CBA VE is endowed with suitable metric validity and then useful as outcome evaluation in cardiovascular rehabilitation settings

Performance Analysis of a Novel Air-based Cavity Receiver

AbstractIn this paper a new design of a novel CSP cavity receiver for parabolic trough collector is analyzed by means of an analytical Matlab model. The receiver, designed by the Swiss company Airlight Energy Manufacturing SA, is 212 m long consisting essentially of a feed pipe, a run-back pipe and 4608 helically coiled heat exchangers designed to capture the incident solar energy concentrated by a parabolic trough. The heat transfer fluid is air heated to temperatures above 600°C.The analytical Matlab model based on a pneumatic - electric circuit analogy was developed to assess the receiver performance in terms of mass flow rate distribution, pressure drop, air outlet temperature and thermal efficiency. A solution was proposed to approximately ensure the same mass flow rate for each cavity.Different skew angles for the incoming solar radiation were considered and the receiver geometry was optimized minimizing the pressure drop and the thermal losses through the runback pipe. The main requirement was to achieve, at the outlet section of the receiver, an air temperature of 650°C; therefore, the total inlet mass flow rate was tuned accordingly.The helically coiled heat exchanger and the receiver insulation sub-models were validated against accurate computational fluid dynamics simulations