Why the economy still plays a major role in shaping support for European integration

The success of Eurosceptic parties is often attributed to cultural factors such as the strength of citizens’ national identities. Chase Foster and Jeff Frieden write that while these cultural considerations can help predict support for European integration, the importance of economic factors should not be overlooked. Drawing on a new study, they illustrate that every percentage-point increase in average unemployment in the EU is associated with a two percentage-point decline in favourable views toward EU membership

Coordination Rights, Competition Law and Varieties of Capitalism

Competition law is a constitutive institution in capitalist markets, establishing the rules for when interfirm coordination is allowed and where competition is required (Paul, 2020). Yet comparativists have spent decades debating the varieties of capitalism framework—which places the issue of coordination at the center of the distinction between capitalist types—while paying virtually no attention to cross-national variation in antitrust rules. This article develops an original theoretical framework to conceptualize the relationship between competition law and the organization of capitalism. We go beyond the usual binaries (coordinated vs. liberal market economies, “restrictive” vs. “permissive” antitrust regimes) to disentangle two dimensions of the law that fundamentally shape patterns of coordination and competition both across regulatory jurisdictions and over time. Applying our framework to analyze the evolution of American and European competition law, we show how a comparative coordination rights framework can be used to conceptualize key institutional changes within contemporary capitalist systems

Do non-steroidal anti-inflammatory drugs provide a protective effect on developing Barrett’s esophagus and esophageal cancer? A systematic review and meta-analysis

This is a protocol of a systematic review

Vegetation Re-development After Fen Meadow Restoration by Topsoil Removal and Hay Transfer

We investigated the effects of different restoration treatments on the development of fen meadow communities: (1) depth of topsoil removal, with shallow (circa 20 cm) and deep (circa 40 cm) soil removal applied, (2) transfer of seed-containing hay, and (3) access of large animals. We carried out a full factorial experiment with all combinations of these factors and monitored it for 4 years. We studied the effect of seed availability in the soil seed bank on species abundance in the vegetation and compared it to the effect of species introduction by hay. We observed large differences in species composition between different treatments after 4 years. The combination of hay transfer, deep soil removal, and exclusion of large animals resulted in a community with highest similarity to the target vegetation. We found that the transfer of seeds with hay had a larger effect on species abundance than the soil seed bank. Hay transfer appeared to have important consequences on vegetation development because it speeded up the establishment of the target vegetation.

Predicting the public health benefit of vaccinating cattle against Escherichia coli O157

Identifying the major sources of risk in disease transmission is key to designing effective controls. However, understanding of transmission dynamics across species boundaries is typically poor, making the design and evaluation of controls particularly challenging for zoonotic pathogens. One such global pathogen is Escherichia coli O157, which causes a serious and sometimes fatal gastrointestinal illness. Cattle are the main reservoir for E. coli O157, and vaccines for cattle now exist. However, adoption of vaccines is being delayed by conflicting responsibilities of veterinary and public health agencies, economic drivers, and because clinical trials cannot easily test interventions across species boundaries, lack of information on the public health benefits. Here, we examine transmission risk across the cattle–human species boundary and show three key results. First, supershedding of the pathogen by cattle is associated with the genetic marker stx2. Second, by quantifying the link between shedding density in cattle and human risk, we show that only the relatively rare supershedding events contribute significantly to human risk. Third, we show that this finding has profound consequences for the public health benefits of the cattle vaccine. A naïve evaluation based on efficacy in cattle would suggest a 50% reduction in risk; however, because the vaccine targets the major source of human risk, we predict a reduction in human cases of nearly 85%. By accounting for nonlinearities in transmission across the human–animal interface, we show that adoption of these vaccines by the livestock industry could prevent substantial numbers of human E. coli O157 cases

