10 research outputs found
Functional Architecture of the Inner Pore of a Voltage-gated Ca2+ Channel
- Publication venue
- The Rockefeller University Press
- Publication date
- Field of study
The inner pore of voltage-gated Ca2+ channels (VGCCs) is functionally important, but little is known about the architecture of this region. In K+ channels, this part of the pore is formed by the S6/M2 transmembrane segments from four symmetrically arranged subunits. The Ca2+ channel pore, however, is formed by four asymmetric domains of the same (α1) subunit. Here we investigated the architecture of the inner pore of P/Q-type Ca2+ channels using the substituted-cysteine accessibility method. Many positions in the S6 segments of all four repeats of the α1 subunit (Cav2.1) were modified by internal methanethiosulfonate ethyltrimethylammonium (MTSET). However, the pattern of modification does not fit any known sequence alignment with K+ channels. In IIS6, five consecutive positions showed clear modification, suggesting a likely aqueous crevice and a loose packing between S6 and S5 segments, a notion further supported by the observation that some S5 positions were also accessible to internal MTSET. These results indicate that the inner pore of VGCCs is indeed formed by the S6 segments but is different from that of K+ channels. Interestingly some residues in IIIS6 and IVS6 whose mutations in L-type Ca2+ channels affect the binding of dihydropyridines and phenylalkylamines and are thought to face the pore appeared not to react with internal MTSET. Probing with qBBr, a rigid thiol-reactive agent with a dimension of 12 Å × 10 Å × 6 Å suggests that the inner pore can open to >10 Å. This work provides an impetus for future studies on ion permeation, gating, and drug binding of VGCCs
Erratum to: Methods for evaluating medical tests and biomarkers
- Author
- Gowri Gopalakrishna
- null null
- Miranda Langendam
- Rob Scholten
- Patrick Bossuyt
- Mariska Leeflang
- Anna Noel-Storr
- James Thomas
- Iain Marshall
- Byron Wallace
- Penny Whiting
- Clare Davenport
- Mariska Leeflang
- Gowri GopalaKrishna
- Isabel de Salis
- Sue Mallett
- Robert Wolff
- Penny Whiting
- Richard Riley
- Marie Westwood
- Jos Kleinen
- Gary Collins
- Hans Reitsma
- Karel Moons
- Antonia Zapf
- Annika Hoyer
- Katharina Kramer
- Oliver Kuss
- J. Ensor
- J. J. Deeks
- E. C. Martin
- R. D. Riley
- Gerta Rücker
- Susanne Steinhauser
- Martin Schumacher
- Richard Riley
- Joie Ensor
- Kym Snell
- Brian Willis
- Thomas Debray
- Karel Moons
- Jon Deeks
- Gary Collins
- Lavinia Ferrante di Ruffano
- Brian Willis
- Clare Davenport
- Sue Mallett
- Sian Taylor-Phillips
- Chris Hyde
- Jon Deeks
- Sue Mallett
- Stuart A. Taylor
- Gauraang Batnagar
- Sian Taylor-Phillips
- Lavinia Ferrante Di Ruffano
- Farah Seedat
- Aileen Clarke
- Jon Deeks
- Sarah Byron
- Frances Nixon
- Rebecca Albrow
- Thomas Walker
- Carla Deakin
- Chris Hyde
- Zhivko Zhelev
- Harriet Hunt
- Lavinia Ferrante di Ruffano
- Yaling Yang
- Lucy Abel
- James Buchanan
- Thomas Fanshawe
- Bethany Shinkins
- Laure Wynants
- Jan Verbakel
- Sabine Van Huffel
- Dirk Timmerman
- Ben Van Calster
- Mariska Leeflang
- Aeliko Zwinderman
- Patrick Bossuyt
- Jason Oke
- Jack O’Sullivan
- Rafael Perera
- Brian Nicholson
- Hannah L. Bromley
- Tracy E. Roberts
- Adele Francis
- Denniis Petrie
- G. Bruce Mann
- Kinga Malottki
- Holly Smith
- Jon Deeks
- Lucinda Billingham
- Alice Sitch
- Sue Mallett
- Jon Deeks
- Oke Gerke
- Mie Holm-Vilstrup
- Eivind Antonsen Segtnan
- Ulrich Halekoh
- Poul Flemming Høilund-Carlsen
- Bernard G. Francq
- Jon Deeks
- Alice Sitch
- Jac Dinnes
- Julie Parkes
- Walter Gregory
- Jenny Hewison
- Doug Altman
- William Rosenberg
- Peter Selby
- Julien Asselineau
- Paul Perez
- Aïssatou Paye
- Emilie Bessede
- Cécile Proust-Lima
- Christiana Naaktgeboren
- Joris de Groot
- Anne Rutjes
- Patrick Bossuyt
- Johannes Reitsma
- Karel Moons
- Gary Collins
- Emmanuel Ogundimu
- Jonathan Cook
- Yannick Le Manach
- Doug Altman
- Laure Wynants
- Yvonne Vergouwe
- Sabine Van Huffel
- Dirk Timmerman
- Ben Van Calster
- Romin Pajouheshnia
- Rolf Groenwold
- Karen Moons
- Johannes Reitsma
- Linda Peelen
- Ben Van Calster
- Daan Nieboer
- Yvonne Vergouwe
- Bavo De Cock
- Micael J. Pencina
- Ewout W. Steyerberg
- Jennifer Cooper
- Sian Taylor-Phillips
- Nick Parsons
- Chris Stinton
- Steve Smith
- Andy Dickens
- Rachel Jordan
- Alexandra Enocson
- David Fitzmaurice
- Alice Sitch
- Peymane Adab
- Bernard G. Francq
- Charles Boachie
- Gaj Vidmar
- Karoline Freeman
- Martin Connock
- Sian Taylor-Phillips
- Rachel Court
- Aileen Clarke
- Joris de Groot
- Christiana Naaktgeboren
- Hans Reitsma
