Los derechos fundamentales en la génesis del constitucionalismo dominicano

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Evolución del control de la corrupción desde la Carta Magna; perspectivas filosófica, ética y constitucional

La Facultad de Ciencias Políticas y Relaciones Internacionales de la Universidad Autónoma de Nuevo León en su responsabilidad de socializar y difundir el conocimiento y en conmemoración del Centenario de la Constitución Política de los Estados Unidos Mexicanos, generó el presente libro buscando llevar a los lectores, las diferentes vertientes que ha generado la carta magna

Gallic acid production with mouldy polyurethane particles obtained from solid state culture of Aspergillus niger GH1

Gallic acid production in a batch bioreactor was evaluated using as catalytic material the mouldy polyurethane solids (MPS) obtained from a solid-state fermentation (SSF) bioprocess carried out for tannase production by Aspergillus niger GH1 on polyurethane foam powder (PUF) with 5 % (v/w) of tannic acid as inducer. Fungal biomass, tannic acid consumption and tannase production were kinetically monitored. SSF was stopped when tannase activity reached its maximum level. Effects of washing with distilled water and drying on the tannase activity of MPS were determined. Better results were obtained with dried and washed MPS retaining 84 % of the tannase activity. Maximum tannase activity produced through SSF after 24 h of incubation was equivalent to 130 U/gS with a specific activity of 36 U/mg. The methylgallate was hydrolysed (45 %) in an easy, cheap and fast bioprocess (30 min). Kinetic parameters of tannase self-immobilized on polyurethane particles were calculated to be 5 mM and 04.1×102 mM/min for K M and V max, respectively. Results demonstrated that the MPS, with tannase activity, can be successfully used for the production of the antioxidant gallic acid from methyl-gallate substrate. Direct use of PMS to produce gallic acid can be advantageous as no previous extraction of enzyme is required, thus reducing production costs.Authors thank the National Council for Science and Technology (CONACYT-Mexico) for the financial support. The present work was performed as part of a cooperative agreement between DIA-Universidad Autonoma de Coahuila (Mexico) and IBB-Universidade do Minho (Portugal) within a specific training stay undertaken at the DEB-UM. Part of the research was funded by a project SEP-CONACYT-CB-2011

Influencia del apego en pacientes con obesidad mórbida candidatos a cirugía bariátrica. Estudio comparativo en función del género

El objetivo de este estudio es comprobar si las variables apego y genero guardan relación alguna con personas candidatas a cirugía bariátrica con obesidad mórbida en comparación con personas que no lo son. De los 274 individuos participantes en este estudio, 162 presentaban obesidad mórbida candidatas a dicha cirugía (72,76% mujeres y 27,33% hombres) y 112 formaron el grupo control, los cuales no presentaban obesidad (75% mujeres y 25 % hombres), seleccionados por el método de conveniencia. Los instrumentos utilizados han sido: Cuestionario de Apego Adulto y unas plantillas con datos sociodemográficos y clínicos. Los datos obtenidos en este estudio ponen de manifiesto que existe una mayor prevalencia de apego preocupado en el grupo no apto para la cirugía bariátrica en comparación con los otros dos grupos comparados. Atendiendo al género, se concluye que existen diferencias significativas, siendo las mujeres las que obtienen mayores puntuaciones en apego preocupadoThe aim of this study is to see if attachment and gender variables are linked in any way to those bariatric surgery sufferenig morbid obesity candidates, in comparison with people that are not. 274 people participated in this study; 162 suffered from morbid obesity and were candidates to the surgery (72.76% were women and 27.33% were men); 112 people were included in the control group and they didn’t suffer from morbid obesity (75% were women and 25% were men). All of them were selected by the convenience method. The instruments used were: Adult Attachment Questionnaire and socio-demographic and clinical data questionnaires. The results of the study show that there is a higher preoccupied attachment prevalence in the group that is not suitable for the bariatric surgery. Regarding gender, there are significant differences: women obtained higher scores in preoccupied attachment

Diferencias de género en pacientes con obesidad mórbida candidatos a cirugía bariátrica: Influencia de ansiedad, depresión y autoestima

