193 research outputs found
Electronic energy band structure of solids Quarterly status report, 16 Mar. - 15 Jun. 1967
Piezoresistance and piezo-Hall effect in semiconducting strontium titanium oxid
Ideal Bose gas in fractal dimensions and superfluid He in porous media
Physical properties of ideal Bose gas with the fractal dimensionality between
D=2 and D=3 are theoretically investigated. Calculation shows that the
characteristic features of the specific heat and the superfluid density of
ideal Bose gas in fractal dimensions are strikingly similar to those of
superfluid Helium-4 in porous media. This result indicates that the geometrical
factor is dominant over mutual interactions in determining physical properties
of Helium-4 in porous media.Comment: 13 pages, 6 figure
Testing Lorentz invariance by use of vacuum and matter filled cavity resonators
We consider tests of Lorentz invariance for the photon and fermion sector
that use vacuum and matter-filled cavities. Assumptions on the wave-function of
the electrons in crystals are eliminated from the underlying theory and
accurate sensitivity coefficients (including some exceptionally large ones) are
calculated for various materials. We derive the Lorentz-violating shift in the
index of refraction n, which leads to additional sensitivity for matter-filled
cavities ; and to birefringence in initially isotropic media. Using published
experimental data, we obtain improved bounds on Lorentz violation for photons
and electrons at levels of 10^-15 and below. We discuss implications for future
experiments and propose a new Michelson-Morley type experiment based on
birefringence in matter.Comment: 15 pages, 8 table
Photogenerated Carriers in SrTiO3 Probed by Mid-Infrared Absorption
Infrared absorption spectra of SrTiO have been measured under
above-band-gap photoexcitations to study the properties of photogenerated
carriers, which should play important roles in previously reported photoinduced
phenomena in SrTiO. A broad absorption band appears over the entire
mid-infrared region under photoexcitation. Detailed energy, temperature, and
excitation power dependences of the photoinduced absorption are reported. This
photo-induced absorption is attributed to the intragap excitations of the
photogenerated carriers. The data show the existence of a high density of
in-gap states for the photocarriers, which extends over a wide energy range
starting from the conduction and valence band edges.Comment: 5 pages, 5 figures, submitted to J. Phys. Soc. Jp
Tuning of metal-insulator transition of two-dimensional electrons at parylene/SrTiO interface by electric field
Electrostatic carrier doping using a field-effect-transistor structure is an
intriguing approach to explore electronic phases by critical control of carrier
concentration. We demonstrate the reversible control of the insulator-metal
transition (IMT) in a two dimensional (2D) electron gas at the interface of
insulating SrTiO single crystals. Superconductivity was observed in a
limited number of devices doped far beyond the IMT, which may imply the
presence of 2D metal-superconductor transition. This realization of a
two-dimensional metallic state on the most widely-used perovskite oxide is the
best manifestation of the potential of oxide electronics
Lattice dynamics effects on small polaron properties
This study details the conditions under which strong-coupling perturbation
theory can be applied to the molecular crystal model, a fundamental theoretical
tool for analysis of the polaron properties. I show that lattice dimensionality
and intermolecular forces play a key role in imposing constraints on the
applicability of the perturbative approach. The polaron effective mass has been
computed in different regimes ranging from the fully antiadiabatic to the fully
adiabatic. The polaron masses become essentially dimension independent for
sufficiently strong intermolecular coupling strengths and converge to much
lower values than those tradition-ally obtained in small-polaron theory. I find
evidence for a self-trapping transition in a moderately adiabatic regime at an
electron-phonon coupling value of .3. Our results point to a substantial
independence of the self-trapping event on dimensionality.Comment: 8 pages, 5 figure
Maternal use of drug substrates of placental transporters and the effect of transporter-mediated drug interactions on the risk of congenital anomalies
Background A number of transporter proteins are expressed in the placenta, and they facilitate the placental transfer of drugs. The inhibition of P-glycoprotein (P-gp) was previously found to be associated with an increase in the risk of congenital anomalies caused by drug substrates of this transporter. We now explore the role of other placental transporter proteins. Methods A population-based case-referent study was performed using cases with congenital anomalies (N = 5,131) from EUROCAT Northern Netherlands, a registry of congenital anomalies. The referent population (N = 31,055) was selected from the pregnancy IADB. nl, a pharmacy prescription database. Results Ten placental transporters known to have comparable expression levels in the placenta to that of P-gp, were selected in this study. In total, 147 drugs were identified to be substrates, inhibitors or inducers, of these transporters. Fifty-eight of these drugs were used by at least one mother in our cases or referent population, and 28 were used in both. The highest user rate was observed for the substrates of multidrug resistance-associated protein 1, mainly folic acid (6% of cases, 8% of referents), and breast cancer resistance protein, mainly nitrofurantoin (2.3% of cases, 2.9% of referents). In contrast to P-gp, drug interactions involving substrates of these transporters did not have a significant effect on the risk of congenital anomalies. Conclusions Some of the drugs which are substrates or inhibitors of placental transporters were commonly used during pregnancy. No significant effect of transporter inhibition was found on fetal drug exposure, possibly due to a limited number of exposures
EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans
Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the genetic basis remains to be elucidated. We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract. Retroillumination revealed development of cortical vacuoles at one month of age; visible cataract appeared around three months, which progressed to mature cataract by six months. EPHA2 protein expression in the lens is spatially and temporally regulated. It is low in anterior epithelial cells, upregulated as the cells enter differentiation at the equator, strongly expressed in the cortical fiber cells, but absent in the nuclei. Deletion of Epha2 caused a significant increase in the expression of HSP25 (murine homologue of human HSP27) before the onset of cataract. The overexpressed HSP25 was in an underphosphorylated form, indicating excessive cellular stress and protein misfolding. The orthologous human EPHA2 gene on chromosome 1p36 was tested in three independent worldwide Caucasian populations for allelic association with cortical cataract. Common variants in EPHA2 were found that showed significant association with cortical cataract, and rs6678616 was the most significant in meta-analyses. In addition, we sequenced exons of EPHA2 in linked families and identified a new missense mutation, Arg721Gln, in the protein kinase domain that significantly alters EPHA2 functions in cellular and biochemical assays. Thus, converging evidence from humans and mice suggests that EPHA2 is important in maintaining lens clarity with age
Persistent acceleration in global sea-level rise since the 1960s
Previous studies reconstructed twentieth-century global mean sea level (GMSL) from sparse tide-gauge records to understand whether the recent high rates obtained from satellite altimetry are part of a longer-term acceleration. However, these analyses used techniques that can only accurately capture either the trend or the variability in GMSL, but not both. Here we present an improved hybrid sea-level reconstruction during 1900–2015 that combines previous techniques at time scales where they perform best. We find a persistent acceleration in GMSL since the 1960s and demonstrate that this is largely (~76%) associated with sea-level changes in the Indo-Pacific and South Atlantic. We show that the initiation of the acceleration in the 1960s is tightly linked to an intensification and a basin-scale equatorward shift of Southern Hemispheric westerlies, leading to increased ocean heat uptake, and hence greater rates of GMSL rise, through changes in the circulation of the Southern Ocean
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