- Carl Moons
- Jessica Harris
- Andrew Mumford
- Zoe Plummer
- Kurtis Lee
- Barnaby Reeves
- Chris Rogers
- Veerle Verheyden
- Gianni D. Angelini
- Gavin J. Murphy
- Jeremy Huddy
- Melody Ni
- Katherine Good
- Graham Cooke
- Patrick Bossuyt
- George Hanna
- Jie Ma
- Doug Altman
- Gary Collins
- K. G. M. Moons
- Joris A. H. de Groot
- Sue Mallett
- Doug G. Altman
- Johannes B. Reitsma
- Gary S. Collins
- Karel G. M. Moons
- Douglas G. Altman
- Johannes B. Reitsma
- Gary S. Collins
- Adina Najwa Kamarudin
- Ruwanthi Kolamunnage-Dona
- Trevor Cox
- Melody Ni
- Jeremy Huddy
- Simone Borsci
- George Hanna
- Teresa Pérez
- M.Carmen Pardo
- Angel Candela-Toha
- Alfonso Muriel
- Javier Zamora
- Sabina Sanghera
- Syed Mohiuddin
- Richard Martin
- Jenny Donovan
- Joanna Coast
- Mikyung Kelly Seo
- John Cairns
- Elizabeth Mitchell
- Alison Smith
- Judy Wright
- Peter Hall
- Michael Messenger
- Nicola Calder
- Nyantara Wickramasekera
- Karen Vinall-Collier
- Andrew Lewington
- Romin Pajouheshnia
- Johanna Damen
- Rolf Groenwold
- Karel Moons
- Linda Peelen
- Michael Messenger
- David Cairns
- Alison Smith
- Michelle Hutchinson
- Judy Wright
- Peter Hall
- Nicola Calder
- Cathie Sturgeon
- Liz Mitchel
- Rebecca Kift
- Sofia Christakoudi
- Manohursingh Rungall
- Paula Mobillo
- Rosa Montero
- Tjir-Li Tsui
- Sui Phin Kon
- Beatriz Tucker
- Steven Sacks
- Chris Farmer
- Terry Strom
- Paramit Chowdhury
- Irene Rebollo-Mesa
- Maria Hernandez-Fuentes
- Johanna A. A. G. Damen
- Thomas P. A. Debray
- Pauline Heus
- Lotty Hooft
- Karel G. M. Moons
- Romin Pajouheshnia
- Johannes B. Reitsma
- Rob J. P. M. Scholten
- Johanna A. A. G. Damen
- Lotty Hooft
- Ewoud Schuit
- Thomas P. A. Debray
- Gary S. Collins
- Ioanna Tzoulaki
- Camille M. Lassale
- George C. M. Siontis
- Virginia Chiocchia
- Corran Roberts
- Michael Maia Schlüssel
- Stephen Gerry
- James A. Black
- Pauline Heus
- Yvonne T. van der Schouw
- Linda M. Peelen
- Karel G. M. Moons
- Johanna A. A. G. Damen
- Thomas P. A. Debray
- Pauline Heus
- Lotty Hooft
- Karel G. M. Moons
- Romin Pajouheshnia
- Johannes B. Reitsma
- Rob J. P. M. Scholten
- Jie Ma
- Doug Altman
- Gary Collins
- Graeme Spence
- David McCartney
- Ann van den Bruel
- Daniel Lasserson
- Gail Hayward
- Werner Vach
- Antoinette de Jong
- Coreline Burggraaff
- Otto Hoekstra
- Josée Zijlstra
- Henrica de Vet
- Harriet Hunt
- Chris Hyde
- Sara Graziadio
- Joy Allen
- Louise Johnston
- Rachel O’Leary
- Michael Power
- Joy Allen
- Sara Graziadio
- Louise Johnson
- Rachel O’Leary
- Michael Power
- Ray Waters
- John Simpson
- Louise Johnston
- Joy Allen
- Sara Graziadio
- Rachel O’Leary
- Ray Waters
- Michael Power
- Sue Mallett
- Thomas R. Fanshawe
- Peter Phillips
- Andrew Plumb
- Emma Helbren
- Steve Halligan
- Stuart A. Taylor
- Alastair Gale
- Sue Mallett
- Peggy Sekula
- Douglas G. Altman
- Willi Sauerbrei
- Sue Mallett
- Thomas R. Fanshawe
- Julia R. Forman
- Susan J. Dutton
- Yemisi Takwoingi
- Elizabeth M. Hensor
- Thomas E. Nichols
- Bethany Shinkins
- Yaling Yang
- Lucy Abel
- Lavinia Ferrante Di Ruffano
- Thomas Fanshawe
- Emmanuelle Kempf
- Raphael Porcher
- Jennifer de Beyer
- Karel Moons
- Douglas Altman
- Hans Reitsma
- Sally Hopewell
- Willi Sauerbrei
- Gary Collins
- John Dennis
- Beverley Shields
- Angus Jones
- William Henley
- Ewan Pearson
- Andrew Hattersley
- Pauline Heus
- Johanna A. A. G. Damen
- Romin Pajouheshnia
- Rob J. P. M. Scholten
- Johannes B. Reitsma
- Gary S. Collins
- Douglas G. Altman
- Karel G. M. Moons
- Lotty Hooft
- Beverley Shields
- John Dennis
- Angus Jones
- William Henley
- Ewan Pearson
- Andrew Hattersley
- Fueloep Scheibler
- Anne Rummer
- Sibylle Sturtz
- Robert Großelfinger
- Katie Banister
- Craig Ramsay
- Augusto Azuara-Blanco
- Jonathan Cook
- Charles Boachie
- Jennifer Burr
- Manjula Kumarasamy
- Rupert Bourne
- Ijeoma Uchegbu
- Simone Borsci
- Jennifer Murphy
- George Hanna
- Ijeoma Uchegbu
- Alex Carter
- Jen Murphy
- Melody Ni
- Joachim Marti
- Julie Eatock
- Ijeoma Uchegbu
- Julie Robotham
- Maria Dudareva
- Mark Gilchrist
- Alison Holmes
- Ijeoma Uchegbu
- Simone Borsci
- Phillip Monaghan
- Sarah Lord
- Andrew StJohn
- Sverre Sandberg
- Christa Cobbaert
- Lieselotte Lennartz
- Wilma Verhagen-Kamerbeek
- Christoph Ebert
- Patrick Bossuyt
- Andrea Horvath
- Kevin Jenniskens
- Christiana Naaktgeboren
- Johannes Reitsma
- Karel Moons
- Joris de Groot
- Chris Hyde
- Jaime Peters
- Bogdan Grigore
- Jaime Peters
- Chris Hyde
- Chris Hyde
- Obi Ukoumunne
- Jaime Peters
- Zhivko Zhelev
- Brooke Levis
- Andrea Benedetti
- Alexander W. Levis
- John P. A. Ioannidis
- Ian Shrier
- Pim Cuijpers
- Simon Gilbody
- Lorie A. Kloda
