Selection Incentives for Health Insurers in the Presence of Sophisticated Risk Adjustment

This article analyzes selection incentives for insurers in the Dutch basic health insurance market, which operates with community-rated premiums and sophisticated risk adjustment. Selection incentives result from the interplay of three market characteristics: possible actions by insurers, consumer response to these actions, and predictable variation in profitability of insurance contracts. After a qualitative analysis of the first two characteristics our prima

Incorporating self-reported health measures in risk equalization through constrained regression

Most health insurance markets with premium-rate restrictions include a risk equalization system to compensate insurers for predictable variation in spending. Recent research has shown, however, that even the most sophisticated risk equalization systems tend to undercompensate (overcompensate) groups of people with poor (good) self-reported health, confronting insurers with incentives for risk selection. Self-reported health measures are generally considered infeasible for use as an explicit ‘risk adjuster’ in risk equalization models. This study examines an alternative way to exploit this information, namely through ‘constrained regression’ (CR). To do so, we use administrative data (N = 17 m) and health survey information (N = 380 k) from the Netherlands. We estimate five CR models and compare these models with the actual Dutch risk equalization model of 2016 which was estimated by ordinary least squares (OLS). In the CR models, the estimated coefficients are restricted, such that t

Risk equalization in competitive health insurance markets: Identifying healthy individuals on the basis of multiple-year low spending

Objective: To study the extent to which risk equalization (RE) in competitive health insurance markets can be improved by including an indicator for being healthy. Study Setting/Data Sources: This study is conducted in the context of the Dutch individual health insurance market. Administrative data on spending and risk characteristics (2011-2014) for the entire population (N = 16.6 m) as well as health survey data from a large sample (N = 387 k) are used. Study Design: The indicator for being healthy is low spending in thr

Phase 1 study of the MDM2 inhibitor AMG 232 in patients with advanced P53 wild-type solid tumors or multiple myeloma

_Background_ This open-label, first-in-human, phase 1 study evaluated AMG 232, an oral selective MDM2 inhibitor in patients with TP53 wild-type (P53WT), advanced solid tumors or multiple myeloma (MM). _Methods_ In the dose escalation (n = 39), patients with P53WT refractory solid tumors enrolled to receive once-dailyAMG 232 (15, 30, 60, 120, 240, 480, and 960 mg) for seven days every 3 weeks (Q3W). In the dose expansion (n = 68), patients with MDM2-amplified (well-differentiated and dedifferentiated liposarcomas [WDLPS and DDLPS], glioblastoma multiforme [GBM], or other solid tumors [OST]), MDM2-overexpressing ER+ breast cancer (BC), or MM received AMG 232 at the maximum tolerated dose (MTD). Safety, pharmacokinetics, pharmacodynamics, and efficacy were assessed. _Results_ AMG 232 had acceptable safety up to up to 240 mg

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Throug

Measurement of forward charged hadron flow harmonics in peripheral PbPb collisions at √sNN = 5.02 TeV with the LHCb detector

Flow harmonic coefficients, v n , which are the key to studying the hydrodynamics of the quark-gluon plasma (QGP) created in heavy-ion collisions, have been measured in various collision systems and kinematic regions and using various particle species. The study of flow harmonics in a wide pseudorapidity range is particularly valuable to understand the temperature dependence of the shear viscosity to entropy density ratio of the QGP. This paper presents the first LHCb results of the second- and the third-order flow harmonic coefficients of charged hadrons as a function of transverse momentum in the forward region, corresponding to pseudorapidities between 2.0 and 4.9, using the data collected from PbPb collisions in 2018 at a center-of-mass energy of 5.02 TeV . The coefficients measured using the two-particle angular correlation analysis method are smaller than the central-pseudorapidity measurements at ALICE and ATLAS from the same collision system but share similar features

Sense of place and experimentation in urban sustainability transitions: the Resilience Lab in Carnisse, Rotterdam, The Netherlands

textabstractExperimentation as a means of governance for sustainability transitions has been advocated for years by transition scholars and geography scholars. We propose that examining the impact of experimentation requires an understanding of its embeddedness in place as a socio-spatial context. This notion of embeddedness, which conceptually aligns well with the understanding of sense of place, is under-examined in sustainability transitions literature. By conjoining the sense of place and sustainability transition literatures, we conceptualize that sense of place can be one outcome of experimentation fostering sustainability transitions. We examine urban living labs as an open format of urban experimentation, where multiple actors interact with the aim to co-design, test, and implement governance innovations. From the literature, we have distilled three phenomena that relate to a sense of place as mechanisms for transformation: a symbolic understanding or meaning of place; a narrative of place that connects to a transformative vision; and new types of relations between people and place. With this conceptual lens, we analyze our case study, an urban living lab called The Resilience Lab in a neighborhood of the city of Rotterdam, The Netherlands. Drawing from a longitudinal case study research, we contend that urban living labs can connect a sense of change (transformation) with a sense of place by co-creating new narratives of place, by co-producing knowledge on new practices and new relations between people and place, and by allowing the co-design or (re)establishment of places with symbolic meaning. As such, urban living labs facilitate urban sustainability transitions