38 research outputs found
Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia
- Author
- Abbaldo A.
- Abraham E.
- Acampora R.
- Addesi D.
- Addolorata M.
- Adobati A.
- Adversi M.
- Agata M. M.
- Agosta L.
- Alberto C.
- Alberto L.
- Alberto S.
- Alberto Z.
- Alessandra B.
- Alessandra F.
- Alessandra F.
- Alessandra P.
- Alessandro C.
- Alessandro D.
- Alessandro G.
- Alessandro G.
- Alessandro M.
- Alessia D.
- Alessio M.
- Alfredo D. G.
- Alice F.
- Alius F.
- Aloisio P.
- Amici S.
- Amoruso R.
- Anastasio L.
- Andrea A.
- Andrea A.
- Andrea B.
- Andrea C.
- Andrea G.
- Andrea S.
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- Andreolli Antonino C. G.
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- Andriolli A.
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- Arenare F.
- Arighi A.
- Asprinio V.
- Assunta S.
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- Azzini M.
- Bacci M.
- Balestri F.
- Ballardini G.
- Ballino E.
- Balotta A.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Get PDFHyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ăngela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez AntĂłnio M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- AntĂŽnio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
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- Beegle Scott H.
- Beitler Jeremy R.
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- Beraldo Daniel O.
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- Berkelmans Frantz
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- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ăamendys-Silva Silvio A.
- Ănal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Get PDFPublisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ℠0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
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- Abad R.D.
- Abe Toshikazu
- Abroug Fekri
- Adams J.C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa T.M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi H.M.
- Al Jabbary A.S.
- Albaiceta G.M.
- Albarrak M.M.
- Albiero Daniela
- Alda R.S.
- Alejandro Risso V.
- Alexander P.
- Alfonso Alec A.Tallet
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- Aliaga Felipe A.
- Alisasis A.U.
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- Alonso J.G.
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- Amin P.
- Amir Fahd
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- An Youzhong
- Andersen F.H.
- Andoh Kohkichi
- Andruszkiewicz P.
- Aneman Anders
- Antonelli Massimo
- AntĂŽnio Ana Carolina P.
- Aoki Nobumasa
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- Arnal Jean-Michel
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- Zumaran Aguilar Ronald
- Ăamendys-Silva S.A.
- ĂŒnal Necmettin
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Get PDFThe aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
The beneficial use of ultramicronized palmitoylethanolamide as add-on therapy to Tapentadol in the treatment of low back pain: a pilot study comparing prospective and retrospective observational arms
- Author
- A Gatti
- A Truini
- AM Boonstra
- B Morlion
- C Aurilio
- C Schifilliti
- Caterina Aurilio
- CM DomĂnguez
- D Bouhassira
- D Bouhassira
- Daniela Fierro
- F Marchand
- G Guida
- G Moalem
- J Pergolizzi
- JC Fairbank
- KJ Reid
- L Canteri
- L Cobellis
- LE Chaparro
- M Barbarisi
- M Monticone
- M Tsuda
- Manlio Barbarisi
- Marco Fiore
- Maria Beatrice Passavanti
- Maria Caterina Pace
- MC Pace
- NR Bachur
- P Desio
- Pasquale Sansone
- R Baron
- R Baron
- R Benyamin
- R Vallejo
- S Petrosino
- SD Skaper
- SD Skaper
- TM Tzschentke
- V Pota
- Vincenzo Pota
- VJ Wirtz
- Y Zuo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textImmunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ăngela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez AntĂłnio
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo
- Antonelli Massimo
- AntĂŽnio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis
- Azad Raman
- Azevedo Luciano Cesar
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- Bajwa Ed
- Balkhi Hicham
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- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
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- Zhao Xian Y.
- Zheng Ruiqiang
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- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ăamendys-Silva Silvio A.
- ĂŒnal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Get PDFBackground: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Childhood asthma outcomes during the COVID-19 pandemic:findings from the PeARL multinational cohort
- Author
- Abou-Taam R. (Rola)
- Agache I. (Ioana)
- Castro-Rodriguez J. A. (Jose A.)