- Dean McMillan
- Scott B Patten
- Russell J. Steele
- Roy C Ziegelstein
- Charles H. Bombardier
- Flavia de Lima Osório
- Jesse R. Fann
- Dwenda Gjerdingen
- Femke Lamers
- Manote Lotrakul
- Sonia R Loureiro
- Bernd Löwe
- Juwita Shaaban
- Lesley Stafford
- Henk C. P. M. van Weert
- Mary A. Whooley
- Linda S. Williams
- Karin A. Wittkampf
- Albert S. Yeung
- Brett D. Thombs
- Jaime Peters
- Chris Cooper
- James Buchanan
- Tom Nieto
- Claire Smith
- Olga Tucker
- Janine Dretzke
- Andrew Beggs
- Nirmala Rai
- Clare Davenport
- Sue Bayliss
- Simon Stevens
- Kym Snell
- Sue Mallet
- Jon Deeks
- Sudha Sundar
- Emma Hall
- Nuria Porta
- David Lorente Estelles
- Johann de Bono
- null null
- null null
- null null
- null null
- null null
- null null
- Publication venue
- Springer Nature
- Publication date
- 01/01/2003
- Field of study
[This corrects the article DOI: 10.1186/s41512-016-0001-y.]
Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments
- Author
- Adele Francis
- Adina Najwa Kamarudin
- Aeliko Zwinderman
- Aileen Clarke
- Aileen Clarke
- Alastair Gale
- Albert S. Yeung
- Alex Carter
- Alexander W. Levis
- Alexandra Enocson
- Alfonso Muriel
- Alice Sitch
- Alice Sitch
- Alice Sitch
- Alison Holmes
- Alison Smith
- Alison Smith
- Andrea Benedetti
- Andrea Horvath
- Andrew Beggs
- Andrew Hattersley
- Andrew Hattersley
- Andrew Lewington
- Andrew Mumford
- Andrew Plumb
- Andrew StJohn
- Andy Dickens
- Angel Candela-Toha
- Angus Jones
- Angus Jones
- Ann van den Bruel
- Anna Noel-Storr
- Anne Rummer
- Anne Rutjes
- Annika Hoyer
- Antoinette de Jong
- Antonia Zapf
- Augusto Azuara-Blanco
- Aïssatou Paye
- Barnaby Reeves
- Bavo De Cock
- Beatriz Tucker
- Ben Van Calster
- Ben Van Calster
- Ben Van Calster
- Bernard G. Francq
- Bernard G. Francq
- Bernd Löwe
- Bethany Shinkins
- Bethany Shinkins
- Beverley Shields
- Beverley Shields
- Bogdan Grigore
- Brett D. Thombs
- Brian Nicholson
- Brian Willis
- Brian Willis
- Brooke Levis
- Byron Wallace
- Camille M. Lassale
- Carl Moons
- Carla Deakin
- Cathie Sturgeon
- Charles Boachie
- Charles Boachie
- Charles H. Bombardier
- Chris Cooper
- Chris Farmer
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Hyde
- Chris Rogers
- Chris Stinton
- Christa Cobbaert
- Christiana Naaktgeboren
- Christiana Naaktgeboren
- Christiana Naaktgeboren
- Christoph Ebert
- Claire Smith
- Clare Davenport
- Clare Davenport
- Clare Davenport
- Coreline Burggraaff
- Corran Roberts
- Craig Ramsay
- Cécile Proust-Lima
- Daan Nieboer
- Daniel Lasserson
- David Cairns
- David Fitzmaurice
- David Lorente Estelles
- David McCartney
- Dean McMillan
- Denniis Petrie
- Dirk Timmerman
- Dirk Timmerman
- Doug Altman
- Doug Altman
- Doug Altman
- Doug Altman
- Doug G. Altman
- Douglas Altman
- Douglas G. Altman
- Douglas G. Altman
- Douglas G. Altman
- Dwenda Gjerdingen
- E. C. Martin
- Eivind Antonsen Segtnan
- Elizabeth M. Hensor
- Elizabeth Mitchell
- Emilie Bessede
- Emma Hall
- Emma Helbren
- Emmanuel Ogundimu
- Emmanuelle Kempf
- Ewan Pearson
- Ewan Pearson
- Ewoud Schuit
- Ewout W. Steyerberg
- Farah Seedat
- Femke Lamers
- Flavia de Lima Osório
- Frances Nixon
- Fueloep Scheibler
- G. Bruce Mann
- Gail Hayward
- Gaj Vidmar
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary S. Collins
- Gary S. Collins
- Gary S. Collins
- Gary S. Collins
- Gauraang Batnagar
- Gavin J. Murphy
- George C. M. Siontis
- George Hanna
- George Hanna
- George Hanna
- Gerta Rücker
- Gianni D. Angelini
- Gowri Gopalakrishna
- Gowri GopalaKrishna
- Graeme Spence
- Graham Cooke
- Hannah L. Bromley
- Hans Reitsma
- Hans Reitsma
- Hans Reitsma
- Harriet Hunt
- Harriet Hunt
- Henk C. P. M. van Weert
- Henrica de Vet
- Holly Smith
- Iain Marshall
- Ian Shrier
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ijeoma Uchegbu
- Ioanna Tzoulaki
- Irene Rebollo-Mesa
- Isabel de Salis
- J. Ensor
- J. J. Deeks
- Jac Dinnes
- Jack O’Sullivan
- Jaime Peters
- Jaime Peters
- Jaime Peters
- Jaime Peters
- James A. Black
- James Buchanan
- James Buchanan
- James Thomas
- Jan Verbakel
- Janine Dretzke
- Jason Oke
- Javier Zamora
- Jen Murphy
- Jennifer Burr
- Jennifer Cooper
- Jennifer de Beyer
- Jennifer Murphy
- Jenny Donovan
- Jenny Hewison
- Jeremy Huddy
- Jeremy Huddy
- Jesse R. Fann
- Jessica Harris
- Jie Ma
- Jie Ma
- Joachim Marti
- Joanna Coast
- Johann de Bono
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna Damen
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes Reitsma
- Johannes Reitsma
- Johannes Reitsma
- John Cairns
- John Dennis
- John Dennis
- John P. A. Ioannidis
- John Simpson
- Joie Ensor
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jonathan Cook
- Jonathan Cook
