7 research outputs found
Effectiveness of absorption and passage through the small intestine, as a model of oral prolactin administration
- Author
- Artursson
- Bachelot
- Balimane
- Barbara Dolińska
- Basit
- Binart
- Bjarnason
- Charoenphandhu
- Costantino
- Craik
- Dolińska
- Dolińska
- Dusza
- Egli
- Florian Ryszka
- Gajda
- Horseman
- Ignacak
- International Conference on Harmonization (ICH)
- Jain
- Jara
- Larsen
- Lucas
- Marano
- Nowatzke
- Parker
- Roelfsema
- Ryszka
- Ryszka
- Ryszka
- Ryszka
- Ryszka
- Sen
- Smart
- Smith
- Varum
- Wioletta Siemiradzka
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
ICH E14 Q&A(R2) document: commentary on the further updated recommendations on thorough QT studies
- Author
- Aitken
- Ansermot
- Bouvy
- Chae
- Committee for Medicinal Products for Human Use (CHMP)
- Committee for Medicinal Products for Human Use (CHMP)
- Darpo
- Dickmann
- Florian
- Frye
- Grilo
- Hartigan-Go
- ICH E14 Implementation Working Group
- International Conference on Harmonisation
- Julian
- Kato
- Krantz
- Lin
- Mbai
- McKibbin
- Sager
- Sager
- Schmitt
- Shah
- Shah
- Sánchez Hernández
- Vorperian
- Waldo
- Zhang
- Zhou
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Real-time quantification of low-dose cohesive formulations within a sampling interface for flowing powders
- Author
- Alvarado-Hernández
- Barletta
- Bellamy
- Benedetti
- Cain
- Chaudhuri
- Corredor
- Dalvi
- De Beer
- De Leersnyder
- DurĂŁo
- Esbensen
- Esbensen
- Escotet-Espinoza
- Florian-algarin
- Freeman
- Freeman
- Geldart
- Goh
- Gosselin
- Hetrick
- Holte
- ICH
- JakliÄŤ
- Järvinen
- Ketterhagen
- Ketterhagen
- Leturia
- Li
- Liew
- Mehrotra
- Muzzio
- Muzzio
- Nobel O. Sierra-Vega
- Ortega-Zúñiga
- Pauli
- Portillo
- Rafael MĂ©ndez
- Rodolfo J. Romañach
- Sharma
- Shi
- Sierra-Vega
- Sierra-Vega
- Sierra-Vega
- Sulub
- Susana
- Vanarase
- Vargas
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Sphärensprünge vom Landleben zur Literatur Von Bräker bis Brandstetter
- Author
- Basel UB
- Bd.
- Beschreibung
- Brandstetter Alois
- Brandstetter Alois
- Bräker
- Bräker Chronik Ulrich
- Derartige Bekundungen
- des Verfassers Vorrede
- Die Angst
- Diesen
- Felder Franz Michael
- Florian Stiftskirche St.
- Hahn Johann Jobst
- Johann Heinrich
- la Roche An Sophie
- LXVIII.
- Martin Schmidt JĂĽngere Untersuchungen
- Nachweis
- Reitz Johann Heinrich
- Rose GĂĽldene
- S.
- S.
- Schenda
- Schenda Rudolf
- Titel von Bräkers Lyrikheft Selbstcharakterisierung
- Todesängsten« Der Geissbub
- Verhältnis Über
- von Alois Stadler Aufgrund
- Waldbauernbub
- Wirth Michael
- Zschokke Johann Heinrich
- zu Eugène Ritter Grundlegend
- »›Ich
- örchen
- Ăśber Christoph
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Rusticano stilo? Papst und Rhetorik im 11. und 12. Jahrhundert
- Author
- Anm Liber Pontificalis
- Anm Liber Pontificalis
- Anm Liber Pontificalis
- Anm Liber Pontificalis
- Anm Papsttum
- Art Zum Liber
- Automatismus Durchsetzung
- Bibliotheken
- Bresslau H.
- Briefen Die Zahl
- der Schriftlichkeit Proportionen
- der »produktiven Die Formulierung
- Dialogi
- Die
- Die
- Edd Ein
- Edd MĂĽller
- Edd Skalweit
- Eingang Die
- Engels Zu Boso
- Engels Zur
- Ex
- Ex
- Florian Ich
- FĂĽr
- Gerberts von Aurillac Zu Reden
- Hehl E.-D.
- In
- Italia Pontificia Selbst
- Johrendt J.
- Kanzlei
- Leo Bereits
- Mittelalter So Deutsche
- Reg VII.
