491 research outputs found
Radiolabelling Pt-based quadruplex DNA binders via click chemistry.
- Publication venue
- 'Elsevier BV'
- Publication date
- 08/11/2022
- Field of study
Guanine-rich sequences of DNA and RNA can fold into intramolecular tetra-helical assemblies known as G-quadruplexes (G4). Their formation in vivo has been associated to a range of biological functions and therefore they have been identified as potential drug targets. Consequently, a broad range of small molecules have been developed to target G4s. Amongst those are metal complexes with Schiff base ligands. Herein, we report the functionalisation of one of these well-established G4 DNA binders (based on a square planar platinum(II)-salphen complex) with two different radiolabelled complexes. An 111In-conjugate was successfully used to assess its in vivo distribution in a mouse tumour model using single-photon emission computed tomography (SPECT) imaging. These studies highlighted the accumulation of this Pt-salphen-111In conjugate in the tumour
Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-Resolution Microscopy
- Author
- Publication venue
- Publication date
- 21/10/2016
- Field of study
Heterogeneity of mitogen-activated protein kinase (MAPK) activation in genetically identical cells, which occurs in response to epidermal growth factor receptor (EGFR) signaling, remains poorly understood. MAPK cascades integrate signals emanating from different EGFR spatial locations, including the plasma membrane and endocytic compartment. We previously hypothesized that in EGF-stimulated cells the MAPK phosphorylation (pMAPK) level and activity are largely determined by the spatial organization of the EGFR clusters within the cell. For experimental testing of this hypothesis, we used super-resolution microscopy to define EGFR clusters by receptor numbers (N) and average intra-cluster distances (d). From this data, we predicted the extent of pMAPK with 85% accuracy on a cell-to-cell basis with control data returning 54% accuracy (P50nm were most predictive for pMAPK level in cells. Electron microscopy revealed that these large clusters were primarily localized to the limiting membrane of multivesicular bodies (MVB). Many tighter packed dimers/multimers (d<50nm) were found on intraluminal vesicles within MVBs, where they were unlikely to activate MAPK because of the physical separation. Our results suggest that cell-to-cell differences in N and d contain crucial information to predict EGFR-activated cellular pMAPK levels and explain pMAPK heterogeneity in isogenic cells
Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 02/12/2020
- Field of study
Supplemental information is available online at: https://www.sciencedirect.com/science/article/pii/S2329050120302515#appsec2 .Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs has been shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical trials. Despite these successes, the in vivo distribution and persistence of adoptively transferred Tregs remained elusive, which hampers clinical translation. Here we isolated human Tregs using a GMP-compatible protocol and lentivirally transduced them with the human sodium iodide symporter to render them traceable in vivo by radionuclide imaging. Engineered human Tregs were characterized for phenotype, survival, suppressive capacity, and reporter function. To study their trafficking behavior, they were subsequently administered to humanized mice with human skin