Main effects for the epidemiologic variables included in the analyses, derived from population-based studies only¹.

<p>Main effects for the epidemiologic variables included in the analyses, derived from population-based studies only^{<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003284#nt104" target="_blank">1</a>}.</p

Odds ratios of gene-environment interaction for risk of breast cancer with p-value<10⁻³ by study.

<p>(A) <i>LSP1</i>-rs3817198 x Number of full-term births (among parous), (B) <i>LSP1</i>-rs3817198 x Number of full-term births (among parous), restricted to subjects not included in previous BCAC report, (C) 1p11-rs11249433 x Parous (yes/no), (D) <i>CASP8</i>-rs17468277 x mean lifetime intake of alcohol (<20 g/day versus > = 20 g/day).</p

List of participating studies and number of Caucasian subjects included in at least one GxE analysis.

<p>List of participating studies and number of Caucasian subjects included in at least one GxE analysis.</p

Per-allele SNP odds ratios and 95% confidence intervals stratified by environmental risk factors of breast cancer, and combined SNP main effect.

<p>(A) <i>LSP1</i>-rs3817198 x Number of full-term births (among parous), (B) 1p11-rs11249433 x Parous (yes/no), (C) <i>CASP8</i>-rs17468277 x mean lifetime intake of alcohol (<20 g/day versus > = 20 g/day).</p

Associations between selected SNPs and breast cancer risk in Caucasians, overall and by ER status (estimated per-allele odds ratios and 95% confidence intervals)¹.

<p>Associations between selected SNPs and breast cancer risk in Caucasians, overall and by ER status (estimated per-allele odds ratios and 95% confidence intervals)^{<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003284#nt107" target="_blank">1</a>}.</p

Per-allele odds ratios and 95% confidence intervals for SNPs by environmental risk factors of breast cancer showing interaction P-value<10⁻³, overall and by estrogen receptor status.

<p>Per-allele odds ratios and 95% confidence intervals for SNPs by environmental risk factors of breast cancer showing interaction P-value<10⁻³, overall and by estrogen receptor status.</p

Association of rs2046210 with breast cancer in Asian ER

<p>−<b>*versus ER+**cases and controls.</b> *Estrogen receptor negative; **Estrogen receptor positive.</p

Association of rs12662670 with breast cancer in European ER

<p>−<b>*versus ER+**cases and controls.</b> *Estrogen receptor negative; **Estrogen receptor positive.</p

Association of rs2046210 and rs12662670 with breast cancer.

<p>Results are presented overall and separately for Europeans and Asians. Pooled analyses adjusted for study only as well as adjusted for rs12662670 or rs2046210, respectively, in addition to study were performed.</p>a<p>P-value derived from the log-additive model.</p>b<p>Odds ratio per minor allele (A allele for rs2046210, G allele for rs12662670).</p>c<p>Odds ratio relative to the major allele homozygous (GT) genotype.</p

Association of rs2046210 with breast cancer in European ER

<p>−<b>*versus ER+*cases and controls.</b> *Estrogen receptor negative; **Estrogen receptor positive.</p