19 research outputs found
Creación de un Laboratorio de Análisis Socio-Político de América Latina (AMELAT -LAB)
El objetivo principal de este proyecto era crear un espacio de colaboración entre estudiantes, investigadores y profesores para el análisis y comprensión de problemáticas y fenómenos sociales y politicos actuales en América Latina
Distortion-product otoacoustic emissions at ultra-high frequencies in parents of individuals with autosomal recessive hearing loss
Extracellular matrix components in atherosclerotic arteries of Apo E/LDL receptor deficient mice: An immunohistochemical study
During accelerated vascular remodeling such
as in atherosclerosis, the composition of the extracellular
matrix becomes altered. The matrix components of the
diseased artery influence cellular processes such as
adhesion, migration and proliferation. Furthermore, in
atherosclerosis, the inability of the cells within the lesion
to produce a mechanically stable matrix may lead to
plaque rupture. In this immunohistochemical study of
atherosclerotic mice aorta, we have reviewed the
presence of ECM components with roles in maintaining
tissue structure and function. These components include
osteopontin and COMP as well as the leucine rich
repeats proteins decorin, PRELP, and fibromodulin.
Immunohistochemistry demonstrated presence of
osteopontin, COMP, decorin, PRELP and fibromodulin
in lesion areas of ApoE/LDLr deficient mice. Some
advanced lesions exhibited areas of cartilage-like
morphology and were shown to represent cartilage by
their content of the cartilage specific proteins collagen II
and aggrecan. The results suggest that cartilageassociated
cell/collagen binding ECM proteins may be
involved in the pathogenesis of atherosclerosis
Long-term treatment with mesalazine in patients with symptomatic uncomplicated diverticular disease
Abstract The aim of this work was to compare the
recurrence of diverticulitis during a 5-year follow-up in a
population of patients affected by symptomatic uncomplicated
diverticular disease (SUDD), taking either 800 mg of
mesalamine b.i.d for 10 days every month or no 5-ASA.
Sixty-seven consecutive patients affected by SUDD followed-
up every 6 months for 5 years. All patients in this
group (M-group) were requested to consume mesalamine
800 mg b.i.d for 10 days every month. A control group
(C-group) of 82 subjects with SUDD allocated in an
institution for the elderly and taking no 5-ASA medications
was also followed-up for the same period. As a result in the
M-group 14.9% of patients did not complete the follow-up,
and diverticulitis developed in two patients (4%; 95% CI
1.1\u201313.5). In the C-group 6.1% patients did not complete
the follow-up, and diverticulitis developed in 8 patients
(10.4%; 95% CI 5.4\u201319.2). The difference between the two
groups was not significant (difference = -6.4%; 95% CI
-15.6 to 4.3; log rank test: p = 0.1256). Cyclic treatment
with mesalazine seems to be clinical, although not statistically
effective in reducing the incidence of diverticulitis.
In future well-designed RCTs are necessary to demonstrate
the therapeutic gain of the use of mesalazine, if any, in the
management of patients with SUD
Helicobacter pylori eradication: are we really all equal? A controlled study in native and immigrant population
Abstract Italy\u2019s shift to a tertiary economy has modified
the working market, concentrating demand also on
unqualified one, which includes most immigrants. It is also
well established that low socio-economical conditions are
associated with an increased prevalence of H. pylori
infection. The aims of this study were to compare: (1) the
efficacy of a 7 days triple therapy in immigrant and in
Italian patients; (2) the prevalence of PUD between these
two groups of patients. A total of 116 consecutive immigrant
and 112 Italian H. pylori infected patients were
recruited between 2007 and 2008. Patients underwent
13C-UBT, endoscopy with biopsies, and were offered a
7-day triple therapy. Eradication rate (ER) was assessed
8 weeks after the end of the treatment using 13C-UBT. The
two populations differed for median age (p\0.01), prevalence
of PUD (p\0.01), and smoking status (p\0.01).
The ER according to the ITT analysis was 70% for Italian
and 48.3% for immigrant (p\0.01). Multivariate analysis
including country of origin, sex, age, PUD, smoking, and
alcohol status found that immigrant had an adjusted OR for
not eradicating of 2.14 (p = 0.03). In immigrant patients
resident in Italy, performance of triple therapy was lower
than expected. Further studies are demanded to confirm and
clarify these intriguing result
Gabaergic and opioid receptors mediate the facilitation of NaCl intake induced by α₂-adrenergic activation in the lateral parabrachial nucleus
Alpha2-adrenergic, gabaergic or opioidergic activation in the lateral parabrachial nucleus (LPBN) increases sodium intake. In the present study, we investigated the effects of single or combined blockade of opioidergic and gabaergic receptors in the LPBN on the increase of 0.3 M NaCl intake induced by 2-adrenoceptor activation in the LPBN. Male Holtzman rats (n = 5–9/group) with cannulas implanted bilaterally in the LPBN were treated with the diuretic furosemide (10 mg/kg b wt.) combined with low dose of the angiotensin converting enzyme inhibitor captopril (5 mg/kg b wt.) subcutaneously. Bilateral injections of moxonidine (alpha2-adrenergic/imidazoline receptor agonist, 0.5 nmol) into the LPBN increased furosemide + captopril-induced 0.3 M NaCl intake (25.8 ± 1.4, vs. vehicle: 3.8 ± 1.1 ml/60 min). The opioidergic receptor antagonist naloxone (100 nmol) or the GABAA receptor antagonist bicuculline (5 nmol) injected into the LPBN partially reduced the increase of 0.3 M NaCl intake produced by LPBN moxonidine (11.8 ± 4.0 and 22.8 ± 4.5, respectively, vs. vehicle + moxonidine: 31.6 ± 4.0 ml/60 min, respectively). Similar to the treatment with each antagonist alone, the combined injections of naloxone (100 nmol) and bicuculline (5 nmol) into the LPBN also partially reduced moxonidine effects on 0.3 M NaCl intake (15.5 ± 6.5 ml/60 min). The GABAB receptor antagonist saclofen (5 nmol) injected into the LPBN did not change the effects of moxonidine on 0.3 M NaCl intake (24.3 ± 7.8 ml/120 min). These results suggest that the increase of 0.3 M NaCl intake by 2-adrenergic receptor activation in the LPBN is partially dependent on GABAA and opioid receptor activation in this area.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq