Communications Biophysics

Contains reports on one research project.National Institutes of Health (Grant 2 TO1 GM01555-06

Infrared astronomical satellite (IRAS) catalogs and atlases. Volume 1: Explanatory supplement

The Infrared Astronomical Satellite (IRAS) was launched on January 26, 1983. During its 300-day mission, IRAS surveyed over 96 pct of the celestial sphere at four infrared wavelengths, centered approximately at 12, 25, 60, and 100 microns. Volume 1 describes the instrument, the mission, and data reduction

Role of prostacyclin in pulmonary hypertension

Date of Acceptance: 11/12/2014 This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY-4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive hormones and a disturbance in the balance of these factors leads to cardiovascular disease including pulmonary arterial hypertension. Since it’s discovery in the 1980s concerted efforts have been made to make the best therapeutic utility of prostacyclin, particularly in the treatment of pulmonary arterial hypertension. This has centred on working out the detailed pharmacology of prostacyclin and then synthesising new molecules based on its structure that are more stable or more easily tolerated. In addition, newer molecules have been developed that are not analogues of prostacyclin but that target the receptors that prostacyclin activates. Prostacyclin and related drugs have without doubt revolutionised the treatment and management of pulmonary arterial hypertension but are seriously limited by side effects within the systemic circulation. With the dawn of nanomedicine and targeted drug or stem cell delivery systems it will, in the very near future, be possible to make new formulations of prostacyclin that can evade the systemic circulation allowing for safe delivery to the pulmonary vessels. In this way, the full therapeutic potential of prostacyclin can be realised opening the possibility that pulmonary arterial hypertension will become, if not curable, a chronic manageable disease that is no longer fatal. This review discusses these and other issues relating to prostacyclin and its use in pulmonary arterial hypertensionPeer reviewedFinal Published versio

Electron-electron interaction corrections to the thermal conductivity in disordered conductors

We evaluate the electron-electron interaction corrections to the electronic thermal conductivity in a disordered conductor in the diffusive regime. We use a diagrammatic many-body method analogous to that of Altshuler and Aronov for the electrical conductivity. We derive results in one, two and three dimensions for both the singlet and triplet channels, and in all cases find that the Wiedemann-Franz law is violated.Comment: 8 pages, 2 figures Typos corrected in formulas (15) and (A.4) and Table 1; discussion of previous work in introduction extended; reference clarifying different definitions of parameter F adde

A Wave Function Describing Superfluidity in a Perfect Crystal

We propose a many-body wave function that exhibits both diagonal and off-diagonal long-range order. Incorporating short-range correlations due to interatomic repulsion, this wave function is shown to allow condensation of zero-point lattice vibrations and phase rigidity. In the presence of an external velocity field, such a perfect crystal will develop non-classical rotational inertia, exhibiting the supersolid behavior. In a sample calculation we show that the superfluid fraction in this state can be as large as of order 0.01 in a reasonable range of microscopic parameters. The relevance to the recent experimental evidence of a supersolid state by Chan and Kim is discussed.Comment: final version to be published in Journal of Statistical Mechanics: Theory and Experimen

Bilayer characteristics of a diether phosphonolipid analog of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine.

Thermal and lyotropic phase behavior was studied by X-ray diffraction and differential scanning calorimetry for a diether phosphonolipid analog (DEPN-8) of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine (DPPC). DEPN-8 differs in an ether, rather than an ester, bond at the acyl chain-backbone linkage and a headgroup phosphonate (isosteric methylene substitution) versus phosphate constituent. Analysis of lamellar diffraction maxima demonstrated that at high relative humidity (98%) and temperatures below the liquid crystal phase transition (approximately 45 degrees C), DEPN-8 formed interdigitated bilayers with a characteristic periodicity of 41.9-46.5 A. At low humidity the gel phase DEPN-8 bilayers were characteristic of a normal L beta phase with a periodicity equivalent to DPPC (57-59 A). Above the liquid crystal thermal phase transition, bilayer spacing for both DEPN-8 and DPPC was 51-52 A, characteristic of the L alpha phase. Complete assessments of both lamellar and in-plane X-ray scattering used to construct electron density profiles and structure-factor plots for DEPN-8 defined more fully the interdigitated bilayer state at high humidity and low temperature. Compared to DPPC, it is energetically favorable for DEPN-8 to form interdigitated bilayers under conditions of excess water and low temperature. The flexible character of the ether bonds in DEPN-8 allows increased hydrophobic interactions between acyl chains, without generating a steric penalty from the increased packing density of the molecules. Additionally, the ether bond and the phosphonate moiety may allow for more energetically favorable interactions between the choline portion of the headgroup and water. The DEPN-8 ether linkage may also contribute to the improved adsorption and film respreading found previously for this phosphonolipid compared to DPPC

Unstable Layers in the Mesopause Region Observed with Na Lidar During the Turbulent Oxygen Mixing Experiment (TOMEX) Campaign

The Na wind/temperature lidar located at Starfire Optical Range near Albuquerque, New Mexico, provided real time measurements of wind, temperature, and Na density in the mesopause region during the TOMEX rocket campaign in October 2000. The state of the atmosphere in which the rocket was launched into was examined using the lidar measurements. Both convectively and dynamically unstable layers were observed at various times and altitudes during the night. The low convective stability region below 90 km was found to be associated with the diurnal tide. The unstable layers are the combined results of wave and tidal perturbations. Comparison with the thermosphere/ionosphere/mesopshere/electrodynamics general circulation model (TIMEGCM) simulation showed that the model can produce the general feature of the observed atmospheric structure (but with a much smaller diurnal amplitude in temperature), which likely leads to underestimate of instability and gravity wave effects

Unstable Layers in the Mesopause Region Observed with Na Lidar During the Turbulent Oxygen Mixing Experiment (TOMEX) Campaign

The Na wind/temperature lidar located at Starfire Optical Range near Albuquerque, New Mexico, provided real time measurements of wind, temperature, and Na density in the mesopause region during the TOMEX rocket campaign in October 2000. The state of the atmosphere in which the rocket was launched into was examined using the lidar measurements. Both convectively and dynamically unstable layers were observed at various times and altitudes during the night. The low convective stability region below 90 km was found to be associated with the diurnal tide. The unstable layers are the combined results of wave and tidal perturbations. Comparison with the thermosphere/ionosphere/mesopshere/electrodynamics general circulation model (TIMEGCM) simulation showed that the model can produce the general feature of the observed atmospheric structure (but with a much smaller diurnal amplitude in temperature), which likely leads to underestimate of instability and gravity wave effects