WHODAS 2.0-BO: dados normativos para avaliação de incapacidade em idosos

OBJETIVO: Examinar os dados de normatização do WHODAS 2.0-BO para idosos brasileiros (World Health Disability Assessment Schedule – Brazilian version for older people) e sua distribuição de acordo com sexo, idade, percepção subjetiva de saúde, desempenho em teste de mobilidade e presença de doenças crônicas e depressão. MÉTODOS: Estudo transversal, com 350 participantes com 60 anos ou mais, homens e mulheres, atendidos em um centro de referência secundário para consultas médicas ou de reabilitação. Os idosos foram avaliados por meio de um questionário semiestruturado, contendo dados sociodemográficos e clínicos, o WHODAS 2.0-BO e a escala de depressão geriátrica (EDG), e submetidos a um teste mobilidade, o Timed Up and Go. Os dados foram analisados por sua distribuição em percentis na população e por análise de variância. RESULTADOS: Duzentos e sessenta e seis (76%) participantes eram mulheres, a idade média foi de 71,8 (DP = 6,7) anos. O escore médio do WHODAS 2.0-BO foi de 4,3 (DP = 5,2) pontos, sendo o maior valor encontrado 33 pontos. O tempo para o Timed up and Go foi de 10,0 (DP = 3,2) segundos. Cerca de 30% dos idosos não relataram nenhuma dificuldade nas tarefas avaliadas pelo WHODAS 2.0-BO e metade da amostra alcançou até dois pontos. CONCLUSÕES: Observou-se um escore de 12 pontos no percentil 90 em uma escala de zero a 40, o que sugere incapacidade grave. O escore do WHODAS 2.0-BO aumentou com o avançar da idade, bem como na presença de comorbidades, de percepção subjetiva de saúde ruim, de depressão, de hipertensão arterial, de dificuldade para enxergar e escutar e de alteração da mobilidade.OBJECTIVE: To examine the normative data of WHODAS 2.0-BO for older Brazilians (World Health Disability Assessment Schedule – Brazilian version for older people) and its distribution according to sex, age, health, subjective health perception, performance in a mobility test and presence of chronic diseases and depression. METHODS: Cross-sectional study, with 350 participants with 60 years of age or older, men and women, patients of a geriatric specialized center for medical consultations or rehabilitation. The older adults were evaluated using a semi-structured questionnaire containing demographic and clinical data (WHODAS 2.0-BO) and the geriatric depression scale (GDS), having been subsequently subjected to a mobility test (Timed Up and Go). The data were analyzed via their distribution in percentiles of the population and via analysis of variance. RESULTS: Two-hundred and sixty-six (76%) participants were women, and the average age was 71.8 (DP = 6.7) years old. The average score in WHODAS 2.0-BO was 4.3 (DP = 5.2) points, the highest value found having corresponded to 33 points. The average time for the Timed Up and Go test was 10.0 (SD = 3.2) seconds. About 30% of the older adults did not report any difficulties in the tasks evaluated by WHODAS 2.0-BO and half of the sample scored up to two points. CONCLUSIONS: A score corresponding to 12 points in the 90 percentile on a scale from zero to 40 was observed, which suggests severe disability. The score in WHODAS 2.0-BO increased with the advance in age, as well as in the presence of comorbidities, negative health perception, depression, high blood pressure, visual and hearing impairment and mobility impairment

Deficiência cognitiva e sua influência sobre os distúrbios de equilíbrio em idosos institucionalizados