Fixed-target serial crystallography at the Structural Biology Center

Serial synchrotron crystallography enables the study of protein structures under physiological temperature and reduced radiation damage by collection of data from thousands of crystals. The Structural Biology Center at Sector 19 of the Advanced Photon Source has implemented a fixed-target approach with a new 3D-printed mesh-holder optimized for sample handling. The holder immobilizes a crystal suspension or droplet emulsion on a nylon mesh, trapping and sealing a near-monolayer of crystals in its mother liquor between two thin Mylar films. Data can be rapidly collected in scan mode and analyzed in near real-time using piezoelectric linear stages assembled in an XYZ arrangement, controlled with a graphical user interface and analyzed using a high-performance computing pipeline. Here, the system was applied to two β-lactamases: a class D serine β-lactamase from Chitinophaga pinensis DSM 2588 and L1 metallo-β-lactamase from Stenotrophomonas maltophilia K279a

Period and chemical evolution of SC stars

The SC and CS stars are thermal-pulsing AGB stars with C/O ratio close to unity. Within this small group, the Mira variable BH Cru recently evolved from spectral type SC (showing ZrO bands) to CS (showing weak C2). Wavelet analysis shows that the spectral evolution was accompanied by a dramatic period increase, from 420 to 540 days, indicating an expanding radius. The pulsation amplitude also increased. Old photographic plates are used to establish that the period before 1940 was around 490 days. Chemical models indicate that the spectral changes were caused by a decrease in stellar temperature, related to the increasing radius. There is no evidence for a change in C/O ratio. The evolution in BH Cru is unlikely to be related to an on-going thermal pulse. Periods of the other SC and CS stars, including nine new periods, are determined. A second SC star, LX Cyg, also shows evidence for a large increase in period, and one further star shows a period inconsistent with a previous determination. Mira periods may be intrinsically unstable for C/O ~ 1; possibly because of a feedback between the molecular opacities, pulsation amplitude, and period. LRS spectra of 6 SC stars suggest a feature at wavelength > 15 micron, which resembles one recently attributed to the iron-sulfide troilite. Chemical models predict a large abundance of FeS in SC stars, in agreement with the proposed association.Comment: 14 pages, 20 figures. MNRAS, 2004, accepted for publication. Janet Mattei, one of the authors, died on 22 March, 2004. This paper is dedicated to her memor

Protostellar mass accretion rates from gravoturbulent fragmentation

We analyse protostellar mass accretion rates from numerical models of star formation based on gravoturbulent fragmentation, considering a large number of different environments. To within one order of magnitude, the mass accretion rate is approximately given by the mean thermal Jeans mass divided by the corresponding free-fall time. However, mass accretion rates are highly time-variant, with a sharp peak shortly after the formation of the protostellar core. We present an empirical exponential fit formula to describe the time evolution of the mass accretion and discuss the resulting fit parameters. There is a positive correlation between the peak accretion rate and the final mass of the protostar. We also investigate the relation of the accretion rate with the turbulent flow velocity as well as with the driving wavenumbers in different environments. We then compare our results with other theoretical models of star formation and with observational data.Comment: 13 pages, 6 figures; accepted by A&

Spatial scaling of forest soil microbial communities across a temperature gradient.

Temperature is an important correlate of global patterns of biodiversity, yet the mechanisms driving these relationships are not well understood. Taxa-area relationships (TARs) have been intensively examined, but the effects of temperature on TARs, particularly for microbial communities, are largely undocumented. Here we present a continental-scale description of temperature-dependent nested TARs of microbial communities (bacteria and archaea) from soils of six forest sites spanning a temperature gradient from subalpine Colorado to tropical Panama. Our results revealed that spatial scaling rates (z-values) of microbial communities varied with both taxonomic resolutions and phylogenetic groups. Additionally, microbial TAR z-values increased with temperature (r = 0.739, P < 0.05), but were not correlated with other environmental variables tested (P > 0.05), indicating that microbial spatial scaling rate is temperature-dependent. Understanding how temperature affects the spatial scaling of microbial biodiversity is of fundamental importance for preservation of soil biodiversity and management of ecosystems