167 research outputs found
The presence of high level soluble herpes virus entry mediator in sera of gastric cancer patients
- Author
- Aggarwal
- Arribas
- Balkwill
- Bass
- Benucci
- Brown
- Byung-Sam Kim
- Coussens
- Crusius
- del Rio
- Duhen
- Fan
- Fortini
- Gyu Yeol Kim
- Heo
- Heo
- Hikita
- Jung
- Kwon
- Mantovani
- Morel
- Neung-Hwa Park
- Piazuelo
- Pierer
- Rose-John
- Sang-Min Park
- Schreiber
- Segal
- Seo
- Seong-A Ju
- Shui
- Sook-Kyoung Heo
- Sun-Min Kim
- Sung Hun Back
- Tamada
- Thu-Ha Thi Nguyen
- Tsujimoto
- Uemura
- Wallach
- Won G. An
- Wong
- Wroblewski
- Ye
- Young Joo Min
- Zhu
- Zou
- Publication venue
- Korean Society for Biochemistry and Molecular Biology
- Publication date
- 01/01/2012
- Field of study
The development of gastric cancer (GC) is closely related to chronic inflammation caused by Helicobacter pylori infection, and herpes virus entry mediator (HVEM) is a receptor expressed on the surface of leukocytes that mediates potent inflammatory responses in animal models. However, the role of HVEM in human GC has not been studied. Previously, we showed that the interaction of HVEM on human leukocytes with its ligand LIGHT induces intracellular calcium mobilization, which results in inflammatory responses including induction of proinflammatory cytokine production and anti-bacterial activities. In this study, we report that leukocytes from GC patients express lower levels of membrane HVEM (mHVEM) and have lower LIGHT-induced bactericidal activities than those from healthy controls (HC). In contrast, levels of soluble HVEM (sHVEM) in the sera of GC patients were significantly higher than in those of HC. We found that monocyte membrane-bound HVEM is released into the medium when cells are activated by proinflammatory cytokines such as TNF-α and IL-8, which are elevated in the sera of GC patients. mHVEM level dropped in parallel with the release of sHVEM, and release was completely blocked by the metalloprotease inhibitor, GM6001. We also found that the low level of mHVEM on GC patient leukocytes was correlated with low LIGHT-induced bactericidal activities against H. pylori and S. aureus and production of reactive oxygen species. Our results indicate that mHVEM on leukocytes and sHVEM in sera may contribute to the development and/or progression of GC
Foreign rule?: transnational, national, and local perspectives on Venice and Venetia within the “multinational” empire
- Author
- Armani
- Barsottini
- Berengo
- Berti
- Bizzocchi
- Bonannini
- Bonannini
- Bonazza
- Bonazza
- Béranger
- Béranger
- Calvi
- Capellini
- Czoernig
- David Laven
- Del Negro
- Dömök
- Fischhof
- Fischhof
- Fischhof
- Fischhof
- Fischhof
- Fortini Brown
- Galante Garrone
- Gilbert
- Ginsborg
- Ginsborg
- Giuseppe
- Gottardi
- Goy
- Gullino
- Haas
- Helfert
- Helfert
- Janowski
- Kann
- Keates
- Körner
- Laura Parker
- Luzio
- Macartney
- Magani
- Martinelli
- Mazohl-Wallnig
- Meriggi
- Meriggi
- Meyer
- Montanari
- Nardo
- Nardo
- Palacký
- Parker
- Pavanello
- Pilot
- Pregnolato
- Rampoldi
- Regli
- Romanin
- Rosselli
- Sondhaus
- Soppelsa
- Soppelsa
- Tapié
- Taylor
- Tommaseo
- Tommaseo
- Tonetti
- Webb Probyn