- Chen Z. (Zhimin)
- Cros P. (Pierrick)
- Custovic A. (Adnan)
- Deschildre A. (Antoine)
- Dubus J.-C. (Jean-Christophe)
- El-Owaidy R. (Rasha)
- El-Sayed Z. A. (Zeinab Awad)
- Feleszko W. (Wojciech)
- Fierro V. (Vincenzo)
- Fiocchi A. (Alessandro)
- Garcia-Marcos L. (Luis)
- Goh A. (Anne)
- Hossny E. M. (Elham M.)
- Huerta Villalobos Y. R. (Yunuen R.)
- Jartti T. (Tuomas)
- Le Roux P. (Pascal)
- Levina J. (Julia)
- Lopez Garcia A. I. (Aida Ines)
- Mathioudakis A. G. (Alexander G.)
- Morais-Almeida M. (Mario)
- Murray C. (Clare)
- Nagaraju K. (Karthik)
- Nagaraju M. K. (Major K.)
- Namazova-Baranova L. (Leyla)
- Navarrete Rodriguez E. M. (Elsy Maureen)
- Nieto Garcia A. (Antonio)
- Papadopoulos N. G. (Nikolaos G.)
- Phipatanakul W. (Wanda)
- Pozo Beltran C. F. (Cesar Fireth)
- Ramos A. M. (Angel Mazon)
- Ratchataswan T. (Thanaporn)
- Rivero Yeverino D. (Daniela)
- Rodriguez Zagal E. (Erendira)
- Schweitzer C. E. (Cyril E.)
- Tulkki M. (Marleena)
- Wasilczuk K. (Katarzyna)
- Wong G. (Gary)
- Xepapadaki P. (Paraskevi)
- Xu D. (Dan)
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
No full textAbstract
Background: The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.
Methods: The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control.
Results: During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEVâ and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged.
Conclusions: Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent
Platelet Count Does Not Predict Bleeding in Cirrhotic Patients: Results from the PRO-LIVER Study
- Author
- Ainora M. E.
- Andreozzi P.
- Andriulli A.
- Angelico F.
- Angelico M.
- Antonio F.
- Anzaldi M.
- Arena U.
- Averna M.
- Barone M.
- Basili S.
- Bazzini C.
- Bergamaschi G.
- Bertoni M.
- Bianchi Giovanni B.
- Bianchi P. I.
- Boari B.
- Bolondi L.
- Bombonato G.
- Bracco C.
- Brocco S.
- Buonauro A.
- Butta C.
- Buzzetti E.
- Cacciola I.
- Calabria S.
- Cangemi R.
- Capeci W.
- Caradio F.
- Carderi I.
- Carleo P.
- Caroleo B.
- Carrabba Maria D.
- Castorani L.
- Cavallo M.
- Cecchetto L.
- Cesaro F.
- Cicco S.
- Cimini C.
- Colombo B. M.
- Corazza G. R.
- Corradini E.
- Corrao S.
- Costantino G.
- Costanzo F.
- Croce G.
- Cuoghi C.
- Curigliano V.
- D'Alitto F.
- D'Amico G.
- Davi G.
- De Franchis R.
- De Giorgi A.
- De Vuono S.
- Debernardi V. W.
- Del Ben M.
- Del Corso L.
- Delitala G.
- Denegri A.
- Di Cesare V.
- Di Giosia P.
- Di Michele D.
- Di Minno G.
- Donnarumma E.
- Drenaggi D.
- Durante-Mangoni E.
- Falsetti L.
- Farcomeni A.
- Farinaro V.
- Fasolato S.
- Ferrari G.
- Fierro T.
- Forgione A.
- Frugiuele P.
- Galati G.
- Gallo P.
- Garcovich M.
- Gargano R.
- Gasbarrini A.
- Gatta A.
- Giammanco A.
- Giannelli G.
- Giorgini P.
- Gobbi P.
- Granito A.
- Grassi D.
- Greco A.
- Grembiale A.
- Gresele P.
- Guidacci Raimondo
- Hijazi D.
- Iacobellis A.
- Iamele L.
- Invernizzi P.
- Ippolito A.
- Laffi G.
- Licata A.
- Liguori M. L.
- Lorusso G.
- Maimone S.
- Manfredini R.
- Marcacci M.
- Marchese A.
- Marinelli S.
- Marra A. M.
- Martino Giuseppe P.
- Masala M.
