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16 research outputs found
Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)
Author
Adjei A. A.
Barrett S. D.
+8Â more
Davies H.
Frémin C.
McCubrey J. A.
Porter A. C.
Sebolt-Leopold J. S.
Spicer J. A.
Wallace E. M.
Yamaguchi T.
Publication venue
'American Chemical Society (ACS)'
Publication date
Field of study
No full text
Crossref
A phase I study of two dosing schedules of oral BI 847325 in patients with advanced solid tumors
Author
Ahmad Awada
Amélie Deleporte
+22Â more
C Frémin
Chooi Lee
David Schnell
EA Eisenhauer
EC Dees
EM Eves
F Marampon
GK Dy
H Zhao
Herlinde Dumez
HT Arkenau
Jo Costermans
JR Infante
Katrien De Block
Marie-Anne Meeus
Maureen Billiet
N Keen
Patrick Schöffski
Philippe Aftimos
Rainer-Georg Goeldner
RR Adams
SF Dent
Publication venue
'Springer Science and Business Media LLC'
Publication date
Field of study
No full text
Crossref
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
Author
AM Grimaldi
B Schoeberl
+72Â more
BB Friday
BN Kholodenko
C Frémin
C Frémin
C Neuzillet
Christine Orr
CR Andersson
DA Ritt
Daniel Kirouac
DB Solit
E Manchado
EM Brey
EM Van Allen
Eva Lin
G Bollag
G Hatzivassiliou
G Hatzivassiliou
Gabriele Schaefer
GKY Chan
GV Long
H Kitai
H Lavoie
Hai Ngu
Hartmut Koeppen
I Amit
J Downward
J Larkin
J Villanueva
Jacob Schwarz
Jason Cheng
Jeffrey Eastham-Anderson
JF Blake
JF Blake
JG Albeck
JM Brondello
Jocelyn Chan
John Moffat
KP Hoeflich
KT Flaherty
Lily Shao
M Singh
M Veta
Marcia Belvin
Margaret Solon
Marie-Claire Wagle
Mark Merchant
Melissa R. Junttila
MK Dougherty
MR Junttila
Nikolas K. Haass
OE Sturm
P Lito
Peter M. Haverty
PI Poulikakos
R Nazarian
R Sever
R Straussman
S Bamford
S-Y Shin
Sheerin Shahidi-Latham
Shih-Min A. Huang
Stephanie J. Wang
T Brummer
Thomas Hunsaker
TR Wilson
V Balan
VT Phan
VW Rebecca
W Kolch
WJ Langlois
WR Greco
Xi Wang
Publication venue
'Public Library of Science (PLoS)'
Publication date
Field of study
No full text
Crossref
Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions
Author
Abe H.
Adjei A. A.
+44Â more
Barrett S. D.
Brenda Burton
Choo E. F.
Christian Wiesmann
Davies B. R.
Edna Choo
Emanuela Gancia
Emily Chan
Fischmann T. O.
Friesner R. A.
Frémin C.
Hatzivassiliou1 G.
Hoeflich K. P.
Hoshino R.
Iverson C.
Jason Boggs
Jocelyn Chan
Laurence C.
Marcia Belvin
Mark Jones
Mark Merchant
Mark Ultsch
Ohren J. F.
Olayioye M. A.
Otwinowski Z.
Pascal Savy
Patrick Rudewicz
Philip Jackson
Pierce A. C.
Politzer P.
Price S.
Qin Yue
Richard Newman
Robert A. Heald
Roberts P. J.
Sebolt-Leopold J. S.
Steve Price
Tecle H.
Toth G.
Trujillo J. I.
Vagin A.
Voth A. R.
Wallace E. M.
Yeh T. C.
