Mathematical model of bursting in dissociated Purkinje neurons

In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na+ current (INaP) to be its burst initiator and SK K+ current (ISK) to be its burst terminator

On a General Computer Algorithm for the Analysis of Models with Limited Dependent Variables

Several econometric models for the analysis of relationships with limited dependent variables have been proposed, including the probit, Tobit, two-limit probit, ordered discrete, and friction models. Widespread application of these methods has been hampered by the lack of suitable computer programs. This paper provides a concise survey of the various models; suggests a general functional model under which they may be formulated and analyzed; reviews the analytic problems and the similarities and dissimilarities of the models; and outlines the appropriate and necessary methods of analysis including, but not limited to, estimation. It is thus intended to serve as a guide for users of the various models, for the preparation of suitable computer programs, for the users of those programs; and, more specifically, for the users of the program package utilizing the functional model as implemented on the NBER TROLL system.

New issues in attendance demand: the case of the English football league

This paper uses an attendance demand model with panel data on over 4,000 games to examine economic problems of fixture congestion in English Football League schedules. We find that televised midweek Champions League matches involving English Premier League clubs have substantial adverse impacts on lower division Football League gate attendance. This suggests that affected clubs may have a case for compensation from the Premier League for loss of gate revenue from this source. Scheduling of home games close to one another also has an adverse impact on attendance. Reorganisation of fixture schedules and/or redistribution of income would help offset adverse impacts on team revenues from midweek scheduling.

Robust estimates of the impact of broadcasting on match attendance in football

The paper employs data from 2,884 matches, of which 158 were televised, in the second tier of English football (currently known as The Football League Championship). It builds a model of the determinants of attendance that is designed to yield estimates of the proportionate changes in the size of crowds resulting from games being shown on either free-to-air or subscription based channels. The model has two innovatory features. First, it controls for the market size of home and away teams very precisely by including local population measures constructed from the application of GIS software and information on competition from other clubs. Second, it employs the Hausman-Taylor random effects estimator in order to take explicit account of the endogeneity of the television coverage variable and of other variables typically included in earlier studies based on ordinary least squares or fixed effects models of attendance. The Hausman-Taylor estimates of the impact of broadcasting are greater than those reported in such studies. In the case of free-to-air television, the negative impact is estimated as over 20 percent but for subscription television, which carried most of the transmissions, the negative effect was only of the order of 5 percent

Generation of attenuation corrected images from lidar data

The interpretation of data generated by aerosol backscatter lidars is often facilitated by presentation of RHI and PPI images. These pictures are especially useful in studies of atmospheric boundary layer structure where convective elements, stratifications and aerosol laden plumes can be easily delineated. Procedures used at the University of Wisconsin to generate lidar images on a color enhanced raster scan display are described

The MICE luminosity monitor

The MICE experiment will provide the first measurement of ionisation cooling, a technique suitable for reducing the transverse emittance of a tertiary muon beam in a future neutrino factory accelerator facility. MICE is presently in the final stages of commissioning its beam line. The MICE luminosity monitor has proved an invaluable tool throughout this process, providing independent measurements of particle rate from the MICE target, normalisation for beam line detectors and verification of simulation codes

Analysis of Qualitative Variables

A variety of qualitative dependent variable models are surveyed with attention focused on the computational aspects of their analysis. The models covered include single equation dichotomous models; single equation polychotomous models with unordered, ordered, and sequential variables; and simultaneous equation models. Care is taken to illucidate the nature of the suggested "full information" and "limited information" approaches to the simultaneous equation models and the formulation of recursive and causal chain models.

The relationship between betting and lottery play: a high frequency time-series analysis

The substitutability of different gambling products is an important concern for any jurisdiction contemplating deregulation of its gambling sector. We apply a novel daily time-series data set of daily turnover from one of Britain's leading bookmakers to analyse potential substitution between lottery play and bookmaker betting. We find some evidence that bettors do substitute away from horse race, dog race and numbers betting when the effective price of lottery tickets is unusually low, i.e. when there is a rollover or Superdraw. This substitution has a highly specific pattern of timing that varies by sector. Our results further suggest that bettors rationally engage in forward-looking substitution within their betting portfolios.