- Masotti M.
- Merla A.
- Miceli G.
- Montebianco A. L.
- Morana I.
- Morelli O.
- Murgia G.
- Naccarato P.
- Napoleone L.
- Neri S.
- Niro G.
- Nobili L.
- Padula D.
- Palasciano G.
- Palmieri V. O.
- Pattoneri P.
- Perego F.
- Perticone F.
- Perticone M.
- Pesce P.
- Petramala L.
- Pettinari I.
- Piano S.
- Picardi A.
- Pietrangelo A.
- Pignataro F. S.
- Pignataro P.
- Pinna M.
- Pinto A.
- Pinto D.
- Polimeni L.
- Pretti V.
- Privitera G.
- Proietti M.
- Pucci G.
- Purrello F.
- Ragone E.
- Raparelli V.
- Restuccia T.
- Riccardi L.
- Rizzetto M.
- Rodriguez-Castro K. I.
- Romanelli R. G.
- Romiti G. F.
- Sacerdoti D.
- Salinaro F.
- Salvi A.
- Salzano A.
- Santangelo G.
- Santarossa C.
- Santilli F.
- Santovito D.
- Scarpini F.
- Schiavone C.
- Scicali R.
- Senzolo M.
- Serra C.
- Serviddio G.
- Sirico D.
- Soresi M.
- Sperduti N.
- Staffolani S.
- Staltari O.
- Stasi C.
- Suppressa P.
- Svegliati B. G.
- Talerico G.
- Talia M.
- Tana C.
- Tassone E. J.
- Todisco T.
- Toriello F.
- Torres D.
- Traversa M.
- Tripepi G.
- Tufano A.
- Tuttolomondo A.
- Varvara D.
- Vazzana N.
- Vecchio Claudia R.
- Vendemiale G.
- Ventura P.
- Vespasiani-Gentilucci U.
- Vestri Anna R.
- Vettore E.
- Vidili G.
- Villani R.
- Vincenzo R.
- Violi F.
- Visioli G.
- Vitale F.
- Zocco M. A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
No full textThrombocytopenia is a hallmark for patients with cirrhosis and it is perceived as a risk factor for bleeding events. However, the relationship between platelet count and bleeding is still unclear
Platelet count does not predict bleeding in cirrhotic patients: Results from the PRO-LIVER Study
- Author
- Ainora M. E.
- Andreozzi P.
- Andriulli A.
- Angelico F.
- Angelico M.
- Antonio F.
- Anzaldi M.
- Arena U.
- Averna M.
- Barone M.
- Basili S.
- Bazzini C.
- Bergamaschi G.
- Bertoni M.
- Bianchi Giovanni B.
- Bianchi P. I.
- Boari B.
- Bolondi L.
- Bombonato G.
- Bracco C.
- Brocco S.
- Buonauro A.
- Butta C.
- Buzzetti E.
- Cacciola I.
- Calabria S.
- Cangemi R.
- Capeci W.
- Caradio F.
- Carderi I.
- Carleo P.
- Caroleo B.
- Carrabba Maria D.
- Castorani L.
- Cavallo M.
- Cecchetto L.
- Cesaro F.
- Cicco S.
- Cimini C.
- Colombo B. M.
- Corazza G. R.
- Corradini E.
- Corrao S.
- Costantino G.
- Costanzo F.
- Croce G.
- Cuoghi C.
- Curigliano V.
- D'Alitto F.
- D'Amico G.
- Davi G.
- De Franchis R.
- De Giorgi A.
- De Vuono S.
- Debernardi V. W.
- Del Ben M.
- Del Corso L.
- Delitala G.
- Denegri A.
- Di Cesare V.
- Di Giosia P.
- Di Michele D.
- Di Minno G.
- Donnarumma E.
- Drenaggi D.
- Durante-Mangoni E.
- Falsetti L.
- Farcomeni A.
- Farinaro V.
- Fasolato S.
- Ferrari G.
- Fierro T.
- Forgione A.
- Frugiuele P.
- Galati G.
- Gallo P.
- Garcovich M.
- Gargano R.
- Gasbarrini A.
- Gatta A.
- Giammanco A.
- Giannelli G.
- Giorgini P.
- Gobbi P.
- Granito A.
- Grassi D.
