In-situ spectroscopy and two-color thermography during microwave irradiation in materials processing

[EN] Concentration of microwave E-field between material particles is considered to cause the enhancement of sintering1 and chemical reaction under microwave irradiation. For example, it is usually required 1700 °C to synthesize AlN by carbothermal reduction method using Al2O3 as a starting material, but microwave processing can proceed this process at 1200 °C2. To understand this phenomenon, it is necessary to understand an occurrence behavior of plasma and a chemical reaction related to radical species generated by a local E-field concentration. In addition, in material synthesis using a raw material powder of several mm, it is suggested that a selective heating in the powder scale occurs. However, to discuss this selective heating behavior on this scale, it is necessary to realize a quantitative temperature measurement system with independent of the emissivity of the material and several mm spatial resolution. In this study, we conducted an in-situ spectroscopy and two-color thermography to verify these non-equilibrium effects during microwave irradiation. For example, in the iron making process, it was investigated that CN plasma was generated, and this CN radical contributed to the reduction reaction (Fig. 1(a))3. In addition, the developed two-dimensional two-color thermography system with a high resolution of 8.8 mm/pixel was enable to discuss local temperature gradients quantitatively (Fig. 1(b)).This work was supported by a JSPS Grant-in-Aid for Scientific Research (S) No. JP17H06156.Fukushima, J.; Takizawa, H. (2019). In-situ spectroscopy and two-color thermography during microwave irradiation in materials processing. En AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating. Editorial Universitat Politècnica de València. 373-377. https://doi.org/10.4995/AMPERE2019.2019.9882OCS37337

Comparing Generalization in Learning with Limited Numbers of Exemplars: Transformer vs. RNN in Attractor Dynamics

ChatGPT, a widely-recognized large language model (LLM), has recently gained substantial attention for its performance scaling, attributed to the billions of web-sourced natural language sentences used for training. Its underlying architecture, Transformer, has found applications across diverse fields, including video, audio signals, and robotic movement. %The crucial question this raises concerns the Transformer's generalization-in-learning (GIL) capacity. However, this raises a crucial question about Transformer's generalization in learning (GIL) capacity. Is ChatGPT's success chiefly due to the vast dataset used for training, or is there more to the story? To investigate this, we compared Transformer's GIL capabilities with those of a traditional Recurrent Neural Network (RNN) in tasks involving attractor dynamics learning. For performance evaluation, the Dynamic Time Warping (DTW) method has been employed. Our simulation results suggest that under conditions of limited data availability, Transformer's GIL abilities are markedly inferior to those of RNN

シャカイキョウイク ノ カンテン カラミタ チイキキョウイク ブンカウンドウ コドモゲキジョウ オヤコゲキジョウ ウンドウ ヲ ジレイ トシテ

論

Sodium Glucose Co-Transporter 2 Inhibitor Ameliorates Autophagic Flux Impairment on Renal Proximal Tubular Cells in Obesity Mice

Obesity is supposed to cause renal injury via autophagy deficiency. Recently, sodium glucose co-transporter 2 inhibitors (SGLT2i) were reported to protect renal injury. However, the mechanisms of SGLT2i for renal protection are unclear. Here, we investigated the effect of SGLT2i for autophagy in renal proximal tubular cells (PTCs) on obesity mice. We fed C57BL/6J mice with a normal diet (ND) or high-fat and -sugar diet (HFSD) for nine weeks, then administered SGLT2i, empagliflozin, or control compound for one week. Each group contained N = 5. The urinary N-acetyl-beta-d-glucosaminidase level in the HFSD group significantly increased compared to ND group. The tubular damage was suppressed in the SGLT2i-HFSD group. In electron microscopic analysis, multi lamellar bodies that increased in autophagy deficiency were increased in PTCs in the HFSD group but significantly suppressed in the SGLT2i group. The autophagosomes of damaged mitochondria in PTCs in the HFSD group frequently appeared in the SGLT2i group. p62 accumulations in PTCs were significantly increased in HFSD group but significantly suppressed by SGLT2i. In addition, the mammalian target of rapamycin was activated in the HFSD group but significantly suppressed in SGLT2i group. These data suggest that SGLT2i has renal protective effects against obesity via improving autophagy flux impairment in PTCs on a HFSD

MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury

Acute kidney injury (AKI) is a clinical syndrome where a rapid decrease in kidney function and/or urine output is observed, which may result in the imbalance of water, electrolytes and acid base. It is associated with poor prognosis and prolonged hospitalization. Therefore, an early diagnosis and treatment to avoid the severe AKI stage are important. While several biomarkers, such as urinary L-FABP and NGAL, can be clinically useful, there is still no gold standard for the early detection of AKI and there are limited therapeutic options against AKI. miRNAs are non-coding and single-stranded RNAs that silence their target genes in the post-transcriptional process and are involved in a wide range of biological processes. Recent accumulated evidence has revealed that miRNAs may be potential biomarkers and therapeutic targets for AKI. In this review article, we summarize the current knowledge about miRNAs as promising biomarkers and potential therapeutic targets for AKI, as well as the challenges in their clinical use

Monitoring Observations of the Jupiter-Family Comet 17P/Holmes during 2014 Perihelion Passage

We performed a monitoring observation of a Jupiter-Family comet, 17P/Holmes, during its 2014 perihelion passage to investigate its secular change in activity. The comet has drawn the attention of astronomers since its historic outburst in 2007, and this occasion was its first perihelion passage since then. We analyzed the obtained data using aperture photometry package and derived the Afrho parameter, a proxy for the dust production rate. We found that Afrho showed asymmetric properties with respect to the perihelion passage: it increased moderately from 100 cm at the heliocentric distance r_h=2.6-3.1 AU to a maximal value of 185 cm at r_h = 2.2 AU (near the perihelion) during the inbound orbit, while dropping rapidly to 35 cm at r_h = 3.2 AU during the outbound orbit. We applied a model for characterizing dust production rates as a function of r_h and found that the fractional active area of the cometary nucleus had dropped from 20%-40% in 2008-2011 (around the aphelion) to 0.1%-0.3% in 2014-2015 (around the perihelion). This result suggests that a dust mantle would have developed rapidly in only one orbital revolution around the sun. Although a minor eruption was observed on UT 2015 January 26 at r_h = 3.0 AU, the areas excavated by the 2007 outburst would be covered with a layer of dust (<~ 10 cm depth) which would be enough to insulate the subsurface ice and to keep the nucleus in a state of low activity.Comment: 25 pages, 6 figures, 2 tables, ApJ accepted on December 29, 201

Role of Semaphorin 3A in Kidney Development and Diseases

Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving in the several pathogeneses of diseases, including eyes and neurons, as well as kidneys. SEMA3A is expressed in podocytes and tubular cells in the normal adult kidney, and recent evidence has revealed that excess SEMA3A expression and the subsequent signaling pathway aggravate kidney injury in a variety of kidney diseases, including nephrotic syndrome, diabetic nephropathy, acute kidney injury, and chronic kidney disease. In addition, several reports have demonstrated that the inhibition of SEMA3A ameliorated kidney injury via a reduction in cell apoptosis, fibrosis and inflammation; thus, SEMA3A may be a potential therapeutic target for kidney diseases. In this review article, we summarized the current knowledge regarding the role of SEMA3A in kidney pathophysiology and their potential use in kidney diseases