Additional file 1: Figure S1. of A mixed methods approach to evaluating community drug distributor performance in the control of neglected tropical diseases

Hour Pictorial Diary. (PDF 390 kb

Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda-2

<p><b>Copyright information:</b></p><p>Taken from "Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda"</p><p>http://www.biomedcentral.com/1741-7015/5/27</p><p>BMC Medicine 2007;5():27-27.</p><p>Published online 3 Sep 2007</p><p>PMCID:PMC2014753.</p><p></p>om eight districts for follow-up monitoring

Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda-0

<p><b>Copyright information:</b></p><p>Taken from "Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda"</p><p>http://www.biomedcentral.com/1741-7015/5/27</p><p>BMC Medicine 2007;5():27-27.</p><p>Published online 3 Sep 2007</p><p>PMCID:PMC2014753.</p><p></p>om eight districts for follow-up monitoring

Richness and Diversity of Nares Microbiota in Infants and their Primary Caregivers.

<p>Richness and Diversity of Nares Microbiota in Infants and their Primary Caregivers.</p

A Study of the Infant Nasal Microbiome Development over the First Year of Life and in Relation to Their Primary Adult Caregivers Using <i>cpn60</i> Universal Target (UT) as a Phylogenetic Marker

<div><p>Whereas the infant gut microbiome is the subject of intense study, relatively little is known regarding the nares microbiome in newborns and during early life. This study aimed to survey the typical composition and diversity of human anterior nare microflora for developing infants over time, and to explore how these correlate to their primary caregivers. Single nare swabs were collected at five time points over a one-year period for each subject from infant-caregiver pairs. Our study comprised of 50 infants (recruited at 2 weeks, post delivery) and their 50 primary caregivers. Applying the chaperonin-60 (<i>cpn60)</i> universal target (UT) amplicon as our molecular barcoding marker to census survey the microbial communities, we longitudinally surveyed infant nares microbiota at 5 time points over the course of the first year of life. The inter- and intra-subject diversity was catalogued and compared, both longitudinally and relative to their adult primary caregivers. Although within-subject variability over time and inter-subject variability were both observed, the assessment detected only one or two predominant genera for individual infant samples, belonging mainly to phyla Actinobacteria, Firmicutes, and Proteobacteria. Consistent with previously observed microbial population dynamics in other body sites, the diversity of nares microflora increased over the first year of life and infants showed differential operational taxonomic units (OTUs) relative to their matched primary caregiver. The collected evidence also support that both temporal and seasonal changes occur with respect to carriage of potentially pathogenic bacteria (PPBs), which may influence host predisposition to infection. This pilot study surveying paired infant/caregiver nare microbiomes provides novel longitudinal diversity information that is pertinent to better understanding nare microbiome development in infants.</p></div

A Study of the Infant Nasal Microbiome Development over the First Year of Life and in Relation to Their Primary Adult Caregivers Using <i>cpn60</i> Universal Target (UT) as a Phylogenetic Marker - Fig 1

<p><b>Average relative abundance of phyla (A) and genera (B) in the nares microbiota of infants and their associated primary caregivers across five time points during the first year of life.</b> Relative abundance depicted represents the average values derived from each subject grouping at each sampling time point T1-T5 (range: 22–35 subjects per time point, in a possible maximum <i>n</i> = 40 study subject pairs).</p

Additional file 1: of Protocol and baseline data for a multi-year cohort study of the effects of different mass drug treatment approaches on functional morbidities from schistosomiasis in four African countries

Document file containing Tables S1-S7. (PDF 142 kb

Tropical Data: Approach and Methodology as Applied to Trachoma Prevalence Surveys

Population-based prevalence surveys are essential for decision-making on interventions to achieve trachoma elimination as a public health problem. This paper outlines the methodologies of Tropical Data, which supports work to undertake those surveys. Tropical Data is a consortium of partners that supports health ministries worldwide to conduct globally standardised prevalence surveys that conform to World Health Organization recommendations. Founding principles are health ministry ownership, partnership and collaboration, and quality assurance and quality control at every step of the survey process. Support covers survey planning, survey design, training, electronic data collection and fieldwork, and data management, analysis and dissemination. Methods are adapted to meet local context and needs. Customisations, operational research and integration of other diseases into routine trachoma surveys have also been supported. Between 29th February 2016 and 24th April 2023, 3373 trachoma surveys across 50 countries have been supported, resulting in 10,818,502 people being examined for trachoma. This health ministry-led, standardised approach, with support from the start to the end of the survey process, has helped all trachoma elimination stakeholders to know where interventions are needed, where interventions can be stopped, and when elimination as a public health problem has been achieved. Flexibility to meet specific country contexts, adaptation to changes in global guidance and adjustments in response to user feedback have facilitated innovation in evidence-based methodologies, and supported health ministries to strive for global disease control targets.</p