Inclusive inelastic scattering of heavy ions and nuclear correlations

Calculations of inclusive inelastic scattering distributions for heavy ion collisions are considered within the high energy optical model. Using ground state sum rules, the inclusive projectile and complete projectile-target inelastic angular distributions are treated in both independent particle and correlated nuclear models. Comparisons between the models introduced are made for alpha particles colliding with He-4, C-12, and O-16 targets and protons colliding with O-16. Results indicate that correlations contribute significantly, at small momentum transfers, to the inelastic sum. Correlation effects are hidden, however, when total scattering distributions are considered because of the dominance of elastic scattering at small momentum transfers

Evidence for Differential Rotation on a T Tauri Star

Five years of photometric monitoring of the T Tauri star HBC 338 in NGC 1333 has revealed that it is a periodic variable, but the period has changed significantly with time. From 2000-2003, a period near 5.6 days was observed, while in the last two seasons, the dominant period is near 4.6 days. No other T Tauri star has been seen to change its period by such a large percentage. We propose a model in which a differentially rotating star is seen nearly equator-on and a high latitude spot has gradually been replaced by a low latitude spot. We show that this model provides an excellent fit to the observed shapes of the light curves at each epoch. The amplitude and sense of the inferred differential rotation is similar to what is seen on the Sun. This may be surprising given the likely high degree of magnetic surface activity on the star relative to the Sun but we note that HBC 338 is clearly an exceptional T Tauri star.Comment: Acepted for publication in PAS

Developing and evaluating interventions to reduce inappropriate prescribing by general practitioners of antibiotics for upper respiratory tract infections: a randomised controlled trial to compare paper-based and web-based modelling experiments

Background: Much implementation research is focused on full-scale trials with little evidence of preceding modelling work. The Medical Research Council Framework for developing and evaluating complex interventions has argued for more and better theoretical and exploratory work prior to a trial as a means of improving intervention development. Intervention modelling experiments (IMEs) are a way of exploring and refining an intervention before moving to a full-scale trial. They do this by delivering key elements of the intervention in a simulation that approximates clinical practice by, for example, presenting general practitioners (GPs) with a clinical scenario about making a treatment decision. Methods: The current proposal will run a full, web-based IME involving 250 GPs that will advance the methodology of IMEs by directly comparing results with an earlier paper-based IME. Moreover, the web-based IME will evaluate an intervention that can be put into a full-scale trial that aims to reduce antibiotic prescribing for upper respiratory tract infections in primary care. The study will also include a trial of email versus postal invitations to participate. Discussion: More effective behaviour change interventions are needed and this study will develop one such intervention and a system to model and test future interventions. This system will be applicable to any situation in the National Health Service where behaviour needs to be modified, including interventions aimed directly at the public. Trial registration: ClinicalTrials (NCT): NCT0120673

Measuring attitude toward theistic faith : assessing the Astley-Francis Scale among Christian, Muslim and secular youth in England

Empirical research within the social scientific study of religion in general and within the psychology of religion in particular remains very conscious of the complex nature of its subject matter. Empirical research in this field needs to take cognisance of the many forms in which religion is expressed (say, Buddhism, Christianity, Hinduism, Islam, Judaism, and Sikhism) and the many facets within the forms (say, beliefs, behaviours and affiliation). Working in the 1970s, Francis (1978a; 1978b) advanced the view that the attitudinal dimension of religion offered a particularly fruitful basis for coordinating empirical enquiry into the correlates, antecedents and consequences of religiosity across the life span

Eikonal solutions to optical model coupled-channel equations

Methods of solution are presented for the Eikonal form of the nucleus-nucleus coupled-channel scattering amplitudes. Analytic solutions are obtained for the second-order optical potential for elastic scattering. A numerical comparison is made between the first and second order optical model solutions for elastic and inelastic scattering of H-1 and He-4 on C-12. The effects of bound-state excitations on total and reaction cross sections are also estimated

Impurity-assisted Andreev reflection at a spin-active half-metal-superconductor interface

The Andreev reflection amplitude at a clean interface between a half-metallic ferromagnet (H) and a superconductor (S) for which the half metal's magnetization has a gradient perpendicular to the interface is proportional to the excitation energy $\varepsilon$ and vanishes at $\varepsilon=0$ [B\'{e}ri {\em et al.}, Phys.\ Rev.\ B {\bf 79}, 024517 (2009)]. Here we show that the presence of impurities at or in the immediate vicinity of the HS interface leads to a finite Andreev reflection amplitude at $\varepsilon=0$. This impurity-assisted Andreev reflection dominates the low-bias conductance of a HS junction and the Josephson current of an SHS junction in the long-junction limit.Comment: 12 pages, 2 figure

Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor

The glucagon-like peptide-1 (GLP-1) receptor is one of the best validated therapeutic targets for the treatment of type 2 diabetes mellitus (T2DM). Over several years, the accumulation of basic, translational, and clinical research helped define the physiologic roles of GLP-1 and its receptor in regulating glucose homeostasis and energy metabolism. These efforts provided much of the foundation for pharmaceutical development of the GLP-1 receptor peptide agonists, exenatide and liraglutide, as novel medicines for patients suffering from T2DM. Now, much attention is focused on better understanding the molecular mechanisms involved in ligand induced signaling of the GLP-1 receptor. For example, advancements in biophysical and structural biology techniques are being applied in attempts to more precisely determine ligand binding and receptor occupancy characteristics at the atomic level. These efforts should better inform three-dimensional modeling of the GLP-1 receptor that will help inspire more rational approaches to identify and optimize small molecule agonists or allosteric modulators targeting the GLP-1 receptor. This article reviews GLP-1 receptor physiology with an emphasis on GLP-1 induced signaling mechanisms in order to highlight new molecular strategies that help determine desired pharmacologic characteristics for guiding development of future nonpeptide GLP-1 receptor activators

Growth or decline in the Church of England during the decade of Evangelism: did the Churchmanship of the Bishop matter?

The Decade of Evangelism occupied the attention of the Church of England throughout the 1990s. The present study employs the statistics routinely published by the Church of England in order to assess two matters: the extent to which these statistics suggest that the 43 individual dioceses finished the decade in a stronger or weaker position than they had entered it and the extent to which, according to these statistics, the performance of dioceses led by bishops shaped in the Evangelical tradition differed from the performance of dioceses led by bishops shaped in the Catholic tradition. The data demonstrated that the majority of dioceses were performing less effectively at the end of the decade than at the beginning, in terms of a range of membership statistics, and that the rate of decline varied considerably from one diocese to another. The only exception to the trend was provided by the diocese of London, which experienced some growth. The data also demonstrated that little depended on the churchmanship of the diocesan bishop in shaping diocesan outcomes on the performance indicators employed in the study

Simplified model for solar cosmic ray exposure in manned Earth orbital flights

A simple calculational model is derived for use in estimating solar cosmic ray exposure to critical body organs in low-Earth orbit at the center of a large spherical shield of fixed thickness. The effects of the Earth's geomagnetic field, including storm conditions and the astronauts' self-shielding, are evaluated explicitly. The magnetic storm model is keyed to the planetary index K(sub p)

Appetite for self-destruction: suicidal biting as a nest defense strategy in Trigona stingless bees

Self-sacrificial behavior represents an extreme and relatively uncommon form of altruism in worker insects. It can occur, however, when inclusive fitness benefits are high, such as when defending the nest. We studied nest defense behaviors in stingless bees, which live in eusocial colonies subject to predation. We introduced a target flag to nest entrances to elicit defensive responses and quantified four measures of defensivity in 12 stingless bee species in São Paulo State, Brazil. These included three Trigona species, which are locally known for their aggression. Species varied significantly in their attack probability (cross species range = 0–1, P < 0.001), attack latency (7.0–23.5 s, P = 0.002), biting duration of individual bees (3.5–508.7 s, P < 0.001), and number of attackers (1.0–10.8, P < 0.001). A “suicide” bioassay on the six most aggressive species determined the proportion of workers willing to suffer fatal damage rather than disengage from an intruder. All six species had at least some suicidal individuals (7–83 %, P < 0.001), reaching 83 % in Trigona hyalinata. Biting pain was positively correlated with an index of overall aggression (P = 0.002). Microscopic examination revealed that all three Trigona species had five sharp teeth per mandible, a possible defensive adaptation and cause of increased pain. Suicidal defense via biting is a new example of self-sacrificial altruism and has both parallels and differences with other self-sacrificial worker insects, such as the honey bee. Our results indicate that suicidal biting may be a widespread defense strategy in stingless bees, but it is not universal