What drives farmers to make top-down or bottom-up adaptation to climate change and fluctuations?:A comparative study on 3 cases of apple farming in Japan and South Africa

Agriculture is one of the most vulnerable sectors to climate change. Farmers have been exposed to multiple stressors including climate change, and they have managed to adapt to those risks. The adaptation actions undertaken by farmers and their decision making are, however, only poorly understood. By studying adaptation practices undertaken by apple farmers in three regions: Nagano and Kazuno in Japan and Elgin in South Africa, we categorize the adaptation actions into two types: farmer initiated bottom-up adaptation and institution led top-down adaptation. We found that the driver which differentiates the type of adaptation likely adopted was strongly related to the farmers' characteristics, particularly their dependence on the institutions, e.g. the farmers' cooperative, in selling their products. The farmers who rely on the farmers' cooperative for their sales are likely to adopt the institution-led adaptation, whereas the farmers who have established their own sales channels tend to start innovative actions by bottom-up. We further argue that even though the two types have contrasting features, the combinations of the both types of adaptations could lead to more successful adaptation particularly in agriculture. This study also emphasizes that more farm-level studies for various crops and regions are warranted to provide substantial feedbacks to adaptation policy

Interferon-γ Decreases Ceramides with Long-Chain Fatty Acids: Possible Involvement in Atopic Dermatitis and Psoriasis

Ceramide (CER) with long-chain fatty acids (FAs) in the human stratum corneum (SC) is important for the skin barrier functions. Changes in the CER profile have been associated with abnormal permeability of dermatoses such as atopic dermatitis (AD) and psoriasis. In addition, interferon-γ (IFN-γ) has been known to be abundant in both AD and psoriatic skin lesions. In this study, we aimed to identify the mechanism underlying the alteration of FA chain length of CERs in these diseases. Mass spectrometry analysis of CERs in the SC showed that the proportion of CERs with long-chain FAs was significantly lower in AD and psoriasis patients than in healthy controls, and this reduction was more pronounced in psoriasis than in AD. Using cultured human keratinocytes and epidermal sheets, we found that only IFN-γ among various cytokines decreased the mRNA expression of elongase of long-chain fatty acids (ELOVL) and ceramide synthase (CerS), enzymes involved in FA chain elongation. Furthermore, quantitative analysis showed that IFN-γ decreased the levels of CERs with long-chain FAs. These results suggest that IFN-γ decreases CERs with long-chain FAs through the downregulation of ELOVL and CerS and that this mechanism may be involved in the CER profile alteration observed in psoriasis and AD

Climate trends and extremes in the Indus River Basin, Pakistan: implications for agricultural production

ABSTRACT: Historical and future projected changes in climatic patterns over the largest irrigated basin in the world, the Indus River Basin (IRB), threaten agricultural production and food security in Pakistan, in particular for vulnerable farming communities. To build a more detailed understanding of the impacts of climate change on agricultures in the IRB, the present study analyzes (1) observed trends in average temperature, precipitation and related extreme indicators, as well as seasonal shifts over a recent historical period (1997-2016); and (2) statistically downscaled future projections (up to 2100) from a set of climate models in conjunction with crop-specific information for the four main crops of the IRB: wheat, cotton, rice and sugarcane. Key findings show an increasing trend of about over 0.1ºC/year in observed minimum temperature across the study area over the historical period, but no significant trend in maximum temperature. Historical precipitation shows a positive annual increase driven mainly by changes in August and September. Future projections highlight continued warming resulting in critical heat thresholds for the four crops analyzed being increasingly exceeded into the future, in particular in the Kharif season. Concurrently, inter-annual rainfall variability is projected to increase up to 10-20% by the end of the 21st century, augmenting uncertainty of water availability in the basin. These findings provide insight into the nature of recent climatic shifts in the IRB and emphasize the importance of using climate impact assessments to develop targeted investments and efficient adaptation measures to ensure resilience of agriculture in Pakistan into the futur