- Zorzi
- Publication venue
- 'Informa UK Limited'
- Publication date
- 21/02/2014
- Field of study
The history of the Habsburg Empire in the post-Napoleonic era is frequently approached from the perspective of its various component nationalities. These were traditionally portrayed in the historiography as engaged in more-or-less open struggle with control from Vienna. This article argues that the over-privileging of such national categories can distort the picture. By looking at a number of case studies – the naming of Lombardy-Venetia, the Biblioteca italiana, the Panteon veneto – the relationship between Venice (and its Terraferma) and Habsburg rule during the second Austrian domination is examined. It will be argued that it is more profitable to see Venetian identities (municipal, local, Italian, and as part of a wider transnational European culture) as capable of working for as well as against the empire, and that Habsburg policy was as often concerned with managing potential local rivalries (notably between Lombards and Venetians) as with controlling a perceived Italian threat. It is also suggested that, while cultivation of local identity was often used to reinforce the national, the Austrian authorities were also happy to annex both to further imperial interests
A Joint Search for Gravitational Wave Bursts with AURIGA and LIGO
- Author
- A Brooks
- A Bullington
- A Bunkowski
- A Buonanno
- A C Searle
- A Cumming
- A Di Credico
- A Dietz
- A Franzen
- A Freise
- A G Wiseman
- A Grant
- A Heptonstall
- A Ivanov
- A Lazzarini
- A M Cruise
- A M Gretarsson
- A M Rogan
- A M Sintes
- A Melissinos
- A Mion
- A Moylan
- A Nishizawa
- A Ortolan
- A Rodriguez
- A Rüdiger
- A S Sengupta
- A Sazonov
- A Sibley
- A Stuver
- A Thüring
- A Vecchio
- A Villar
- A Vinante
- A Weidner
- A Weinstein
- Abbott B
- Abbott B
- B Allen
- B Barr
- B Bhawal
- B Bland
- B C Barish
- B F Schutz
- B F Whiting
- B Hage
- B J J Slagmolen
- B J Owen
- B Johnson
- B Krishnan
- B Lantz
- B Lee
- B Machenschalk
- B O'Reilly
- B Rivera
- B S Sathyaprakash
- B Sears
- B Willke
- Baggio L Prodi G A
- C A Cantley
- C Aulbert
- C Barker
- C C Wipf
- C Cepeda
- C Gray
- C Hanna
- C J Messenger
- C Kim
- C MowLowry
- C N Colacino
- C Parameswariah
- C Robinson
- C Torres
- C Torrie
- C Ungarelli
- C Van Den Broeck
- C Vorvick
- C Wilkinson
- C Zhao
- Cadonati L
- Cadonati L
- Cadonati L
- D A Brown
- D B Tanner
- D Barker
- D Blair
- D Busby
- D Chin
- D Cook
- D Coward
- D Coyne
- D DeBra
- D E McClelland
- D Fazi
- D G Keppel
- D H Reitze
- D H Shoemaker
- D Hammer
- D Hoak
- D Hosken
- D Hoyland
- D I Jones
- D Ingram
- D J Ottaway
- D Jackrel
- D Kasprzyk
- D Kozak
- D M Strom
- D M Whitbeck
- D Meyers
- D Mudge
- D R M Crooks
- D Rabeling
- D Sellers
- D Sigg
- D Ugolini
- D Webber
- D Woods
- E Black
- E Chalkley
- E Chin
- E D'Ambrosio
- E E Doomes
- E Espinoza
- E Goetz
- E Harstad
- E Hirose
- E Howell
- E Innerhofer
- E Katsavounidis
- E L Robinson
- E Maros
- E Mikhailov
- E Myers
- F Chiadini
- F Kawazoe
- F Marin
- F Nocera
- F Postiglione
- F Raab
- F Salemi
- F Seifert
- F Ya Khalili
- Finn L S
- G A Prodi
- G Billingsley
