The health and sport engagement (HASE) intervention and evaluation project: protocol for the design, outcome, process and economic evaluation of a complex community sport intervention to increase levels of physical activity.

INTRODUCTION: Sport is being promoted to raise population levels of physical activity for health. National sport participation policy focuses on complex community provision tailored to diverse local users. Few quality research studies exist that examine the role of community sport interventions in raising physical activity levels and no research to date has examined the costs and cost-effectiveness of such provision. This study is a protocol for the design, outcome, process and economic evaluation of a complex community sport intervention to increase levels of physical activity, the Health and Sport Engagement (HASE) project part of the national Get Healthy Get Active programme led by Sport England. METHODS AND ANALYSIS: The HASE study is a collaborative partnership between local community sport deliverers and sport and public health researchers. It involves designing, delivering and evaluating community sport interventions. The aim is to engage previously inactive people in sustained sporting activity for 1×30 min a week and to examine associated health and well-being outcomes. The study uses mixed methods. Outcomes (physical activity, health, well-being costs to individuals) will be measured by a series of self-report questionnaires and attendance data and evaluated using interrupted time series analysis controlling for a range of sociodemographic factors. Resource use will be identified and measured using diaries, interviews and records and presented alongside effectiveness data as incremental cost-effectiveness ratios and cost-effectiveness acceptability curves. A longitudinal process evaluation (focus groups, structured observations, in-depth interview methods) will examine the efficacy of the project for achieving its aim using the principles of thematic analysis. ETHICS AND DISSEMINATION: The results of this study will be disseminated through peer-reviewed publications, academic conference presentations, Sport England and national public health organisation policy conferences, and practice-based case studies. Ethical approval was obtained through Brunel University London's research ethics committee (reference number RE33-12)

Event Indexing Systems for Efficient Selection and Analysis of HERA Data

The design and implementation of two software systems introduced to improve the efficiency of offline analysis of event data taken with the ZEUS Detector at the HERA electron-proton collider at DESY are presented. Two different approaches were made, one using a set of event directories and the other using a tag database based on a commercial object-oriented database management system. These are described and compared. Both systems provide quick direct access to individual collision events in a sequential data store of several terabytes, and they both considerably improve the event analysis efficiency. In particular the tag database provides a very flexible selection mechanism and can dramatically reduce the computing time needed to extract small subsamples from the total event sample. Gains as large as a factor 20 have been obtained.Comment: Accepted for publication in Computer Physics Communication

Baryogenesis, Dark Matter and the Pentagon

We present a new mechanism for baryogenesis, which links the baryon asymmetry of the universe to the dark matter density. The mechanism arises naturally in the Pentagon model of TeV scale physics. In that context, it forces a re-evaluation of some of the assumptions of the model, and we detail the changes that are required in order to fit observations.Comment: JHEP3 LaTeX, 15 pages. New version corrects errors in the electroweak baryon violating and matter radiation temperatures, which were pointed out by the referee. Substantial quantitative but no qualitative change to our conclusion

Near-Terminator Venus Ionosphere: Evidence for a Dawn/Dusk Asymmetry in the Thermosphere

Recent models of the near-terminator ionosphere of Venus constructed using neutral density profiles from the VTS3 model of Hedin et al. (1983) have shown that altitudes of the electron density peaks are in agreement with those measured by Pioneer Venus (PV) Orbiter Radio Occultation (ORO) and other radio occultation profiles in the solar zenith angle (SZA) range 60 to 70°, where they are near 140 km (Fox, 2007). The model peaks in the 75–85° range, however, do not decrease in altitude to near 135 km, as do the PV ORO electron density peaks shown in the study of Cravens et al. (1981). We investigate here possible reasons for this decrease. The PV Orbiter Neutral Mass Spectrometer (ONMS) measured densities of CO2, O, CO, N2, N, and He for many of the first 600 orbits. We have chosen 10 orbits in the dawn sector and 12 orbits in the dusk sector for which the solar zenith angles at periapsis were in the 75–85° range, and we have examined the ONMS density profiles reported in the PV Unified Abstract Data System. We find that for most of the orbits, the appropriately normalized ONMS measured densities for CO2 and O are, however, either similar to or larger than those generated from the VTS3 model for the same solar zenith angle and F 10.7 flux, and the use of these densities in our models would therefore produce a higher, rather than a lower, peak. The VTS3 models are, however, not expected to be accurate in the terminator region because of the small number of spherical harmonics used in the models and the large density changes that are expected near the terminators. We have also investigated a possible dawn/dusk asymmetry in the ionosphere. All the low-altitude PV radio occultation electron density peaks reported in the study of Cravens et al. (1981) in the 70 to 85° range were in the dawn sector at high latitudes. In the VTS3 models, the exospheric temperatures are predicted to be smaller at dawn that at dusk, but the asymmetries are confined to the region above ∼165 km. Thus use of the VTS3 model densities and temperatures in the near-terminator dawn sector models cannot produce electron density peaks that are lower in altitude than those in the dusk sector. We suggest that there is a high-latitude asymmetry between the dawn and dusk neutral densities that extends down to within ∼20 km above the expected altitude of the electron density peaks, and that produces a significantly asymmetrical ionosphere

Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort

Background: Several different classes of medications have been shown to be efficacious at preventing fractures in patients with osteoporosis. No study has compared real world efficacy at preventing fractures between all currently approved medications. Objectives: To directly compare the efficacy of all currently available osteoporosis medications by using a large population claims database. Methods: The Truven Health Analytics MarketScan® database from 2008 - 2012 was used to identify all patients who started a new osteoporosis medication. Patients who experienced a fracture after at least 12 months of treatment were identified and risk factors for fracture for all patients were recorded. Logistic regression was used to account for and quantify the contribution of risk factors, and to make direct comparisons between different osteoporosis medications. Results: A total of 51649 patients were included in the cohort, with an average age of 56 years. The overall incidence rate of fracture was 1.55 per 100 person - years of treatment. Orally administered medications had the lowest fracture rates, led by raloxifene and alendronate (1.24 and 1.54 respectively), while parenterally administered medications including teriparatide and zolerdonic acid had the highest rates (3.90 and 1.98 respectively). No statistically significant differences found between oral or parenterally administered bisphosphonate medications. Conclusions: While patients taking orally administered drugs including bisphosphonates had less frequent incident fracture no statistically significant differences were found between most drugs in head - to - head comparisons, even considering the route of administration of bisphosphonates. These findings support previous evidence that minimal differences in efficacy exist between different osteoporosis medications. This is the first study using a large database to compare all currently available osteoporosis treatments and will hopefully be augmented by further study to provide more evidence to make clinical decisions on osteoporosis medication use. © 2017 American Association of Neuropathologists, Inc

Magnetodielectric coupling in Mn3O4

We have investigated the dielectric anomalies associated with spin ordering transitions in the tetragonal spinel Mn$_3$O$_4$, using thermodynamic, magnetic, and dielectric measurements. We find that two of the three magnetic ordering transitions in Mn$_3$O$_4$ lead to decreases in the temperature dependent dielectric constant at zero applied field. Applying a magnetic field to the polycrystalline sample leaves these two dielectric anomalies practically unchanged, but leads to an increase in the dielectric constant at the intermediate spin-ordering transition. We discuss possible origins for this magnetodielectric behavior in terms of spin-phonon coupling. Band structure calculations suggest that in its ferrimagnetic state, Mn$_3$O$_4$ corresponds to a semiconductor with no orbital degeneracy due to strong Jahn-Teller distortion.Comment: 6 pages, 7 figure

Complex Systems Science: Dreams of Universality, Reality of Interdisciplinarity

Using a large database (~ 215 000 records) of relevant articles, we empirically study the "complex systems" field and its claims to find universal principles applying to systems in general. The study of references shared by the papers allows us to obtain a global point of view on the structure of this highly interdisciplinary field. We show that its overall coherence does not arise from a universal theory but instead from computational techniques and fruitful adaptations of the idea of self-organization to specific systems. We also find that communication between different disciplines goes through specific "trading zones", ie sub-communities that create an interface around specific tools (a DNA microchip) or concepts (a network).Comment: Journal of the American Society for Information Science and Technology (2012) 10.1002/asi.2264