- Joris A. H. de Groot
- Joris de Groot
- Joris de Groot
- Joris de Groot
- Jos Kleinen
- Josée Zijlstra
- Joy Allen
- Joy Allen
- Joy Allen
- Judy Wright
- Judy Wright
- Julia R. Forman
- Julie Eatock
- Julie Parkes
- Julie Robotham
- Julien Asselineau
- Juwita Shaaban
- K. G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karen Moons
- Karen Vinall-Collier
- Karin A. Wittkampf
- Karoline Freeman
- Katharina Kramer
- Katherine Good
- Katie Banister
- Kevin Jenniskens
- Kinga Malottki
- Kurtis Lee
- Kym Snell
- Kym Snell
- Laure Wynants
- Laure Wynants
- Lavinia Ferrante di Ruffano
- Lavinia Ferrante Di Ruffano
- Lavinia Ferrante di Ruffano
- Lavinia Ferrante Di Ruffano
- Lesley Stafford
- Lieselotte Lennartz
- Linda M. Peelen
- Linda Peelen
- Linda Peelen
- Linda S. Williams
- Liz Mitchel
- Lorie A. Kloda
- Lotty Hooft
- Lotty Hooft
- Lotty Hooft
- Lotty Hooft
- Louise Johnson
- Louise Johnston
- Louise Johnston
- Lucinda Billingham
- Lucy Abel
- Lucy Abel
- M.Carmen Pardo
- Manjula Kumarasamy
- Manohursingh Rungall
- Manote Lotrakul
- Maria Dudareva
- Maria Hernandez-Fuentes
- Marie Westwood
- Mariska Leeflang
- Mariska Leeflang
- Mariska Leeflang
- Mark Gilchrist
- Martin Connock
- Martin Schumacher
- Mary A. Whooley
- Melody Ni
- Melody Ni
- Melody Ni
- Micael J. Pencina
- Michael Maia Schlüssel
- Michael Messenger
- Michael Messenger
- Michael Power
- Michael Power
- Michael Power
- Michelle Hutchinson
- Mie Holm-Vilstrup
- Mikyung Kelly Seo
- Miranda Langendam
- Nick Parsons
- Nicola Calder
- Nicola Calder
- Nirmala Rai
- null null
- null null
- null null
- null null
- null null
- null null
- null null
- Nuria Porta
- Nyantara Wickramasekera
- Obi Ukoumunne
- Oke Gerke
- Olga Tucker
- Oliver Kuss
- Otto Hoekstra
- Paramit Chowdhury
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Patrick Bossuyt
- Paul Perez
- Paula Mobillo
- Pauline Heus
- Pauline Heus
- Pauline Heus
- Pauline Heus
- Peggy Sekula
- Penny Whiting
- Penny Whiting
- Peter Hall
- Peter Hall
- Peter Phillips
- Peter Selby
- Peymane Adab
- Phillip Monaghan
- Pim Cuijpers
- Poul Flemming Høilund-Carlsen
- R. D. Riley
- Rachel Court
- Rachel Jordan
- Rachel O’Leary
- Rachel O’Leary
- Rachel O’Leary
- Rafael Perera
- Raphael Porcher
- Ray Waters
- Ray Waters
- Rebecca Albrow
- Rebecca Kift
- Richard Martin
- Richard Riley
- Richard Riley
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob Scholten
- Robert Großelfinger
- Robert Wolff
- Rolf Groenwold
- Rolf Groenwold
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Rosa Montero
- Roy C Ziegelstein
- Rupert Bourne
- Russell J. Steele
- Ruwanthi Kolamunnage-Dona
- Sabina Sanghera
- Sabine Van Huffel
- Sabine Van Huffel
- Sally Hopewell
- Sara Graziadio
- Sara Graziadio
- Sara Graziadio
- Sarah Byron
- Sarah Lord
- Scott B Patten
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sibylle Sturtz
- Simon Gilbody
- Simon Stevens
- Simone Borsci
- Simone Borsci
- Simone Borsci
- Sofia Christakoudi
- Sonia R Loureiro
- Stephen Gerry
- Steve Halligan
- Steve Smith
- Steven Sacks
- Stuart A. Taylor
- Stuart A. Taylor
- Sudha Sundar
- Sue Bayliss
- Sue Mallet
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sui Phin Kon
- Susan J. Dutton
- Susanne Steinhauser
- Sverre Sandberg
- Syed Mohiuddin
- Teresa Pérez
- Terry Strom
- Thomas Debray
- Thomas E. Nichols
- Thomas Fanshawe
- Thomas Fanshawe
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas R. Fanshawe
- Thomas R. Fanshawe
- Thomas Walker
- Tjir-Li Tsui
- Tom Nieto
- Tracy E. Roberts
- Trevor Cox
- Ulrich Halekoh
- Veerle Verheyden
- Virginia Chiocchia
- Walter Gregory
- Werner Vach
- Willi Sauerbrei
- Willi Sauerbrei
- William Henley
- William Henley
- William Rosenberg
- Wilma Verhagen-Kamerbeek
- Yaling Yang
- Yaling Yang
- Yannick Le Manach
- Yemisi Takwoingi
- Yvonne T. van der Schouw
- Yvonne Vergouwe
- Yvonne Vergouwe
- Zhivko Zhelev
- Zhivko Zhelev
- Zoe Plummer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests
Erratum to: Methods for evaluating medical tests and biomarkers
- Author
- Adele Francis
- Adina Najwa Kamarudin
- Aeliko Zwinderman
- Aileen Clarke
- Aileen Clarke
- Alastair Gale
- Albert S. Yeung
- Alex Carter
- Alexander W. Levis
- Alexandra Enocson
- Alfonso Muriel
- Alice Sitch
- Alice Sitch
- Alice Sitch
- Alison Holmes
- Alison Smith
- Alison Smith
- Andrea Benedetti
- Andrea Horvath
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- Andrew Hattersley
- Andrew Hattersley
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- Andrew StJohn
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- Angel Candela-Toha
- Angus Jones
- Angus Jones
