Figure 1

<div><p>Cardiovascular mortality in the Botnia cohort in patients with previous MI according to MHC2TA -168 A→G genotypes.</p> <p>Kaplan Meier survival curves illustrating a higher risk for CV mortality (HR 1.76 [1.09–2.82], p = 0.02) in AG/GG genotype carriers with previous history of MI.</p></div

Sample characteristics.

<p>Shown are sample characteristics with mean and standard deviation for age in years, percent male for sex and percent exposed individuals for diabetes, hypertension and current smoking.</p

Description of SNPs included in the study.

*<p>Reference sequence NT_009775.16.</p><p>MAF∶minor allele frequency, HWE: Hardy-Weinberg equilibrium.</p

Schematic map of the genomic region containing <i>OASL</i>, <i>P2RX7</i>, <i>P2RX4</i> and <i>CAMKK2</i>.

<p>A) Filled boxes represent genes. Arrows indicate transcriptional direction. B) Filled boxes indicate exonic regions. The position of each SNP included in the study is indicated by vertical arrows.</p

Patterns of linkage disequilibrium within <i>P2RX7</i>, <i>OASL</i>, <i>CAMKK2</i> and <i>P2RX4</i>.

<p>Shown are r²-values between polymorphic loci in the LSR sample. SNPs lying within blocks are depicted in bold type. Dark grey background: strong linkage; light grey background: uninformative; white background: recombination.</p