1,430 research outputs found
Range Queries on Uncertain Data
Given a set of uncertain points on the real line, each represented by
its one-dimensional probability density function, we consider the problem of
building data structures on to answer range queries of the following three
types for any query interval : (1) top- query: find the point in that
lies in with the highest probability, (2) top- query: given any integer
as part of the query, return the points in that lie in
with the highest probabilities, and (3) threshold query: given any threshold
as part of the query, return all points of that lie in with
probabilities at least . We present data structures for these range
queries with linear or nearly linear space and efficient query time.Comment: 26 pages. A preliminary version of this paper appeared in ISAAC 2014.
In this full version, we also present solutions to the most general case of
the problem (i.e., the histogram bounded case), which were left as open
problems in the preliminary versio
The complexity of selection and ranking in X + Y and matrices with sorted columns
AbstractThe complexity of selection is analyzed for two sets, X + Y and matrices with sorted columns. Algorithms are presented that run in time which depends nontrivially on the rank k of the element to be selected and which is sublinear with respect to set cardinality. Identical bounds are also shown for the problem of ranking elements in these sets, and all bounds are shown to be optimal to within a constant multiplicative factor
Successful use of axonal transport for drug delivery by synthetic molecular vehicles
We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up to a hundred reversibly attached drug molecules. The complex efficiently enters nerve terminals after intramuscular or intradermal administration and travels within axonal processes to neuron cell bodies. The tripartite agent provided 100-fold amplification of saturable neural uptake events, delivering multiple drug molecules per complex. _In vivo_, analgesic drug delivery to systemic and to non-targeted neural tissues was greatly reduced compared to existing routes of administration, thus exemplifying the possibility of specific nerve root targeting and effectively increasing the potency of the candidate drug gabapentin 300-fold relative to oral administration
Selection from read-only memory with limited workspace
Given an unordered array of elements drawn from a totally ordered set and
an integer in the range from to , in the classic selection problem
the task is to find the -th smallest element in the array. We study the
complexity of this problem in the space-restricted random-access model: The
input array is stored on read-only memory, and the algorithm has access to a
limited amount of workspace. We prove that the linear-time prune-and-search
algorithm---presented in most textbooks on algorithms---can be modified to use
bits instead of words of extra space. Prior to our
work, the best known algorithm by Frederickson could perform the task with
bits of extra space in time. Our result separates
the space-restricted random-access model and the multi-pass streaming model,
since we can surpass the lower bound known for the latter
model. We also generalize our algorithm for the case when the size of the
workspace is bits, where . The running time
of our generalized algorithm is ,
slightly improving over the
bound of Frederickson's algorithm. To obtain the improvements mentioned above,
we developed a new data structure, called the wavelet stack, that we use for
repeated pruning. We expect the wavelet stack to be a useful tool in other
applications as well.Comment: 16 pages, 1 figure, Preliminary version appeared in COCOON-201
Spatial Structure of Stationary Nonequilibrium States in the Thermostatted Periodic Lorentz Gas
We investigate analytically and numerically the spatial structure of the
non-equilibrium stationary states (NESS) of a point particle moving in a two
dimensional periodic Lorentz gas (Sinai Billiard). The particle is subject to a
constant external electric field E as well as a Gaussian thermostat which keeps
the speed |v| constant. We show that despite the singular nature of the SRB
measure its projections on the space coordinates are absolutely continuous. We
further show that these projections satisfy linear response laws for small E.
Some of them are computed numerically. We compare these results with those
obtained from simple models in which the collisions with the obstacles are
replaced by random collisions.Similarities and differences are noted.Comment: 24 pages with 9 figure
Reviewing quality of governance:New perspectives and future research
In the concluding chapter, the editors address the central topics of the book as well as some lessons learnt on quality of governance. Public values do matter, but how do they relate (and conflict), with many actors involved in public governance, including at street level and in public-private networks? A broad panorama of values appears to be important for the quality of governance, but the interpretation of the values differs and context is always relevant (macro, meso, and micro). Thus, the work in progress and the chapter define an agenda for future research and offers food for thought for all levels of governance
Laser-initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues
Organic dyes have found increasing use a s sensitizers in laser surgical procedures, due to their high optical absorbances. Little is known, however, about the nature of the degradation products formed when these dyes are irradiated with a laser. Previous work in our laboratories has shown that irradiation of polymeric and biological tissues with CO2 and Nd:YAG lasers produces a host of volatile and semivolatile by-products, some of which are known to be potential carcinogens. This work focuses on the identification of the chemical by-products formed by diode laser and Nd:YAG laser irradiation of indocyanine green (ICG) and carbon black based ink sensitized tissues, including bone, tendon and sheep\u27s teeth. Samples were mounted in a 0.5-L Pyrex sample chamber equipped with quartz optical windows, charcoal filtered air inlet and an outlet attached to an appropriate sample trap and a constant flow pump. By-products were analyzed by GC/MS and HPLC. Volatiles identified included benzene and formaldehyde. Semi-volatiles included traces of polycyclic aromatics, arising from the biological matrix and inks, as well as fragments of ICG and the carbon ink components. The significance of these results will be discussed, including the necessity of using appropriate evacuation devices when utilizing lasers for surgical procedures
Multi-Informant Predictors of Social Inclusion for Students with Autism Spectrum Disorders Attending Mainstream School
This study examined differential profiles of behavioural characteristics predictive of successful inclusion in mainstream education for children with autism spectrum disorders (ASD) and comparison students. Multiple regression analyses using behavioural ratings from parents, teachers and peers found some evidence for differential profiles predicting peer acceptance and rejection. High levels of peer-rated shyness significantly predicted social rejection in comparison students only. Parent-rated prosocial behaviour also differentially predicted social acceptance; high-levels of prosocial behaviour predicted acceptance in comparison students, but low-levels were predictive for students with ASD. These findings suggest that schools may seek to augment traditional social skills programmes with awareness raising about ASD among mainstream pupils to utilise peers’ apparent willingness to discount characteristics such as ‘shyness’
- …