Novel MEMS Sensor for Detecting Magnetic Particles in Liquids

We present a novel MEMS sensor for the detection of magnetic particles in liquids, which consists of a microcantilever excited piezoelectrically in resonance and having an integrated planar coil on its free end. Due to the latter component, magnetic particles are attracted and accumulate on the sensor surface. The additional mass introduced by the particles changes the resonance frequency of the microcantilever serving as measured quantity. To evaluate our design, we dispersed 250 nm iron-oxide particles in de-ionized water and monitored the resonance frequency during particle accumulation. 100 min after measurement start, a total resonance frequency shift of 6 kHz was found, which can easily be measured and shows the high potential of the proposed sensor design

Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer\u27s Disease Treatment

A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes