Autism and neurodevelopmental disorders: the Sars-Cov-2 pandemic implications

The Special Issue (SI) “Autism and Neurodevelopmental Disorders: The SARS-CoV-2 Pandemic Implications” is an interesting project that adopted a scientific point of view with important implications in clinical and practical fields [...

Modeling Knowledge in Environmental Analysis: A New Approach to Soundscape Ecology

Planning activities are inherently technical, political and organizational exercises, being both constructions of action optimization over time and “social” organizations promoting action. Thus, they require organization and consensus. In this context, the concept of processes that develop based on diffused interactions between different agents appears useful and rather effective. Cognitive agents and reactive agents coexist in a system of relations and interactions. This allows the context in which environmental management and/or planning processes take place to be modeled in its essential parts. Scholars and researchers have often wondered if behavioral proxies of the environment-agent can be singled out for possible inclusion in a multi-agent system (MAS) layout. This challenge is of particular interest today, considering the potential offered by the spread of intelligent sensor networks, able to represent and model various “behaviors” of the environment-agent. Today’s growing interest in research in the field of planning is enhanced by an awareness of the complexity issue embedded in planning. In this framework, this paper is realized as a pilot study on the knowledge of sound and soundscapes as elements characterizing the environment-agent in the context of environmental planning processes. The study reflects a contextual difficulty of collecting extensive data in uneasy conditions: nevertheless it reports results and suggestions useful in an innovative MAS-oriented perspective

HST Observations of the Globular Cluster NGC 6402 (M14) and Its Peculiar Multiple Populations

We present Hubble Space Telescope (HST) photometric results for NGC 6402, a highly reddened, very luminous Galactic globular cluster (GC). Recent spectroscopic observations of its red giant stars have shown a quite peculiar behavior in the chemistry of its multiple populations. These results have prompted UV and optical HST observations aimed at obtaining the cluster's "chromosome map" (ChM), an efficient tool for classifying GCs and characterizing their multiple populations. We find that the discontinuity in the abundance distributions of O, Mg, Al, and Na inferred from spectroscopy is more nuanced in the ChM, which is mostly sensitive to nitrogen. Nevertheless, photometry in optical bands reveals a double main sequence, indicating a discontinuity in the helium content of the populations. The population with the largest chemical anomalies (extreme) peaks at a helium mass fraction Y similar to 0.31. This helium content is consistent with results from the analysis of the distribution of horizontal branch stars and the spectrophotometry of the red giants. The ChM and the color-magnitude diagrams are compared with those of NGC 2808, a prototype GC with helium abundances up to Y greater than or similar to 0.35, and both confirm that NGC 6402 does not host stellar populations with such extreme helium content. Further, the ChM reveals the presence of a group of stars with higher metallicity, thus indicating that NGC 6402 is a Type II cluster. The modalities of formation of the multiple populations in NGC 6402 are briefly surveyed, with main attention on the asymptotic giant branch and supermassive star models, and on possible cluster merging

A novel multidimensional questionnaire for the assessment of emotional dysregulation in adolescents: Reactivity, Intensity, Polarity and Stability questionnaire-youth version (RIPoSt-Y)

Background: The failure to regulate emotions, namely emotional dysregulation (ED), is a relevant construct in adolescent psychiatry, in terms of prognostic and developmental implications. We developed and validated a novel self-report questionnaire for the assessment of ED, the RIPoSt-Y, both in clinical and non-clinical samples. Methods: Items selection and subscales construction were conducted on healthy controls (n=374), while test-retest reliability was evaluated in a subsample (n=72); internal consistency was examined both in the control group and in two clinical samples, respectively including patients with Bipolar Spectrum Disorders (BSD; n=44) and ADHD (n=34). Construct, concurrent and convergent validity were also assessed. Results: Thirty-one items were finally retained, and three subscales were identified (Affective Instability, Emotional Reactivity, Interpersonal Sensitivity). Test-retest was significant for each subscale with moderate-to-good correlations, and internal consistency showed good-to-excellent coefficients. Construct validity was supported by significant differences between patients and controls and gender-related differences. Concurrent validity was confirmed through significant associations with two subscales of the CHT-Q, while convergent validity proved to be significant with the CBCL/YSR dysregulation-profile. Cut-offs were also computed to discriminate clinically significant scores of ED. Limitations: The use of a school-based survey to recruit controls could have biased our results; gender distributions between clinical and non-clinical samples were significantly different. Conclusions: Our novel questionnaire proved to be a valid and reliable tool able to assess the presence of ED in youths and to characterize this fundamental construct in its multidimensional facets

One-year impact of bariatric surgery on serum anti-Mullerian-hormone levels in severely obese women

International audienceINTRODUCTION: Although bariatric surgery seems to increase spontaneous fertility by improving ovulatory function in young women, its impact on ovarian reserve remains largely unknown.OBJECTIVE: To evaluate changes in serum anti-Mullerian hormone (AMH) levels in reproductive-age severely obese women after bariatric surgery (BS).METHODS: AMH levels were measured retrospectively in 39 women (mean age 34.6 ± 1.1 years, range 18-45) that underwent a sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) at baseline, and 6 and 12 months after BS. Metabolic and micronutrient status, including fasting plasma insulin and glucose, HOMA-IR, leptin, adiponectin, calcium, albumin, transthyretin, ferritin, vitamins (B9, B12, B1, A, E, D), zinc, and selenium, were assessed in all patients before and 1 year after BS.RESULTS: Of the patients, 79% had class-3 obesity. At 6 and 12 months, mean total weight losses (TWL) were 26 and 30%; mean excess weight losses (EWL) were 61.7 and 70.2%. Compared to baseline, AMH levels significantly decreased by 18% at 6 months, and 32% at 12 months post-operatively (p = 0.010 and p = 0.001, respectively). There was no correlation between AMH variation and changes in metabolic parameters or micronutrient levels. Remarkably, changes in AMH levels did not differ between sleeve and RYGB patients and were not correlated with EWL.CONCLUSION: This pilot study shows a drastic reduction in AMH levels at 1 year after BS in reproductive-age severely obese women, which was not related to weight loss: this suggests a negative impact of BS on ovarian reserve, at least in the short term

Augmented reality (AR) in minimally invasive surgery (MIS) training: where are we now in Italy? The Italian Society of Endoscopic Surgery (SICE) ARMIS survey

Minimally invasive surgery (MIS) is a widespread approach in general surgery. Computer guiding software, such as the augmented reality (AR), the virtual reality (VR) and mixed reality (MR), has been proposed to help surgeons during MIS. This study aims to report these technologies' current knowledge and diffusion during surgical training in Italy. A web-based survey was developed under the aegis of the Italian Society of Endoscopic Surgery (SICE). Two hundred and seventeen medical doctors' answers were analyzed. Participants were surgeons (138, 63.6%) and residents in surgery (79, 36.4%). The mean knowledge of the role of the VR, AR and MR in surgery was 4.9 ± 2.4 (range 1-10). Most of the participants (122, 56.2%) did not have experience with any proposed technologies. However, although the lack of experience in this field, the answers about the functioning of the technologies were correct in most cases. Most of the participants answered that VR, AR and MR should be used more frequently for the teaching and training and during the clinical activity (170, 80.3%) and that such technologies would make a significant contribution, especially in training (183, 84.3%) and didactic (156, 71.9%). Finally, the main limitations to the diffusion of these technologies were the insufficient knowledge (182, 83.9%) and costs (175, 80.6%). Based on the present study, in Italy, the knowledge and dissemination of these technologies are still limited. Further studies are required to establish the usefulness of AR, VR and MR in surgical training