36 research outputs found
Morphology of the earliest reconstructable tetrapod Parmastega aelidae.
- Author
- A Gelman
- CR Congreve
- D Chen
- E Jarvik
- E LukĆĄeviÄs
- EB Daeschler
- EB Daeschler
- EB Daeschler
- EB Daeschler
- EI Vorobyeva
- ErvÄ«ns LukĆĄeviÄs
- F Ronquist
- G Clément
- G Clément
- G NiedĆșwiedzki
- G SÀve-Söderbergh
- GT Lloyd
- H Blom
- H-P Schultze
- I Stössel
- J Felsenstein
- JA Clack
- JA Clack
- JA Clack
- JA Clack
- JA Clack
- JA Clack
- JA Clack
- Jennifer A. Clack
- JP Downs
- JS Farris
- KSW Campbell
- LB Porro
- M Wilkinson
- M Wilkinson
- M Zhu
- MA MacIver
- Marcello Ruta
- MD Brazeau
- MI Coates
- MI Coates
- MI Coates
- NH Shubin
- NH Shubin
- OA Lebedev
- OA Lebedev
- OA Lebedev
- OA Lebedev
- P Beznosov
- PA Goloboff
- Pavel A. Beznosov
- PE Ahlberg
- PE Ahlberg
- PE Ahlberg
- PE Ahlberg
- PE Ahlberg
- PE Ahlberg
- PE Ahlberg
- PE Ahlberg
- Per Erik Ahlberg
- R Gess
- S Olive
- S Sanchez
- V Callier
- Publication venue
- Nature
- Publication date
- 01/10/2019
- Field of study
The known diversity of tetrapods of the Devonian period has increased markedly in recent decades, but their fossil record consists mostly of tantalizing fragments1-15. The framework for interpreting the morphology and palaeobiology of Devonian tetrapods is dominated by the near complete fossils of Ichthyostega and Acanthostega; the less complete, but partly reconstructable, Ventastega and Tulerpeton have supporting roles2,4,16-34. All four of these genera date to the late Famennian age (about 365-359 million years ago)-they are 10 million years younger than the earliest known tetrapod fragments5,10, and nearly 30 million years younger than the oldest known tetrapod footprints35. Here we describe Parmastega aelidae gen. et sp. nov., a tetrapod from Russia dated to the earliest Famennian age (about 372 million years ago), represented by three-dimensional material that enables the reconstruction of the skull and shoulder girdle. The raised orbits, lateral line canals and weakly ossified postcranial skeleton of P. aelidae suggest a largely aquatic, surface-cruising animal. In Bayesian and parsimony-based phylogenetic analyses, the majority of trees place Parmastega as a sister group to all other tetrapods
Simple Nudges for Better Password Creation
- Author
- Acquisti A Adjerid I, Balebako R, Brandimarte L, Cranor L, Komanduri S, Wilson S
- Angeli A Coutts M, Coventry L, Johnson G, Cameron D, Fischer M
- Blythe J Coventry L, Little L
- Bonneau J
- Bonneau J Preibusch S
- Boss S Kirsch L, Angermeier I, Shingler R, Boss R
- Chiasson S Forget A, Biddle R, van Oorschot P
- Dhamija R Perrig A
- Dunphy P Nicholson J, Olivier P
- Dunphy P Olivier P
- Dunphy P Yan J
- Egelman S Sotirakopoulos A, Muslukhov I, Beznosov K, Herley C
- Florencio D Herley C, Oorschot P
- Forget A Chiasson S, Van Oorschot P, Biddle R
- Gaw S Felten E
- Government Communications Headquarters
- Grawemeyer B Johnson H
- Isola P Xiao J, Torralba A, Oliva A
- Ives B Walsh K, Schneider H
- Just M Aspinall D
- Komanduri S Shay R, Kelley P, Mazurek M, Bauer L, Christin N, Egelman S
- Kovach S
- Maddux J Rogers R
- Mason W Watts D
- Nelson D Vu K
- Newswire P
- Nicholson J Briggs P, Coventry L
- Nicholson J Coventry L, Briggs P
- Nicholson J Coventry L, Briggs P
- Pagliery J
- Paul I
- Renaud K Just M
- Renaud K McBryan A, Siebert P
- Shay R Cranor L, Komanduri S, Durity A, Huh P, Mazurek M, Christin N
- Shay R Kelley P, Komanduri S, Mazurek M, Ur B, Vidas T, Cranor L
- Shay R Kelley P, Komanduri S, Mazurek M, Ur B, Vidas T, Cranor L
- Shay R Kelley P, Leon P, Mazurek M, Christin N, Cranor L
- Stubblefield A Simon D
- Turland J Coventry L, Jeske D, Briggs P, van Moorsel A
- Ur B Kelley P, Komanduri S, Lee J, Maass M, Mazurek M, Cranor L
- Ur B Noma F, Bees J, Segreti S, Shay R, Bauer L, Cranor L
- van Oorschot P Salehi-Abari A, Thorpe J
- Vijayan J
- Weir M Aggarwal S, Collins M, Stern H
- Yan J Blackwell A, Anderson R
- Zakrzewski C
- Publication venue
- Publication date
- 06/07/2018
- Field of study
Recent security breaches have highlighted the consequences of reusing passwords across online accounts. Recent guidance on password policies by the UK government recommend an emphasis on password length over an extended character set for generating secure but memorable passwords without cognitive overload. This paper explores the role of three nudges in creating website-specific passwords: financial incentive (present vs absent), length instruction (long password vs no instruction) and stimulus (picture present vs not present). Mechanical Turk workers were asked to create a password in one of these conditions and the resulting passwords were evaluated based on character length, resistance to automated guessing attacks, and time taken to create the password. We found that users created longer passwords when asked to do so or when given a financial incentive and these longer passwords were harder to guess than passwords created with no instruction. Using a picture nudge to support password creation did not lead to passwords that were either longer or more resistant to attacks but did lead to account-specific passwords
