Using R-based VOStat as a low resolution spectrum analysis tool

We describe here an online software suite VOStat written mainly for the Virtual Observatory, a novel structure in which astronomers share terabyte scale data. Written mostly in the public-domain statistical computing language and environment R, it can do a variety of statistical analysis on multidimensional, multi-epoch data with errors. Included are techniques which allow astronomers to start with multi-color data in the form of low-resolution spectra and select special kinds of sources in a variety of ways including color outliers. Here we describe the tool and demonstrate it with an example from Palomar-QUEST, a synoptic sky survey

Using R-based VOStat as a Low-Resolution Spectrum Analysis Tool

We describe here an online software suite VOStat written mainly for the Virtual Observatory, a novel structure in which astronomers share terabyte scale data. Written mostly in the public-domain statistical computing language and environment R, it can do a variety of statistical analysis on multidimensional, multi-epoch data with errors. Included are techniques which allow astronomers to start with multi-color data in the form of low-resolution spectra and select special kinds of sources in a variety of ways including color outliers. Here we describe the tool and demonstrate it with an example from Palomar-QUEST, a synoptic sky survey.

Friction of a slider on a granular layer: Non-monotonic thickness dependence and effect of boundary conditions

We investigate the effective friction encountered by a mass sliding on a granular layer as a function of bed thickness and boundary roughness conditions. The observed friction has minima for a small number of layers before it increases and saturates to a value which depends on the roughness of the sliding surface. We use an index-matched interstitial liquid to probe the internal motion of the grains with fluorescence imaging in a regime where the liquid has no significant effect on the measured friction. The shear profiles obtained as a function of depth show decrease in slip near the sliding surface as the layer thickness is increased. We propose that the friction depends on the degree of grain confinement relative to the sliding surfaces.Comment: 4 pages, 6 figure

Some considerations on coastal processes relevant to sea level rise

The effects of potential sea level rise on the shoreline and shore environment have been briefly examined by considering the interactions between sea level rise and relevant coastal processes. These interactions have been reviewed beginning with a discussion of the need to reanalyze previous estimates of eustatic sea level rise and compaction effects in water level measurement. This is followed by considerations on sea level effects on coastal and estuarine tidal ranges, storm surge and water level response, and interaction with natural and constructed shoreline features. The desirability to reevaluate the well known Bruun Rule for estimating shoreline recession has been noted. The mechanics of ground and surface water intrusion with reference to sea level rise are then reviewed. This is followed by sedimentary processes in the estuaries including wetland response. Finally comments are included on some probable effects of sea level rise on coastal ecosystems. These interactions are complex and lead to shoreline evolution (under a sea level rise) which is highly site-specific. Models which determine shoreline change on the basis of inundation of terrestrial topography without considering relevant coastal processes are likely to lead to erroneous shoreline scenarios, particularly where the shoreline is composed of erodible sedimentary material. With some exceptions, present day knowledge of shoreline response to hydrodynamic forcing is inadequate for long-term quantitative predictions. A series of interrelated basic and applied research issues must be addressed in the coming decades to determine shoreline response to sea level change with an acceptable degree of confidence. (PDF contains 189 pages.

Discovery of Two Spectroscopically Peculiar, Low-Luminosity Quasars at z~4

We report the discovery of two low-luminosity quasars at z~4, both of which show prominent N IV] 1486A emission. This line is extremely rare in quasar spectra at any redshift; detecting it in two out of a sample of 23 objects (i.e., ~ 9% of the sample) is intriguing and is likely due to the low-luminosity, high-redshift quasar sample we are studying. This is still a poorly explored regime, where contributions from associated, early starbursts may be significant. One interpretation of this line posits photoionization by very massive young stars. Seeing N IV] 1486A emission in a high-redshift quasar may thus be understood in the context of co-formation and early co-evolution of galaxies and their supermassive black holes. Alternatively, we may be seeing a phenomenon related to the early evolution of quasar broad emission line regions. The non-detection (and possibly even broad absorption) of N V 1240A line in the spectrum of one of these quasars may support that interpretation. These two objects may signal a new faint quasar population or an early AGN evolutionary stage at high redshifts.Comment: 15 pages, 5 figures, Accepted for publicated in ApJ Letter

De-novo design of complementary (antisense) peptide mini-receptor inhibitor of interleukin 18 (IL-18).

Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected surface features of biologically important proteins thereby inhibiting protein-cognate receptor interactions and subsequent biological effects. Previously, we described a complementary peptide mini-receptor inhibitor of interleukin-1beta (IL-1beta) that was designed to bind to an external surface loop (beta-bulge) of IL-1beta (Boraschi loop) clearly identified in the X-ray crystal structure of this cytokine. Here, we report the de-novo design and rational development of a complementary peptide mini-receptor inhibitor of cytokine interleukin-18 (IL-18), a protein for which there is no known X-ray crystal structure. Using sequence homology comparisons with IL-1beta, putative IL-18 surface loops are identified and used as a starting point for design, including a loop region 1 thought to be equivalent with the Boraschi loop of IL-1beta. Only loop region 1 complementary peptides are found to be promising leads as mini-receptor inhibitors of IL-18 but these are prevented from being properly successful owing to solubility problems. The application of "M-I pair mutagenesis" and inclusion of a C-terminal arginine residue are then sufficient to solve this problem and convert one lead peptide into a functional complementary peptide mini-receptor inhibitor of IL-18. This suggests that the biophysical and biological properties of complementary peptides can be improved in a rational and logical manner where appropriate, further strengthening the potential importance of complementary peptides as inhibitors of protein-protein interactions, even when X-ray crystal structural information is not readily available

Coalescence of Water Drops in Water-ULSD Dispersions via Electrowetting

Coalescence of water droplets is an important phenomenon in many industrial applications. One approach for coalescing water droplets is by applying an external voltage across the drops. Coalescence occurs when spreading and motion of the drops due to the electrical field brings the drops into contact. Electrowettable surfaces were prepared with poly(styrene-co-methyl methacrylate) as the dielectric film and Fluropelâ„¢ as the hydrophobic surface layer. The surface of a stainless steel disk was coated in a way that the dielectric coating layer thickness varied with radial position with minimum thicknesses at the center and at the outer edge of the disk and a maximum at an intermediate radial position of the disk surface. The thickness gradient influenced the droplet movement and contributed to the coalescence. Two disks were assembled with a thin slit between the disks. Emulsions of water droplets in ultra low sulfur diesel fuel were pumped through the thin slit. Experiments showed significant increase in drop sizes when the disks were electrified compared to non-electrified disks