The Parasitoid Complex of Forest Tent Caterpillar, \u3ci\u3eMalacosoma Disstria\u3c/i\u3e (Lepidoptera: Lasiocampidae), in Eastern Wyoming Shelterbelts

A parasitoid complex affecting the forest tent caterpillar, Malacosoma disstria, was investigated during 1978-79 in shelterbelts in eastern Wyoming. Egg parasitoids included five species: Ablerus clisiocampae, Ooencyrtus clisiocampae, Telenomus clisiocampae, Tetrastichus sp. 1 and Telenomus sp. Thirteen hymenopterous species and five dipterous species were reared from larvae and pupae of the forest tent caterpillar. The most common 5th-instar larval parasitoids were the tachinid flies, Lespesia archippivora and Archytas lateralis. Of the pupal parasitoids reared, 640/0 were Diptera and 36% were Hymenoptera. Four previously unrecorded parasitoids of M. disstria were reared: Cotesia alalantae, Macrocentrus irridescens, Pimpla sanguinipes erythropus, and Lespesia flavifrons.

An extension of the Markowitz portfolio selection model to include variable transactions' costs, short sales, leverage policies and taxes

Based on the earlier paper, Portfolio selection, in the Journal of finance

An inter-temporal model for investment management,

Based on the author's Doctoral dissertation, An adaptive model for investment management, Carnegie-Mellon University, 1967

Nonlinear Dynamics of Human Aortas for Material Characterization

Evaluating the nonlinear dynamics of human descending thoracic aortas is essential for building the next generation of vascular prostheses. This study characterizes the nonlinear dynamics, viscoelastic material properties, and fluid-structure interaction of 11 ex-vivo human descending thoracic aortas the full range of physiological heart rates. The aortic segments are harvested from heart-beating donors screened for transplants. A mock circulatory loop is developed to reproduce physiological pulsatile pressure and flow. The results show cyclic axisymmetric diameter changes, which are satisfactorily compared to in-vivo measurements at a resting pulse rate of 60 bpm, with an additional bending vibration. An increase of the dynamic stiffness (i.e., storage modulus) with age is also observed. This increase is accompanied by a strong reduction with age of the cyclic diameter change during the heart pulsation at 60 bpm and by a significant reduction of the loss factor (i.e., damping). Large dissipation is observed at higher pulse rates due to the combined effects of fluid-structure interaction and viscoelasticity of the aortic wall. This study presents data necessary for developing innovative grafts that better mimic the dynamics of the aorta

Systemic absorption of oral vancomycin in a peripheral blood stem cell transplant patient with severe graft-versus-host disease of the gastrointestinal tract

Oral vancomycin is often considered the drug of choice for severe Clostridium difficile- associated disease due to both its efficacy and pharmacokinetics. The potential for absorption is not well described in patients with impaired gastrointestinal (GI) mucosa. We describe a case of significant and potentially toxic absorption of oral vancomycin in a peripheral blood stem cell transplant patient with grade IV graft-versus-host disease (GVHD) of the GI tract. In patients with GI GVHD clinicians need to be aware of the potential for oral absorption and, in select cases, monitoring of levels may be appropriate.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74898/1/j.1399-3062.2009.00426.x.pd

In Vitro Assessment of Combined Polymyxin B and Minocycline Therapy against Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae

ABSTRACT The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes with intravenous minocycline-based combination treatments have been reported for infections caused by carbapenemase-producing bacteria. The objective of this study was to evaluate the in vitro activity of polymyxin B and minocycline combination therapy against six KPC-2-producing K. pneumoniae isolates (minocycline MIC range, 2 to 32 mg/liter). Polymyxin B monotherapy (0.5, 1, 2, 4, and 16 mg/liter) resulted in a rapid reduction of up to 6 log in bactericidal activity followed by regrowth by 24 h. Minocycline monotherapy (1, 2, 4, 8, and 16 mg/liter) showed no reduction of activity of >1.34 log against all isolates, although concentrations of 8 and 16 mg/liter prolonged the time to regrowth. When the therapies were used in combination, rapid bactericidal activity was followed by slower regrowth, with synergy (60 of 120 combinations at 24 h, 19 of 120 combinations at 48 h) and additivity (43 of 120 combinations at 24 h, 44 of 120 combinations at 48 h) against all isolates. The extent of killing was greatest against the more susceptible polymyxin B isolates (MICs of ≤0.5 mg/liter) regardless of the minocycline MIC. The pharmacodynamic activity of combined polymyxin B-minocycline therapy against KPC-producing K. pneumoniae is dependent on polymyxin B susceptibility. Further in vitro and animal studies must be performed to fully evaluate the efficacy of this drug combination