HE-LHC: The High-Energy Large Hadron Collider â Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Ahnen J. von
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- AlĂa R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- ApolinĂĄrio L.
- Apollinari G.
- Apollonio A.
- Appelö D.
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- Publication venue
- Springer Verlag
- Publication date
- 09/02/2021
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-ee: The Lepton Collider â Future Circular Collider Conceptual Design Report Volume 2
- Author
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- Abbrescia M.
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- Zhao Z.
- Zhong Y. -M.
- Zhou D.
- Zhou J.
- Zhuang P.
- Zick G.
- Zimmermann F.
- Zinn-Justin J.
- Zivkovic L.
- Zlobin A. V.
- Zobov M.
- Zupan J.
- Zurita J.
- Ăzcan V.
- Ăzdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 14/11/2019
- Field of study
Effects of N-Glycosylation Site Removal in Archaellins on the Assembly and Function of Archaella in Methanococcus maripaludis
- Author
- A Ghosh
- A Larkin
- A Paiment
- Alison Berezuk
- B Chaban
- B Chaban
- BA Stocker
- BC Moore
- BH Meyer
- BH Meyer
- BH Meyer
- BH Meyer
- BS Wojczyk
- C Josenhans
- C Papworth
- Cezar M. Khursigara
- CL Giltner
- CP Ewing
- DJ Vandyke
- DL Tumbula
- E Peyfoon
- E Weerapana
- F Taguchi
- F Taguchi
- F Wieland
- Frederique Lisacek
- G Kuwajima
- GM Jones
- H Asakura
- H Harvey
- H Nothaft
- H Nothaft
- H Towbin
- J Dubuisson
- J Eichler
- J Kelly
- J Keswani
- JA Leigh
- James P. J. Chong
- JG Smedley 3rd
- K Lassak
- K Yamaguchi
- Kaoru Uchida
- Kathleen Murphy
- Ken F. Jarrell
- KF Jarrell
- KF Jarrell
- KF Jarrell
- KF Jarrell
- KF Jarrell
- L Kaminski
- L Kaminski
- L Kaminski
- LC Nguyen
- M Abu-Qarn
- M Abu-Qarn
- M Aebi
- M Pohlschroder
- M Schirm
- M Tripepi
- M Tripepi
- ML Kalmokoff
- NA Thomas
- P Burda
- P Castric
- R Shahapure
- RE Corder
- S Cohen-Krausz
- S Merino
- S Trachtenberg
- S Voisin
- S Yurist-Doutsch
- S Yurist-Doutsch
- Shin-Ichi Aizawa
- SL Bardy
- SL Bardy
- SM Logan
- SN Beznosov
- SV Albers
- SYM Ng
- TJ Kirn
- WE Balch
- WL Gardner
- Y Ding
- Yan Ding
- Z Guan
- Z Yang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 20/02/2015
- Field of study
In Methanococcus maripaludis S2, the swimming organelle, the archaellum, is composed of three archaellins, FlaB1S2, FlaB2S2 and FlaB3S2. All three are modified with an N-linked tetrasaccharide at multiple sites. Disruption of the N-linked glycosylation pathway is known to cause defects in archaella assembly or function. Here, we explored the potential requirement of N-glycosylation of archaellins on archaellation by investigating the effects of eliminating the 4 N-glycosylation sites in the wildtype FlaB2S2 protein in all possible combinations either by Asn to Glu (N to Q) substitution or Asn to Asp (N to D) substitutions of the N-glycosylation sequon asparagine. The ability of these mutant derivatives to complement a non-archaellated ÎflaB2S2 strain was examined by electron microscopy (for archaella assembly) and swarm plates (for analysis of swimming). Western blot results showed that all mutated FlaB2S2 proteins were expressed and of smaller apparent molecular mass compared to wildtype FlaB2S2, consistent with the loss of glycosylation sites. In the 8 single-site mutant complements, archaella were observed on the surface of Q2, D2 and D4 (numbers after N or Q refer to the 1st to 4th glycosylation site). Of the 6 double-site mutation complementations all were archaellated except D1,3. Of the 4 triple-site mutation complements, only D2,3,4 was archaellated. Elimination of all 4 N-glycosylation sites resulted in non-archaellated cells, indicating some minimum amount of archaellin glycosylation was necessary for their incorporation into stable archaella. All complementations that led to a return of archaella also resulted in motile cells with the exception of the D4 version. In addition, a series of FlaB2S2 scanning deletions each missing 10 amino acids was also generated and tested for their ability to complement the ÎflaB2S2 strain. While most variants were expressed, none of them restored archaellation, although FlaB2S2 harbouring a smaller 3-amino acid deletion was able to partially restore archaellation