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- Anne Rutjes
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- Antonia Zapf
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- Beatriz Tucker
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- Ben Van Calster
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- Bernard G. Francq
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- Beverley Shields
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- Charles Boachie
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- Chris Farmer
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- Chris Hyde
- Chris Hyde
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- Clare Davenport
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- Daniel Lasserson
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- Dean McMillan
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- Dirk Timmerman
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- Doug Altman
- Doug Altman
- Doug Altman
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- Douglas G. Altman
- Douglas G. Altman
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- Dwenda Gjerdingen
- E. C. Martin
- Eivind Antonsen Segtnan
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- Ewan Pearson
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- Fueloep Scheibler
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- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
- Gary Collins
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- Gary S. Collins
- Gary S. Collins
- Gary S. Collins
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- Gavin J. Murphy
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- Gowri GopalaKrishna
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- Hans Reitsma
- Hans Reitsma
- Harriet Hunt
- Harriet Hunt
- Henk C. P. M. van Weert
- Henrica de Vet
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- Iain Marshall
- Ian Shrier
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- Ijeoma Uchegbu
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- J. Ensor
- J. J. Deeks
- Jac Dinnes
- Jack O’Sullivan
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- Jaime Peters
- Jaime Peters
- Jaime Peters
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- James Buchanan
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- Jeremy Huddy
- Jeremy Huddy
- Jesse R. Fann
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- Jie Ma
- Joachim Marti
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- Johann de Bono
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna A. A. G. Damen
- Johanna Damen
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes B. Reitsma
- Johannes Reitsma
- Johannes Reitsma
- Johannes Reitsma
- John Cairns
- John Dennis
- John Dennis
- John P. A. Ioannidis
- John Simpson
- Joie Ensor
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jon Deeks
- Jonathan Cook
- Jonathan Cook
- Joris A. H. de Groot
- Joris de Groot
- Joris de Groot
- Joris de Groot
- Jos Kleinen
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- Joy Allen
- Joy Allen
- Joy Allen
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- Judy Wright
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- Juwita Shaaban
- K. G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel G. M. Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karel Moons
- Karen Moons
- Karen Vinall-Collier
- Karin A. Wittkampf
- Karoline Freeman
- Katharina Kramer
- Katherine Good
- Katie Banister
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- Kurtis Lee
- Kym Snell
- Kym Snell
- Laure Wynants
- Laure Wynants
- Lavinia Ferrante di Ruffano
- Lavinia Ferrante Di Ruffano
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- Lesley Stafford
- Lieselotte Lennartz
- Linda M. Peelen
- Linda Peelen
- Linda Peelen
- Linda S. Williams
- Liz Mitchel
- Lorie A. Kloda
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- Lotty Hooft
- Lotty Hooft
- Lotty Hooft
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- Louise Johnston
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- Lucy Abel
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- Mariska Leeflang
- Mariska Leeflang
- Mark Gilchrist
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- Mary A. Whooley
- Melody Ni
- Melody Ni
- Melody Ni
- Micael J. Pencina
- Michael Maia Schlüssel
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- Michael Messenger
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- Michael Power
- Michael Power
- Michelle Hutchinson
- Mie Holm-Vilstrup
- Mikyung Kelly Seo
- Miranda Langendam
- Nick Parsons
- Nicola Calder
