778 research outputs found

    EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF Avicennia alba (BLUME) ON PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

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    Objective: To study the hepatoprotective activity of ethanolic extracts of Avicennia alba leaves against paracetamol induced liver damage in rats. Methods: Hepatotoxicity was induced by paracetamol and the biochemical parameters such as serum aspartate amino transferase (AST), alkaline phosphatase (ALP), alanine amino transferase (ALT) and total bilirubin (SB) and the antioxidant such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx), Glutathione (GSH), Vitamin-C & E and Thiobarbituric acid reactive substances (TBARS) were recorded and histopathological changes in liver were studied along with silymarin as standard hepatoprotective agents. Results: The phytochemical investigation of the extracts showed presence of alkaloids, flavonoids, tannins, terpenoids, proteins and steroids. Treatment with herbal extract to paracetamol administered rats caused a significant reduction in the values of AST, ALP, ALT and total bilirubin (P < 0.05) almost comparable to silymarin. The hepatoprotective was confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusion: From the results it can be concluded that A.alba leaves possesses hepatoprotective effect against paracetamol-induced liver damage in rats

    Green synthesis of magnesium oxide nanoparticles and their antibacterial activity

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    1210-1215Nanotechnology has prospects of opening new avenues to fight and prevent diseases using atomic-scale tailoring of materials. As the nano revolution emerges, it is imperative to develop “nano‑naturo” links between nanotechnology and green domains of the nature. The present investigation describes the mangrove Rhizophora lamarckii’s property of synthesizing magnesium oxide nanoparticles . The newly synthesized magnesium oxide nanoparticle morphology is nanohexagonal and spherical. The particles range in dimensions between 20 and 50 nm and are crystalline in nature. The functional groups of the mangrove, amine, and alkane are found to act as reductants and stabilizers. The newly synthesized MgO nanoparticles are found to have potent antibacterial activity

    Hepatoprotective and antioxidant activity of ethanolic leaves extract of Avicennia marina against alcohol-induced liver toxicity in rats

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    Plants play an important role in the life of human, as the major source of food, as well as for the maintenance and improvement of health and for the elimination of the enemies since ages. Plants are the basic source of knowledge of modern medicine. The present study was conducted to evaluate the hepatoprotective activity of ethanolic leaves extract  of Avicennia marina are evaluated in alcohol induced hepatotoxicity in rats. Silymarin (100mg/kg) was given as reference standard. The ethanolic leaves extract  of Avicennia marina have shown very significant hepatoprotection against alcohol induced hepatotoxicity in albino rats in reducing SGOT, SGPT, Alkaline phosphatase (ALP) and GGT and levels of total bilirubin and total protein were investigated and showed an increase in alcohol induced rats when compared to control. The extracts of the test plant exhibited significant (p < 0.01) hepatoprotective activity against the alcohol induced liver models by improving liver function which was indicated by reduction in the levels of SGOT, SGPT, ALP, GGT, total bilirubin and total protein. Keywords: Avicennia marina, Hepatoprotective, Liver Enzymes, Silymari

    Assessment of safety, usability and performance of sterile latex surgical glove pre-powdered of Healthium Medtech limited: a survey study based on questionnaire

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    Background: Medical gloves worn during patient examinations and procedures aids in the reduction of cross-contamination between healthcare professionals and patients. Gloves have to be strong enough to protect the wearer and comfortable enough not to choke the hand of the user. The aim of the study was to assess the incidence of allergic reactions, usability, and performance of Truskin gloves (Sterile latex surgical glove pre-powdered).Methods: The objective of this study was to evaluate the safety and performance of Truskin gloves by assessing the incidence of allergic reactions and usability in terms of manual dexterity, tactile sensitivity, handgrip strength, muscle activity, comfort level during usage and product complaints/issues. Consent was obtained from all the participants (healthcare professionals from various hospitals across India) involved in the study. The questionnaire was distributed among healthcare professionals to provide their feedback and experience with use of Truskin gloves.Results: The clinical investigation was initiated on April 10, 2021 and completed on July 10, 2021. Responses from 472 participating health care professionals were considered for assessment of safety and performance of Truskin gloves. The results from the safety variables assessed in this study indicate that about 5.51% users had experienced allergic reactions typical of powdered latex surgical gloves. More than 80% users have responded with a score of 04 and 05 (most comfortable) for all the variables associated with comfort and convenience of usage of Truskin gloves.Conclusions: The results from this study demonstrates both the safety and performance of Truskin gloves

    Livelihood gains and ecological costs of NTFP dependence: assessing the roles of dependence, ecological knowledge and market structure in three contrasting human and ecological settings in south India

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    Non-timber forest products (NTFPs) constitute the single largest determinant of livelihoods for scores of forest fringe communities and poor people in the tropics. In India over 50 million people are believed to be directly dependent upon NTFPs for their subsistence. However, such human dependence on NTFPs for livelihood gains (win) has most frequently been at a certain ecological cost (lose). If livelihoods are to be maintained, the existing ‘win-lose’ settings have to be steered to a ‘win-win’ mode, otherwise, there could be severe erosion of the biological resources and loss of livelihoods (‘lose-lose’). Examining the dependence of forest fringe communities on NTFPs at three sites in south India with contrasting human and ecological settings, three key factors (extent of dependence on NTFPs, indigenous ecological knowledge and market organization) are likely to constrain reaching the win-win situation. How these factors shape the ecological cost of harvesting NTFPs at the three sites is examined. Within the parameter space of these factors, it is possible to predict outcomes and associations that will conform to win-win or win-lose situations. Empirical data derived from the three study sites demonstrate the causality of the observed associations. The key for long-term livelihood gains lies in reducing the ecological cost. Certain interventions and recommendations that could optimize the balance between livelihood gains and ecological cost are proposed
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