Alien Registration- Nicholas, Christie A. (Dover-Foxcroft, Piscataquis County)

https://digitalmaine.com/alien_docs/10361/thumbnail.jp

Development and evaluation of an interactive booklet for use in primary care consultations with children with respiratory tract infections

Respiratory tract infections are the most common reason for children to consult, and be prescribed antibiotics, in primary care. Parental anxiety and misinformation can contribute to increased consulting which, combined with perceived expectations for antibiotics, can increase prescribing. Clinicians are exhorted to rationalise antibiotic prescribing, but lack evidence-based tools to achieve this. Patient education using printed materials presented by a healthcare professional has been shown to reduce reconsulting and antibiotic prescribing. I developed an interactive booklet on respiratory tract infections in children for use in primary care consultations, and training in its use. The booklet aims to address unrealistic expectations about symptom duration and antibiotic effectiveness, and increase parental empowerment by prompting clinicians to address parental concerns and expectations, and providing information about treatment options, and features that should prompt reconsultation. Booklet development was guided by behaviour change theories and guidance on developing patient materials. It involved summarising relevant scientific evidence and consulting with parents and clinicians through focus groups, and other professionals (graphic designer and a literacy expert). The intervention (booklet and training in its use) was compared with usual care in a cluster randomised controlled trial. 83 practices were randomised and 61 recruited 557 children with an acute RTI. Reconsulting, antibiotic prescribing, and parental satisfaction, enablement, and other outcomes were assessed via a telephone interview at two-weeks. Use of the intervention resulted in a non-statistically significant reduction in reconsulting, a statistically significant and clinically meaningful reduction in antibiotic prescribing (OR 0.27,95% CI 0.14 to 0.60), and no statistically significant difference in enablement, satisfaction, reassurance, or consulting over the following year. There was no statistically significant difference in total cost between study arms. Changes in clinicians' beliefs about the importance of rationalising prescribing, and using the booklet as an aide-memoir, and to support a non-prescribing approach, appear to be responsible for the reduction in prescribing.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Appetite for self-destruction: suicidal biting as a nest defense strategy in Trigona stingless bees

Self-sacrificial behavior represents an extreme and relatively uncommon form of altruism in worker insects. It can occur, however, when inclusive fitness benefits are high, such as when defending the nest. We studied nest defense behaviors in stingless bees, which live in eusocial colonies subject to predation. We introduced a target flag to nest entrances to elicit defensive responses and quantified four measures of defensivity in 12 stingless bee species in São Paulo State, Brazil. These included three Trigona species, which are locally known for their aggression. Species varied significantly in their attack probability (cross species range = 0–1, P < 0.001), attack latency (7.0–23.5 s, P = 0.002), biting duration of individual bees (3.5–508.7 s, P < 0.001), and number of attackers (1.0–10.8, P < 0.001). A “suicide” bioassay on the six most aggressive species determined the proportion of workers willing to suffer fatal damage rather than disengage from an intruder. All six species had at least some suicidal individuals (7–83 %, P < 0.001), reaching 83 % in Trigona hyalinata. Biting pain was positively correlated with an index of overall aggression (P = 0.002). Microscopic examination revealed that all three Trigona species had five sharp teeth per mandible, a possible defensive adaptation and cause of increased pain. Suicidal defense via biting is a new example of self-sacrificial altruism and has both parallels and differences with other self-sacrificial worker insects, such as the honey bee. Our results indicate that suicidal biting may be a widespread defense strategy in stingless bees, but it is not universal

Constraints on terrestrial planet formation timescales and equilibration processes in the Grand Tack scenario from Hf-W isotopic evolution

We examine 141 N-body simulations of terrestrial planet late-stage accretion that use the Grand Tack scenario, coupling the collisional results with a hafnium-tungsten (Hf-W) isotopic evolution model. Accretion in the Grand Tack scenario results in faster planet formation than classical accretion models because of higher planetesimal surface density induced by a migrating Jupiter. Planetary embryos that grow rapidly experience radiogenic ingrowth of mantle $^{182}$W that is inconsistent with the measured terrestrial composition, unless much of the tungsten is removed by an impactor core that mixes thoroughly with the target mantle. For physically Earth-like surviving planets, we find that the fraction of equilibrating impactor core $k_\text{core} \geq 0.6$ is required to produce results agreeing with observed terrestrial tungsten anomalies (assuming equilibration with relatively large volumes of target mantle material; smaller equilibrating mantle volumes would require even larger $k_\text{core}$). This requirement of substantial core re-equilibration may be difficult to reconcile with fluid dynamical predictions and hydrocode simulations of mixing during large impacts, and hence this result does not favor the rapid planet building that results from Grand Tack accretion.Comment: 34 pages, 5 figures, published in EPS

Measuring attitude towards Buddhism and Sikhism : internal consistency reliability for two new instruments

This paper describes and discusses the development and empirical properties of two new 24-item scales – one measuring attitude toward Buddhism and the other measuring attitude toward Sikhism. The scale is designed to facilitate inter-faith comparisons within the psychology of religion alongside the well-established Francis Scale of Attitude toward Christianity. Data were obtained from a multi-religious sample of 369 school pupils aged between 13 and 15 in London. Application of the two scales demonstrated that adolescents had a more positive attitude to Buddhism than Sikhism. The findings confirm the reliability of the scales and commend them for further use

Commercialization of Herbicide-Tolerant Soybeans in China: Perverse Domestic and International Trade Effects

Replaced with revised version of paper 06/12/07.Crop Production/Industries, International Relations/Trade,

A novel strategy for the targeted analysis of protein and peptide metabolites

The detection and quantitation of exogenously administered biological macromolecules (e.g. vaccines, peptide and protein therapeutics) and their metabolites is frequently complicated by the presence of a complex endogenous mixture of closely related compounds. We describe a method that incorporates stable isotope labeling of the compound of interest allowing the selective screening of the intact molecule and all metabolites using a modified precursor ion scan. This method involves monitoring the low molecular weight fragment ions produced during MS/MS that distinguish isotopically labelled material from related endogenous compounds. All isotopically labelled substances can be selected using this scanning technique for further analysis whilst other unlabelled and irrelevant substances are ignored. The potential for this technique to be used in metabolism and pharmacokinetic experiments is discussed with specific examples looking at the metabolism of &#x3b1;-synuclein in serum and the brain

Subterranean clover in W.A. 2. Characteristics required for agronomic success

Development of subterranean clover varieties is a rapidly changing scene, particularly in terms of farmer acceptance, disease and persistency problems. This is only to be expected, because this is an agricultural plant of only some 50 to 70 years standing, whereas many other pasture plants have been in common use for thousands of years

Self-concept in poor readers : A systematic review and meta-analysis

Background The aims of this systematic review and meta-analyses were to determine if there is a statistically reliable association between poor reading and poor self-concept, and if such an association is moderated by domain of self-concept, type of reading impairment, or contextual factors including age, gender, reading instruction, and school environment. Methodology We searched 10 key databases for published and unpublished studies, as well as reference lists of included studies, and studies that cited included studies. We calculated standardised mean differences (SMDs) and 95% confidence intervals for one primary outcome (average self-concept) and 10 secondary outcomes (10 domains of self-concept). We assessed the data for risk of bias, heterogeneity, sensitivity, reporting bias, and quality of evidence. Results Thirteen studies with 3,348 participants met our selection criteria. Meta-analyses revealed statistically significant SMDs for average self-concept (−0.57) and five domains of self-concept (reading/writing/spelling: −1.03; academic: −0.67; math: −0.64; behaviour: −0.32; physical appearance: −0.28). The quality of evidence for the primary outcome was moderate, and for secondary outcomes was low, due to lack of data. Conclusions These outcomes suggest a probable moderate association between poor reading and average self-concept; a possible strong association between poor reading and reading-writing-spelling self-concept; and possible moderate associations between poor reading and self-concept in the self-concept domains of academia, mathematics, behaviour, and physical appearance

Dermatology life quality index (DLQI) as a psoriasis referral triage tool

Most primary care psoriasis referrals in the UK are triaged as ‘routine’, in part because of the prioritisation of skin cancer. As a result, patients with severe psoriasis may wait several months to be seen, enduring quality of life (QoL) impairment that could have been reduced. Furthermore some patients may spontaneously improve by the time they are seen by a specialist, making the appointment unnecessary at that time. Therefore, following approval from the local ethics committee, we conducted a prospective study to evaluate the usefulness of Dermatology Life Quality Index (DLQI) scores in triaging patients with psoriasis referred to our dermatology secondary health care services