Language and the making of meaning for individuals diagnosed with bipolar disorder

This qualitative phenomenological research study examines language, specifically the language of diagnosis, and the making of meaning for individuals who have been diagnosed with bipolar disorder. The study sample consists of six participants who had received a diagnosis of bipolar disorder three or more years ago. Data were collected through hour-long, semi-structured interviews with each participant at a single point in time. Findings revealed three broad themes: (a) The participants\u27 experience of language, (b) The participants\u27 making of meaning, or where strength was found, and (c) The function of language

Light and Electron Microscopic Features of Reproductive Tissues of the Mare

This study was designed to investigate the light and electron microscopic features of tissues of the reproductive tract of the mare. Tissues examined with the light microscope included vagina, uterus, uterine cervix, oviduct, and ovary. The uterus, uterine cervix, and vagina also were examined in electron microscopic preparations. The findings included previously unreported features as well as confirming some features reported by other investigators. These results may serve as the basis for further studies of normal and abnormal conditions of the female equine reproductive system.Veterinary Patholog

Annual Survey of Virginia Law: Damages for Medical Malpractice in Virginia

As a general rule, a plaintiff in actions for personal injury and wrongful death in Virginia, regardless ofwhether the cause derives from medical malpractice, may state a claim for any medical expenses incurred as a result of the alleged injury or death. By definition, an expense is incurred when it has been paid or one become[s] legally obligated to pay it. A tortfeasor is bound and obligated to make the plaintiff whole, which means the injured party or his estate must be reasonably compensated for the fair and reasonable value of incurred medical expenses

The Best Field Trip Ever: An Artistic and Scientific Analysis of the Value of Field Trips to an Environmental Center

The Center for the Urban River at Beczak is a 3900-square-foot environmental education and research facility located on 2 acres of Hudson riverfront park in downtown Yonkers. It is operated by Sarah Lawrence College in cooperation with the Beczak Environmental Education Center. The objective of this study was to measure the effects of a field trip to CURB on students’ environmental empathy, environmental engagement, cultural awareness, and interest in CURB. This was achieved with qualitative and quantitative measures, including a multi-case study (Bogdan & Biklen, 1998) and a quantitative survey. The qualitative multi-case study, in the field of participatory action research (Denzin & Lincoln, 2000), included note-taking and observation of students attending CURB programs

Prioritizing progressive MS rehabilitation research: A call from the International Progressive MS Alliance

Cognition; Fatigue; MobilityCognición; Fatiga; MovilidadCognició; Fatiga; MobilitatBackground: People with multiple sclerosis (MS) experience myriad symptoms that negatively affect their quality of life. Despite significant progress in rehabilitation strategies for people living with relapsing-remitting MS (RRMS), the development of similar strategies for people with progressive MS has received little attention. Objective: To highlight key symptoms of importance to people with progressive MS and stimulate the design and implementation of high-quality studies focused on symptom management and rehabilitation. Methods: A group of international research experts, representatives from industry, and people affected by progressive MS was convened by the International Progressive MS Alliance to devise research priorities for addressing symptoms in progressive MS. Results: Based on information from the MS community, we outline a rationale for highlighting four symptoms of particular interest: fatigue, mobility and upper extremity impairment, pain, and cognitive impairment. Factors such as depression, resilience, comorbidities, and psychosocial support are described, as they affect treatment efficacy. Conclusions: This coordinated call to action—to the research community to prioritize investigation of effective symptom management strategies, and to funders to support them—is an important step in addressing gaps in rehabilitation research for people affected by progressive MS

Phase Change Material and Applications

A thermal energy storage heat exchanger can include a core defining a plurality of airflow passages to receive an air­stream therethrough. The core can be made of a composite of a phase change material shape-stabilized by a polymer. The phase change material can be structurally supported by the polymer and the phase change material can be config­ured to change phases to store energy from and deliver stored energy to the airstream when the airflow passes through the core

Evaluation of Sysmex XT-2000iV analyzer performance across a network of five veterinary laboratories using a commercially available quality control material