- Remigii Anselmi Remensis
- Texte Le Liber
- Vgl So
- von Montecassino Die Chronik
- Wesentliche Merkmale
- Zu
- Zu Gelasius
- Zu Predigten
- Zum
- Zur Synode
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
V. Moscheebaukonflikte in Ă–sterreich: Chronologie und Fallstudien
- Author
- Abbildung
- Alfred Pfeiffenberger Zitiert
- Angst« In
- Ausfälle« Jutta Berger
- Austria Statistik
- Bei
- Beispiel Zum
- Berger Jutta
- Bischof Klaus
- Bundespräsident Kein Kleingeld
- BĂĽrgermeister Florian Kasseroler Ich
- BĂĽrgermeister Josef Katzenmayer Interview
- Christoph Universitätsprofessor Dr. Dr.
- de Haltung« Bischof
- den Informationen Quelle
- den Wahlkampf« Salzburgs Politiker
- Der
- der Abgeordneten Strache EntschlieĂźungsantrag
- der Abgeordneten Strache EntschlieĂźungsantrag
- der Drau Interview
- des Evangelischen Der Bote
- des Meinungsforschers Edwin Berndt Aussage
- Dipl Interview
- Dr Interview
- Erklärung« Spittaler
- Feldkirch Diözese
- Fischer Bischof Elmar
- Folgenden Zum
- Fragen von Bischof Fischer« Muslime
- Gefälschtes Moschee
- Gemeinde Pfarre Traun
- GĂĽnther Ahmed Ruznak Telefonisches Interview
- Heil‹ »›Sieg
- Herrn Stadtamtsdirektor Mag Ich
- Hinweis
- Hirsch Philipp
- Hr FĂĽr
- Hr FĂĽr Hinweise
- Hr Interview
- Hr Telefonisches
- Hr Telefonisches Interview
- Hr Telefonisches Interview
- Hr Telefonisches Interview
- Information
- Inhalts der Ă„nderungen Zusammenfassung
- Interview
- Islam-Demo« Aufgeheizte Stimmung
- Islamische Das
- Jahre Sechste Beilage
- Jörg« Einfach
- Kameraden« Neonazi-Disput
- Kap S.
- Korn Salomon
- Kärnten Freiheitlicher Landtagsklub
- Landeskorrespondenz Vorarlberger
- Landschaftsakten
- Landtag Kärntner
- Landtag Vorarlberger
- Landtag Vorarlberger
- Linz Moschee
- Linz« Blaue Angst
- Man
- Minarett
- Minarett
- Minarett Kirche
- Minarett-Pläne« Land
- Minarett-Polarisierung« Schulterschluss
- Minarette« ZÖ
- Minarett« Unterschriften
- Mit
- Nationalrat
- Nenzing« Moschee-Plan B‹
- Ohne Minarett
- OĂ– Nachrichten Moschee-Plan
- Parteien Die Rede
- Pressestunde ORF
- PÖ-Obmann Gerald Ausländerwahlkampf
- Quelle
- Quelle
- Quelle
- Reaktionen zu Minarett« »Überwiegend
- S.
- S.
- S.
- S.
- S. Kap
- Sausgruber Landeshauptmann Herbert
- Schwarz Bischof Ludwig
- Schöberl Andreas
- Schöberl Andreas
- Schöberl Andreas
- Spittal« Sicher
- Stellungnahme des Verfassungsjuristen Prof Siehe
- Telfer
- Telfser Bürgermeister« Drohungen
- Telfser Minarett« Wende
- Telfs« Der Bischof
- Traun Stadt
- Trauns Innenstadt« Streit
- Union Interview
- Vizedirektorin des Islamischen Forums Penzberg Gespräch
- Volkszählung Statistik
- Volkszählung Statistik
- Vorarlbergs Minarett-Bau
- Vorwort«
- Walgau« Moschee-Neubau
- Website
- Website
- WeiĂź
- Werner Ringer Interview
- Wohl
- Zugriff
- Zum Folgenden
- »okay Website
- ändert Pläne
- öglicht Deal
- Ă–sterreich Republik
- ĂĽber Bludenzer
- ĂĽbrigen Europa Die
- ĂĽnes OĂ–
- ür Gebetshaus« Mülldeponie
- ĂĽr Moscheen Bau-Verbot
- ĂĽr Schakfeh
- ür Schützen Provokation« Minarett
- ür Trauner Moschee« Muslime
- ›am Traun
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
- Andrews A
- Angel J
- Anscombe R
- Anthony A
- Antle S
- Antman EM
- Antman EM
- Antonino M
- Anzai T
- Apetrei E
- Apostolovic S
- Appelros P
- Aquino M
- Arakawa S
- AraĂşjo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
- Arias J
- Armas BH
- Arneja J
- Arnold T
- Arora T
- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
- Astier L
- Ata N
- Ata N
- Atar D
- Atar D
- Atar S
- Atie J
- Atkinson C
- Attanti S
- Aude Y
- Augusto Alves da Costa F
- Aull L
- Ault S
- Ausperger KM
- Avellar K
- Averett P
- Avery D
- Avila H
- Avvaru G
- Awasty V
- Awtry E
- Ayasse D
- Ayau Milla O
- Ayesu K
- Aylward P
- Azhdari M
- Azua MG
- Babbar A
- Babbolin M
- Babilonia N
- Babilonia N
- Babu P
- Babu R
- Babuty D
- Badenhorst J
- Badila E
- Bae HJ
- Bagatin J
- Bagby J
- Bai F
- Baine S
- Bakliza Z
- Balboa W
- Baldwin E
- Ball E
- Ballyuzek M
- Baman R
- Bamhorst M
- Bamrungpong P
- Banaeian F
- Banikova A
- Banikova A
- Banker D
- Bansal N
- Banville P
- Bar M
- Barai A
- Baranyai M
- Barash B
- Barbarash O
- Barber M
- Barbera S
- Barcinas R
- Barker T
- Barnhorst M
- Barquero R
- Barrington P
- Barros R
- Barroso D
- Bart B
- Bartholomaus D
- Bartkowiak A
- Bartos D
- Bashkireva A
- Basson M
- Baszak J
- Baszak J
- Batchell K
- Batista M
- Batta C
- Battistelli E
- Batushkin V
- Bauch F
- Bauch F
- Bauer K
- Bautista C
- Bayata S
- Bayata S
- Baylacher M
- Bayram Llamas E
- Bazylevych A
- Beasley R
- Beck P
- Bedenko E
- Bedoya R
- Bedregal SA
- Bedwell N
- Beerts C
- Beeton I
- Behm K
- Beinart S
- Bekal S
- Belatsky V
- Belcuore M
- Belenky D
- Belhassane A
- Beloscar J
- Belousova L
- Ben Ari M
- Benatar J
- Bengtsson AS
- Bengus C
- Benicka E
- Benjarge P
- Bensimhon D
- Bentivenga L
- Benton J
- Berbari H
- Berbari H
- Bereznyakov I
- Berger CJ
- Berger N
- Bergovec M
- Bergovec M
- Berk M
- Berka L
- Berli M
- Berli M
- Bernard J
- Bernhardt P
- Berni A
- Berns S
- Berrouschot J
- Bertolim Precoma D
- Betcher J
- Beyer-Westendorf J
- Bharani A
- Bhargava R
- Bhargava V
- Bhaskarwar P
- Bhuti M
- Bianchini M
- Bilal B
- Bilazarian S
- Bingham S
- Biniek D
- Biniwale A
- Binns M
- Biscardi R
- Bjelobrk M
- Blagden M
- Blanc J
- Blanc JJ
- Blanco Coronado J
- Blihar O
- Block T
- Blom KB
- Blomström P
- Blonder R
- Bloomberg K
- Bloomberg R
- Blue B
- Bobade M
- Bobbie C
- Bobescu E
- Bocanera M
- Bognar A
- Bojanowska E
- Bokarev I
- Bollova D
- Bolohan F
- Bolohan F
- Bolton R
- Bonds C
- Bonin K
- Bonora M
- Boriani G
- Borowski W
- Borsheim M
- Borthwick L
- Bosco B
- Bose S
- Bossaers J
- Botelho R
- Botero R
- Botha L
- Bouchard A
- Bourlios P
- Boursin P
- Bouzo M
- Bowden W
- Bowen L
- Bowman B
- Boyer M
- Bozek B
- Bradley A
- Braemer U
- Braun D
- Braun R
- Braunwald E
- Braunwald E
- Breschi M
- Bridge C
- Brilakis E
- Briscoe C
- Broberg M
- Brodova P
- Brondani R
- Bronisz M
- Brown F
- Brown H
- Brown R
- Browning J
- Brtko M
- Brtko M
- Brubaker S
- Bruguera Cortada J
- Bruning T
- Bruton T
- Buchholz M
- Budassi N
- Buelow-Johansen B
- Bugueño C
- Buhler A
- Buhr M