transplants. Traceable Tregs were quantified in skin grafts by non-invasive nano-single-photon emission computed tomography (nanoSPECT)/computed tomography (CT) for up to 40 days, and the results were validated ex vivo. Using this approach, we demonstrated that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1+ innate immune cells. We demonstrated the utility of radionuclide reporter gene-afforded quantitative Treg in vivo tracking, addressing a fundamental need in Treg therapy development and offering a clinically compatible methodology for future Treg therapy imaging in humans.This work was supported by the British Heart Foundation (RG/13/12/30395), the MRC Centre for Transplantation at King's College London (MR/J006742/1), Cancer Research UK (C48390/A21153), and the Wellcome/EPSRC Centre for Medical Engineering (WT203148/Z/16/Z). This research was funded/supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London and/or the NIHR Clinical Research Facility
Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor
- Author
- A B Tabor
- A Cheung
- A Mantovani
- A Pal
- Andrew Z. Wang
- B Molon
- B Ruffell
- B Vojnovic
- BG Ongarora
- C Tros de Ilarduya
- CA Hudis
- CA Hurley
- CA Hurley
- CH Heldin
- CH Switzer
- DE Oppenheim
- DW Fry
- E Årstad
- F Festy
- FM Mickler
- G O Fruhwirth
- G Weitsman
- GO Fruhwirth
- H C Hailes
- J Arrowsmith
- J Charan
- J Condeelis
- J N Arnold
- J Wyckoff
- JB Wyckoff
- K Kurokawa
- K Pietras
- K Pietras
- K Sander
- L Kudsiova
- LA Carey
- LB Saltz
- M Gerlinger
- M Keese
- M Keppler
- M Kullberg
- M Lythgoe
- M Nobis
- M Peter
- MF Mustapa
- MF Mustapa
- MN Dickler
- N J Mitchell
- N Mitchell
- OP Medina
- P Gordon
- P Nuciforo
- P R Barber
- P Workman
- PL Felgner
- PR Barber
- QM Fan
- R Bofinger
- R Evans
- S Ameer-Beg
- S Irshad
- S Kobayashi
- S Modi
- S Park
- S Song
- SM Grosse
- T de Koning
- T Kasic
- T L Kalber
- T Ng
- T Ng
- T Tagawa
- TO Nielsen
- U Prabhakar
- V Bronte
- W Wulaningsih
- YS Fan
- Z Li
- Z V F Wright
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2017
- Field of study
Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the improvement of overall survival. Intratumoral heterogeneity is proposed as a major mechanism underlying treatment failure of these molecule-targeted agents. Here we highlight the application of fluorescence lifetime microscopy (FLIM)-based biosensing to demonstrate intratumoral heterogeneity of EGFR activity. For sensing EGFR activity in cells, we used a genetically encoded CrkII-based biosensor which undergoes conformational changes upon tyrosine-221 phosphorylation by EGFR. We transfected this biosensor into EGFR-positive tumour cells using targeted lipopolyplexes bearing EGFR-binding peptides at their surfaces. In a murine model of basal-like breast cancer, we demonstrated a significant degree of intratumoral heterogeneity in EGFR activity, as well as the pharmacodynamic effect of a radionuclide-labeled EGFR inhibitor in situ. Furthermore, a significant correlation between high EGFR activity in tumour cells and macrophage-tumour cell proximity was found to in part account for the intratumoral heterogeneity in EGFR activity observed. The same effect of macrophage infiltrate on EGFR activation was also seen in a colorectal cancer xenograft. In contrast, a non-small cell lung cancer xenograft expressing a constitutively active EGFR conformational mutant exhibited macrophage proximity-independent EGFR activity. Our study validates the use of this methodology to monitor therapeutic response in terms of EGFR activity. In addition, we found iNOS gene induction in macrophages that are cultured in tumour cell-conditioned media as well as an iNOS activity-dependent increase in EGFR activity in tumour cells. These findings point towards an immune microenvironment-mediated regulation that gives rise to the observed intratumoral heterogeneity of EGFR signalling activity in tumour cells in vivo
