Corridor Talk: Conservation Humanities and the Future of Europe’s National Parks

Corridor Talk: Conservation Humanities and the Future of Europe’s National Parks is a DFG-AHRC funded project at the Rachel Carson Center for Environment and Society at LMU Munich (Germany), and the University of Leeds (UK). The project focuses on three European transboundary national park areas: the Pyrenees, the Bavarian Forest and Šumava, and the Wadden Sea Biosphere Reserve. It uses comparative literature, visual ethnography and environmental history methodologies to connect insights into human culture, values, history, and behaviour that are central to humanities and social sciences research to nature conservation science and practice. It aims to foster a conservation that is more culturally aware, more aware of human behaviour and values, and more aware of the ethical complexities of its work by applying the “corridor talk” metaphor in three ways: to address and support the material ecological corridors that link protected sites; to address and support the symbolic corridors that connect governance and cultural perspectives on protected sites; and to bring humanities research into discussions on nature conservation

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp. has been identified as a candidate target and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from T. brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. 8 compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development

Fusobacterium necrophorum causing infective endocarditis and liver and splenic abscesses

A 25-year-old male without prior co-morbidities was admitted to hospital with Fusobacterium necrophorum bacteremia, where he was found to have liver and splenic abscesses. Further evaluation with echocardiography revealed a bicuspid aortic valve with severe insufficiency and a 1.68 x 0.86 cm vegetation. The patient required abscess drainage, intravenous antimicrobial therapy and aortic valve replacement. Complete resolution of the infection was achieved after valve replacement and a prolonged course of intravenous antimicrobial therapy. A brief analysis of the patient's clinical course and review of the literature is presented

“I’m only a dog!” : the Rwandan genocide, dehumanisation and the graphic novel

Graphic novels written in response to the 1994 Rwandan genocide do not confine their depictions of traumatic violence to humans, but extend their coverage to show how the genocide impacted on animals and the environment. Through analysis of the presentation of people and their relationships with other species across a range of graphic narratives, this article shows how animal imagery was used to justify inhumane actions during the genocide, and argues that representations of animals remain central to the recuperation processes in a post-genocide context too. Whilst novels and films that respond to the genocide have been the focus of scholarly work (Dauge-Roth, 2010), the graphic novel has yet to receive substantial critical attention. This article therefore unlocks the archive of French-, Dutch- and English-language graphic narratives written in response to the genocide by providing the first in-depth, comparative analysis of their animal representations. It draws on recent methodological approaches derived from philosophy (Derrida, [2008] trans. 2009), postcolonial ecocriticism (Huggan and Tiffin, 2010) and postcolonial trauma theory (Craps, 2012) in order show how human-centred strategies for recovery, and associated symbolic orders that forcefully position the animal outside of human law, continue to engender unequal and potentially violent relationships between humans, and humans and other species. In this way, graphic narratives that gesture towards more equitable relationships between humans, animals and the environment can be seen to support the processes of recovery and reconciliation in post-genocide Rwanda