- G Cagnoli
- G Castaldi
- G Davies
- G Diederichs
- G Giusfredi
- G González
- G H Sanders
- G Harry
- G Jones
- G Mendell
- G Mitselmakher
- G Moreno
- G Mueller
- G Newton
- G Soranzo
- G Traylor
- G Vedovato
- G Woan
- H Armandula
- H Bantilan
- H Grote
- H Lück
- H Müller-Ebhardt
- H Overmier
- H Pletsch
- H Radkins
- H Rehbein
- H Takahashi
- H Vahlbruch
- H Ward
- H Yamamoto
- H zur Mühlen
- I A Bilenko
- I Gholami
- I Leonor
- I M Pinto
- I Martin
- I S Heng
- I Wilmut
- I Yakushin
- J A Giaime
- J Agresti
- J B Camp
- J Betzwieser
- J Bogenstahl
- J Cannizzo
- J Cao
- J Chow
- J Clark
- J D E Creighton
- J D Romano
- J Dalrymple
- J Degallaix
- J Dickson
- J E Brau
- J G Dwyer
- J Garofoli
- J Greenhalgh
- J Hanson
- J Harms
- J Heefner
- J Hough
- J Leiner
- J Markowitz
- J Munch
- J Myers
- J N Marx
- J P Zendri
- J R Smith
- J Rollins
- J Romie
- J S Kissel
- J Slutsky
- J T Whelan
- J Thacker
- J Veitch
- J W C McNabb
- J Worden
- J Zhang
- J Zweizig
- J-C Dumas
- James F
- K A Strain
- K A Thorne
- K Bayer
- K Belczynski
- K Blackburn
- K Cannon
- K Carter
- K D Giardina
- K Danzmann
- K Goda
- K Kawabe
- K Kokeyama
- K Libbrecht
- K Mailand
- K Mason
- K McKenzie
- K Mossavi
- K Numata
- K Rawlins
- K Riles
- K Ryan
- K S Ganezer
- K S Thorne
- K Somiya
- K Urbanek
- K V Tokmakov
- K Watts
- K Wette
- K Y Franzen
- K-X Sun
- L Baggio
- L Blackburn
- L Bogue
- L Cadonati
- L Cardenas
- L Ju
- L M Goggin
- L Matone
- L Ribichini
- L Ruet
- L S Finn
- L Sancho de la Jordana
- L Taffarello
- L Wallace
- L Williams
- L Zhang
- M A Barton
- M A Papa
- M Arain
- M Araya
- M Ashley
- M Bignotto
- M Bonaldi
- M Brinkmann
- M Cerdonio
- M De Rosa
- M Degree
- M Díaz
- M Evans
- M Fyffe
- M Gray
- M Guenther
- M Heurs
- M Hewitson
- M Inguscio
- M Ito
- M Landry
- M Lei
- M Longo
- M Lormand
- M Lubinski
- M M Casey
- M M Fejer
- M MacInnis
- M Mageswaran
- M Malec
- M McHugh
- M Pedraza
- M Pitkin
- M R Smith
- M Rakhmanov
- M Ramsunder
- M Samidi
- M Sung
- M Tarallo
- M Tinto
- M Trias
- M V Plissi
- M Vallisneri
- M van Putten
- M Varvella
- M Weinert
- M Zanolin
- M Zucker
- N A Lockerbie
- N A Robertson
- N Christensen
- N Fotopoulos
- N Liguori
- N Mavalvala
- N Rainer
- N Yunes
- N Zotov
- O Burmeister
- O Miyakawa
- P A Willems
- P Ajith
- P Aufmuth
- P Barriga
- P Charlton
- P Cochrane
- P Ehrens
- P Falferi
- P Fortini
- P Fritschel
- P J Sutton
- P K Lam
- P Kalmus
- P King
- P Kwee
- P Lindquist
- P Murray
- P Patel
- P R Brady
- P R Saulson
- P Russell
- P Sarin
- P Savov
- P Schwinberg
- P Shawhan
- P T Beyersdorf
- P Veitch
- Poggi S
- Poggi S
- R A Mercer
- R Abbott
- R Adhikari
- R Amin
- R Biswas
- R Bork
- R Coldwell
- R Conte
- R DeSalvo
- R Frey
- R Grosso
- R Gustafson
- R J Dupuis
- R Jones
- R K Kopparapu
- R L Byer
- R McCarthy
- R Mezzena
- R Mittleman
- R O'Shaughnessy
- R P Croce
- R Prix
- R Rahkola
- R Riesen
- R Route
- R Savage
- R Schilling
- R Schnabel
- R Schofield
- R Taylor
- R Taylor
- R W P Drever
- R Ward
- R Weiss
- R Wooley
- S Aston
- S B Anderson
- S Babak
- S Ballmer
- S Bose
- S C McGuire
- S Chatterji
- S Chelkowski
- S Desai
- S Dhurandhar
- S E Whitcomb
