81 research outputs found
Allosteric modulation of adenosine receptors
Allosteric modulators for adenosine receptors may have potential therapeutic advantage over orthosteric ligands. Allosteric enhancers at the adenosine A1 receptor have been linked to antiarrhythmic and antilipolytic activity. They may also have therapeutic potential as analgesics and neuroprotective agents. A3 allosteric enhancers are postulated to be useful against ischemic conditions or as antitumor agents. In this review, we address recent developments regarding the medicinal chemistry of such compounds. Most efforts have been and are directed toward adenosine A1 and A3 receptors, whereas limited or no information is available for A2A and A2B receptors. We also discuss some findings, mostly receptor mutation studies, regarding localization of the allosteric binding sites on the receptors
Az ĂrĂł szemĂ©lyĂ©nek megállapĂtása kĂ©zsĂ©rĂĽlĂ©s esetĂ©n
The author provides an overview of how forensic experts can identify handwriting.A szerzĹ‘ áttekintĂ©st nyĂşjt arrĂłl, hogy az igazságĂĽgyi szakĂ©rtĹ‘k hogyan tudják azonosĂtani a kĂ©zĂrást
Lokális energiaforrások távhő célú felhasználási lehetőségének vizsgálata
A globális felmelegedĂ©ssel Ă©s az ezzel összefĂĽggĹ‘ fosszilis energiahordozĂłk kimerĂĽlĂ©sĂ©vel – mint az emberisĂ©g jövĹ‘jĂ©vel kapcsolatos kĂ©t legfontosabb problĂ©májával - kapcsolatban rengeteg tanulmány Ă©s találgatás jelent meg. A magashegysĂ©gi gleccserek Ă©s a sarki jĂ©gtakarĂł olvadása, a permafrost terĂĽletek csökkenĂ©se, az ipari termelĂ©s okozta kibocsátás növekedĂ©s, a Föld lakosságának rendkĂvĂĽl gyors gyarapodása, stb. mind azt mutatják, hogy a problĂ©ma valĂłs Ă©s rendkĂvĂĽl gyors Ă©s hatĂ©kony beavatkozást igĂ©nyel. A dolgozat a lokális energiaforrások távhĹ‘ cĂ©lĂş felhasználási lehetĹ‘sĂ©gĂ©t vizsgálja
GolyĂłsirĂłnĂrások Ă©s bĂ©lyegzĹ‘lenyomatok vonalkeresztezĹ‘dĂ©seinek vizsgálati lehetĹ‘sĂ©ge
The author provides an overview of how testing equipment and methods can be used in analyzing solvent ink.A szerző áttekintést nyújt arról, hogy a vizsgálati eszközök és módszerek hogyan használhatók az oldószeres tinta elemzéséhez
Comparison of three soil cultivation method in case of grape
Our results show that the different cultivation methods have effect on the yield and the grape quality as well. In 2008 and 2009 the straw mulch proved to be the best solution regarding the yield. The soil compaction was reduced in these plots and the photosintetical activity was also higher. Straw mulch could conserve the moisture content of the soil. The less yield was observed in case of barely covered vines and also the vegetative growth of the grape was less intensive in case of these vines, but it seems to be contributed to the conformation of suitable microclimate for Botrytis infection
Comparison of three soil cultivation method in case of grape
Our results show that the different cultivation methods have effect on the yield and the grape quality as well. In 2008 and 2009 thestraw mulch proved to be the best solution regarding the yield. The soil compaction was reduced in these plots and the photosintetical activitywas also higher. Straw mulch could conserve the moisture content of the soil. The less yield was observed in case of barely covered vines andalso the vegetative growth of the grape was less intensive in case of these vines, but it seems to be contributed to the conformation of suitablemicroclimate for Botrytis infection
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