BackgroundLaboratory and instrument harmonization is seldom reported in the veterinary literature despite its advantages to clinical interpretation, including the use of interchangeable results and common reference intervals within a system of laboratories.ObjectivesA three-step process was employed to evaluate and optimize performance and then assess the appropriateness of common reference intervals across a network of six Sysmex XT-2000iV hematology analyzers at 5 commercial veterinary laboratory sites. The aims were to discover if harmonization was feasible in veterinary hematology and which quality parameters would best identify performance deviations to ensure a harmonized status could be maintained.MethodsThe performance of 10 measurands of a commercially available quality control material (Level 2—Normal e-CHECK (XE)-Hematology Control) was evaluated during three 1-month time periods. Precision and bias were assessed with Six Sigma, American Society of Veterinary Clinical Pathology (ASVCP) total error quality goals and biologic variation (BV)-based quality goal approaches to performance measurement.ResultsInstrument adjustments were made to 1 analyzer twice and 3 analyzers once between evaluations to improve performance and achieve harmonization. Sigma metrics improved from 37/50 > 6 to 58/60 > 6 and to all >5 over the course of the harmonization project. BV-based quality goals for desirable bias and for laboratory systems of 0.33 × CVI (within-subject biologic variation) were more sensitive and useful for assessing performance than the ASVCP total error goals.ConclusionsOptimization and harmonization were achieved, and because BV-derived bias goals were achieved, common reference intervals could be implemented across the network of analyzers

Acute synovitis and intra-articular methylprednisolone acetate in ponies

AbstractObjective: To determine how acute synovitis, with and without intra-articular methylprednisolone acetate (MPA), affect synthesis of proteoglycan, total protein, and collagen in articular cartilage and total protein synthesis in synovial membrane.Design: Synovitis was induced in 10 ponies by the injection of 0.5 ng lipopolysaccharide (LPS) into the left radiocarpal and midcarpal joints every 2 days for a total of four treatments. Synovitis was documented by clinical examination and synovial fluid analyses. Two days before euthanasia, MPA (0.1 mg/kg) was injected with the last dose of LPS into both the left and right radiocarpal and midcarpal joints of five of these ponies. Proteoglycan synthesis in articular cartilage explants from these joints was measured by incorporation of sodium [35S]sulfate. The size of the proteoglycan monomers and their aggregation with hyaluronan was assessed by size-exclusion chromatography. Protein synthesis in articular cartilage was measured by incorporation of [3H]proline and collagen synthesis by conversion of [3H]proline into [3H]hydroxyproline. Protein synthesis was measured in synovial membrane explants by incorporation of [35S]methionine.Results: Ponies developed carpal effusion and mild lameness accompanied by increased total nucleated cell count and total solids in synovial fluid in response to the LPS injections. Moderate to severe synovial membrane proliferation and inflammation were observed histopathologically in joints injected with LPS but no consistent light-microscopical changes were observed in the articular cartilage from these joints. Intra-articular MPA alone was associated with decreased proteoglycan synthesis and increased protein and collagen synthesis in the cartilage explants. Total protein synthesis by synovial membrane was also increased by MPA alone. In contrast, no differences in protein or proteoglycan synthesis were observed in explants from the joints with synovitis, with or without intra-articular MPA. Treatment with MPA, LPS, and LPS/MPA did not alter proteoglycan aggregate size, but LPS-induced synovitis resulted in an increase in the second largest population of monomers. MPA increased the synthesis of small proteoglycan monomers.Conclusion: Based on the methods used, acute synovitis prevented changes induced by intra-articular MPA alone. Results suggested that the effect of intra-articular MPA on joint metabolism was different between inflamed and normal joints. Experimental studies must consider the effect of inflammation, as well as the potential to introducein vitroculture artifacts when investigating the effect of intra-articular corticosteroids on chondrocyte function

Towards integration of environmental and health impact assessments for wild capture fishing and farmed fish with particular reference to public health and occupational health dimensions

The paper offers a review and commentary, with particular reference to the production of fish from wild capture fisheries and aquaculture, on neglected aspects of health impact assessments which are viewed by a range of international and national health bodies and development agencies as valuable and necessary project tools. Assessments sometimes include environmental health impact assessments but rarely include specific occupational health and safety impact assessments especially integrated into a wider public health assessment. This is in contrast to the extensive application of environmental impact assessments to fishing and the comparatively large body of research now generated on the public health effects of eating fish. The value of expanding and applying the broader assessments would be considerable because in 2004 the United Nations Food and Agriculture Organization reports there were 41,408,000 people in the total ‘fishing’ sector including 11,289,000 in aquaculture. The paper explores some of the complex interactions that occur with regard to fishing activities and proposes the wider adoption of health impact assessment tools in these neglected sectors through an integrated public health impact assessment tool