- Buiks C
- Buiks C
- Builes A
- Buksa B
- Bulgari M
- Bulygin S
- Burianova H
- Burianova H
- Bush D
- Bustamante G
- Bustamante Labarta G
- Busz-Papiez B
- Butcher S
- Buza V
- Buzzetti C
- Bybee K
- Cabero P
- Cabrera J
- Caccavo A
- Caceres M
- Cader C
- Cajulis C
- Cakmak N
- Calambur N
- Calderon M
- Calik A
- Calvo C
- Calvo G
- Calvo M
- Calvo Vargas C
- Camm J
- Camm J
- Cammell R
- Campbell G
- Campisto Y
- Canaday D
- Cannoni S
- Cano N
- Canosa R
- Capasso-Gulve E
- Capiau L
- Caplan J
- Car S
- Cardona Muñoz E
- Cardoza T
- Carevic V
- Carey G
- Carey J
- Carlsson T
- Carne M
- Carr K
- Carraro A
- Carrasco GT
- Carrillo J
- Carrion A
- Carroll L
- Cartasegna L
- Caruso O
- Casares E
- Casas R
- Castro C
- Caterini T
- Cavanna L
- Cayli M
- Cayli M
- Ceirano C
- Celic V
- Cemerlic Adjic N
- Cendali G
- Cermak O
- Cermak O
- Cervellione K
- Cervi E
- Ceyhan C
- Ceyhan C
- Cha J
- Cha JK
- Cha MJ
- Chacon L
- Champagne M
- Chang M
- Chapman O
- Charlat M
- Chaturvedi S
- Chaves Junior H
- Chavez C
- Chehayeb R
- Chen JZ
- Chen SA
- Chen XP
- Chen YF
- Chen YP
- Chendey T
- Cheng CC
- Cheng CC
- Chernyavskaya T
- Cherrico M
- Chiang CE
- Chiang FT
- Chilvers M
- Chiou CW
- Chiu CZ
- Chmielowski A
- Cho BR
- Choi HH
- Choi KJ
- Choi Y
- Chompalova B
- Chopda M
- Choy A
- Christensen H
- Christensen L
- Christian T. Ruff
- Chumakova G
- Chun MY
- Chung A
- Chung N
- Chung WS
- Ciaramita J
- Cieslak B
- Ciezak P
- Ciglenecki N
- Ciobotaru G
- Ciortea M
- Clapp T
- Claussen H
- Clay A
- Cleveland D
- Clifton R
- Clinckemaille N
- Cobos D
- Cobos J
- Coching R
- Codutti O
- Cohen A
- Cohen A
- Cohen R
- Coisne D
- Colan D
- Cole J
- Colin MA
- Colombo H
- Colquhoun D
- Coman I
- Comi G
- Concha M
- Connolly S
- Constance C
- Constantinescu M
- Constantinescu M
- Contzen C
- Cook S
- Coombs V
- Copley M
- Corbalan R
- Corbalán R
- Corbett B
- Corbut S
- Corchado D
- Correia J
- Correia J
- Cossu S
- Costache L
- Costantini C
- Costi P
- Cottiero R
- Coutinho E
- Coutu B
- Cowan L
- Cox C
- Coyle GS
- Cozma M
- Craft D
- Craig M
- Crerand W
- Creteanu M
- Crimmins D
- Cristaldi J
- Cristea M
- Crisu D
- Croce K
- Cuccia C
- Cuello J
- Cullen T
- Cuneo C
- Cunha S
- Curt V
- Curtis B
- Curtis S
- Cury C
- Cush S
- Cymerman K
- Cymerman K
- Cásares Ramirez M
- D'Amico A
- D'Costa D
- D'Souza A
- Dabrowska M
- Dagan T
- Daitz C
- Dalby A
- Dalby A
- Dandekar U
- Dang N
- Daniels R
- Daniels S
- Dart A
- Daskalaki A
- Dastoli K
- Datta S
- Daut W
- Dave B
- Dave K
- Davicevic Z
- David D
- Davids M
- Davies D
- Davis A
- Davis C
- Davis C
- Davis S
- Davolos M
- Davuluri A
- Davé J
- de Arce Borda A
- De Bleecker J
- De Bruyne L
- De Caterina R
- de Groot J
- de Koning K
- de la Mora S
- De Lemos J
- de Melo RF
- De Pace D
- De Patta M
- De Servi S
- De Tollenaere M
- de Vos R
- de Vos R
- Dean J
- Debes C
- Decoulx E
- Deenadayalu N
- DeGarmo R
- Degtyareva E
- Delgadillo T
- Delgado A
- Delgado MD
- Delgado P
- Delgado Restrepo J
- Delgado S
- Demir H
- Demir H
- Demko A
- Denchev S
- Denie D
- Denis I
- Dennison K
