WebCinema

Uno sguardo sul panorama audiovisivo presente sulla rete internet,dalla fiction alla videoarte interattiva ai nuovi progetti di film per il web. si cercherà di delineare per quanto possibile un linguaggio comune a tutte queste esperienze, che seppur diverse, sfruttano tutte lo stesso medium. Un'attenzione particolare al ruolo del nuovo spettatore

IAU Office of Astronomy for Education, OAE Center Italy - Annual Report 2022

Annual report 2023 of the the IAU OAE Center Italy, an international office addressed to education and hosted and financed by Inaf. OAE Center Italy was established on the 3rd of March 2021, thanks to a Memorandum of Understanding signed by three parties: IAU, the Office of Astronomy for Education and INAF. OAE Center Italy is a joint project of a consortium of Italian partners, led and represented by INAF and of the IAU OAE, and is operated by INAF. The Italian partners are INAF, the Italian Astronomical Society (SAIt) and the University of Rome Tor Vergata (ToV). Index of contents 1. Professionalize astronomy education 11 1.1 The 4th Shaw-IAU workshop of Astronomy for Education 12 1.2 “Officina degli Errori” Pilot Programme 14 1.3 Educational path for transversal skills and professional orientation through Game-Based Learning 16 2. Provide access to good resources 18 2.1 astroEDU 19 2.2 Shared astronomical Glossary 21 2.3 Astrophotography contest 23 3. Promote astronomy in curricula 24 3.1 MIRTO - Mediterranean Informal Round Table – online 25 3.2 STEAM-MED - Lampedusa workshop on Astronomy Education 2022 27 3.3 Teacher Training Pilot Program (TTPP) 35 3.4 Organisation and delivery of the 16 hour-course for PhD students "Designing innovative public-engagement activities", at the University of Padova. 36 3.5 Castellaro Lagusello Astronomy Festival 37 4. OAE Networking 38 4.1 Participation in Expo 2020, Dubai, Italian Pavilion 39 4.2 Under the same Moon: building bridges through sky and astronomy 40 5. Spread the news 41 5.1 Under the same sky: an exhibition in Rome 42 5.2 Il Cielo itinerante – Italy shines 42 5.3 Universe World / EduINAF column 43 5.4 Time machines, an astronomy exhibition 43 5.5 Workshops 43 5.6 Press release, announcements and new

IAU Office of Astronomy for Education, OAE Center Italy - Annual Report 2021

First annual report of the the IAU OAE Center Italy, an international office addressed to education and hosted and financed by Inaf. OAE Center Italy was established on the 3rd of March 2021, thanks to a Memorandum of Understanding signed by three parties: IAU, the Office of Astronomy for Education and INAF. OAE Center Italy is a joint project of a consortium of Italian partners, led and represented by INAF and of the IAU OAE, and is operated by INAF. The Italian partners are INAF, the Italian Astronomical Society (SAIt) and the University of Rome Tor Vergata (ToV)

IAU Office of Astronomy for Education OAE Center Italy - Quarterly Report 1 January-March 2022

The IAU O!ce of Astronomy for Education Center Italy (I-OAE) is a joint project of a consortium of Italian partners led and represented by Istituto Nazionale di Astrofisica (INAF, National Institute for Astrophysics), the International Astronomical Union (IAU) and the IAU O!ce of Astronomy for Education. The Italian consortium is constituted by: INAF, the Italian Astronomical Society (SAIt) and the University of Rome Tor Vergata (ToV). I-OAE HQ are hosted by the INAF - Rome Astronomical Observatory, in Monteporzio. Personnel is selected on voluntary bases according to their interests and competence, in agreement with the Institutes they work for. Brochure of the 2021 activities: https://www.flipsnack.com/eduinaf/oaei-brochure.htmlQuarterly Report 1 January-March 2022 is the report of the activities from January to March 2022 of the IAU Office of Astronomy for Education OAE Center Italy Attachment: brochure of the activities and project 202