- Nicola Calder
- Nirmala Rai
- null null
- null null
- null null
- null null
- null null
- null null
- null null
- Nuria Porta
- Nyantara Wickramasekera
- Obi Ukoumunne
- Oke Gerke
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- Patrick Bossuyt
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- Penny Whiting
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- Pim Cuijpers
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- R. D. Riley
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- Rachel O’Leary
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- Rafael Perera
- Raphael Porcher
- Ray Waters
- Ray Waters
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- Rebecca Kift
- Richard Martin
- Richard Riley
- Richard Riley
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob J. P. M. Scholten
- Rob Scholten
- Robert Großelfinger
- Robert Wolff
- Rolf Groenwold
- Rolf Groenwold
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Romin Pajouheshnia
- Rosa Montero
- Roy C Ziegelstein
- Rupert Bourne
- Russell J. Steele
- Ruwanthi Kolamunnage-Dona
- Sabina Sanghera
- Sabine Van Huffel
- Sabine Van Huffel
- Sally Hopewell
- Sara Graziadio
- Sara Graziadio
- Sara Graziadio
- Sarah Byron
- Sarah Lord
- Scott B Patten
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sian Taylor-Phillips
- Sibylle Sturtz
- Simon Gilbody
- Simon Stevens
- Simone Borsci
- Simone Borsci
- Simone Borsci
- Sofia Christakoudi
- Sonia R Loureiro
- Stephen Gerry
- Steve Halligan
- Steve Smith
- Steven Sacks
- Stuart A. Taylor
- Stuart A. Taylor
- Sudha Sundar
- Sue Bayliss
- Sue Mallet
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sue Mallett
- Sui Phin Kon
- Susan J. Dutton
- Susanne Steinhauser
- Sverre Sandberg
- Syed Mohiuddin
- Teresa Pérez
- Terry Strom
- Thomas Debray
- Thomas E. Nichols
- Thomas Fanshawe
- Thomas Fanshawe
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas P. A. Debray
- Thomas R. Fanshawe
- Thomas R. Fanshawe
- Thomas Walker
- Tjir-Li Tsui
- Tom Nieto
- Tracy E. Roberts
- Trevor Cox
- Ulrich Halekoh
- Veerle Verheyden
- Virginia Chiocchia
- Walter Gregory
- Werner Vach
- Willi Sauerbrei
- Willi Sauerbrei
- William Henley
- William Henley
- William Rosenberg
- Wilma Verhagen-Kamerbeek
- Yaling Yang
- Yaling Yang
- Yannick Le Manach
- Yemisi Takwoingi
- Yvonne T. van der Schouw
- Yvonne Vergouwe
- Yvonne Vergouwe
- Zhivko Zhelev
- Zhivko Zhelev
- Zoe Plummer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
[This corrects the article DOI: 10.1186/s41512-016-0001-y.]
Discovery of Vibegron: A Potent and Selective β<sub>3</sub> Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
- Author
- Aileen Fitzmaurice (1417000)
- Amanda L. Hurley (1417039)
- Andra S. Stevenson (1417027)
- Ann E. Weber (1416991)
- Anthony Sanfiz (1416982)
- Bart Harper (1417048)
- Beata Zamlynny (1417051)
- Beatrice Sacre-Salem (1417018)
- Cheng Zhu (138742)
- Christopher R. Moyes (1416988)
- Dong-Ming Shen (523843)
- Dorothy Levorse (1417012)
- Gino M. Salituro (1416994)
- Gregori Morriello (1416976)
- Hiroshi Nagabukuro (1417024)
- James Ormes (1416997)
- Jerry Di Salvo (1417030)
- Karen Dingley (1416979)
- Katherine Villa (1416970)
- Liping Wang (561851)
- Loise N. Gichuru (1417009)
- Mary Struthers (1416985)
- Nam Fung Kar (1416973)
- Nina Jochnowitz (1417003)
- Randy R. Miller (1417006)
- Richard Ball (1417015)
- Richard Berger (1417021)
- Scott D. Edmondson (1416967)
- Shruty Mistry (1417036)
- Sookhee Ha (1417042)
- Stephen D. Goble (1417033)
- Stuart Green (113477)
- Tara Frenkl (1417045)
- Publication venue
- Publication date
- Field of study
The discovery of vibegron, a potent
and selective human β<sub>3</sub>-AR agonist for the treatment
of overactive bladder (OAB),
is described. An early-generation clinical β<sub>3</sub>-AR
agonist MK-0634 (<b>3</b>) exhibited efficacy in humans for
the treatment of OAB, but development was discontinued due to unacceptable
structure-based toxicity in preclinical species. Optimization of a
series of second-generation pyrrolidine-derived β<sub>3</sub>-AR agonists included reducing the risk for phospholipidosis, the
risk of formation of disproportionate human metabolites, and the risk
of formation of high levels of circulating metabolites in preclinical
species. These efforts resulted in the discovery of vibegron, which
possesses improved druglike properties and an overall superior preclinical
profile compared to MK-0634. Structure–activity relationships
leading to the discovery of vibegron and a summary of its preclinical
profile are described
Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β 3
- Author
- Abrams P.