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alexander J
- Aliev T
- Allfrey P
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Asaadi J
- Asghar MI
- Askew A
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avery P
- Avetisyan A
- Awad A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ballin J
- Ban Y
- Bandurin D
- Banerjee S
- Banerjee S
- Bansal S
- Banzuzi K
- Barbagli G
- Barberis E
- Barbone L
- Barge D
- Baringer P
- Barker A
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Barrett M
- Bartalini P
- Barth C
- Basegmez S
- Basso L
- Battilana C
- Baty C
- Bauer G
- Bauer J
- Bauerdick LAT
- Baumgartel D
- Baur U
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaupere N
- Bedjidian M
- Bedoya CF
- Behrenhoff W
- Behrens U
- Belforte S
- Beliy N
- Bell AJ
- Bell KW
- Bell P
- Bellan P
- Bellan R
- Bellinger JN
- Belotelov I
- Belyaev A
- Benaglia A
- Bencze G
- Bendavid J
- Bender W
- Benedetti D
- Benelli G
- Beni N
- Benucci L
- Benussi L
- Benvenuti AC
- Beretvas A
- Bergauer T
- Bergholz M
- Beri SB
- Bernardini J
- Bernet C
- Berry D
- Berry E
- Berryhill J
- Bertl W
- Berzano U
- Besancon M
- Besson A
- Betchart B
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Bialas W
- Bian JG
- Bianchini L
- Bianco S
- Biasini M
- Biino C
- Bilei GM
- Bilinskas MJ
- Bilki B
- Bilmis S
- Biselli A
- Bisello D
- Bitioukov S
- Blekman F
- Bloch D
- Bloch I
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Blyweert S
- Bobrovskyi S
- Boccali T
- Bocci A
- Bochenek J
- Bodek A
- Bodin D
- Boeriu O
- Boldizsar L
- Bolla G
- Bolognesi S
- Bolton T
- Bonacorsi D
- Bonato A
- Bondar N
- Bondu O
- Bontenackels M
- Boos E
- Borcherding F
- Borgia MA
- Bornheim A
- Borras K
- Borrello L
- Bortignon P
- Bortoletto D
- Bose S
- Bose T
- Bostock F
- Botta C
- Boucerneur M
- Boudoul G
- Boulahouache C
- Boumediene D
- Bourilkov D
- Boutle S
- Braibant-Giacomelli S
- Branca A
- Branson JG
- Breedon R
- Breuker H
- Brew C
- Brigliadori L
- Brigljevic V
- Broccolo G
- Brom JM
- Brona G
- Brooke JJ
- Broutin C
- Brown RM
- Brownson E
- Brun H
- Bruno G
- Bryer AG
- Buchmuller O
- Buege V
- Buehler M
- Bunin P
- Bunkowski K
- Bunn J
- Buontempo S
- Burelo ED
- Burkett K
- Busson P
- Busza W
- Butler JN
- Butler PH
- Butt J
- Butz E
- Bylsma B
- Caballero IG
- Cabrera A
- Cabrillo IJ
- Caebergs T
- Cakir A
- Calabria C
- Calderon A
- Cali IA
- Callner J
- Calvo E
- Camanzi B
- Caminada L
- Campagnari C
- Campbell A
- Campderros JD
- Camporesi T
- Cankocak K
- Cano E
- Capiluppi P
- Caponeri B
- Cappello G
- Cardaci M
- Carlin R
- Carlsmith D
- Carroll R
- Cartiglia N
- Carvalho W
- Castaldi R
- Castello R
- Castro A
- Castro E
- Caudron J
- Cavallari F
- Cavallo FR
- Cavanaugh R
- Ceard L
- Ceballos GG
- Cebra D
- Cepeda M
- Cerati GB
- Cerci S
- Cerizza G
- Cerminara G
- Cerny K
- Ceron C
- Cerrada M
- Chabert EC
- Chadwick M
- Chakaberia I
- Chan M
- Chang P
- Chang S
- Chang YH
- Chang YH
- Chang YW
- Chanon N
- Chao Y
- Charaf O
- Charlot C
- Chasco M
- Chatterjee A
- Chauhan S
