Reduced and declining physical function in prevalent dialysis patients – identifying the vulnerable

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Does Migration Make You Happy?:A Longitudinal Study of Internal Migration and Subjective Well-Being

The majority of modelling studies on consequences of internal migration focus almost exclusively on the labour market outcomes and the material well-being of migrants. We investigate whether individuals who migrate within the UK become happier after the move than they were before it and whether the effect is permanent or transient. Using life satisfaction responses from 12 waves of the British Household Panel Survey (BHPS) and employing a fixed-effects model, we derive a temporal pattern of migrants’ subjective wellbeing (SWB) around the time of the migration event. Our findings make an original contribution by revealing for the first time that, on average, migration is preceded by a period when individuals experience a significant decline in happiness. The boost that is received through migration appears to bring people back to their initial level of happiness. As opposed to labour market outcomes of migration, SWB outcomes do not differ significantly between men and women. Perhaps surprisingly, long-distance migrants are at least as happy as short-distance migrants despite the higher social costs that are involved

Weight changes following lower limb arthroplasty : a prospective observational study

The aim of this study was to assess patterns of weight loss/gain following total hip or knee joint replacement. Four hundred and fifty primary lower limb arthroplasty patients, where the current surgery was the last limiting factor to improved mobility, were selected. Over a one year period 212 gained weight (mean 5.03kg), 92 remained static, and 146 lost weight. The median change was a weight gain of 0.50Kg (p=0.002). All patients had a significant improvement in Oxford outcome scores. Hip arthroplasty patients were statistically more likely to gain weight than knee arthroplasty patients. A successful arthroplasty, restoring a patient's mobility, does not necessarily lead to subsequent weight loss. The majority of patients put on weight with an overall net weight gain. No adverse effect on functional outcome was noted

Unbiased flux calibration methods for spectral-line radio observations

Position and frequency switching techniques used for the removal of the bandpass dependence of radio astronomical spectra are presented and discussed in detail. Both methods are widely used, although the frequency dependence of the system temperature and/or noise diode is often neglected. This leads to systematic errors in the calibration that potentially have a significant impact on scientific results, especially when using large-bandwidth receivers or performing statistical analyses. We present methods to derive an unbiased calibration using a noise diode, which is part of many heterodyne receivers. We compare the proposed methods and describe the advantages and bottlenecks of the various approaches. Monte Carlo simulations are used to qualitatively investigate both systematics and the error distribution of the reconstructed flux estimates about the correct flux values for the new methods but also the 'classical' case. Finally, the determination of the frequency-dependent noise temperature of the calibration diode using hot-cold measurements or observations of well-known continuum sources is also briefly discussed.Comment: 25 pages, 30 figures. Accepted for publication in A&

The organic crisis of British capitalism and race: the experience of the seventies

Chapter 1 of the "Empire Strikes Back" examines the place of "race" and racism in the political transformation of Britain at the end of the 1970s, and argues that Britain has entered a long-term political and economic crisis which has brought new urgency to the politics of race and nation. The authors argue that the British state is very far from its popular image as a liberal democracy, and all our notions of culture, nation and class are based on deeply racist structures

Renal replacement modality and stroke risk in end-stage renal disease—a national registry study

Background: The risk of stroke in end-stage renal disease (ESRD) on renal replacement therapy (RRT) is up to 10-fold greater than the general population. However, whether this increased risk differs by RRT modality is unclear. Methods: We used data contained in the Scottish Renal Registry and the Scottish Stroke Care Audit to identify stroke in all adult patients who commenced RRT for ESRD from 2005 to 2013. Incidence rate was calculated and regression analyses were performed to identify variables associated with stroke. We explored the effect of RRT modality at initiation and cumulative dialysis exposure by time-dependent regression analysis, using transplant recipients as the reference group. Results: A total of 4957 patients commenced RRT for ESRD. Median age was 64.5 years, 41.5% were female and 277 patients suffered a stroke (incidence rate was 18.6/1000 patient-years). Patients who had stroke were older, had higher blood pressure and were more likely to be female and have diabetes. On multivariable regression older age, female sex, diabetes and higher serum phosphate were associated with risk of stroke. RRT modality at initiation was not. On time-dependent analysis, haemodialysis (HD) exposure was independently associated with increased risk of stroke. Conclusions: In patients with ESRD who initiate RRT, HD use independently increases risk of stroke compared with transplantation. Use of peritoneal dialysis did not increase risk on adjusted analysis