Publication venue
'American Chemical Society (ACS)'
Publication date
Field of study
No full text
Crossref
RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
Author
A Bessard
A Bessard
+54Â more
A Fautrel
AM Fischer
C Dahlgren
C Fremin
C Frémin
C Rescan
C Vantaggiato
CM Schmidt
D Wang
DA Braasch
DR Alessi
DT Dudley
E Morel-Chany
F Ezan
G Baffet
G Pages
G Pages
H Huynh
H Sanjo
H Talarmin
HR Stennicke
J Elmen
JH Albrecht
JH Albrecht
JM Brondello
JS Sebolt-Leopold
JS Sebolt-Leopold
JS Sebolt-Leopold
L Gailhouste
L Liu
LO Andrieux
MA Arslan
MA Behlke
MD Reuber
MK Saba-El-Leil
N Normanno
NK Haass
NS Duesbery
OR Mook
P Loyer
PA Wabnitz
PJ Klein
PM Lorusso
R Lefloch
RA Hilger
RK Leung
S Aharinejad
S Gysin
SM Elbashir
SP Davies
TC Yeh
X Liu
Y Ito
Y Takei
Publication venue
'Springer Science and Business Media LLC'
Publication date
Field of study
No full text
Crossref
A Method for the Acute and Rapid Degradation of Endogenous Proteins
Author
Aguzzi
Banaszynski
+68Â more
Betz
Binyam Mogessie
Brohawn
Capecchi
Caussinus
Chen
Chirichella
Chow
Clift
Clift
Damke
Dean Clift
Deshaies
Doudna
Eijpe
Elbashir
Fan
Fletcher
Freund
Frémin
Gilmore
Hanahan
Hauler
Helma
Hoffmann
Holland
Hornung
Hu
James
James
Jansen
Kanda
Kaseda
Keeble
Laplante
Larisa I. Labzin
Lee
Leo C. James
Liman
Mallery
Mayer
Mayer
McEwan
McEwan
Melina Schuh
Miller
Morgan
Narain
Neklesa
Nishimura
Olson
Papin
Pfender
Pleiner
Robinson
Rossi
Sarbassov
Schroder
Schuh
Smoak
Sutterwala
Tachibana-Konwalski
Takeda
Toyama
Vera Konieczny
Watkinson
William A. McEwan
Yoshimi
Publication venue
'Elsevier BV'
Publication date
Field of study
No full text
Crossref
Intracellular and Extracellular pH and Ca Are Bound to Control Mitosis in the Early Sea Urchin Embryo via ERK and MPF Activities
Author
A Lopo
AM Ruknudin
+55Â more
BB Rees
Brigitte Ciapa
C Amirand
C Carballeira
C Frémin
C Toyoshima
CH Johnson
D Arion
D Epel
EM Soliman
FA Suprynowicz
G Grynkiewicz
H Kurihara
HL Roderick
IC Tseng
J Santo-Domingo
J Yue
JL Grainger
JQ Wu
JR Casey
Laetitia Philippe
LK Putney
M Edgecombe
M Hara
M Kumano
M Stumpp
M Whitaker
M Wilding
ME Malo
MF McCarty
MJ Berridge
MJ O’Donnell
MS Hamaguchi
MS Murakami
O Haccard
P Payan
P Uhlén
PK Harrison
Qing-Yuan Sun
R Patel
R Philipova
R Zorec
RD Vaughan-Jones
S Chiri
S Martin
S Mukai
SP Davies
SP Place
T Kishimoto
T Sato
TR Kleyman
WC Huang
WG Sunda
WL Zhang
Y Liu
Publication venue
'Public Library of Science (PLoS)'
Publication date
Field of study
No full text
Crossref
GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
Author
Addis
Adiels
+58Â more
Ai
Alexander A. Soukas
Alice E. Palmer
Antoine Rimbert
Arito
Barrows
Brown
Brown
Chad A. Cowan
Cuchel
Defesche
Do
Fang Xia
Folch
Frémin
Gokey
Goldstein
Graf
Guégan
Haojie Yu
Hegele
Hokanson
Horton
Horton
Ivanova
Jan Albert Kuivenhoven
Klarin
Kotzka
Kotzka
Lee
Leonardo M.R. Ferreira
Liang
Liping Zhao
Liu
Matsuda
Michael C. Kacergis
Moon
Natalia Loaiza
Nathaniel Brooks Horwitz
Ozaki
Rader
Rong
Sanjana
Sekar Kathiresan
Slakey
Subramanian
Takafumi Toyohara
Tao Chen
Teslovich
van Biesen
Wang
Westra
Willer
Yang
Yu
Yulei Xia
Zhernakova
Zhifen Chen
Publication venue
'Elsevier BV'
Publication date
Field of study
No full text
Crossref
Long-term dynamics of multisite phosphorylation
Author
Alessi DR
Alessi DR
+84Â more
Alex Mogilner
Alexander M. Berezhkovskii
Anastasaki C
Aoidi R
Aoki K
Aoki K
Boris Y. Rubinstein
Bott CM
Brunner D
Burack WR
Canagarajah BJ
Caunt CJ
Caunt CJ
Conradi C
Conradi C
Cox DA
Dhooge A
Dowd S
Ferrell JE
Ferrell JEJ
Frémin C
Futran AS
Gopich IV
Gopich IV
Groom LA
Guan KL
Gunawardena J
Hahn B
Harrington HA
Harrington HA
Haystead TA
Hell J
Hendriks W
Henry H. Mattingly
Humphreys JM
Jindal GA
Jolley CC
Kapuy O
Keyse SM
Kim Y
King AG
Lewis T
Lim B
Liu P
Manrai AK
Markevich NI
Mattingly HH
Michailovici I
Misra-Press A
Mourey RJ
Muda M
Ogata M
Patwardhan P
Payne DM
Piala AT
Prabakaran S
Prabakaran S
Pulido R
Qiao L
Rintelen F
Rust MJ
Salazar C
Salazar C
Salazar C
Saxena M
Sharma E
Shaul YD
Shindo Y
Shiozuka K
Stanislav Y. Shvartsman
Sun H
Suwanmajo T
Takahashi K
Tanoue T
Thomson M
Verdugo A
Wang L
Ward Y
Yang L
Yi H
Zhang JL
Zhao Y
Zhou B
Zhou B
Publication venue
'American Society for Cell Biology (ASCB)'
Publication date
Field of study
No full text
Crossref
Phase I/II Study of Refametinib (BAY 86-9766) in Combination with Gemcitabine in Advanced Pancreatic cancer
Author
A Goncalves
A Loboda
+59Â more
AA Zweeden van
Alberto Zaniboni
Anke Schulz
B Langmead
Barrett H. Childs
BB Friday
Bohuslav Melichar
C Frémin
C Iverson
CD Weekes
Colin Weekes
D Cunningham
D Kim
David Van Brummelen
DD Hoff Von
DJ Birnbaum
F Barlési
G Cunha Santos da
H Kinugasa
H Xia
HA Burris
Hanno Riess
Henrik Seidel
Jacek Jassem
Jean-Luc Van Laethem
John Bridgewater
JP Morris
JR Infante
Katrin Roth
M Ignatiadis
M Kanda
M Li
Marc Peeters
Marius Giurescu
Michael Haas
Michael Teufel
MJ Borad
MJ Higgins
MJ Moore
ML Rothenberg
Patrick Michl
Paul Ross
Piotr Saramak
PJ Roberts
Prabhu Rajagopalan
Q Lin
R Herrmann
S Eser
S Yu
SM Stein
ST Kim
Stefano Cascinu
Svein Dueland
T Conroy
T Ogura
Uwe M. Martens
Vittorio L. Garosi
Wollf Schmiegel
Y Nakai
Publication venue
'Springer Science and Business Media LLC'
Publication date
Field of study
No full text
Crossref
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