Adeno-Associated Viral Vectors in Neuroscience Research

Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neurocircuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences

Evolution of suprathermal seed particle and solar energetic particle abundances

We report on a survey of the composition of solar-wind suprathermal tails and solar energetic particles (SEPs) including data from 1998 to 2010, with a focus on 2007 to 2010. The start of solar cycle 24 included several SEP events that were unusually He-poor. We conclude that these He-poor events are more likely related to Q/M-dependent spectral variations than to seed-particle composition changes. We also find that the quiet-time suprathermal Fe/O ratio during the 2008-2009 solar-minimum was dramatically lower (Fe/O ≤ 0.01) than earlier due in part to very low solar activity, but also suggesting contributions from an oxygen-rich source of suprathermal ions of unknown origin

Solar Energetic Particle Spectral Breaks

The five large solar particle events during October–November 2003 presented an opportunity to test shock acceleration models with in-situ observations. We use solar particle spectra of H to Fe ions, measured by instruments on ACE, SAMPEX, and GOES-11, to investigate the Q/M-dependence of spectral breaks in the 28 October 2003 event. We find that the break energies scale as (Q/M)^b with b ≈ 1.56 to 1.75, somewhat less than predicted. We also conclude that SEP spectra >100 MeV/nucleon are best fit by a double power-law shape. ©2005 American Institute of Physic

Radiation risks from large solar energetic particle events

Solar energetic particles (SEPs) constitute a radiation hazard to both humans and hardware in space. Over the past few years there have been significant advances in our knowledge of the composition and energy spectra of SEP events, leading to new insights into the conditions that contribute to the largest events. This paper summarizes the energy spectra and frequency of large SEP events, and discusses the interplanetary conditions that affect the intensity of the largest events

Isolation and Phase-Space Energization Analysis of the Instabilities in Collisionless Shocks

We analyze the generation of kinetic instabilities and their effect on the energization of ions in non-relativistic, oblique collisionless shocks using a 3D-3V simulation by $\texttt{dHybridR}$, a hybrid particle-in-cell code. At sufficiently high Mach number, quasi-perpendicular and oblique shocks can experience rippling of the shock surface caused by kinetic instabilities arising from free energy in the ion velocity distribution due to the combination of the incoming ion beam and the population of ions reflected at the shock front. To understand the role of the ripple on particle energization, we devise the new instability isolation method to identify the unstable modes underlying the ripple and interpret the results in terms of the governing kinetic instability. We generate velocity-space signatures using the field-particle correlation technique to look at energy transfer in phase space from the isolated instability driving the shock ripple, providing a viewpoint on the different dynamics of distinct populations of ions in phase space. We generate velocity-space signatures of the energy transfer in phase space of the isolated instability driving the shock ripple using the field-particle correlation technique. Together, the field-particle correlation technique and our new instability isolation method provide a unique viewpoint on the different dynamics of distinct populations of ions in phase space and allow us to completely characterize the energetics of the collisionless shock under investigation.Comment: 32 pages, 14 figures, accepted by the Journal of Plasma Physic

Observations of the longitudinal spread of solar energetic particle events in solar cycle 24

With the twin STEREO spacecraft, significantly separated from L1-based satellites such as ACE, simultaneous multi-point measurements of solar energetic particle (SEP) events can be made for H-Fe ions from a few hundred keV/nuc to over 100 MeV/nuc and for electrons from tens to hundreds of keV. These observations allow studies of the longitudinal characteristics of SEP events to advance beyond statistical analysis of single point measurements. Although there have been few large SEP events thus far in cycle 24, there have been a number of smaller events that have been detected by more than one spacecraft. The composition of these SEP events, as indicated by the H/He and Fe/O abundance ratios, shows a dependence on longitudinal distance from the solar source in some events, at times with ratios varying by an order of magnitude. However, these variations are not organized by either the speed or width of the associated coronal mass ejections

Fe Enhancements in SEP Onsets: Flare/CME Mixture or Transport Effect?

During the onset phases of SEP events, the Fe/O ratio is often observed to be initially enhanced (˜1) over typical SEP values, followed by a decline to values close to typical averages over entire events (Fe/O ˜0.1). Two mechanisms have been suggested to explain this behavior, namely (1) a two-step process with an initial injection of “flare" particles with high Fe/O followed by shock-accelerated particles with lower Fe/O, and (2) a transport effect wherein the lower charge-to-mass ratio of Fe vs. O results in faster transport of Fe to the observer, leading to enhanced Fe/O in the early stages of the event. Distinguishing between these two scenarios is important to building a basic picture of processes taking place in large SEP events. We have carried out a detailed study of 17 large SEP events where energetic particle data were fitted by a state-of-the-art model whose computed time-intensity profiles were compared to the observed profiles of H, He, O, and Fe over a very broad energy range. We find that the observed decrease in Fe/O during the rise phase can be reasonably fitted by the transport model where the differences in Fe vs. O transport are due to the slope of the turbulence spectrum of the interplanetary magnetic field (IMF)

Observations of Solar Energetic Particles from ^3He-rich Events over a Wide Range of Heliographic Longitude

A prevailing model for the origin of ^3He-rich solar energetic particle (SEP) events attributes particle acceleration to processes associated with the reconnection between closed magnetic field lines in an active region and neighboring open field lines. The open field from the small reconnection volume then provides a path along which accelerated particles escape into a relatively narrow range of angles in the heliosphere. The narrow width (standard deviation 60°. We present the observations of the ^3He-rich event of 2010 February 7, which was detected at all three spacecraft when they spanned 136° in heliographic longitude. Measured fluences of ^3He in this event were found to have a strong dependence on longitude which is well fit by a Gaussian with standard deviation ~48° centered at the longitude that is connected to the source region by a nominal Parker spiral magnetic field. We discuss several mechanisms for distributing flare-accelerated particles over a wide range of heliographic longitudes including interplanetary diffusion perpendicular to the magnetic field, spreading of a compact cluster of open field lines between the active region and the source surface where the field becomes radial and opens out into the heliosphere, and distortion of the interplanetary field by a preceding coronal mass ejection. Statistical studies of additional ^3He-rich events detected at multiple spacecraft will be needed to establish the relative importance of the various mechanisms

Influence of diffraction on the spectrum and wavefunctions of an open system

In this paper, we demonstrate the existence and significance of diffractive orbits in an open microwave billiard, both experimentally and theoretically. Orbits that diffract off of a sharp edge of the system are found to have a strong influence on the transmission spectrum of the system, especially in the regime where there are no stable classical orbits. On resonance, the wavefunctions are influenced by both classical and diffractive orbits. Off resonance, the wavefunctions are determined by the constructive interference of multiple transient, nonperiodic orbits. Experimental, numerical, and semiclassical results are presented.Comment: 27 pages, 29 figures, and 3 tables. Submitted to Physical Review E. A copy with higher resolution figures is available at http://monsoon.harvard.edu/~hersch/papers.htm