The melanocortin 4 receptor: Oligomer formation, interaction sites and functional significance

This study involves the structural and functional properties of the recombinant melanocortin 4 receptor (MC4R) expressed in the HEK-293 cell line. Using co-immuno-purification approaches, the receptor appears to be an oligomer, which can be crosslinked through disulphide bonds involving a native cysteine residue (84) to give a dimeric species. This position is located near the cytosolic region of transmembrane segment 2 and it is suggested that this is an interacting interface between MC4R monomers. Using co-expression of the native protein and a C84A mutant, it appears that the receptor also forms higher order oligomers via alternative interfaces. Interestingly, disulphide crosslink formation does not occur if the receptor is uncoupled from its G-protein, even though the oligomeric state is preserved. This suggests that the conformational changes, which occur on activation, affect the TM2 interface. The pharmacology of the agonist, NDP-MSH, indicates that the MC4R retains high affinity for the ligand in the absence of the G-protein but occupancy for the ligand is increased. The data can be interpreted to suggest that the G-protein exerts a negative allosteric effect on the receptor. Co-expression of one receptor lacking the ability to signal with another, which cannot bind the agonist, restored ligand-dependent activation of the G-protein to situations in which neither receptor on its own could activate the G-protein. Such transactivation suggests meaningful cross talk between the receptor subunits in the oligomeric complex. These studies demonstrate further unique features of the MC4R

Does Migration Make You Happy?:A Longitudinal Study of Internal Migration and Subjective Well-Being

The authors acknowledge financial support from the Economic and Social Research Council (ESRC) (RES-625-28-0001). This project is part of the ESRC Centre for Population Change (CPC). Financial support from the Marie Curie programme under the European Union's Seventh Framework Programme (FP/2007-2013) / Career Integration Grant n. PCIG10-GA-2011-303728 (CIG Grant NBHCHOICE, Neighbourhood choice, neighbourhood sorting, and neighbourhood effects).The majority of quantitative studies on the consequences of internal migration focus almost exclusively on the labour-market outcomes and the material well-being of migrants. We investigate whether individuals who migrate within the UK become happier after the move than they were before, and whether the effect is permanent or transient. Using life-satisfaction responses from twelve waves of the British Household Panel Survey and employing a fixed-effects model, we derive a temporal pattern of migrants’ subjective well-being around the time of the migration event. Our findings make an original contribution by revealing that, on average, migration is preceded by a period when individuals experience a significant decline in happiness for a variety of reasons, including changes in personal living arrangements. Migration itself causes a boost in happiness, and brings people back to their initial levels. The research contributes, therefore, to advancing an understanding of migration in relation to set-point theory. Perhaps surprisingly, long-distance migrants are at least as happy as short-distance migrants despite the higher social and psychological costs involved. The findings of this paper add to the pressure to retheorize migration within a conceptual framework that accounts for social well-being from a life-course perspective.PostprintPeer reviewe

Non relativistic Broad Band wake fields and potential-well distortion

The study of the interaction between a particle beam and wake fields is usually based on the assumption of ultra relativistic beams. This is not the case, for example, for the Proton Synchrotron Booster(PSB), in which protons cover the energy range. There are some examples in literature which derive nonultra relativistic formulae for the resistive wall impedance. In this paper we have extended the Broad-Band resonator model, allowing the impedance to have poles even in the upper half complex plane, in order to obtain a wake function different from zero for. The Haissinski equation has been numerically solved showing longitudinal bunch shape changes with. In addition some longitudinal bunch profile measurements, taken for two different bunch intensities at the PSB, are shown