- Greco A.
- Grembiale A.
- Gresele P.
- Guidacci Raimondo
- Hijazi D.
- Iacobellis A.
- Iamele L.
- Invernizzi P.
- Ippolito A.
- Laffi G.
- Licata A.
- Liguori M. L.
- Lorusso G.
- Maimone S.
- Manfredini R.
- Marcacci M.
- Marchese A.
- Marinelli S.
- Marra A. M.
- Martino Giuseppe P.
- Masala M.
- Masotti M.
- Merla A.
- Miceli G.
- Montebianco A. L.
- Morana I.
- Morelli O.
- Murgia G.
- Naccarato P.
- Napoleone L.
- Neri S.
- Niro G.
- Nobili L.
- Padula D.
- Palasciano G.
- Palmieri V. O.
- Pattoneri P.
- Perego F.
- Perticone F.
- Perticone M.
- Pesce P.
- Petramala L.
- Pettinari I.
- Piano S.
- Picardi A.
- Pietrangelo A.
- Pignataro F. S.
- Pignataro P.
- Pinna M.
- Pinto A.
- Pinto D.
- Polimeni L.
- Pretti V.
- Privitera G.
- Proietti M.
- Pucci G.
- Purrello F.
- Ragone E.
- Raparelli V.
- Restuccia T.
- Riccardi L.
- Rizzetto M.
- Rodriguez-Castro K. I.
- Romanelli R. G.
- Romiti G. F.
- Sacerdoti D.
- Salinaro F.
- Salvi A.
- Salzano A.
- Santangelo G.
- Santarossa C.
- Santilli F.
- Santovito D.
- Scarpini F.
- Schiavone C.
- Scicali R.
- Senzolo M.
- Serra C.
- Serviddio G.
- Sirico D.
- Soresi M.
- Sperduti N.
- Staffolani S.
- Staltari O.
- Stasi C.
- Suppressa P.
- Svegliati B. G.
- Talerico G.
- Talia M.
- Tana C.
- Tassone E. J.
- Todisco T.
- Toriello F.
- Torres D.
- Traversa M.
- Tripepi G.
- Tufano A.
- Tuttolomondo A.
- Varvara D.
- Vazzana N.
- Vecchio Claudia R.
- Vendemiale G.
- Ventura P.
- Vespasiani-Gentilucci U.
- Vestri Anna R.
- Vettore E.
- Vidili G.
- Villani R.
- Vincenzo R.
- Violi F.
- Visioli G.
- Vitale F.
- Zocco M. A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
No full textOBJECTIVES: Thrombocytopenia is a hallmark for patients with cirrhosis and it is perceived as a risk factor for bleeding events. However, the relationship between platelet count and bleeding is still unclear. METHODS: We investigated the relationship between platelet count and major or clinical relevant nonmajor bleedings during a follow-up of âŒ4 years. RESULTS: A total of 280 cirrhotic patients with different degrees of liver disease (67% males; age 64±37 years; 47% ChildâPugh B and C) were followed up for a median of 1,129 (interquartile range: 800â1,498) days yielding 953.12 patient-year of observation. The annual rate of any significant bleeding was 5.45%/year (3.57%/year and 1.89%/year for major and minor bleeding, respectively). Fifty-two (18.6%) patients experienced a major (n=34) or minor (n=18) bleeding event, predominantly from gastrointestinal origin. Platelet counts progressively decreased with the worsening of liver disease and were similar in patients with or without major or minor bleeding: a platelet count â€50Ă103/ÎŒl was detected in 3 (6%) patients with and in 20 (9%) patients without any bleeding event. Conversely, prothrombin time-international normalized ratio was slightly higher in patients with overall or major bleeding. On Cox proportional hazard analysis, only a previous gastrointestinal bleeding (hazard ratio (HR): 1.96; 95% confidence interval: 1.11â3.47; P=0.020) and encephalopathy (HR: 2.05; 95% confidence interval: 1.16â3.62; P=0.013) independently predicted overall bleeding events. CONCLUSIONS: Platelet count does not predict unprovoked major or minor bleeding in cirrhotic patients
Platelet Count Does Not Predict Bleeding in Cirrhotic Patients: Results from the PRO-LIVER Study
- Author
- Ainora M. E.