- Aileen Fitzmaurice
- Airu S. Chen
- Alka Bansal
- Amanda L. Hurley
- Andra S. Stevenson
- Ann E. Weber
- Anthony Sanfiz
- Arch J. R. S.
- Arch J. R. S.
- Bart Harper
- Beata Zamlynny
- Birder L. A.
- Christopher R. Moyes
- Dmochowski R.
- Dong-Ming Shen
- Evans D. A.
- Fujimura T.
- Gino M. Salituro
- Goble S. D.
- Harada H.
- Hartmann H. A.
- Hattori K.
- Hiroshi Nagabukuro
- Irwin D. E.
- Jerry Di Salvo
- Kalgutkar A. S.
- Karen H. Dingley
- Katherine Villa
- Liping Wang
- Loise N. Gichuru
- Lynch J. J.
- Mary Struthers
- Mathvink R. J.
- Mathvink R. J.
- Morriello G. J.
- Nagabukuro H.
- Nina Jochnowitz
- Patricia N. Brown
- Randall R. Miller
- Richard Berger
- Schoemaker H.
- Scott D. Edmondson
- Sennitt M. V.
- Shruty Mistry
- Stearns R. A.
- Stephen D. Goble
- Stevens F. C.
- Strosberg A. D.
- Sum F.-W.
- Suzuki M.
- Svendson A.
- Takusagawa S.
- Tang W.
- Uehling D. E.
- Weber A. E.
- Woods M.
- Yamanishi T.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Erratum to: Methods for evaluating medical tests and biomarkers
- Author
- Abel Lucy
- Adab Peymane
- Albrow Rebecca
- Allen Joy
- Altman Doug
- Altman Doug G.
- Altman Douglas
- Altman Douglas G.
- Angelini Gianni D.
- Asselineau Julien
- Azuara-Blanco Augusto
- Banister Katie
- Batnagar Gauraang
- Bayliss Sue
- Beggs Andrew
- Benedetti Andrea
- Bessede Emilie
- Billingham Lucinda
- Black James A.
- Boachie Charles
- Bombardier Charles H.
- Borsci Simone
- Bossuyt Patrick
- Bourne Rupert
- Bromley Hannah L.
- Buchanan James
- Burggraaff Coreline
- Burr Jennifer
- Byron Sarah
- Cairns David
- Cairns John
- Calder Nicola
- Candela-Toha Angel
- Carter Alex
- Chiocchia Virginia
- Chowdhury Paramit
- Christakoudi Sofia
- Clarke Aileen
- Coast Joanna
- Cobbaert Christa
- Collins Gary
- Collins Gary S.
- Connock Martin
- Cook Jonathan
- Cooke Graham
- Cooper Chris
- Cooper Jennifer
- Court Rachel
- Cox Trevor
- Cuijpers Pim
- Damen Johanna
- Damen Johanna A. A. G.
- Davenport Clare
- de Beyer Jennifer
- de Bono Johann
- De Cock Bavo
- de Groot Joris
- de Groot Joris A. H.
- de Jong Antoinette
- de Salis Isabel
- de Vet Henrica
- Deakin Carla
- Debray Thomas
- Debray Thomas P. A.
- Deeks J. J.
- Deeks Jon
- Dennis John
- di Ruffano Lavinia Ferrante
- Di Ruffano Lavinia Ferrante
- Dickens Andy
- Dinnes Jac
- Donovan Jenny
- Dretzke Janine
- Dudareva Maria
- Dutton Susan J.
- Eatock Julie
- Ebert Christoph
- Enocson Alexandra
- Ensor J.
- Ensor Joie
- Estelles David Lorente
- Fann Jesse R.
- Fanshawe Thomas
- Fanshawe Thomas R.
- Farmer Chris
- Fitzmaurice David
- Forman Julia R.
- Francis Adele
- Francq Bernard G.
- Freeman Karoline
- Gale Alastair
- Gerke Oke
- Gerry Stephen
- Gilbody Simon
- Gilchrist Mark
- Gjerdingen Dwenda
- Good Katherine
- Gopalakrishna Gowri
- GopalaKrishna Gowri
- Graziadio Sara
- Gregory Walter
- Grigore Bogdan
- Groenwold Rolf
- Großelfinger Robert
- Halekoh Ulrich
- Hall Emma
- Hall Peter
- Halligan Steve
- Hanna George
- Harris Jessica
- Hattersley Andrew
- Hayward Gail
- Helbren Emma
- Henley William
- Hensor Elizabeth M.
- Hernandez-Fuentes Maria
- Heus Pauline
- Hewison Jenny
- Hoekstra Otto
- Holm-Vilstrup Mie
- Holmes Alison
- Hooft Lotty
- Hopewell Sally
- Horvath Andrea
- Hoyer Annika
- Huddy Jeremy
- Hunt Harriet
- Hutchinson Michelle
- Hyde Chris
- Høilund-Carlsen Poul Flemming
- Investigators METRIC
- Investigators STREAMLINE COLON
- Investigators STREAMLINE LUNG
- Ioannidis John P. A.
- Jenniskens Kevin
- Johnson Louise
- Johnston Louise
- Jones Angus
- Jordan Rachel
- Kamarudin Adina Najwa
- Kempf Emmanuelle
- Kift Rebecca
- Kleinen Jos
- Kloda Lorie A.
- Kolamunnage-Dona Ruwanthi
- Kon Sui Phin
- Kramer Katharina
- Kumarasamy Manjula
- Kuss Oliver
- Lamers Femke
- Langendam Miranda
- Lassale Camille M.