- S Fairhurst
- S Fattori
- S Giampanis
- S Gossler
- S Gras
- S Grunewald
- S H Huttner
- S Hild
- S J Waldman
- S Kawamura
- S Klimenko
- S Longo
- S M Scott
- S Marano
- S McWilliams
- S Meshkov
- S Mitra
- S Mohanty
- S Mukherjee
- S Márka
- S P Vyachanin
- S Penn
- S Poggi
- S Ray-Majumder
- S Reid
- S Roddy
- S Rowan
- S Sakata
- S Saraf
- S Sato
- S Schediwy
- S Sinha
- S Vass
- S Vitale
- S Wen
- S Wiley
- S Wise
- S Yoshida
- T Cokelaer
- T Corbitt
- T D Creighton
- T Demma
- T Etzel
- T Evans
- T Fricke
- T Hayler
- T Meier
- T Nash
- T Regimbau
- T Z Summerscales
- V B Braginsky
- V Boschi
- V Dergachev
- V Fiumara
- V Galdi
- V Kalogera
- V Kondrashov
- V Leonhardt
- V Mandic
- V Matta
- V P Mitrofanov
- V Parameshwaraiah
- V Pierro
- V Quetschke
- V Re
- V Sandberg
- V Sannibale
- V V Frolov
- Vinante A
- W E Butler
- W G Anderson
- W Kells
- W Tyler
- W W Johnson
- W Winkler
- W Wu
- X Siemens
- Y Chen
- Y Fan
- Y Itoh
- Y Pan
- Yakushin I Klimenko S Rakhmanov M
- Z Yan
- Zendri J P Dumarchez J Thanh Van J Tran
- Publication venue
- 'IOP Publishing'
- Publication date
- 02/10/2007
- Field of study
The first simultaneous operation of the AURIGA detector and the LIGO
observatory was an opportunity to explore real data, joint analysis methods
between two very different types of gravitational wave detectors: resonant bars
and interferometers. This paper describes a coincident gravitational wave burst
search, where data from the LIGO interferometers are cross-correlated at the
time of AURIGA candidate events to identify coherent transients. The analysis
pipeline is tuned with two thresholds, on the signal-to-noise ratio of AURIGA
candidate events and on the significance of the cross-correlation test in LIGO.
The false alarm rate is estimated by introducing time shifts between data sets
and the network detection efficiency is measured with simulated signals with
power in the narrower AURIGA band. In the absence of a detection, we discuss
how to set an upper limit on the rate of gravitational waves and to interpret
it according to different source models. Due to the short amount of analyzed
data and to the high rate of non-Gaussian transients in the detectors noise at
the time, the relevance of this study is methodological: this was the first
joint search for gravitational wave bursts among detectors with such different
spectral sensitivity and the first opportunity for the resonant and
interferometric communities to unify languages and techniques in the pursuit of
their common goal.Comment: 18 pages, IOP, 12 EPS figure
DNA demethylation pathways: Additional players and regulators.
- Author
- Abdouni
- An
- Arakawa
- Barreto
- Bellon
- Bhutani
- Bhutani
- Blaschke
- Boorstein
- Bourc'his
- Bransteitter
- Brown
- Buganim
- Chakraborty
- Chen
- Chen
- Chen
- Chowdhury
- Chung
- Cortazar
- Cortellino
- Costa
- Dai
- Dai
- Dang
- Dawlaty
- Dawlaty
- Dawlaty
- Delhommeau
- Doege
- Dominguez
- Engel
- Fortini
- Foshay
- Fousteri
- Franchini
- Fritz
- Fritz
- Gao
- Ge
- Gehring
- Gjini
- Grin
- Gu
- Guo
- Guo
- Habib
- Hajkova
- Hashimoto
- Hashimoto
- Hashimoto
- Hashimoto
- Hata
- Hata
- He
- Henson
- Hildrestrand