- Andreozzi P.
- Andriulli A.
- Angelico F.
- Angelico M.
- Antonio F.
- Anzaldi M.
- Arena U.
- Averna M.
- Barone M.
- Basili S.
- Bazzini C.
- Bergamaschi G.
- Bertoni M.
- Bianchi Giovanni B.
- Bianchi P. I.
- Boari B.
- Bolondi L.
- Bombonato G.
- Bracco C.
- Brocco S.
- Buonauro A.
- Butta C.
- Buzzetti E.
- Cacciola I.
- Calabria S.
- Cangemi R.
- Capeci W.
- Caradio F.
- Carderi I.
- Carleo P.
- Caroleo B.
- Carrabba Maria D.
- Castorani L.
- Cavallo M.
- Cecchetto L.
- Cesaro F.
- Cicco S.
- Cimini C.
- Colombo B. M.
- Corazza G. R.
- Corradini E.
- Corrao S.
- Costantino G.
- Costanzo F.
- Croce G.
- Cuoghi C.
- Curigliano V.
- D'Alitto F.
- D'Amico G.
- Davi G.
- De Franchis R.
- De Giorgi A.
- De Vuono S.
- Debernardi V. W.
- Del Ben M.
- Del Corso L.
- Delitala G.
- Denegri A.
- Di Cesare V.
- Di Giosia P.
- Di Michele D.
- Di Minno G.
- Donnarumma E.
- Drenaggi D.
- Durante-Mangoni E.
- Falsetti L.
- Farcomeni A.
- Farinaro V.
- Fasolato S.
- Ferrari G.
- Fierro T.
- Forgione A.
- Frugiuele P.
- Galati G.
- Gallo P.
- Garcovich M.
- Gargano R.
- Gasbarrini A.
- Gatta A.
- Giammanco A.
- Giannelli G.
- Giorgini P.
- Gobbi P.
- Granito A.
- Grassi D.
- Greco A.
- Grembiale A.
- Gresele P.
- Hijazi D.
- Iacobellis A.
- Iamele L.
- Invernizzi P.
- Ippolito A.
- Laffi G.
- Licata A.
- Liguori M. L.
- Lorusso G.
- Maimone S.
- Manfredini R.
- Marcacci M.
- Marchese A.
- Marinelli S.
- Marra A. M.
- Martino Giuseppe P.
- Masala M.
- Masotti M.
- Merla A.
- Miceli G.
- Montebianco A. L.
- Morana I.
- Morelli O.
- Murgia G.
- Naccarato P.
- Napoleone L.
- Neri S.
- Niro G.
- Nobili L.
- Padula D.
- Palasciano G.
- Palmieri V. O.
- Pattoneri P.
- Perego F.
- Perticone F.
- Perticone M.
- Pesce P.
- Petramala L.
- Pettinari I.
- Piano S.
- Picardi A.
- Pietrangelo A.
- Pignataro F. S.
- Pignataro P.
- Pinna M.
- Pinto A.
- Pinto D.
- Polimeni L.
- Pretti V.
- Privitera G.
- Proietti M.
- Pucci G.
- Purrello F.
- Ragone E.
- Raimondo G.
- Raparelli V.
- Restuccia T.
- Riccardi L.
- Rizzetto M.
- Rodriguez-Castro K. I.
- Romanelli R. G.
- Romiti G. F.
- Sacerdoti D.
- Salinaro F.
- Salvi A.
- Salzano A.
- Santangelo G.
- Santarossa C.
- Santilli F.
- Santovito D.
- Scarpini F.
- Schiavone C.
- Scicali R.
- Senzolo M.
- Serra C.
- Serviddio G.
- Sirico D.
- Soresi M.
- Sperduti N.
- Staffolani S.
- Staltari O.
- Stasi C.
- Suppressa P.
- Svegliati B. G.
- Talerico G.
- Talia M.
- Tana C.
- Tassone E. J.
- Todisco T.
- Toriello F.
- Torres D.
- Traversa M.
- Tripepi G.
- Tufano A.
- Tuttolomondo A.
- Varvara D.
- Vazzana N.
- Vecchio Claudia R.
- Vendemiale G.
- Ventura P.
- Vespasiani-Gentilucci U.
- Vestri Anna R.