Debido a la gravedad actual de la obesidad mórbida, siendo causa de muerte de muchos casos en la población, la cirugía bariátrica es una buena solución para esta enfermedad. Ante dicha situación este estudio analiza las diferencias significativas que pueden darse entre un grupo de candidatos a cirugía bariátrica, un grupo no candidato a esta cirugía y una muestra control en diferentes variables, como son la ansiedad, la depresión y la autoestima, viéndose la posible influencia del género en todo ello. Se utilizó una muestra de 274 individuos a través de un método de selección de conveniencia. El diseño realizado fue ex post facto prospectivo. Una vez realizado el estudio, se concluye que existen diferencias significativas entre los tres grupos en todas las variables. Sin embargo, no existen dichas diferencias con respecto a los hombres en ninguna de las variables, excepto en autoestima.Currently, the majority of the morbid obesity patients die due to the severity levels of that disease, thus the bariatric surgery seems to be a good solution nowadays. Taking into account the actual situation, this research tries to analyse the significantly differences between a group of patients proposed to bariatric surgery, a group of patients who are not proposed to bariatric surgery and a control sample with different variables, such as anxiety, depression and self-steem, taking into account the possible gender influence among all conditions. The sample is composed of 274 individuals. The design was ex post facto prospective. The results of the research show significant differences between the 3 groups in all the variables conditions. However, there are no significant differences with the male group in any of the variables conditions, except for self-estee

Impact of amyloid-PET in daily clinical management of patients with cognitive impairment fulfilling appropriate use criteria

To evaluate the use of amyloid-positron emission tomography (PET) in routine clinical practice, in a selected population with cognitive impairment that meets appropriate use criteria (AUC). A multicenter, observational, prospective case-series study of 211patients from 2 level-3 hospitals who fulfilled clinical AUC for amyloid-PET scan in a naturalistic setting. Certainty degree was evaluated using a 5-point Likert scale: 0 (very low probability); 1 (low probability); 2 (intermediate probability); 3 (high probability); and 4 (practically sure), before and after amyloid PET. The treatment plan was considered as cognition-specific or noncognition-specific. Amyloid-PET was positive in 118 patients (55.9%) and negative in 93 patients (44.1%). Diagnostic prescan confidence according amyloid-PET results showed that in both, negative and positive-PET subgroup, the most frequent category was intermediate probability (45.7% and 55.1%, respectively). After the amyloid-PET, the diagnostic confidence showed a very different distribution, that was, in the negative-PET group the most frequent categories are very unlikely (70.7%) and unlikely (29.3%), while in the positive- PET group were very probable (57.6%) and practically sure (39%). Only in 14/211 patients (6.6%) the result of the amyloid-PET did not influence the diagnostic confidence, while in 194 patients (93.4%), the diagnostic confidence improved significantly after amyloid- PET results. The therapeutic intention was modified in 93 patients (44.1%). Specific treatment for Alzheimer disease was started, before amyloid-PET, in 80 patients (37.9%). This naturalistic study provides evidence that the implementation of amyloid-PET is associated with a significant improvement in diagnostic confidence and has a high impact on the therapeutic management of patients with mild cognitive impairment fulfilled clinical AUC

Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

Background: To assess the performance of Candida albicans germ tube antibody (CAGTA), (1???3)-ß-D-glucan (BDG), mannan antigen (mannan-Ag), anti-mannan antibodies (mannan-Ab), and Candida DNA for diagnosing invasive candidiasis (IC) in ICU patients with severe abdominal conditions (SAC). Methods: A prospective study of 233 non-neutropenic patients with SAC on ICU admission and expected stay?=?7 days. CAGTA (cutoff positivity?=?1/160), BDG (=80, 100 and 200 pg/mL), mannan-Ag (=60 pg/mL), mannan-Ab (=10 UA/mL) were measured twice a week, and Candida DNA only in patients treated with systemic antifungals. IC diagnosis required positivities of two biomarkers in a single sample or positivities of any biomarker in two consecutive samples. Patients were classified as neither colonized nor infected (n?=?48), Candida spp. colonization (n?=?154) (low-grade, n?=?130; high-grade, n?=?24), and IC (n?=?31) (intra-abdominal candidiasis, n?=?20; candidemia, n?=?11). Results: The combination of CAGTA and BDG positivities in a single sample or at least one of the two biomarkers positive in two consecutive samples showed 90.3 % (95 % CI 74.2–98.0) sensitivity, 42.1 % (95 % CI 35.2–98.8) specificity, and 96.6 % (95 % CI 90.5–98.8) negative predictive value. BDG positivities in two consecutive samples had 76.7 % (95 % CI 57.7–90.1) sensitivity and 57.2 % (95 % CI 49.9–64.3) specificity. Mannan-Ag, mannan-Ab, and Candida DNA individually or combined showed a low discriminating capacity. Conclusions: Positive Candida albicans germ tube antibody and (1???3)-ß-D-glucan in a single blood sample or (1???3)-ß-D-glucan positivity in two consecutive blood samples allowed discriminating invasive candidiasis from Candida spp. colonization in critically ill patients with severe abdominal conditions. These findings may be helpful to tailor empirical antifungal therapy in this patient population