- Hogenbirk
- Hollander
- Hon
- Hu
- Hu
- Iiams
- Inoue
- Iqbal
- Ito
- Iyer
- Jin
- Jin
- Jiricny
- Jones
- Kagiwada
- Kaneda
- Kellinger
- Ko
- Kosmider
- Kou
- Kriaucionis
- Krokan
- Kumar
- Langemeijer
- Larijani
- Laukka
- Lenz
- Li
- Li
- Li
- Li
- Liu
- Liutkeviciute
- Lorsbach
- Lu
- Ma
- Maiti
- Maiti
- Marusawa
- Mayer
- Moran-Crusio
- Muller
- Muramatsu
- Muramatsu
- Nabel
- Nakanishi
- Nemec
- Niehrs
- Nilsen
- Ohno
- Okano
- Ooi
- Pais
- Pastor
- Perez
- Petersen-Mahrt
- Pfaffeneder
- Pollard
- Popp
- Rai
- Raiber
- Ramiro
- Rangam
- Revy
- Rommel
- Rusmintratip
- Sabag
- Sajadian
- Santos
- Schiesser
- Schiesser
- Schmitz
- Schomacher
- Sciacovelli
- Sejersted
- Shen
- Shen
- Shibutani
- Shimamoto
- Shimoda
- Silverman
- Spruijt
- Stier
- Szulik
- Tahiliani
- Tamura
- Tan
- Vartanian
- Verdine
- Wagner
- Wang
- Weber
- Wijesinghe
- Wojciechowski
- Wu
- Xiao
- Xu
- Xu
- Xu
- Xue
- Yamazaki
- Yin
- Young
- Zanotti
- Zhao
- Zhu
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2017
- Field of study
DNA demethylation can occur passively by "dilution" of methylation marks by DNA replication, or actively and independently of DNA replication. Direct conversion of 5-methylcytosine (5mC) to cytosine (C), as originally proposed, does not occur. Instead, active DNA methylation involves oxidation of the methylated base by ten-eleven translocations (TETs), or deamination of the methylated or a nearby base by activation induced deaminase (AID). The modified nucleotide, possibly together with surrounding nucleotides, is then replaced by the BER pathway. Recent data clarify the roles and the regulation of well-known enzymes in this process. They identify base excision repair (BER) glycosylases that may cooperate with or replace thymine DNA glycosylase (TDG) in the base excision step, and suggest possible involvement of DNA damage repair pathways other than BER in active DNA demethylation. Here, we review these new developments
A Drosophila-centric view of protein tyrosine phosphatases
- Author
- Abujarour
- Adams
- Aguirre
- Alonso
- Alphey
- Altschul
- Amin
- Amoasii
- Andersen
- Andersen
- Andrew P. Hutchins
- Artavanis-Tsakonas
- Ashrafi
- Au
- Babault
- Baeg
- Bakhoum
- Bardet
- Barisic
- Bauler
- Beeser
- Bellen
- Bemmann
- Berset
- Bier
- Biernacki
- Boldrini
- Bollen
- Bolos
- Bolos
- Bonini
- Boudeau
- Bourdeau
- Bourdeau
- Broggini
- Brown
- Bu
- Bugga
- Bussieres-Marmen
- Buszard
- Butchar
- Byrum
- Cammarato
- Cao
- Caprara
- Carlucci
- Caunt
- Chagnon
- Chang
- Chao
- Chaussade
- Chen
- Cheng
- Chirivi
- Cohen
- Colaiacovo
- Coles
- Cook
- Cowling
- Das
- Degl'innocenti
- Denu
- Desai
- Deshpande
- Di Cristofano
- Diego Miranda-Saavedra
- Dray
- Duan
- Dustin
- Edgar
- Edwards
- Ejsmont
- Fabrizio
- Farrell
- Feldhammer
- Felsenstein
- Finch
- Fisher
- Flicek
- Fortini
- Fox
- Fry
- Fukuda
- Gaiano
- Galaktionov
- Gaunt
- Ghedin
- Gilbert
- Gingras
- Gloria-Bottini
- Gray
- Gray
- Grego-Bessa
- Gregory
- Gutch
- Hao
- Harrington
- Hasler
- Hatzihristidis
- He
- Hendriks
- Hendriks
- Hitoshi
- Hofmeyer
- Horn
- Huerta-Cepas
- Hutchins
- Hutter
- Inaba
- Issigonis
- Ito
- Jaillon
- Jean
- Jeon
- Jeon
