Devenir en Padres: Un análisis de las prácticas de resistencia de la organización H.I.J.O.S Bogotá

Reseña del artículo "Devenir en padres: un análisis de las prácticas de resistencia de la organización HIJOS Bogotá

A Guide to Evaluate and Diagnose Range Management Programs in Extensive Cattle Ranches

Commonly, range managers and ranchers apply range management principles and practices without a guide, conventional protocol, or a reference frame. This happens because knowledge in education and even in extension or consultant programs is obtained over time in a diversity of ways and, in turn, transmitted or applied in a diversity of methods, according to the experience, academic degree, or organization sense of the rancher himself, or his technician. Existing range management knowledge should be organized and applied in a systematic and conventional way. Medical science provides a good example of systematic management. Patients are “inventoried”, evaluated, diagnosed and treated in this sequence. Their health status is evaluated and classified. Treatment is established to attain objectives and goals. Therapeutic actions are placed on a daily based calendar to attain the referred objectives and goals in a time horizon. The same manner, range management knowledge should be “packaged” in a range management program, as well as the remainder 7 proposed programs (administration, reproduct-ion, health, nutrition, infrastructure, wildlife, and intensive forage production) to inventory, evaluate, diagnose or even to certify all ranch operation plan (Vásquez et al. 2006). According to this idea, a guide based on 50 indicators is proposed to inventory, evaluate, diagnose and classify a specific range management program. The “Los Ángeles” cattle ranch, in northern México, is the reference ranch

Probing neutralino dark matter in the MSSM & the NMSSM with directional detection

We investigate the capability of directional detectors to probe neutralino dark matter in the Minimal Supersymmetric Standard Model and the Next-to-Minimal Supersymmetric Standard Model with parameters defined at the weak scale. We show that directional detectors such as the future MIMAC detector will probe spin dependent dark matter scattering on nucleons that are beyond the reach of current spin independent detectors. The complementarity between indirect searches, in particular using gamma rays from dwarf spheroidal galaxies, spin dependent and spin independent direct search techniques is emphasized. We comment on the impact of the negative results on squark searches at the LHC. Finally, we investigate how the fundamental parameters of the models can be constrained in the event of a dark matter signal.Comment: 21 pages, 16 figure

Homogeneous metallicities and radial velocities for Galactic globular clusters. II. New CaT metallicities for 28 distant and reddened globular clusters

Although the globular clusters in the Milky Way have been studied for a long time, a significant fraction of them lack homogeneous metallicity and radial velocity measurements. In an earlier paper we presented the first part of a project to obtain metallicities and radial velocities of Galactic globular clusters from multiobject spectroscopy of their member stars using the ESO Very Large Telescope. In this paper we add metallicities and radial velocities for a new sample of 28 globular clusters, including in particular globular clusters in the MW halo and the Galactic bulge. Together with our previous results, this study brings the number of globular clusters with homogeneous measurements to $\sim 69$ \% of those listed in the W. Harris' catalogue. As in our previous work, we have used the CaII triplet lines to derive metallicities and radial velocities. For most of the clusters in this study, this is the first analysis based on spectroscopy of individual member stars. The metallicities derived from the CaII triplet are then compared to the results of our parallel study based on spectral fitting in the optical region and the implications for different calibrations of the CaII triplet line strengths are discussed. We also comment on some interesting clusters and investigate the presence of an abundance spread in the globular clusters here. A hint of a possible intrinsic spread is found for NGC 6256, which therefore appears to be a good candidate for further study.Comment: 13 pages, 9 figures, accepted for publication in Astronomy and Astrophysic

Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles

Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/ A/dDt c(lhatbt.pw:/e/dbstc.cloabm.w/seobfst.wcoamre/-stoofotlws aarned-tools and http://teqip.jdvu.ac.in/QSAR_Tools/). SDG. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB. In the present study, we have carried out an extensive structure-activity relationship analysis of a series of 41 aryloxypropanolamine compounds based on three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques. This is the first combined comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) study in a series of selective aryloxypropanolamines displaying anti-diabetes and anti-obesity pharmacological profiles. The best CoMFA and CoMSIA models presented values of r2 ncv = 0.993 and 0.984 and values of r2 test = 0.865 and 0.918, respectively. The results obtained were subjected to extensive external validation (q2, r2, r2 m, etc.) and a final series of compounds was designed and their biological activity was predicted (best pEC50 = 8.561). © 2018 by the authors.https://www.mdpi.com/1420-3049/23/5/119

CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.