- Vettore E.
- Vidili G.
- Villani R.
- Vincenzo R.
- Violi F.
- Visioli G.
- Vitale F.
- Zocco M. A.
- Publication venue
- Publication date
- 01/01/2018
- Field of study
No full textThrombocytopenia is a hallmark for patients with cirrhosis and it is perceived as a risk factor for bleeding events. However, the relationship between platelet count and bleeding is still unclear
CMS TriDAS project: Technical Design Report, Volume 1: The Trigger Systems
- Author
- Aarnio Pertti A
- Abadjiev K
- Abbaneo D
- Abbrescia M
- Abdullin S
- Abramov A
- Abramov V
- Acharya B S
- Acosta D
- Adam W
- Adams M R
- Adams N
- Adzic P
- Afanasiev S V
- Aftab Z
- Ageron M
- Aguilar-BenĂtez M
- Ahmad J R
- Ahmad M A
- Ahn S
- Akchurin N
- Akgun U
- Alam J J
- Albajar C
- Alberdi J
- Albergo S
- Albert A
- Alemany-Fernandez R
- Almeida C
- Almeida N
- Altieri S
- Alverson G
- Amaglobeli N S
- Amapane N
- Amsler Claude
- An Q
- Anderhub H
- Anderson E W
- Andriyash A
- Anfreville M G
- Angarano M M
- Angelini F
- Anguelov T
- Anisimov I
- Annenkov A N
- Antchev G
- Antunovic Z
- Apollinari G
- Apollonio M
- Arce P
- Arcelli S
- Arisaka K
- Arneodo M
- Asimidis A
- Aspell P
- Atac Muzaffer
- Atamanchuk A G
- Atanasov I H
- Atoyan G S
- Attal A
- Auffray Etiennette
- Augusto J
- Avery P
- Avezov A
- Awan I U
- Axer M
- Ayan A S
- Azhgirey L S
- Aziz S
- Aziz T
- Azzi P
- Azzurri P
- Babucci E
- Baccaro S
- Bacchetta N
- Baden D
- Badertscher A
- Badier J
- Baek Y W
- Baer Howard W
- Bagaturia Yu S
- Bagliesi G
- Bagoly Z
- Bahk S Y
- Bailey D S
- Baillon Paul
- Baird S A
- Baker N
- Baksay L
- Bala S B
- Ball A
- Ballo P
- Ban Y
- Bandurin D V
- Banerjee Sudeshna
- Banerjee Sunanda
- Banicz K
- Banzuzi K
- Barashko V
- Barata-Monteiro T
- Barber G J
- Barbero M
- Barcala J M
- Barczyk A
- Bard R L
- Bardi A
- BarillĂšre R
- Barlow R A
- Barnes Virgil E
- Barnett B A
- Barney D
- Barone L
- Barone M
- Barry A
- Barsotti E
- Bartoloni A
- Bartsch V
- Bartz E
- Baryshevsky V G
- Basti A
- Bateman E
- Bauer G
- Bauerdick L A T
- Baumbaugh A E
- Baumbaugh B
- Baur R
- Baur Ulrich
- Bayatyan G L
- Beaumont W
- Bechstein S
- Beckers T
- Bedjidian Marc
- Beetz C P
- Beissel F
- Belkov A A
- Bell K W
- Bellato M
- Bellazzini R
- Belli G
- Bellini V
- Bellucci L
- Belov M
- Belsky A
- Bencze G L
- Benettoni M
- Benvenuti Alberto C
- Bercher M
- Beretvas A
- Berger C
- Bernardini J
- Berst J D
- Berti L
- Bertl W
- Bertoldi M
- Bertolino F
- Bertrand D
- Betev B L
- Beuselinck R
- Bhardwaj A I
- Bhatnagar V
- Bhatt K
- Bhattacharya S
- Bhatti N
- Bheesette S
- Bian J G
- Bian Z
- Biasini M
- Biasotto M
- Biggeri U
- Biino-Palestini C
- Biland A
- Bilei G M
- Binkley M
- Bisello D
- Bisenov N T
- Bishop J M
- Bitioukov S
- Blaes R
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- Wulz Claudia Elisabeth
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- Publication venue
- Publication date
- 22/01/2004
- Field of study
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