Quasiparticle Corrections to the Electronic Properties of Anion Vacancies at GaAs(110) and InP(110)

We propose a new method for calculating optical defect levels and thermodynamic charge-transition levels of point defects in semiconductors, which includes quasiparticle corrections to the Kohn-Sham eigenvalues of density-functional theory. Its applicability is demonstrated for anion vacancies at the (110) surfaces of III-V semiconductors. We find the (+/0) charge-transition level to be 0.49 eV above the surface valence-band maximum for GaAs(110) and 0.82 eV for InP(110). The results show a clear improvement over the local-density approximation and agree closely with an experimental analysis.Comment: 4 pages including 1 figure, RevTe

A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes

We have constructed target cells by cotransfection of the MHC gene Ld and fragments of murine cytomegalovirus (MCMV) DNA coding for nonstructural immediate-early (IE) proteins. Transfectants were tested by using CTL clone IE1 with specificity for an IE epitope presented in association with Ld. Data show that clone IE1 recognizes a product of the ie1 transcription unit of MCMV, and that its specificity is shared by approximately 25% of polyclonal IE-specific CTL. The results provide the first definite evidence that expression of a herpes virus IE gene encoding a regulatory protein gives rise to antigen expression detectable by specific CT

Nonlinear multidimensional cosmological models with form fields: stabilization of extra dimensions and the cosmological constant problem

We consider multidimensional gravitational models with a nonlinear scalar curvature term and form fields in the action functional. In our scenario it is assumed that the higher dimensional spacetime undergoes a spontaneous compactification to a warped product manifold. Particular attention is paid to models with quadratic scalar curvature terms and a Freund-Rubin-like ansatz for solitonic form fields. It is shown that for certain parameter ranges the extra dimensions are stabilized. In particular, stabilization is possible for any sign of the internal space curvature, the bulk cosmological constant and of the effective four-dimensional cosmological constant. Moreover, the effective cosmological constant can satisfy the observable limit on the dark energy density. Finally, we discuss the restrictions on the parameters of the considered nonlinear models and how they follow from the connection between the D-dimensional and the four-dimensional fundamental mass scales.Comment: 21 pages, LaTeX2e, minor changes, improved references, fonts include

Fluid-rock interaction, skarn genesis, and hydrothermal alteration within an upper crustal fault zone (Island of Elba, Italy)

The Terranera magnetite-hematite-pyrite deposit of the Island of Elba (Italy) is an historical skarn deposit hosted by a fault zone of regional importance (Zuccale Fault) and by its hanging wall rocks. We combine field observations with petrographic data, electron probe microanalyses (EPMA), XRPD data, fluid inclusion microthermometry, and element imaging by Laser Ablation-Inductively Coupled Plasma-Time of Flight Mass Spectrometry (LA-ICP-TOFMS) to define the ore-forming process at Terranera. We show that in this location the fault is made of four levels of mineralized fault rocks having distinct mineral compositions. In these levels, a mineral association made of diopside, clinozoisite, and other Mg-rich minerals is replaced by magnetite, hematite, pyrite, Mg-hornblende, clinochlore, and other Mg-rich phyllosilicates. This paragenesis is overprinted by goethite and clay minerals. Chlorite-quartz geothermometry and fluid inclusion microthermometry show that ore precipitation occurred at 350–180 °C from fluids of distinct bulk salinities, but goethite and clay mineral overprinting progressed at lower T. We propose that Terranera is a magnesian Fe skarn formed due to the interaction between distinct hydrothermal fluids and a dolomitic protolith, which was preserved within the fault zone. These fluids mixed and cooled during protolith metasomatism, causing ore precipitation due to oxidation and desulfidation. A very similar process was described in a large deposit of Elba (Rio Marina). Argillic alteration was widespread within the fault but met permanently intermediate sulfidation conditions. Trace element composition of hematite shows that Terranera has features that overlap those of skarn and epithermal deposits. In particular, elements that are typical of epithermal deposits (Sb, Ga, Ge, As) occur at mass fractions (50–200 μg/g) that are either unreported or not typical of hematite from skarn deposits. These features identify Terranera as formed in an ore environment that was transitional between that of a skarn and of an epithermal deposit. These features are shared by other historical deposits located at Elba and in the massive pyritic ore district of south Tuscany (e.g., Gavorrano, Fenice Capanne). This indicates that a similar environment might have occurred during the Neogene beyond Elba, in a much larger ore district of south Tuscany

Compactification of Type IIB String Theory on Calabi-Yau Threefolds

We study compactifications of type IIB supergravity on Calabi-Yau threefolds. The resulting low energy effective Lagrangian is displayed in the large volume limit and its symmetry properties - with specific emphasis on the SL(2,Z) - are discussed. The explicit map to type IIA string theory compactified on a mirror Calabi-Yau is derived. We argue that strong coupling effects on the worldsheet break the SL(2,Z).Comment: 19 page

Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration

Artículo científicoThe use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen independently of blood perfusion by generating chimeric animal-plant tissues during dermal regeneration. In this work, we demonstrate the safety and efficacy of photosynthetic biomaterials in vivo after engraftment in a fully immunocompetent mouse skin defect model. Further, we show that it is also possible to genetically engineer such photosynthetic scaffolds to deliver other key molecules in addition to oxygen. As a proof-of-concept, biomaterials were loaded with gene modified microalgae expressing the angiogenic recombinant protein VEGF. Survival of the algae, growth factor delivery and regenerative potential were evaluated in vitro and in vivo. This work proposes the use of photosynthetic gene therapy in regenerative medicine and provides scientific evidence for the use of engineered microalgae as an alternative to deliver recombinant molecules for gene therapy

Universal hypermultiplet metrics

Some instanton corrections to the universal hypermultiplet moduli space metric of the type-IIA string theory compactified on a Calabi-Yau threefold arise due to multiple wrapping of BPS membranes and fivebranes around certain cycles of Calabi-Yau. The classical universal hypermultipet metric is locally equivalent to the Bergmann metric of the symmetric quaternionic space SU(2,1)/U(2), whereas its generic quaternionic deformations are governed by the integrable SU(infinity) Toda equation. We calculate the exact (non-perturbative) UH metrics in the special cases of (i) the D-instantons (the wrapped D2-branes) in the absence of fivebranes, and (ii) the fivebrane instantons with vanishing charges, in the absence of D-instantons. The solutions of the first type preserve the U(1)xU(1) classical symmetry, while they can be interpreted as the gravitational dressing of the hyper-K"ahler D-instanton solutions. The second type solution preserves the non-abelian SU(2) classical symmetry, while it can be interpreted as a gradient flow in the universal hypermultiplet moduli space.Comment: 30 pages, LaTe

Dietary Silicon Deficiency Does Not Exacerbate Diet-Induced Fatty Lesions in Female ApoE Knockout Mice.

BACKGROUND: Dietary silicon has been positively linked with vascular health and protection against atherosclerotic plaque formation, but the mechanism of action is unclear. OBJECTIVES: We investigated the effect of dietary silicon on 1) serum and aorta silicon concentrations, 2) the development of aortic lesions and serum lipid concentrations, and 3) the structural and biomechanic properties of the aorta. METHODS: Two studies, of the same design, were conducted to address the above objectives. Female mice, lacking the apolipoprotein E (apoE) gene, and therefore susceptible to atherosclerosis, were separated into 3 groups of 10-15 mice, each exposed to a high-fat diet (21% wt milk fat and 1.5% wt cholesterol) but with differing concentrations of dietary silicon, namely: silicon-deprived (-Si; <3-μg silicon/g feed), silicon-replete in feed (+Si-feed; 100-μg silicon/g feed), and silicon-replete in drinking water (+Si-water; 115-μg silicon/mL) for 15-19 wk. Silicon supplementation was in the form of sodium metasilicate (feed) or monomethylsilanetriol (drinking water). RESULTS: The serum silicon concentration in the -Si group was significantly lower than in the +Si-feed (by up to 78%; P < 0.003) and the +Si-water (by up to 84%; P < 0.006) groups. The aorta silicon concentration was also lower in the -Si group than in the +Si-feed group (by 65%; P = 0.025), but not compared with the +Si-water group. There were no differences in serum and aorta silicon concentrations between the silicon-replete groups. Body weights, tissue wet weights at necropsy, and structural, biomechanic, and morphologic properties of the aorta were not affected by dietary silicon; nor were the development of fatty lesions and serum lipid concentrations. CONCLUSIONS: These findings suggest that dietary silicon has no effect on atherosclerosis development and vascular health in the apoE mouse model of diet-induced atherosclerosis, contrary to the reported findings in the cholesterol-fed rabbit model

Virus Detection and Monitoring of Viral Load in Crimean-Congo Hemorrhagic Fever Virus Patients

We developed a real-time reverse transcription–-PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection

Quasi-periodic oscillations in accreting magnetic white dwarfs II. The asset of numerical modelling for interpreting observations

Magnetic cataclysmic variables are close binary systems containing a strongly magnetized white dwarf that accretes matter coming from an M-dwarf companion. High-energy radiation coming from those objects is emitted from the accretion column close to the white dwarf photosphere at the impact region. Its properties depend on the characteristics of the white dwarf and an accurate accretion column model allows the properties of the binary system to be inferred, such as the white dwarf mass, its magnetic field, and the accretion rate. We study the temporal and spectral behaviour of the accretion region and use the tools we developed to accurately connect the simulation results to the X-ray and optical astronomical observations. The radiation hydrodynamics code Hades was adapted to simulate this specific accretion phenomena. Classical approaches were used to model the radiative losses of the two main radiative processes: bremsstrahlung and cyclotron. The oscillation frequencies and amplitudes in the X-ray and optical domains are studied to compare those numerical results to observational ones. Different dimensional formulae were developed to complete the numerical evaluations. The complete characterization of the emitting region is described for the two main radiative regimes: when only the bremsstrahlung losses and when both cyclotron and bremsstrahlung losses are considered. The effect of the non-linear cooling in- stability regime on the accretion column behaviour is analysed. Variation in luminosity on short timescales (~ 1 s quasi-periodic oscillations) is an expected consequence of this specific dynamic. The importance of secondary shock instability on the quasi-periodic oscillation phenomenon is discussed. The stabilization effect of the cyclotron process is confirmed by our numerical simulations, as well as the power distribution in the various modes of oscillation.Comment: 13 pages, 13 figures, 2 tables. Accepted for publication in A&