AGN outflows and feedback twenty years on

It is the twentieth anniversary of the publication of the seminal papers by Magorrian et al. and Silk & Rees which, along with other related work, ignited an explosion of publications connecting active galactic nuclei (AGN)-driven outflows to galaxy evolution. With a surge in observations of AGN outflows, studies are attempting to directly test AGN feedback models using the outflow properties. With a focus on outflows traced by optical and CO emission lines, we discuss significant challenges which greatly complicate this task from both an observational and theoretical perspective. We highlight observational uncertainties involved, and the assumptions required, when deriving kinetic coupling efficiencies (i.e., outflow kinetic power as a fraction of AGN luminosity) from typical observations. Based on recent models we demonstrate that extreme caution should taken when comparing observationally-derived kinetic coupling efficiencies to coupling efficiencies from fiducial feedback models.Comment: Authors' version (all referee comments addressed). 7 pages + references. Published in Nature Astronom

Photoionization spectroscopy of CH3C3N in the vacuum-ultraviolet range

International audienceUsing vacuum-ultraviolet (VUV) synchrotron radiation, threshold and dissociative photoionization of cyanopropyne (CH3C3N) in the gas phase have been studied from 86 000 cm−1 up to 180 000 cm−1 by recording Threshold-PhotoElectron Spectrum (TPES) and PhotoIon Yield (PIY). Ionization energies of the four lowest electronic states X̃+2E,Ã+2A1,B̃+2E and C̃+ of CH3C3N+ are derived from the TPES with a better accuracy than previously reported. The adiabatic ionization potential of CH3C3N is measured as 86872±20 cm−1. A description of the vibrational structure of these states is proposed leading to the first determination of the vibrational frequencies for most modes. The vibrational assignments of the X̃+ state are supported by density functional theory calculations. In addition, dissociative photoionization spectra have been recorded for several cationic fragments in the range 12–15.5 eV (96 790–125 000 cm−1) and they bring new information on the photophysics of CH3C3N+. Threshold energies for the cationic dissociative channels leading to CH2C3N+, CHC3N+, HC3H+, HCNH+ and CH3+ have been measured for the first time and are compared with quantum chemical calculations

The final data release of ALLSMOG: a survey of CO in typical local low-M* star-forming galaxies

We present the final data release of the APEX low-redshift legacy survey for molecular gas (ALLSMOG), comprising CO(2-1) emission line observations of 88 nearby, low-mass (10^8.5<M* [M_Sun]<10^10) star-forming galaxies carried out with the 230 GHz APEX-1 receiver on the APEX telescope. The main goal of ALLSMOG is to probe the molecular gas content of more typical and lower stellar mass galaxies than have been studied by previous CO surveys. We also present IRAM 30m observations of the CO(1-0) and CO(2-1) emission lines in nine galaxies aimed at increasing the M*<10^9 M_Sun sample size. In this paper we describe the observations, data reduction and analysis methods and we present the final CO spectra together with archival HI 21cm line observations for the entire sample of 97 galaxies. At the sensitivity limit of ALLSMOG, we register a total CO detection rate of 47%. Galaxies with higher M*, SFR, nebular extinction (A_V), gas-phase metallicity (O/H), and HI gas mass have systematically higher CO detection rates. In particular, the parameter according to which CO detections and non-detections show the strongest statistical differences is the gas-phase metallicity, for any of the five metallicity calibrations examined in this work. We investigate scaling relations between the CO(1-0) line luminosity and galaxy-averaged properties using ALLSMOG and a sub-sample of COLD GASS for a total of 185 sources that probe the local main sequence (MS) of star-forming galaxies and its +-0.3 dex intrinsic scatter from M* = 10^8.5 M_Sun to M* = 10^11 M_Sun. L'_{CO(1-0)} is most strongly correlated with the SFR, but the correlation with M* is closer to linear and almost comparably tight. The relation between L'_{CO(1-0)} and metallicity is the steepest one, although deeper CO observations of galaxies with A_V<0.5 mag may reveal an as much steep correlation with A_V. [abridged