- Checchia P
- Chen GM
- Chen HS
- Chen J
- Chen KF
- Chen KH
- Chen M
- Chen WT
- Chen Y
- Chen Z
- Cheng TL
- Chertok M
- Chetluru V
- Cheung HWK
- Chierici R
- Chiochia V
- Chiorboli M
- Chlebana F
- Choi M
- Choi S
- Choi Y
- Choi YK
- Chou JP
- Choudhary BC
- Choudhury RK
- Choudhury S
- Christiansen T
- Chuang SH
- Chung J
- Chung YS
- Chwalek T
- Ciesielski R
- Cifuentes JAB
- Cihangir S
- Cimmino A
- Cirino G
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Cole P
- Colino N
- Collard C
- Colling D
- Conetti S
- Contardo D
- Conte E
- Conte E
- Conway J
- Cooper SI
- Cortabitarte RV
- Cossutti F
- Costa M
- Costa S
- Costantini S
- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Creanza D
- Cremaldi LM
- Cripps N
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cuplov V
- Cure B
- Cushman P
- Cussans D
- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Silva WLP
- Dahmes B
- Dahms T
- Dallavalle GM
- Damgov J
- Damiao DD
- Dammann D
- Danielson T
- Darmenov N
- Das S
- Daskalakis G
- Dasu S
- Daubie E
- David A
- Davids M
- Davies G
- De Araujo FTD
- de Barbaro P
- De Benedetti A
- De Boer W
- de Cassagnac RG
- De Cosa A
- de Fatis TT
- De Filippis N
- De Gruttola M
- De Guio F
- De Jeneret JD
- De La Cruz B
- De Lentdecker G
- De Mattia M
- de Monchenault GH
- De Palma M
- De Roeck A
- De Souza SF
- de Troconiz JF
- De Visscher S
- De Wolf EA
- Debreczeni G
- Deisher A
- Deiters K
- Dejardin M
- del Arbol PMR
- Del Re D
- Delaere C
- Deliomeroglu M
- Dell'Orso R
- Della Negra M
- Della Ricca G
- Demaria N
- Demarteau M
- Demin P
- Demina R
- Demir D
- Demir Z
- Demortier L
- Denegri D
- Deniz M
- Depasse P
- Dero V
- Devroede O
- Dhingra N
- Di Giovanni GP
- Di Guida S
- Di Marco E
- Di Matteo L
- Diamond B
- Dias FA
- Dias MAF
- Diemoz M
- Dierlamm A
- Dimitrov A
- Dimitrov L
- Dinardo ME
- Dirkes G
- Dissertori G
- Dittmar M
- Djordjevic M
- Do Amaral SMS
- Dobrzynski L
- Dobur D
- Doesburg R
- Dolen J
- Dominguez A
- Dominik W
- Dorigo T
- Dorney B
- Doroba K
- Dosselli U
- Dozen C
- Draeger J
- Dragicevic M
- Dragoiu C
- Drell BR
- Dremin I
- Drouhin F
- Drozdetskiy A
- Dubinin M
- Duda M
- Dudero PR
- Dudko L
- Dugad S
- Duggan D
- Dumanoglu I
- Duric S
- Duris J
- Durkin LS
- Duru F
- Dusinberre E
- Dutta D
- Dutta S
- Dutta V
- Dyulendarova M
- Dzelalija M
- Eads M
- Eartly DP
- Eckerlin G
- Ecklund KM
- Eckstein D
- Edelhoff M
- Edelmaier CJ
- Eerola P
- Efron J
- Eggert N
- El Mamouni H
- Elliott-Peisert A
- Ellison J
- Elmer P
- Elvira VD
- Enderle H
- Engh D
- Eno SC
- Epshteyn V
- Erbacher R
- Erdmann M
- Erdmann W
- Erhan S
- Ero J
- Ershov A
- Esen S
- Eshaq Y
- Eskew C
- Eskut E
- Etesami SM
- Eugster J
- Eusebi R
- Evangelou I
- Evans D
- Everaerts P
- Everett A
- Fabbri F
- Fabbri F
- Fabbricatore P
- Fabbro B
- Fabjan C
- Fabozzi F
- Faccioli P
- Fahim A
- Falkiewicz A
- Fanfani A
- Fano L
- Fantasia C
- Fanzago F
- Farrell C
- Fasanella D
- Fassi F
- Faure JL
- Favaro C
- Favart D
- Fay J
- Fehling D
- Feindt M
- Felcini M
- Feld L
- Ferapontov A
- Ferencek D
- Ferguson T
- Fernandez M
- Ferrando A
- Ferri F
- Ferro C
- Field RD
- Fields LJ
- Finger M
- Finger M
- Fiore L
- Fiori F
- Fisher M
- Fisk I
- Flacher H
- Flix J
- Florez C
- Flossdorf A
- Flowers K
- Flucke G
- Flugge G
- Foa L
- Focardi E
- Folgueras S
- Fontaine JC
- Ford WT
- Foudas C
- Fouz MC
- Franci D
- Francis B
- Frangenheim J
- Franzoni G
- Frazier R
- Freeman J
- Freudenreich K
- Friedl M
- Friis E
- Frisch B
- Frosali S