- Jeon
- Jinno
- Justiniano
- Kemmler
- Kim
- Kim
- Kim
- Kim
- Kiyokawa
- Kligys
- Kokel
- Kozarova
- Krndija
- Ku
- Kurusu
- Kwon
- Lee
- Lee
- Leslie
- Leulier
- Levy-Nissenbaum
- Levy-Nissenbaum
- Li
- Li
- Li
- Lin
- Lin
- Lin
- Lindqvist
- Liu
- Liu
- Lu
- Magis
- Martin
- McEwen
- McGinnis
- Michel L. Tremblay
- Miller
- Miller
- Miranda-Saavedra
- Miura
- Mocciaro
- Mohn
- Mohr
- Morata
- Morgan
- Morillo
- Morrison
- Mruk
- Muda
- Mukai
- Muller
- Muller
- Nandurkar
- Naughtin
- Nguyen
- Nikita Desai
- Nobta
- Nusse
- Nusse
- Oishi
- Paardekooper Overman
- Pagliarini
- Pagliarini
- Palka
- Pandey
- Patterson
- Penel
- Perkins
- Pignoni
- Pike
- Piya
- Poernbacher
- Polzonetti
- Powell
- Pryszcz
- Qian
- Raftopoulou
- Rahmouni
- Rajan
- Rajan
- Rehkop
- Reiter
- Rijsewijk
- Rios
- Robinson
- Roy
- Russell
- Saito
- Salzer
- Santhanam
- Santhanam
- Schindelholz
- Schreiber
- Schwer
- Shekels
- Simmer
- Sodergren
- Song
- Srivastava
- Su
- Su
- Sun
- Sun
- Sun
- Sun
- Swaminathan
- Szatmari
- Tadjuidje
- Tamagawa
- Taxman
- Teri Hatzihristidis
- Teruel
- Tiganis
- Tonks
- Tonks
- Tonks
- Tosch
- Traverso
- Tremblay
- Trop
- Trusolino
- Tweedie
- Tzu-Ching Meng
- Uetani
- Ursuliak
- Van Vactor
- Vandepoele
- Velichkova
- Venken
- Vergne
- Waterhouse
- Wharton
- Whited
- Wo
- Wu
- Yamaguchi
- Yamaguchi
- Yang
- Yu
- Yuan
- Yuan
- Zeqiraj
- Zou
- Zou
- Publication venue
- Federation of European Biochemical Societies. Published by Elsevier B.V.
- Publication date
- 13/04/2015
- Field of study
AbstractMost of our knowledge on protein tyrosine phosphatases (PTPs) is derived from human pathologies and mouse knockout models. These models largely correlate well with human disease phenotypes, but can be ambiguous due to compensatory mechanisms introduced by paralogous genes. Here we present the analysis of the PTP complement of the fruit fly and the complementary view that PTP studies in Drosophila will accelerate our understanding of PTPs in physiological and pathological conditions. With only 44 PTP genes, Drosophila represents a streamlined version of the human complement. Our integrated analysis places the Drosophila PTPs into evolutionary and functional contexts, thereby providing a platform for the exploitation of the fly for PTP research and the transfer of knowledge onto other model systems
Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study
- Author
- Aagaard L.
- Acquavita S.P.
- Adam A.
- Adam A.
- Adam C.
- Aguinaldo L.D.
- Ahmed K.
- Akkari C.
- Alabani V.
- Alvarado N.J.
- Andersen R.M.
- Andersson C.
- Andreasson S.
- Andrews M.
- Andréasson S.
- Angus C.
- Apodaca T.R.
- Atkinson A.
- Auerbach M.
- Bakshi A.-S.
- Barbosa C.
- Barker A.
- Barrio P.
- Barticevic N.
- Barton M.B.
- Baumeister S.E.
- Bauroth S.
- Beatty J.R.
- Beaulieu M.
- Bedimo R.
- Bendtsen P.
- Bensley K.M.
- Berman A.H.
- Bernal C.
- Bertholet N.
- Bhatt C.
- Blake-Lamb T.
- Blankers M.
- Blosnich J.R.
- Boniface S.
- Borsari B.
- Braddick F.
- Bradley M.
- Bray J.
- Brehm B.J.
- Brennan A.
- Brolin M.
- Brown B.S.
- Brown J.
- Brown R.L.
- Bruguera C.
- Bruguera P.
- Bryant K.J.
- Burnham E.L.
- Capell J.W.
- Cariola L.