Report EduINAF anno 2021/2022

Il periodo a cui fa riferimento questo Report (Anno scolastico 2021/2022: Settembre 2021-Agosto 2022) è stato caratterizzato dal protrarsi dell’emergenza COVID in Italia con conseguenti difficoltà delle scuole e periodi di ricorso alla Didattica a Distanza (DaD). Il 2021/2022 è stato anche il terzo anno di attività della testata registrata EduINAF, il magazine di Didattica e Divulgazione dell’Istituto Nazionale di Astrofisica. In questo periodo, la redazione di EduINAF, oltre a pubblicare risorse didattiche e contenuti informativi sul mondo della Didattica e Divulgazione della scienza, ha organizzato e contribuito a organizzare numerose iniziative a sostegno della scuola e della società, come le dirette osservative della Serie “Il Cielo in Salotto”, i concorsi per le scuole e altre campagne di engagement. In questo Report si presentano le attività svolte nell’arco di tempo indicato e si analizzano i risultati ottenuti in termini di audience, di comportamento e di gradimento del pubblico. L’obiettivo è quello di fornire il contesto per strutturare il Piano Editoriale 2022/2023 che conterrà le linee guida per la programmazione del prossimo anno scolastico

Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception

Cardiovascular Pharmacogenomics

Background: Variability in response to pharmacological treatment is one of the most important issues in the clinical practice at first exclusively attributed to clinical and demographic factors such as age, sex, nutritional status, alcohol abuse, smoking, presence of comorbidities and polypharmacy. Nowadays, it is well known that also genetic factors can modify the outcomes of pharmacological treatments. Polymorphisms in genes encoding molecules involved in both pharmacodynamics and pharmacokinetics may influence efficacy, tolerability, and safety of medications; thus, the knowledge of these genetic variants may help physicians to individualize and optimize the therapies. Objective: The main aim of this review is to summarize the current scientific evidence about cardiovascular pharmacogenomics. Conclusion: Cardiovascular pharmacogenomics is recommended only for some antiplatelet, anticoagulant and antihypercholesterolemic drugs thanks to standardized pharmacogenetic tests that are helpful in preventing thromboembolic and hemorrhagic events. Despite many studies have demonstrated that the application of pharmacogenetics may be useful also to individualize the therapy with other cardiovascular drugs, the paucity of large clinical trials and of cost-effectiveness studies limits the translation of such knowledge into clinical practice

Stimulatory Interactions between Human Coronary Smooth Muscle Cells and Dendritic Cells

<div><p>Despite inflammatory and immune mechanisms participating to atherogenesis and dendritic cells (DCs) driving immune and non-immune tissue injury response, the interactions between DCs and vascular smooth muscle cells (VSMCs) possibly relevant to vascular pathology including atherogenesis are still unclear. To address this issue, immature DCs (iDCs) generated from CD14⁺ cells isolated from healthy donors were matured either with cytokines (mDCs), or co-cultured (ccDCs) with human coronary artery VSMCs (CASMCs) using transwell chambers. Co-culture induced DC immunophenotypical and functional maturation similar to cytokines, as demonstrated by flow cytometry and mixed lymphocyte reaction. In turn, factors from mDCs and ccDCs induced CASMC migration. MCP-1 and TNFα, secreted from DCs, and IL-6 and MCP-1, secreted from CASMCs, were primarily involved. mDCs adhesion to CASMCs was enhanced by CASMC pre-treatment with IFNγ and TNFα ICAM-1 and VCAM-1 were involved, since the expression of specific mRNAs for these molecules increased and adhesion was inhibited by neutralizing antibodies to the counter-receptors CD11c and CD18. Adhesion was also inhibited by CASMC pre-treatment with the HMG-CoA-reductase inhibitor atorvastatin and the PPARγ agonist rosiglitazone, which suggests a further mechanism for the anti-inflammatory action of these drugs. Adhesion of DCs to VSMCs was shown also <i>in vivo</i> in rat carotid 7 to 21 days after crush and incision injury. The findings indicate that DCs and VSMCs can interact with reciprocal stimulation, possibly leading to perpetuate inflammation and vascular wall remodelling, and that the interaction is enhanced by a cytokine-rich inflammatory environment and down-regulated by HMGCoA-reductase inhibitors and PPARγ agonists.</p></div