- Frueboes T
- Fruhwirth R
- Fu Y
- Fulcher J
- Funk W
- Furic IK
- Futyan D
- Gabathuler K
- Gabella W
- Gaddi A
- Galanti M
- Gallinaro M
- Gallo E
- Gamsizkan H
- Ganjour S
- Gao Y
- Garcia JMV
- Garcia-Abia R
- Garcia-Bellido A
- Garcia-Solis EJ
- Garfinkel AF
- Garrido RGR
- Gartner J
- Gary JW
- Gascon S
- Gasparini F
- Gasparini U
- Gataullin M
- Gaultney V
- Gauthier L
- Gavrilov V
- Gay APR
- Gaz A
- Gebbert U
- Gecse Z
- Geenen H
- Geffert P
- Geiser A
- Gele D
- Genchev V
- Gennai S
- Gentit FX
- Georgiou G
- Geralis T
- Gerbaudo D
- Gerber CE
- Gershtein Y
- Gerwig H
- Geurts FJM
- Ghete VM
- Ghezzi A
- Giacomelli P
- Giammanco A
- Giassi A
- Gibbons LK
- Giffels M
- Gigi D
- Gill K
- Gilmore J
- Giordano D
- Giordano F
- Girgis S
- Giubilato P
- Giunta M
- Giurgiu G
- Givernaud A
- Glege F
- Gleyzer SV
- Glushkov I
- Gninenko S
- Go A
- Gobbo B
- Godang R
- Godinovic N
- Godshalk A
- Goerlach U
- Goh J
- Gokbulut G
- Gokieli R
- Goldberg S
- Goldenzweig P
- Goldstein J
- Golf F
- Gollapinni S
- Golovtsov V
- Golubev N
- Golutvin I
- Gomez G
- Gomez JA
- Gomez JP
- Goncharov M
- Gonzalez JS
- Gonzi S
- Gorski M
- Gotra Y
- Gottschalk E
- Goulianos K
- Gouskos L
- Gouzevitch M
- Govoni P
- Gowdy S
- Grab C
- Grachov O
- Grandi C
- Gras P
- Grassi M
- Gray L
- Gray R
- Graziano A
- Greder S
- Green D
- Gregoire G
- Gregores EM
- Gresele A
- Gribushin A
- Grigelionis I
- Grimes M
- Grishin V
- Gritsan AV
- Grogg KS
- Gronberg J
- Grothe M
- Grunewald M
- Gruschke J
- Gu J
- Guchait M
- Guiducci L
- Guler AM
- Guler Y
- Gulmez E
- Gunthoti K
- Guo S
- Guo Y
- Guo ZJ
- Gupta P
- Gupta R
- Guragain S
- Gurpinar E
- Gurrola A
- Gurtu A
- Gutay L
- Gutsche O
- Haas J
- Hackstein C
- Hadjiiska R
- Hadley NJ
- Hagopian S
- Hagopian V
- Haguenauer M
- Hahn A
- Hahn KA
- Hajdu C
- Halkiadakis E
- Hall G
- Hall-Wilton R
- Halu A
- Halyo V
- Hammad GH
- Hammer J
- Han J
- Hanlon J
- Hansel S
- Hansen M
- Hansen N
- Hanson G
- Harder K
- Harel A
- Harkonen J
- Harper S
- Harr R
- Harris P
- Harris RM
- Hartl C
- Hartley D
- Hartmann F
- Harvey J
- Hashemi M
- Hatakeyama K
- Hatherell Z
- Hauk J
- Haupt J
- Hauser J
- Hays J
- Heath GP
- Heath HF
- Hebbeker T
- Hebda P
- Hegeman J
- Hegner B
- Heikkinen A
- Heindl SM
- Heinrich M
- Heintz U
- Heister A
- Hektor A
- Held H
- Heltsley B
- Henderson C
- Heo SG
- Heracleous N
- Hernandez AS
- Hernandez JM
- Herndon M
- Herve A
- Hesketh G
- Heyburn B
- Heydhausen D
- Hidas D
- Hildreth M
- Hill C
- Hindrichs O
- Hintz W
- Hinzmann A
- Hirosky R
- Hirschauer J
- Hits D
- Hobson PR
- Hoch M
- Hoepfner K
- Hof C
- Hoffmann HF
- Hoffmann KH
- Hofman DJ
- Hohlmann M
- Hollar J
- Hollingsworth M
- Holzner A
- Honc S
- Hong B
- Honma A
- Hooberman B
- Hoorani HR
- Hopkins W
- Horisberger R
- Hormann N
- Horvath D
- Hos I
- Hou WS
- Hreus T
- Hrubec J
- Hsiung Y
- Hu G
- Hu Z
- Huang XT
- Huckvale B
- Hunt A
- Iaselli G
- Iashvili I
- Iaydjiev P
- Ibarguen HAS
- Iglesias LL
- Ignatenko M
- Iiyama Y
- Iles G
- Ille B
- Incandela J
- Ingram Q
- Innocente V
- Iorio AOM
- Isildak B
- Ivanov A
- Ivanov Y
- Jabeen S
- Jackson J
- Jafari A
- Jain S
- Jain S
- Jain S
- James E
- Jang DW
- Janot R
- Janssen X
- Janulis M
- Jarrin EC
- Jarry P
- Jarvis C
- Jeitler M
- Jeng GY
- Jenkins M
- Jensen H
- Jeong C
- Jessop C
- Jiang CH
- Jimeno AR
- Jindal M
- Jindal P
- Jo M
- John J
- Johns W
- Johnson KF
- Johnson M
- Jones J
- Jones M
- Jorda C
- Josa MI
- Joshi U
- Juillot P
- Jun SY
- Jung H
- Jussen R
- Justus C