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The structure and function of Alzheimer's gamma secretase enzyme complex
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- Publication date
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- Field of study
The production and accumulation of the beta amyloid protein (Aβ) is a key event in the cascade of oxidative and inflammatory processes that characterizes Alzheimer’s disease (AD). A multi-subunit enzyme complex, referred to as gamma (γ) secretase, plays a pivotal role in the generation of Aβ from its parent molecule, the amyloid precursor protein (APP). Four core components (presenilin, nicastrin, aph-1, and pen-2) interact in a high-molecular-weight complex to perform intramembrane proteolysis on a number of membrane-bound proteins, including APP and Notch. Inhibitors and modulators of this enzyme have been assessed for their therapeutic benefit in AD. However, although these agents reduce Aβ levels, the majority have been shown to have severe side effects in pre-clinical animal studies, most likely due to the enzymes role in processing other proteins involved in normal cellular function. Current research is directed at understanding this enzyme and, in particular, at elucidating the roles that each of the core proteins plays in its function. In addition, a number of interacting proteins that are not components of γ-secretase also appear to play important roles in modulating enzyme activity. This review will discuss the structural and functional complexity of the γ-secretase enzyme and the effects of inhibiting its activity
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- Álvarez ÉMC
- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
- Agnello M.
- Agostinis P.
- Agrewala J. N.
- Agrotis A.
- Aguilar P. V.
- Ahmad S. T.
- Ahmed Z. M.
- Ahumada-Castro U.
- Aits S.
- Aizawa S.
- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
- Aliwaini S.
- Alizadeh J.
- Almacellas E.
- Almasan A.
- Alonso A.
- Alonso G. D.
- Altan-Bonnet N.
- Altieri D. C.
- Alvarez E. M. C.
- Alves da Costa C.
- Alves S.
- Alzaharna M. M.
- Amadio M.
- Amantini C.
- Amaral C.
- Ambrosio S.
- Amer A. O.
- Ammanathan V.
- An Z.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Recommended from our members
Proceedings of the 13th annual conference of INEBRIA
- Author
- Adam J. Gordon
- Aisha Holloway
- Akula Morris
- Ambrose Melson
- Amy C. Justice
- Andrew Briggs
- Andrew McKenzie
- André Luzi Monezi Andrade
- Andy Bogart
- Angela Abreu
- Angeline Adam
- Anja Bischof
- Anna D. Rubinsky
- Anne H Berman
- Anthony Spirito
- Antoni Gual
- Arethusa S. Kirk
- Barry S. Brown
- Beate Gaertner
- Bertrand Yersin
- Bettina Besser
- Bob Mash
- Brian Williams
- Brittany L. Stevenson
- Carolina Barbosa
- Caroline Graap
- Caroline Graap
- Christian Meyer
- Christine Godfrey
- Christopher J. Cutter
- Christopher Sundström
- Claire Jones
- Claudia Fahlke
- Colin Drummond
- Colleen Hosler
- Constance Weisner
- Cosma Aguiar
- Cristiana Fortini
- Cristina Casajuana
- Cynthia Gilbert
- Cátia Gonçalves
- David A. Fiellin
- David Lounsbury
- David Mountain
- David Rimland
- Deborah S. Finnell
- Dena Henry
- Duncan Stewart
- E. Jennifer Edelman
- Elena Dimova
- Elina Renko
- Elizabeth Geelhoed
- Elizabeth Murray
- Elizabeth White
- Emily C. Williams
- Emily M. Sargent
- Emmanuel Bussières
- Erin Kelty
- Falko F Sniehotta
- Felicia Chi
- Fiona L Hamilton
- Freida Payne
- Gallus Bischof
- Gary K. Hulse
- Gaurav Sharma
- Geetha Subramaniam
- Gerhard Gmel
- Gerhard Gmel
- Gerson Marinho
- Gillian W Shorter
- Gwen T. Lapham
- Hana Sovinová
- Hannah R. Graves
- Hans-Juergen Rumpf
- Hans-Jürgen Rumpf
- Helen Cheyne
- Hervé Bonnefoi
- Hugo López-Pelayo
- Iain K Crombie
- Ian R. White
- Inga Schnuerer
- Irene Petersen
- Irwin Nazareth
- J. Aaron Johnson
- J. Paul Seale
- Jacques Gaume
- James Dziura
- James Morris
- Jan Gryczynski
- Jan R. Böhnke
- Jean-Bernard Daeppen
- Jean-Bernard Daeppen
- Jennifer J. Bobb
- Jennifer McNeely
- Jennis Freyer-Adam
- Jeremy W Bray
- Jim McCambridge
- Joan Colom
- Joan Colom-Farran
- Joanna Milward
- John A. Cunningham
- John Isitt
- John Norrie
- John R. Knight
- Jonathan Robbins
- Joseph Studer
- Joseph Studer
- Juan Manuel Mendive-Arbeloa
- Kara M. Bensley
- Katharine A. Bradley
- Katherine Everett-Murphy
- Katherine. J. Hoggatt
- Kathleen A. McGinnis
- Kathryn Angus
- Kathryn B Cunningham
- Katia M’Bailara
- Katja Haberecht
- Kendall J. Bryant
- Kenneth Conner
- Kevin L. Kraemer
- Kimberly A. Hepner
- Kristi Dusek
- Ladislav Csémy
- Laia Miquel
- Laisa Marcorela Andreoli Sartes
- Laura J. Veach
- Lawrence Doi
- Leigh Z. Dongre
- Leticia Echeverria
- Li-Tzy Wu
- Lidia Segura-Garcia
- Linda Bauld
- Linda Irvine
- Linda Tuck
- Lisa Schölin
- Lluisa Ortega
- Lon Sherritt
- Louise Marston
- Lucinda Teoh
- Lutz Wartberg
- Lynn E. Fiellin
- Lynn Hernandez
- Lídia Teixidó
- M. Mohler-Kuo
- Magnus Johansson
- Manel Anoro-Perminger
- Marc Auriacombe
- Marc Dupuis
- Marcus Achison
- Maria Lucia O. Souza Formigoni
- Maria Rodriguez-Barradas
- Marianne Saint-Jacques
- Marianthi Deligianni
- Marion Barrault-Couchouron
- Marion Béracochéa
- Marla Oros
- Martin Kraepelien
- María Mercedes Balcells
- Matthew P. Kramer
- Melissa Skanderson
- Michael Simberkoff
- Michel Dorval
- Molly Magill
- Mª Angeles Piñar-Mateos
- Nathan B. Hansen
- Niamh Fitzgerald
- Nicolas Arnaud
- Nicolas Bertholet
- Nicolas Bertholet
- Niels Eék
- Noreen D Mdege
- null null
- Nuria Ibañez-Martinez
- Olivia Currin
- P. Todd Korthuis
- Pablo Barrio
- Pako Diaz-Gallego
- Paolo Deluca
- Patrick G. O’Connor
- Paul Toner
- Paul Wallace
- Pedro Parreira
- Peter Rice
- Peter W Slane
- Preston R. Miller
- Rafael Jomar
- Rainer Thomasius
- Reid Hester
- Riany M. Brites
- Richard N. Jones
- Robert D. Dvorak
- Robert J. Tait
- Robert P. Schwartz
- Rod Watson
- Rod Watson
- Roger Bedimo
- Ruth Jepson
- Sara J. Becker
- Sara Wallhed Finn
- Sarah Copelas
- Sarah L Hardoon
- Shannon G. Mitchell
- Sharon Chalmers
- Sheryl L. Catz
- Silke Diestelkamp
- Silvia Morales
- Sion K. Harris
- Sophie Baumann
- Sophie Paroz
- Sophie Paroz
- Stacy Sterling
- Stephanie Fincham-Campbell
- Stephen A. Maisto
- Stephen Maisto
- Stéphanie Baggio
- Susan E Collins
- Susan E. Collins
- Susan Shortreed
- Susan Zickmund
- Susan. M. Paddock
- Sven Andreasson
- Teresa Barroso
- Tess M. Kilwein
- Tracy Stecker
- Ulrich John
- Valérie Barthélémy
- Vanesa Luna
- Viktor Kaldo
- Vincent Allafort
- Vincent C. Marconi
- Vlad Kushnir
- Véronique Garguil
- Véronique Grazioli
- Véronique S Grazioli
- Véronique S. Grazioli
- Véronique S. Grazioli
- Véronique S. Grazioli
- Wendy Lu
- William Campbell
- Zarnie Khadjesari
- Zelra Malan
- Zhi Li
- Ângela Abreu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
CITATION: Watson, R., et al. 2016. Proceedings of the 13th annual conference of INEBRIA. Addiction Science & Clinical Practice, 11:13, doi:10.1186/s13722-016-0062-9.The original publication is available at https://ascpjournal.biomedcentral.comENGLISH SUMMARY : Meeting abstracts.https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-016-0062-9Publisher's versio
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