HIV-1 protease inhibition potential of functionalized polyoxometalates

Polyoxometalates (POMs) are interesting biomedical agents due to their versatile anticancer and antiviral properties, such as remarkable anti-HIV activity. Although POMs are tunable and easily accessible inorganic drug prototypes in principle, their full potential can only be tapped by enhancing their biocompatibility, for example, through organic functionalization. We have therefore investigated the HIV-1 protease inhibition potential of functionalized Keggin- and Dawson-type POMs with organic side chains. Their inhibitory performance was furthermore compared to other POM types, and the buffer dependence of the results is discussed. In addition, chemical shift mapping NMR experiments were performed to exclude POM-substrate interactions. Whereas the introduction of organic side chains into POMs is a promising approach in principle, the influence of secondary effects on the reaction system also merits detailed investigation

Risk Factors for Whole Carcass Condemnations in the Swiss Slaughter Cattle Population

We used meat-inspection data collected over a period of three years in Switzerland to evaluate slaughterhouse-level, farm-level and animal-level factors that may be associated with whole carcass condemnation (WCC) in cattle after slaughter. The objective of this study was to identify WCC risk factors so they can be communicated to, and managed by, the slaughter industry and veterinary services. During meat inspection, there were three main important predictors of the risk of WCC; the slaughtered animal's sex, age, and the size of the slaughterhouse it was processed in. WCC for injuries and significant weight loss (visible welfare indicators) were almost exclusive to smaller slaughterhouses. Cattle exhibiting clinical syndromes that were not externally visible (e.g. pneumonia lesions) and that are associated with fattening of cattle, end up in larger slaughterhouses. For this reason, it is important for animal health surveillance to collect data from both types of slaughterhouses. Other important risk factors for WCC were on-farm mortality rate and the number of cattle on the farm of origin. This study highlights the fact that the many risk factors for WCC are as complex as the production system itself, with risk factors interacting with one another in ways which are sometimes difficult to interpret biologically. Risk-based surveillance aimed at farms with reoccurring health problems (e.g. a history of above average condemnation rates) may be more appropriate than the selection, of higher-risk animals arriving at slaughter. In Switzerland, the introduction of a benchmarking system that would provide feedback to the farmer with information on condemnation reasons, and his/her performance compared to the national/regional average could be a first step towards improving herd-management and financial returns for producers

One century of vegetation change on Isla Persa, a nunatak in the Bernina massif in the Swiss Alps

Question: How did the vascular plant species composition of a nunatak in the alpine vegetation belt change over a time span of 100 years? Location: A 5.6-ha nunatak, Isla Persa in the Swiss Alps, that remained ice-free during the last maximum glacier advance in the 1850s and is today partly covered with climactic alpine grassland and dwarf heath shrubs. Methods: Floristic inventories in 1906, 1927, 1972, 1995, 2003 and 2004 and a comparative analysis of the species composition over the period 1906-2004. Results: 31 species that were not recorded in the first inventory were found in the following surveys. However, among them only six were common by 2004. Generally, the new species prefer warmer conditions than those previously present and most newcomers are associated with montane or sub-alpine grasslands and woodlands. In particular, the observed increase of Vaccinium myrtillus and the arrival of shrub and tree species further substantiate a trend towards vegetation composition of the lower altitudinal belt. Ferns represented 26% of the newcomers, probably due to the high dispersal ability of their lightweight spores. The observed species enrichment was globally small compared to previously inventoried summits. Conclusion: Floristic change strongly suggests warmer climatic conditions as the main factor contributing to species compositional change. The relative stability of species richness may be explained by several factors: the isolation of the nunatak and the difficulties for plants to reach the site, the colder local climate, a limited available species pool and interactions of established alpine plants with newly immigrating taxa. Supplementary data collected at a similar altitude would be necessary to better understand the influence of climate change on alpine grasslands

Advances in the Application of Designed Ankyrin Repeat Proteins (DARPins) as Research Tools and Protein Therapeutics

Nonimmunoglobulin scaffolds have been developed to overcome the limitations of monoclonal antibodies with regard to stability and size. Of these scaffolds, the class of designed ankyrin repeat proteins (DARPins) has advanced the most in biochemical and biomedical applications. This review focuses on the recent progress in DARPin technology, highlighting the scaffold's potential and possibilities.</p