- Kaadze K
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- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunovic Z
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- Winer BL
- Winn D
- Winstrom L
- Wissing C
- Wittich P
- Wittmer B
- Woehri HK
- Wolf M
- Wolf R
- Womersley WJ
- Won S
- Wood D
- Wood J
- Wood JS
- Worm SD
- Wright D
- Wrochna G
- Wu W
- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babb J
- Babucci E
- Baccaro S
- Bacchetta N
- Bacchi W
- Bachtis M
- Baden D
- Badgett W
- Baechler J
- Baer H
- Baesso P
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- Zachariadou A
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Search for resonances in the mass spectrum of muon pairs produced in association with b quark jets in proton-proton collisions at root 8 and 13 TeV
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- Zalewski P.
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- Zorbilmez C.
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- Zucchetta A.
- Zumerle G.
- Zuo X.
- Zuolo D.
- Publication venue
- Springer
- Publication date
- 01/01/2018
- Field of study
A search for resonances in the mass range 12-70 GeV produced in association with a b quark jet and a second jet, and decaying to a muon pair, is reported. The analysis is based on data from proton-proton collisions at center-of-mass energies of 8 and 13 TeV, collected with the CMS detector at the LHC and corresponding to integrated luminosities of 19.7 and 35.9 fb(-1), respectively. The search is carried out in two mutually exclusive event categories. Events in the first category are required to have a b quark jet in the central region (|| 2.4) and at least one jet in the forward region (|| > 2.4). Events in the second category are required to have two jets in the central region, at least one of which is identified as a b quark jet, no jets in the forward region, and low missing transverse momentum. An excess of events above the background near a dimuon mass of 28 GeV is observed in the 8 TeV data, corresponding to local significances of 4.2 and 2.9 standard deviations for the first and second event categories, respectively. A similar analysis conducted with the 13 TeV data results in a mild excess over the background in the first event category corresponding to a local significance of 2.0 standard deviations, while the second category results in a 1.4 standard deviation deficit. The fiducial cross section measurements and 95% confidence level upper limits on those for a resonance consistent with the 8 TeV excess are provided at both collision energies
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
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- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Observation of Charge-Dependent Azimuthal Correlations in p-Pb Collisions and Its Implication for the Search for the Chiral Magnetic Effect
- Author
- Aarrestad T. K.
- Abad D. R.
- Abbaneo D.
- Abbiendi G.
- Abbrescia M.
- Abdelalim A. A.
- Abdullah Watw
- Abdullin S.
- Abdulsalam A.
- Abercrombie D.
- Abu Zeid S.
- Ackert A.
- Acosta D.
- Acosta J. G.
- Acosta M. V.
- Adair A.
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- Adzic P.
- Afanasiev S.
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- Zientek M.
- Zolkapli Z.
- Zorbakir I. S.
- Zorbilmez C.
- Zotto P.
- Zou D.
- Zsigmond A. J.
- Zucchetta A.
- Zumerle G.
- Zuranski A.
- Zykunov V.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
- …