Natural Drugs in DNA Repair

Natural products have been used in medicine right from the ancient civilisation. Natural products are used in many types of diseases, together with chemotherapy and radiotherapy. Many products are used against cancer. Many diseases are genetically derived. The drugs which have the capacity to act at genome level gains significant importance in any disease scenario. The genetic information essential for the identity and function of eukaryotic cells exist in DNA and during the lifetime of the cell DNA can be repeatedly damaged due to different factors. The stability and the fidelity of the replication process are meant to be the most remarkable features of the genetic material. The stability can be affected at any time. Compound which can enhance the DNA repair are applicable in many disease condition. Our study was focussed on the DNA repair enhancing property of a glucan from the macro fungi Ganoderma lucidum. Comet assay and chromosomal aberrations in mouse bone marrow were used as end points of study. Glucan was found to have DNA repair enhancing property in human lymphocytes

Giant pleomorphic adenoma of parotid gland

Salivary gland tumors are rare, comprising less than 3% of all neoplasia of head and neck region. Pleomorphic adenomas are the most common benign neoplasms of the parotid gland. The vast majority are 2-6cms in size, when resected. Untreated pleomorphic adenomas can enlarge in size and weigh several kilograms. There are only few cases of giant pleomorphic adenomas reported in the literature. Here we present one of such case

A study of correlation of expression of ER, PR and HER2/neu receptor status with clinico-pathological parameters in breast carcinoma at a tertiary care centre

Background: In English literature it is documented that the expression of ER and PR is low in Asian countries when compared to that of Western countries. HER2/neu over expression is uniform throughout the world. Studies have shown that triple-negative breast carcinomas are aggressive, likely to spread beyond the breast and recur after treatment. Aims and objectives: To correlate the expression of ER, PR and HER 2/neu with clinico-pathological parameters in infiltrating ductal carcinoma and other variants of breast carcinoma. To determine the clinicopathological parameters in triple negative cases.Methods: This is a prospective study for a period of two years in the Department of Pathology, Andhra Medical College, a tertiary care centre. We received 111 mastectomy specimens during this period out of which 52 patients were funded under Arogyasri and were subjected for ER, PR, HER2/neu receptor study.Results: In the present study total cases analyzed were 52. Infiltrating ductal carcinoma was 41/52 (78.84%) and other variants were 11/52 (21.15%). In our institute infiltrating duct cell carcinoma (NOS) type was the commonest type of carcinoma breast with significant group occurring in less than 45 years of age, 95 % of women were multipara with two or more children and triple negative tumors being 54.83%.In infiltrating ductal carcinoma ER, PR positive expression has no association with age and size of tumor. Their expression was higher in grade 1 tumors 83.3%.The ER,PR negative expression was more in size of tumor being greater than 2 cm; (92.5%),positive lymph nodes (51.8%) and stage II and stage III tumors (96.2%). HER2/neu negative expression was seen in 51.61% of cases. Triple negative receptor expression was seen in 54.83% of infiltrating ductal carcinoma. In the English literature medullary carcinoma is negative for HER2/neu expression but in the present study in 2 cases the expression for HER2/neu was positive.Conclusion: In the present study significant group occurred in less than 45 years of age presenting in advanced stage of the disease. Triple negative cases were seen in 54.8% cases of infiltrating duct cell carcinoma indicating bad prognosis.

4-[(E)-(Hy­droxy­imino)­meth­yl]-N,N-di­methyl­anilinium chloride

In the title compound, C9H13N2O+·Cl−, the cation, apart from the methyl groups, is almost planar, with a maximum deviation of 0.040 (1) Å; the methyl C atoms deviate by 0.389 (2) and −1.247 (1) Å, from the mean plane. In the crystal, cations and anions associate through C—H⋯Cl hydrogen bonds, forming a helical arrangement. In addition, inter­molecular O—H⋯Cl, N—H⋯Cl and C—H⋯N inter­actions are observed

Effect of land configurations and Pongamia mulch on soil moisture content and yield of yellow pericarp sorghum during kharif

The present work aims to determine the effect of land configurations and Pongamia pinnata mulch on soil moisture content and yield of yellow sorghum during kharif, 2018-19 on sandy clay loam soils of Hyderabad. The experiment was conducted at the College of Agriculture, Professor Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad. The treatments included land configurations (Flatbed, Ridge and furrow, Broad bed and furrow, Flatbed + Mulch, Ridge and Furrow + Mulch, Broad bed and furrow + Mulch) and yellow sorghum genotypes (PYPS 101, PYPS 102, PYPS 103 and PYPS 104). Mulch used in this investigation was Pongamia leaf mulch applied @ 6 t ha-1 uniformly at 20 DAS. Soil moisture played a vital role in increasing crop yields in the rainfed regions of the semi-arid tropics. During most crop growth stages, the availability of soil water was increased by Broad bed and furrow + mulch, resulting in increased grain yield by 37 % (1701 kg ha-1) of yellow sorghum over flatbed. Ridge and furrow + mulch were found to be the next best treatment, with a grain yield of 1590 kg ha-1. Mulched treatments of flatbed, ridge and furrow and broad bed and furrow increased the grain yield by 20%, 28% and 37%, respectively, compared to flatbed without mulch. The present study will help in recognizing profitable moisture conservation practices and the role of Pongamia mulch in soil moisture conservation and yield maximization of yellow sorghum

Development of Beneficiation Process for High Alumina Iron Ores of Bellary-Hospet Region

JSW Steel is operating a 4.2 Mtpa capacity Pellet Plant to produce iron oxide pellets from the iron ore fines avail-able in the surrounding Bellary-Hospet region of southern India. Iron ore fines which get generated during mining are soft and rich in alumina with high amount of ultra fines. These characteristics of iron ore fines make it difficult to produce good grade pellets for use in COREX iron making units. Apart from this, high alumina in the pellets increases the slag volume in Corex, which demands additional heat energy, resulting in increased fuel rate. Hence, it was decided to set up a beneficiation plant to reduce the alumina content of the ore fines. Iron ore fines from several sources available in the Bellary- Hospet region were evaluated for their suitability for beneficiation as each source differs in chemistry, particle size distribution and washability characteris-tics. A technique called "Sizewise Washability Technique" was developed to study the washability characteristics of the ore fines to determine the extent of alumina reduction on washing and corresponding yield of concentrate. Iron ore fines from 13 sources were tested and were classified as Preferable, Tolerable and Not- Washable depending on their suitability for beneficiation. Mineralogical studies were also undertaken to understand the liberation characterist-ics of gangue minerals to achieve proper alumina reduction during beneficiation

Improvement and Optimization of Performance of Iron Ore Beneficiation Plant

JSW steel in an integrated steel plant of 2.5 Mtpa crude steel capacity and is being expanded to 10 Mtpa in phases. The plant facilities include 3 Mt Iron Ore Beneficiation Plant, 4.2 Mt Pellet Plant, 1.6 Mt Corex iron making, 0.9 Mt Blast Furnace, 2.5 Mt BOF — CCP and 2 Mt Hot Strip Mill. In order to control alumina in iron ore fines, the iron ore beneficiation plant was installed based on in-house developed process. During its operation of last two years, number of improvements and innovations have been introdu-ced to improve the reduction in alumina, improve yield and reduce moisture of concentrate

Resorcinol ninhydrin complex: 1,5,9-trihy­droxy-8-oxatetra­cyclo­[7.7.0.02,7.010,15]hexa­deca-2,4,6,10(15),11,13-hexaen-16-one

In the title compound, C15H10O5, the cyclo­penta­none (r.m.s. deviation = 0.049 Å) and oxolane (r.m.s. deviation = 0.048 Å) rings make a dihedral angle of 67.91 (4)°. An intra­molecular O—H⋯O hydrogen bond is observed. In the crystal, mol­ecules associate via O—H⋯O hydrogen bonds, forming a three-dimensional network

Resistance Screening of Groundnut Advanced Breeding Lines against Collar Rot and Stem Rot Pathogens

Forty groundnut advanced breeding lines along with susceptible checks JL-24, J-11 and TMV-2 were used for collar rot (Aspergillus niger) and stem rot (Sclerotium rolfsii) disease screening. Based on the per cent number of plants affected by the collar rot pathogen, the advanced breeding lines were categorized into four groups. The lines present in group I (Resistant) having < 15% incidence, group II (Moderately resistant) having 15.1 to 30%, group III (Susceptible) having 30.1 to 45 % and group IV (Highly susceptible) having > 45% incidence. Similarly among 40 breeding lines only three lines (ICGV86699, ICGV91114 and ICGV 89280) have shown stem rot disease reaction below 3 (up to 25 % plants were symptomatic) and considered to be moderately resistant to stem rot pathogen. The advanced breeding line ICGV99058 has recorded a disease reaction of 5 scale (> 50 % of the plants symptomatic) equal to the susceptible checks which is considered to be highly susceptible to stem rot pathogen