BackgroundIdentifying biomarkers for cells harboring replication-competent HIV is a major research priority. Recently, there have been mixed reports addressing the possibility that CD32-expressing T cells are enriched for HIV. There is growing evidence that CD32 expression increases with cellular activation that may be related to, but not necessarily specific for, infection with HIV. However, the relationship of CD32 expression to HIV-infection in subtypes of tissue-resident leukocytes is unclear.MethodsFirst, we used duplex chromogenic in situ hybridization to identify cells actively transcribing RNA for both CD32 and HIV on human gut tissues. Then we performed multiplexed immunofluorescence and in situ hybridization (mIFISH) on sections from the same tissues to determine the phenotype of individual cells co-expressing HIV-RNA and CD32-RNA.ResultsHIV-RNA+ cells were more abundant in tissues from viremic individuals than in those receiving suppressive anti-retroviral therapy (ART). However, staining by both methods indicated that a higher proportion of HIV-RNA+ cells co-expressed CD32-RNA in ART-suppressed individuals than in those with viremia. The majority of HIV-RNA+ cells were CD3+.ConclusionsOur data suggest that the transcription of CD32-RNA is correlated with HIV transcriptional activity in CD3+ cells found within human gut tissue. Whether or not up-regulation of CD32-RNA is a direct result of HIV transcription or more global T-cell activation remains unclear

Overcoming Language Dichotomies: Toward Effective Program Comprehension for Mobile App Development

Mobile devices and platforms have become an established target for modern software developers due to performant hardware and a large and growing user base numbering in the billions. Despite their popularity, the software development process for mobile apps comes with a set of unique, domain-specific challenges rooted in program comprehension. Many of these challenges stem from developer difficulties in reasoning about different representations of a program, a phenomenon we define as a "language dichotomy". In this paper, we reflect upon the various language dichotomies that contribute to open problems in program comprehension and development for mobile apps. Furthermore, to help guide the research community towards effective solutions for these problems, we provide a roadmap of directions for future work.Comment: Invited Keynote Paper for the 26th IEEE/ACM International Conference on Program Comprehension (ICPC'18

How Can Active Region Plasma Escape into the Solar Wind from below a Closed Helmet Streamer?

Recent studies show that active-region (AR) upflowing plasma, observed by the EUV-Imaging Spectrometer (EIS), onboard Hinode, can gain access to open field-lines and be released into the solar wind (SW) via magnetic-interchange reconnection at magnetic null-points in pseudo-streamer configurations. When only one bipolar AR is present on the Sun and it is fully covered by the separatrix of a streamer, such as AR 10978 in December 2007, it seems unlikely that the upflowing AR plasma can find its way into the slow SW. However, signatures of plasma with AR composition have been found at 1 AU by Culhane et al. (2014) apparently originating from the West of AR 10978. We present a detailed topology analysis of AR 10978 and the surrounding large-scale corona based on a potential-field source-surface (PFSS) model. Our study shows that it is possible for the AR plasma to get around the streamer separatrix and be released into the SW via magnetic reconnection, occurring in at least two main steps. We analyse data from the Nan\c{c}ay Radioheliograph (NRH) searching for evidence of the chain of magnetic reconnections proposed. We find a noise storm above the AR and several varying sources at 150.9 MHz. Their locations suggest that they could be associated with particles accelerated during the first-step reconnection process and at a null point well outside of the AR. However, we find no evidence of the second-step reconnection in the radio data. Our results demonstrate that even when it appears highly improbable for the AR plasma to reach the SW, indirect channels involving a sequence of reconnections can make it possible.Comment: 26 pages, 10 figures. appears in Solar Physics, 201