Informe del Comité Científico de la Agencia Española de Consumo, Seguridad Alimentaria y Nutrición (AECOSAN) sobre la seguridad de uso de los cigarrillos electrónicos

El Comite´ Cienti´fico de la Agencia Espan~ola de Consumo, Seguridad Alimentaria y Nutricio´n (AE- COSAN) ha evaluado el riesgo para la salud de uso de los cigarrillos electro´nicos. La evaluacio´n realizada permite concluir que la seguridad de los cigarrillos electro´nicos es incierta. Hay una gran variacio´n entre los distintos tipos de cigarrillos, la cantidad de los ingredientes en el li´quido a vaporizar, asi´ como en el contenido que se libera tras la vaporizacio´n. Los efectos sobre la salud a largo plazo son desconocidos. A corto plazo incluyen in amacio´n de boca y garganta, nauseas, vo´mitos y tos. En el vapor que se genera tras el “vapeado” se han encontrado, propilenglicol, glicerina, nicotina, aromatizantes, carcino´genos, metales pesados y otros productos qui´micos. No hay estudios a largo plazo que demuestren que el uso estos cigarrillos sea e caz para tratar la adiccio´n al tabaco, ni tampoco estudios de toxicidad cro´nica en roedores para conocer los efectos a largo plazo de la exposicio´n por el uso de los cigarrillos electro´nicos. Los estudios in vitro sobre los efectos del vapeado de los cigarrillos electro´nicos sobre la regulacio´n del ciclo celular, estre´s oxidativo y mitocondrial y dan~o del ADN asociado con las ce´lulas de las vi´as ae´reas humanas seri´an de gran utilidad para la evaluacio´n del riesgo para la salud. Se necesitan tambie´n datos epidemiolo´gicos sobre los efectos adversos que causan sobre la salud los cigarrillos electro´nicos, especialmente en la poblacio´n ma´s vulnerable. Por otra parte, en la actualidad se esta´ llevando a cabo la transposicio´n de la normativa europea en lo referente a fabricacio´n, presentacio´n y venta de los productos del tabaco

A deep learning LSTM-based approach for forecasting annual pollen curves: Olea and Urticaceae pollen types as a case study

Airborne pollen can trigger allergic rhinitis and other respiratory diseases in the synthesised population, which makes it one of the most relevant biological contaminants. Therefore, implementing accurate forecast systems is a priority for public health. The current forecast models are generally useful, but they falter when long time series of data are managed. The emergence of new computational techniques such as the LSTM algorithms could constitute a significant improvement for the pollen risk assessment. In this study, several LSTM variants were applied to forecast monthly pollen integrals in Málaga (southern Spain) using meteorological variables as predictors. Olea and Urticaceae pollen types were modelled as proxies of different annual pollen curves, using data from the period 1992–2022. The aims of this study were to determine the LSTM variants with the highest accuracy when forecasting monthly pollen integrals as well as to compare their performance with the traditional pollen forecast methods. The results showed that the CNN-LSTM were the most accurate when forecasting the monthly pollen integrals for both pollen types. Moreover, the traditional forecast methods were outperformed by all the LSTM variants. These findings highlight the importance of implementing LSTM models in pollen forecasting for public health and research applications.Funding for open Access charge: Universidad de Málaga / CBUA. This work has been partially funded by the Spanish Ministry of Science and Innovation via grant (funded by MCIN/AEI/10.13039/5011 00011033/) PID2020-112540RB-C41, AETHER-UMA (A smart data holistic approach for context-aware data analytics: semantics and context exploitation), and grant ‘‘Environmental and Biodiversity Climate Change Lab (EnBiC2-Lab)’’ LIFEWATCH-2019-11-UMA-01 (AEI/FEDER, UE). A. Picornell has been supported by a postdoctoral grant financed by the Consejería de Transformación Económica, Industria, Conocimiento Universidades (Junta de Andalucía, POSTDOC_21_00056)