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
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- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appelo D
- Appleby RB
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- Arduini G
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- Armesto N
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- Azatov A
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- Baker MJ
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with todayâs technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
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- Ahnen JV
- Aiba M
- Aichinger I
- Aielli G
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- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
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- Alexahin Y
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- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
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- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
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- Zick G
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- Zobov M
- Zupan J
- Zurita J
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
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- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
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- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
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- Azzolini O
- Azzurri P
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- Baek YW
- Baglin V
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- Baker MJ
- Baldwin MJ
- Ball AH
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- Barber DP
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- de Vivie de Regie JB
- Deandrea A
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- Dubovyk I
- Duda P
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- Eskola KJ
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- Falkowski A
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- Fawcett WJ
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- Fiorendi S
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- Yao W-M
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- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
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- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
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- Zhang Z
- Zhao Z
- Zhong Y-M
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- Zinn-Justin J
- Zivkovic L
- Zlobin AV
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- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
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- Appeloe D
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- Avino F
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- Ball AH
- Ballarino A
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- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
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- Bellafont I
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- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
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- Bernet C
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- Bishara F
- Blanco-Garcia OR
- Blanquez FR
- Blekman F
- Blondel A
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- Boland MJ
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- Bonvini M
- Boos E
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- Boscherini D
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- Bosley RR
- Bossu F
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- Costa Pinto P
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- da Silveira GG
- Dachauer C
- Daibo M
- Dainese A
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- Dam M
- Das SP
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- David A
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- de Florian D
- de Jong SJ
- De Lucia E
- De Renstrom P Brueckman
- de Rijk G
- De Roeck A
- de Vivie de Regie JB
- Deandrea A
- Debono CJ
- Deghaye S
- Del Bo C
- Del Duca V
- Delikaris D
- Deliot F
- Dell'Acqua A
- Delle Rose L
- Delmastro M
- Demarteau M
- Denegri D
- Deniau L
- Denisov D
- Denizli H
- Denner A
- Derue F
- Deschamps O
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- Dev PSB
- Dewanjee RK
- Di Ciaccio A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries