1,289 research outputs found
Conceptual and methodological challenges to measuring political commitment to respond to HIV
Background: Researchers have long recognized the importance of a central governmentâs political âcommitmentâ in order to mount an effective response to HIV. The concept of political commitment remains ill-defined, however, and little guidance has been given on how to measure this construct and its relationship with HIV-related outcomes. Several countries have experienced declines in HIV infection rates, but conceptual difficulties arise in linking these declines to political commitment as opposed to underlying social and behavioural factors. Methods: This paper first presents a critical review of the literature on existing efforts to conceptualize and measure political commitment to respond to HIV and the linkages between political commitment and HIV-related outcomes. Based on the elements identified in this review, the paper then develops and presents a framework to assist researchers in making choices about how to assess a government's level of political commitment to respond to HIV and how to link political commitment to HIV-related outcomes. Results: The review of existing studies identifies three components of commitment (expressed, institutional and budgetary commitment) as different dimensions along which commitment can be measured. The review also identifies normative and ideological aspects of commitment and a set of variables that mediate and moderate political commitment that need to be accounted for in order to draw valid inferences about the relationship between political commitment and HIV-related outcomes. The framework summarizes a set of steps that researchers can follow in order to assess a government's level of commitment to respond to HIV and suggests ways to apply the framework to country cases. Conclusions: Whereas existing studies have adopted a limited and often ambiguous conception of political commitment, we argue that conceiving of political commitment along a greater number of dimensions will allow researchers to draw a more complete picture of political commitment to respond to HIV that avoids making invalid inferences about the relationship between political commitment and HIV outcomes
Maturation of auditory temporal integration and inhibition assessed with event-related potentials (ERPs)
Background: We examined development of auditory temporal integration and inhibition by assessing electrophysiological responses to tone pairs separated by interstimulus intervals (ISIs) of 25, 50, 100, 200, 400, and 800 ms in 28 children aged 7 to 9 years, and 15 adults.Results: In adults a distinct neural response was elicited to tones presented at ISIs of 25 ms or longer, whereas in children this was only seen in response to tones presented at ISIs above 100 ms. In adults, late N1 amplitude was larger for the second tone of the tone pair when separated by ISIs as short as 100 ms, consistent with the perceptual integration of successive stimuli within the temporal window of integration. In contrast, children showed enhanced negativity only when tone pairs were separated by ISIs of 200 ms. In children, the amplitude of the P1 component was attenuated at ISIs below 200 ms, consistent with a refractory process.Conclusions: These results indicate that adults integrate sequential auditory information into smaller temporal segments than children. These results suggest that there are marked maturational changes from childhood to adulthood in the perceptual processes underpinning the grouping of incoming auditory sensory information, and that electrophysiological measures provide a sensitive, non-invasive method allowing further examination of these changes
Hemispheric asymmetries in rapid temporal processing at age 7 predict subsequent phonemic decoding 2 years later:A longitudinal event-related potential (ERP) study
Osteomyelitis of the ribs in children: a rare and potentially challenging diagnosis
Background
Rib osteomyelitis is rare in children and can mimic other pathologies. Imaging has a major role in the diagnosing rib osteomyelitis.
Objective
To evaluate clinical presentation and imaging findings in children with rib osteomyelitis.
Materials and methods
We performed a retrospective (2009â2018) study on children with rib osteomyelitis verified by either positive culture or pathology. We excluded children with multifocal osteomyelitis or empyema necessitans. We reviewed medical charts for clinical, laboratory and pathology data, and treatment. All imaging modalities for rib abnormalities were evaluated for presence and location of osteomyelitis and abscess. We calculated descriptive statistics to compare patient demographics, clinical presentation and imaging findings.
Results
The study group included 10 children (6 boys, 4 girls), with an average age of 7.3 years (range, 3 months to 15.9 years). The most common clinical presentations were fever (n=8) and pain (n=5). Eight children had elevated inflammatory indices (leukocytosis, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]). Localized chest wall swelling was found initially in six children and later in two more children. Rib osteomyelitis was suspected on presentation in only two children. All children had chest radiographs. Rib lytic changes were found on only one chest radiograph, in two of the four ultrasound studies, and in four of eight CTs. Bone marrow signal abnormalities were seen in all eight MRIs. In nine children the osteomyelitis involved the costochondral junction. Six children had an associated abscess. Staphylococcus aureus was cultured in eight children. Osteomyelitis was diagnosed based on pathology in one child with negative cultures.
Conclusion
While rib osteomyelitis is rare, imaging findings of lytic changes at the costochondral junction combined with a history of fever, elevated inflammatory markers or localized soft-tissue swelling in the chest should raise suspicion for this disease
A Hierarchical NeuroBayes-based Algorithm for Full Reconstruction of B Mesons at B Factories
We describe a new B-meson full reconstruction algorithm designed for the
Belle experiment at the B-factory KEKB, an asymmetric e+e- collider that
collected a data sample of 771.6 x 10^6 BBbar pairs during its running time. To
maximize the number of reconstructed B decay channels, it utilizes a
hierarchical reconstruction procedure and probabilistic calculus instead of
classical selection cuts. The multivariate analysis package NeuroBayes was used
extensively to hold the balance between highest possible efficiency, robustness
and acceptable consumption of CPU time.
In total, 1104 exclusive decay channels were reconstructed, employing 71
neural networks altogether. Overall, we correctly reconstruct one B+/- or B0
candidate in 0.28% or 0.18% of the BBbar events, respectively. Compared to the
cut-based classical reconstruction algorithm used at the Belle experiment, this
is an improvement in efficiency by roughly a factor of 2, depending on the
analysis considered.
The new framework also features the ability to choose the desired purity or
efficiency of the fully reconstructed sample freely. If the same purity as for
the classical full reconstruction code is desired ~25%, the efficiency is still
larger by nearly a factor of 2. If, on the other hand, the efficiency is chosen
at a similar level as the classical full reconstruction, the purity rises from
~25% to nearly 90%
Predicting the public health benefit of vaccinating cattle against Escherichia coli O157
Identifying the major sources of risk in disease transmission is key to designing effective controls. However, understanding of transmission dynamics across species boundaries is typically poor, making the design and evaluation of controls particularly challenging for zoonotic pathogens. One such global pathogen is Escherichia coli O157, which causes a serious and sometimes fatal gastrointestinal illness. Cattle are the main reservoir for E. coli O157, and vaccines for cattle now exist. However, adoption of vaccines is being delayed by conflicting responsibilities of veterinary and public health agencies, economic drivers, and because clinical trials cannot easily test interventions across species boundaries, lack of information on the public health benefits. Here, we examine transmission risk across the cattleâhuman species boundary and show three key results. First, supershedding of the pathogen by cattle is associated with the genetic marker stx2. Second, by quantifying the link between shedding density in cattle and human risk, we show that only the relatively rare supershedding events contribute significantly to human risk. Third, we show that this finding has profound consequences for the public health benefits of the cattle vaccine. A naĂŻve evaluation based on efficacy in cattle would suggest a 50% reduction in risk; however, because the vaccine targets the major source of human risk, we predict a reduction in human cases of nearly 85%. By accounting for nonlinearities in transmission across the humanâanimal interface, we show that adoption of these vaccines by the livestock industry could prevent substantial numbers of human E. coli O157 cases
Constraints on the Ultra-High Energy Neutrino Flux from Gamma-Ray Bursts from a Prototype Station of the Askaryan Radio Array
We report on a search for ultra-high-energy (UHE) neutrinos from gamma-ray
bursts (GRBs) in the data set collected by the Testbed station of the Askaryan
Radio Array (ARA) in 2011 and 2012. From 57 selected GRBs, we observed no
events that survive our cuts, which is consistent with 0.12 expected background
events. Using NeuCosmA as a numerical GRB reference emission model, we estimate
upper limits on the prompt UHE GRB neutrino fluence and quasi-diffuse flux from
to GeV. This is the first limit on the prompt UHE GRB
neutrino quasi-diffuse flux above GeV.Comment: 14 pages, 8 figures, Published in Astroparticle Physics Journa
First Constraints on the Ultra-High Energy Neutrino Flux from a Prototype Station of the Askaryan Radio Array
The Askaryan Radio Array (ARA) is an ultra-high energy ( eV) cosmic
neutrino detector in phased construction near the South Pole. ARA searches for
radio Cherenkov emission from particle cascades induced by neutrino
interactions in the ice using radio frequency antennas ( MHz)
deployed at a design depth of 200 m in the Antarctic ice. A prototype ARA
Testbed station was deployed at m depth in the 2010-2011 season and
the first three full ARA stations were deployed in the 2011-2012 and 2012-2013
seasons. We present the first neutrino search with ARA using data taken in 2011
and 2012 with the ARA Testbed and the resulting constraints on the neutrino
flux from eV.Comment: 26 pages, 15 figures. Since first revision, added section on
systematic uncertainties, updated limits and uncertainty band with
improvements to simulation, added appendix describing ray tracing algorithm.
Final revision includes a section on cosmic ray backgrounds. Published in
Astropart. Phys.
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