- Lasserson Daniel
- Le Manach Yannick
- Lee Kurtis
- Leeflang Mariska
- Lennartz Lieselotte
- Levis Alexander W.
- Levis Brooke
- Lewington Andrew
- Lord Sarah
- Lotrakul Manote
- Loureiro Sonia R
- Löwe Bernd
- Ma Jie
- Mallet Sue
- Mallett Sue
- Malottki Kinga
- Mann G. Bruce
- Marshall Iain
- Marti Joachim
- Martin E. C.
- Martin Richard
- McCartney David
- McMillan Dean
- Messenger Michael
- Mitchel Liz
- Mitchell Elizabeth
- Mobillo Paula
- Mohiuddin Syed
- Monaghan Phillip
- Montero Rosa
- Moons Carl
- Moons K. G. M.
- Moons Karel
- Moons Karel G. M.
- Moons Karen
- Mumford Andrew
- Muriel Alfonso
- Murphy Gavin J.
- Murphy Jen
- Murphy Jennifer
- Naaktgeboren Christiana
- Ni Melody
- Nichols Thomas E.
- Nicholson Brian
- Nieboer Daan
- Nieto Tom
- Nixon Frances
- Noel-Storr Anna
- Ogundimu Emmanuel
- Oke Jason
- on behalf of the CTC-STOP protocol development group
- Osório Flavia de Lima
- O’Leary Rachel
- O’Sullivan Jack
- Pajouheshnia Romin
- Pardo M.Carmen
- Parkes Julie
- Parsons Nick
- Patten Scott B
- Paye Aïssatou
- Pearson Ewan
- Peelen Linda
- Peelen Linda M.
- Pencina Micael J.
- Perera Rafael
- Perez Paul
- Peters Jaime
- Petrie Denniis
- Phillips Peter
- Plumb Andrew
- Plummer Zoe
- Porcher Raphael
- Porta Nuria
- Power Michael
- Proust-Lima Cécile
- Pérez Teresa
- Rai Nirmala
- Ramsay Craig
- Rebollo-Mesa Irene
- Reeves Barnaby
- Reitsma Hans
- Reitsma Johannes
- Reitsma Johannes B.
- Riley R. D.
- Riley Richard
- Roberts Corran
- Roberts Tracy E.
- Robotham Julie
- Rogers Chris
- Rosenberg William
- Rummer Anne
- Rungall Manohursingh
- Rutjes Anne
- Rücker Gerta
- Sacks Steven
- Sandberg Sverre
- Sanghera Sabina
- Sauerbrei Willi
- Scheibler Fueloep
- Schlüssel Michael Maia
- Scholten Rob
- Scholten Rob J. P. M.
- Schuit Ewoud
- Schumacher Martin
- Seedat Farah
- Segtnan Eivind Antonsen
- Sekula Peggy
- Selby Peter
- Seo Mikyung Kelly
- Shaaban Juwita
- Shields Beverley
- Shinkins Bethany
- Shrier Ian
- Simpson John
- Siontis George C. M.
- Sitch Alice
- Smith Alison
- Smith Claire
- Smith Holly
- Smith Steve
- Snell Kym
- Spence Graeme
- Stafford Lesley
- Steele Russell J.
- Steinhauser Susanne
- Stevens Simon
- Steyerberg Ewout W.
- Stinton Chris
- StJohn Andrew
- Strom Terry
- Sturgeon Cathie
- Sturtz Sibylle
- Sundar Sudha
- Takwoingi Yemisi
- Taylor Stuart A.
- Taylor-Phillips Sian
- Thomas James
- Thombs Brett D.
- Timmerman Dirk
- Tsui Tjir-Li
- Tucker Beatriz
- Tucker Olga
- Tzoulaki Ioanna
- Uchegbu Ijeoma
- Ukoumunne Obi
- Vach Werner
- Van Calster Ben
- van den Bruel Ann
- van der Schouw Yvonne T.
- Van Huffel Sabine
- van Weert Henk C. P. M.
- Verbakel Jan
- Vergouwe Yvonne
- Verhagen-Kamerbeek Wilma
- Verheyden Veerle
- Vidmar Gaj
- Vinall-Collier Karen
- Walker Thomas
- Wallace Byron
- Waters Ray
- Westwood Marie
- Whiting Penny
- Whooley Mary A.
- Wickramasekera Nyantara
- Williams Linda S.
- Willis Brian
- Wittkampf Karin A.
- Wolff Robert
- Wright Judy
- Wynants Laure
- Yang Yaling
- Yang Ying
- Yeung Albert S.
- Zamora Javier
- Zapf Antonia
- Zhelev Zhivko
- Ziegelstein Roy C
- Zijlstra Josée
- Zwinderman Aeliko
- Publication venue
- BioMed Central
- Publication date
- 01/12/2017
- Field of study
The original MEMTAB Abstracts in Diagnostic and Prognostic Research contains the incorrect year on individual abstracts in the PDF [1].“Diagnostic and Prognostic Research 2016” under the correspondence line should therefore have been written as “Diagnostic and Prognostic Research 2017” as the journal did not launch until 2017
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
- Bae Sang Cheol
- Baek Ae Lee
- Baglioni Gregorio
- Bai Chunlin
- Baksh Farisha
- Balaraju Swathi
- Ball Kelly
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- Mantovani Lorenzo G.
- Manzanal Rey Aranza
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- Yamamoto Kunihiko
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- Yamasawa Masanori
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- Yamazoe Masahiro
- Yang Jingshan
- Yang Lingli
- Yang Zhiming
- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
- Yokota Naoto
- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes