Child care and women's labor force participation in Romania

The authors model the household demand for child care, the mother's participation in the labor force, and her working hours in Romania. Their model estimates the effects of the price of child care, the mother's wage, and household income on household behavior relating to child care and mothers working outside the home. They find that: Both the maternal decision to take a job and the decision to use out-of-home care are sensitive to the price of child care. A decrease in the price of child care can increase the number of mothers who work and thus reduce poverty in some households. The potential market wage of the mother has a significant positive effect on the decision to purchase market care and the decision to engage in paid employment. The level of household nonwage income has little effect on maternal employment and the demand for child care. In addition to facilitating women's work, kindergartens and cr?hes appear to provide educational and social benefits for children. Close to half the children in these facilities have mothers who do not work. Further research is needed to assess the cost and nature of these benefits and to determine the appropriate roles for the private and public sectors in providing, financing, and regulating such services for working and nonworking mothers.Primary Education,Health Systems Development&Reform,Early Childhood Development,Children and Youth,Public Health Promotion,Street Children,Primary Education,Health Systems Development&Reform,Youth and Governance,Children and Youth

Effects of RANKL-Targeted Therapy in Immunity and Cancer.

The role of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK system is well characterized within bone, where RANKL/RANK signaling mediates osteoclastogenesis and bone resorption. However, this system has also been shown to influence biologic processes beyond the skeletal system, including in the immune system and in cancer. RANKL/RANK signaling is important in lymph-node development, lymphocyte differentiation, dendritic cell survival, T-cell activation, and tolerance induction. The RANKL/RANK axis may also have direct, osteoclast-independent effects on tumor cells. Indeed, activity of the RANKL/RANK pathway in cancer cells has been correlated with tumor progression and advanced disease. Denosumab, a fully human monoclonal antibody against RANKL, inhibits osteoclastogenesis and is widely used not just for the treatment of osteoporosis, but for the prevention of skeletal-related events from bone metastases in solid malignancies such as breast and prostate cancer. The potential effects of denosumab on the immune system have been largely ignored. Nevertheless, with the emergence of immunotherapies for cancer, denosumab may impact the effectiveness of these therapies, especially if they are given in combination. In this article, we review the role of RANKL/RANK in bone, immunity, and cancer. Examining the potential effects of routine treatment with denosumab beyond the bone represents an important area of investigation

Communitywide Database Designs for Tracking Innovation Impact: COMETS, STARS and Nanobank

Data availability is arguably the greatest impediment to advancing the science of science and innovation policy and practice (SciSIPP). This paper describes the contents, methodology and use of the public online COMETS (Connecting Outcome Measures in Entrepreneurship Technology and Science) database spanning all sciences, technologies, and high-tech industries; its parent COMETSandSTARS database which adds more data at organization and individual scientist-inventor-entrepreneur level restricted by vendor licenses to onsite use at NBER and/or UCLA; and their prototype Nanobank covering only nano-scale sciences and technologies. Some or all of these databases include or will include: US patents (granted and applications); NIH, NSF, SBIR, STTR Grants; Thomson Reuters Web of Knowledge; ISI Highly Cited; US doctoral dissertations; IPEDS/HEGIS universities; all firms and other organizations which ever publish in ISI listed journals beginning in 1981, are assigned US patents (from 1975), or are listed on a covered grant; additional nanotechnology firms based on web search. Ticker/CUSIP codes enable linking public firms to the major databases covering them. A major matching/disambiguation effort assigns unique identifiers for an organization or individual so that their appearances are linked within and across the constituent legacy databases. Extensive geographic coding enables analysis at country, region, state, county, or city levels. The databases provide very flexible sources of data for serious research on many issues in the study of organizations in innovation systems in the development and spread of knowledge, and the economics of science. Enabling the study of these topics, among others, COMETS contributes substantially to the science of science and technology.

Experimental Study and Modeling of the GM-I Dependence of Long-Channel Mosfets

This thesis describes an experimental study and modeling of the current-transconductance dependence of the ALD1106, ALD1107, and CD4007 arrays. The study tests the hypothesis that the I-gm dependence of these 7.8 µm to 10 µm MOSFETs conforms to the Advanced Compact Model (ACM). Results from performed measurements, however, do not support this expectation. Despite the relatively large length, both ALD1106 and ALD1107 show sufficiently pronounced ‘short-channel’ effects to render the ACM inadequate. As a byproduct of this effort, we confirmed the modified ACM equation. With an m factor of approximately 0.6, it captures the I-gm dependence with sub-28% maximum error and sub-10% average error. The paper also introduces several formulas and procedures for I-gm model extraction and tuning. These are not specific to the ALD transistor family and can apply to MOSFETs with different physical size and electrical performance

Shape optimization for surface functionals in Navier--Stokes flow using a phase field approach

We consider shape and topology optimization for fluids which are governed by the Navier--Stokes equations. Shapes are modelled with the help of a phase field approach and the solid body is relaxed to be a porous medium. The phase field method uses a Ginzburg--Landau functional in order to approximate a perimeter penalization. We focus on surface functionals and carefully introduce a new modelling variant, show existence of minimizers and derive first order necessary conditions. These conditions are related to classical shape derivatives by identifying the sharp interface limit with the help of formally matched asymptotic expansions. Finally, we present numerical computations based on a Cahn--Hilliard type gradient descent which demonstrate that the method can be used to solve shape optimization problems for fluids with the help of the new approach