- Deokar M
- Derlaga B
- Deruche E
- Derycker K
- Desai A
- Desai A
- DeSalle D
- Desfontaines P
- Desire A
- Despotovic N
- Dettmann S
- Devenport S
- Dewar C
- Dhar S
- Dharmarao A
- Di Lenarda A
- Di Niro M
- Di Pasquale G
- Dias P
- Diaz IA
- Diaz PA
- Diaz-Pintado M
- Dichristin U
- Dicker D
- Dickinson D
- Dickinson D
- DiCorcia L
- Dieckheuer U
- Diez Tejedor E
- DiGiovanna M
- Dimitra K
- Dinanian S
- Dioszeghy P
- Djokic I
- Djokovic A
- Djordjevic-Radojkovic D
- do Val R
- Dobre I
- Dobreanu D
- Doctor A
- Dodt K
- Doka B
- Domanska E
- Domingo D
- Donahue S
- Dong YG
- Dongas B
- Donova T
- Donovan D
- Dorn S
- Dorobantu M
- Dotani I
- Dotsenko S
- Dougal K
- Doughty R
- Douglas H
- Douglas S
- Dovgalevsky P
- Dovgan N
- Dowling C
- Dragomir D
- Dran R
- Drapchak I
- Drapkina O
- Drescher T
- Drew B
- Dreykluft K
- Dronov D
- Drozdiak R
- du Preez M
- Duda N
- Duff J
- Dufresne M
- Dugal J
- Duggal A
- Dukat A
- Duki Y
- Dulka T
- Dulkova K
- Duncan D
- Dunn K
- Dunn S
- Duprat C
- Duris T
- Duris T
- Dutka C
- Dutra O
- Dutter S
- Dvoieglazova M
- Dzublik Y
- Dzupina A
- Dzupinova M
- Dzyak G
- Eade J
- Easton JD
- Ebano P
- Ebano P
- Ebert J
- Ebina E
- Ebreo N
- Edelstein J
- Eden M
- Edes I
- Edlund M
- Egorova L
- Egorova L
- Eikelboom J
- El Jarroudi F
- El Jarroudi F
- El Jarroudi M
- Elbl L
- Elbl L
- Eldadah Z
- Eldred R
- Elias M
- Elliott M. Antman
- Ellis G
- Ellis J
- Enad C
- Endo H
- Engdahl J
- Engelbrecht J
- Enger S
- Ensminger E
- Erasmus L
- Erceg P
- Erdogan D
- Erdogan D
- Erenrich N
- Erenrich N
- Eriksson G
- Ermis C
- Ermis C
- Erofeeva S
- Esip V
- Essop M
- Estol C
- Ettinger N
- Eugene Braunwald
- Everhart B
- Ewing B
- Exarchou E
- Ezekowitz M
- Facello A
- Facello M
- Faghih M
- Faghih M
- Fahmy R
- Faircloth C
- Falu E
- Fattore L
- Faucett S
- Faustino Saporito W
- Faynyk A
- Fedacko J
- Fedotov S
- Feil JF
- Fekete A
- Feld L
- Feldman J
- Felsman D
- Felten W
- Femenia F
- Feng C
- Fenu L
- Ferguson D
- Ferkl R
- Ferkl R
- Fernandez E
- Fernandez M
- Fernández Ruiz R
- Ferraz RF
- Ferreira L
- Ferri Certic J
- Fialkow J
- Filatov A
- Finimundi H
- Fink P
- Finkel M
- Finkelstein S
- Finlayson M
- Finsterbusch T
- Fiok J
- Fischell T
- Fishbein G
- Fisher M
- Fisher M
- Fisher M
- Fisher M
- Fisher R
- Fleck N
- Flecknoe-Brown S
- Fleets J
- Flint L
- Florenzano F
- Flores E
- Florian J
- Florian J
- Fonseca J
- Forck-Boedeker K
- Forgione C
- Forman S
- Formoso I
- Fortin C
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- Zamlynskyy M
- Zamorano JL
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- Zateyshchikov D
- Zateyshchikova A
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- Zharinov O
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- Zhukova N
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- Zidkova E
- Zidkova E
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- Zimmermann EB
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- Zubeeva G
- Zyatenkova E
- Ă…kerberg A
- Ă–stberg S
- Ĺśpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)