Immune function and parasite resistance in male and polymorphic female Coenagrion puella

Background: Colour polymorphisms are widespread and one of the prime examples is the colour polymorphism in female coenagrionid damselflies: one female morph resembles the male colour (andromorph) while one, or more, female morphs are described as typically female (gynomorph). However, the selective pressures leading to the evolution and maintenance of this polymorphism are not clear. Here, based on the hypothesis that coloration and especially black patterning can be related to resistance against pathogens, we investigated the differences in immune function and parasite resistance between the different female morphs and males. Results: Our studies of immune function revealed no differences in immune function between the female morphs but between the sexes in adult damselflies. In an experimental infection females infected shortly after emergence showed a higher resistance against a fungal pathogen than males, however female morphs did not differ in resistance. In a field sample of adult damselflies we did not find differences in infection rates with watermites and gregarines. Conclusion: With respect to resistance and immune function 'andromorph' blue females of Coenagrion puella do not resemble the males. Therefore the colour polymorphism in coenagrionid damselflies is unlikely to be maintained by differences in immunity

Interviewer Effects on Nonresponse

In face-to-face surveys interviewers play a crucial role in making contact with and gaining cooperation from sample units. While some analyses investigate the influence of interviewers on nonresponse, they are typically restricted to single-country studies. However, interviewer training, contacting and cooperation strategies as well as survey climates may differ across countries. Combining call-record data from the European Social Survey (ESS) with data from a detailed interviewer questionnaire on attitudes and doorstep behavior we find systematic country differences in nonresponse processes, which can in part be explained by differences in interviewer characteristics, such as contacting strategies and avowed doorstep behavior.

The scatter and evolution of the global hot gas properties of simulated galaxy cluster populations

We use the cosmo-OWLS suite of cosmological hydrodynamical simulations to investigate the scatter and evolution of the global hot gas properties of large simulated populations of galaxy groups and clusters. Our aim is to compare the predictions of different physical models and to explore the extent to which commonly-adopted assumptions in observational analyses (e.g. self-similar evolution) are violated. We examine the relations between (true) halo mass and the X-ray temperature, X-ray luminosity, gas mass, Sunyaev-Zel'dovich (SZ) flux, the X-ray analogue of the SZ flux ($Y_X$) and the hydrostatic mass. For the most realistic models, which include AGN feedback, the slopes of the various mass-observable relations deviate substantially from the self-similar ones, particularly at late times and for low-mass clusters. The amplitude of the mass-temperature relation shows negative evolution with respect to the self-similar prediction (i.e. slower than the prediction) for all models, driven by an increase in non-thermal pressure support at higher redshifts. The AGN models predict strong positive evolution of the gas mass fractions at low halo masses. The SZ flux and $Y_X$ show positive evolution with respect to self-similarity at low mass but negative evolution at high mass. The scatter about the relations is well approximated by log-normal distributions, with widths that depend mildly on halo mass. The scatter decreases significantly with increasing redshift. The exception is the hydrostatic mass-halo mass relation, for which the scatter increases with redshift. Finally, we discuss the relative merits of various hot gas-based mass proxies.Comment: 31 pages (21 before appendices), 19 figures, 12 tables, accepted by MNRAS after minor revisio

The impact of baryonic processes on the two-point correlation functions of galaxies, subhaloes and matter

The observed clustering of galaxies and the cross-correlation of galaxies and mass provide important constraints on both cosmology and models of galaxy formation. Even though the dissipation and feedback processes associated with galaxy formation are thought to affect the distribution of matter, essentially all models used to predict clustering data are based on collisionless simulations. Here, we use large hydrodynamical simulations to investigate how galaxy formation affects the autocorrelation functions of galaxies and subhaloes, as well as their cross-correlation with matter. We show that the changes due to the inclusion of baryons are not limited to small scales and are even present in samples selected by subhalo mass. Samples selected by subhalo mass cluster ~10% more strongly in a baryonic run on scales r > 1Mpc/h, and this difference increases for smaller separations. While the inclusion of baryons boosts the clustering at fixed subhalo mass on all scales, the sign of the effect on the cross-correlation of subhaloes with matter can vary with radius. We show that the large-scale effects are due to the change in subhalo mass caused by the strong feedback associated with galaxy formation and may therefore not affect samples selected by number density. However, on scales r < r_vir significant differences remain after accounting for the change in subhalo mass. We conclude that predictions for galaxy-galaxy and galaxy-mass clustering from models based on collisionless simulations will have errors greater than 10% on sub-Mpc scales, unless the simulation results are modified to correctly account for the effects of baryons on the distributions of mass and satellites.Comment: 15 pages, 9 figures. Replaced to match the version accepted by MNRA

Ultraviolet Line Emission from Metals in the Low-Redshift Intergalactic Medium

We use a high-resolution cosmological simulation that includes hydrodynamics, multiphase star formation, and galactic winds to predict the distribution of metal line emission at z~0 from the intergalactic medium (IGM). We focus on two ultraviolet doublet transitions, OVI 1032,1038 and CIV 1548,1551. Emission from filaments with moderate overdensities is orders of magnitude smaller than the background, but isolated emission from enriched, dense regions with T~10^5-10^5.5 K and characteristic sizes of 50-100 kpc can be detected above the background. We show that the emission from these regions is substantially greater when we use the metallicities predicted by the simulation (which includes enrichment through galactic winds) than when we assume a uniform IGM metallicity. Luminous regions correspond to volumes that have recently been influenced by galactic winds. We also show that the line emission is clustered on scales ~1 h^-1 Mpc. We argue that although these transitions are not effective tracers of the warm-hot intergalactic medium, they do provide a route to study the chemical enrichment of the IGM and the physics of galactic winds.Comment: replaced by version to appear in ApJ (conclusions unchanged, one new figure), 16 pages (emulateapj), 11 figures, version with higher resolution figures available at http://www.tapir.caltech.edu/~sfurlane/metals/coverpage.htm

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

Hepatic stellate cells (HSCs) known as “master producers” and macrophages as “master regulators”, are the key cell types that strongly contribute to the progression of liver fibrosis. Since Notch signaling regulates multiple cellular processes, we aimed to study the role of Notch signaling in HSCs differentiation and macrophages polarization and to evaluate its implication in liver fibrogenesis. Notch pathway components were found to be significantly upregulated in TGFβ-activated HSCs, inflammatory M1 macrophages, and in mouse and human fibrotic livers. Interestingly, inhibition of Notch using a selective γ-secretase inhibitor, Avagacestat, significantly inhibited TGFβ-induced HSC activation and contractility, and suppressed M1 macrophages. Additionally, Avagacestat inhibited M1 driven-fibroblasts activation and fibroblasts-driven M1 polarization (nitric oxide release) in fibroblasts and macrophages co-culture, and conditioned medium studies. In vivo, post-disease treatment with Avagacestat significantly attenuated fibrogenesis in CCl4-induced liver fibrosis mouse model. These effects were attributed to the reduction in HSCs activation, and inhibition of inflammatory M1 macrophages and upregulation of suppressive M2 macrophages. These findings suggest that Notch signaling plays a crucial role in HSC activation and M1/M2 polarization of macrophages in liver fibrosis. These results provide new insights for the development of novel therapies against liver fibrosis through modulation of Notch signaling