Introdução: O envelhecimento fisiológico pode trazer declínio das capacidades físicas e cognitivas dos idosos. Esse declínio pode influenciar a capacidade do idoso manter-se estável, pois o controle postural engloba tarefas motoras complexas que envolvem a interação entre componentes musculoesqueléticos e informações do sistema visual, vestibular e proprioceptivo. Além disso, estudos apontam que quando o indivíduo é colocado frente a múltiplas tarefas, sua demanda de atenção aumenta e se torna mais difícil manter o equilíbrio. Dessa forma, o presente estudo enfatiza a importância de se realizar um diagnóstico precoce de distúrbios de equilíbrio, que podem ou não estar associados à deficiência cognitiva, a fim de realizar futuras intervenções melhorando a qualidade de vida do idoso. Objetivo: Identificar o perfil de idosos residentes em uma Instituição de Longa Permanência para Idosos (ILPI) e investigar se há associação entre deficiência cognitiva e distúrbios de equilíbrio. Metodologia: Estudo transversal, realizado em uma ILPI de Bragança Paulista - SP, que consistiu em análise dos prontuários de 80 idosos. A função cognitiva foi avaliada por meio do escore do Mini Exame do Estado Mental (MEEM) e o equilíbrio foi avaliado por meio do registro das Estratégias Motoras Compensatórias e do Teste Romberg. Para analisar as possíveis associações foi realizada análise descritiva com o programa estatístico SPSS 22.0 e Teste Qui-Quadrado com nível de significância de p ≤ 0,05. Conclusão: O presente estudo possibilitou identificar o perfil funcional dos idosos residentes na Instituição, não sendo observada associação entre deficiência cognitiva e distúrbios de equilíbrio

Microrregulation of access to the care network in physiotherapy: strategies for improving the care flow in a secondary care service

El objetivo de este estudio fue caracterizar un servicio de fisioterapia municipal, evaluar e identificar el perfil de los pacientes en lista de espera y proponer estrategias de microregulación del acceso al atendimiento fisioterapéutico en nivel secundario para mejorar la capacidad de resolución del sistema. Se trata de un estudio transversal realizado con el equipo de fisioterapia de atención secundaria y 70 pacientes en lista de espera. El equipo fue entrevistado y los pacientes fueron evaluados y encaminados para los diferentes puntos de atención de acuerdo con sus necesidades. Las informaciones obtenidas con las entrevistas de los profesionales y triaje de los pacientes fueron utilizadas para proponer mejorías y una mayor capacidad de resolución al servicio. Se observó que el equipo de fisioterapia de atención secundaria tiene alta demanda. El origen de los encaminamientos fue primeramente de ortopedistas/traumatólogos (88%) y diagnóstico clínico de osteoartrosis (36%). Después de la evaluación, se verificó que el 72% de los pacientes no necesitaban de la complejidad de un atendimiento fisioterapéutico secundario. Los problemas encontrados fueron relacionados a la baja capacidad de resolución en la atención primaria, a la ausencia de coordinación entre los equipos de fisioterapia, a la falta de comunicación con los otros profesionales y a los criterios de triaje y atendimiento a nivel secundario de atención. La falta de comprensión acerca de la organización de la red de servicios repercutió en una larga lista de espera para atendimiento fisioterapéutico secundario. A partir de la identificación de los principales problemas, las estrategias indicadas fueron el triaje por el equipo de atención primaria y por profesionales médicos de atención especializada y la instauración de una coordinadoría para la mejora del diálogo entre los puntos de atención en fisioterapia.We characterized a physiotherapy service of the city. The profile of patients on the waiting list was assessed and identified to propose strategies for micro-regulation on the access to secondary-level physiotherapy to improve the resolution rate of the system. This is a cross-sectional study carried out with the physiotherapy team of the secondary care and 70 patients on the waiting list. The team was interviewed and patients were assessed and forwarded to the different care points according to their needs. The information obtained from the interviews of professionals and triage of patients was used to propose improvements and greater resolution. The secondary care physiotherapy team has a high demand. The origin of the referrals was first from Orthopedists/Traumatologists (88%), and clinical diagnosis of Osteoarthritis (36%). After the evaluation, 72% of patients did not need the complexity of a secondary physiotherapy service. The problems found were related to low resolution on primary health care, lack of coordination for physiotherapy teams, lack of dialogue with other professionals, and screening and care criteria in the secondary level of care. The lack of understanding of the network organization of services reflected in a long waiting list for secondary physiotherapy. From the identification of the main problems, strategies indicated were the screening by the primary care staff and medical professionals of the specialized care; and coordinator for improving dialogue between the care points of physiotherapy.O objetivo deste estudo foi caracterizar um serviço de fisioterapia municipal, avaliar e identificar o perfil dos pacientes em lista de espera e propor estratégias de microrregulação do acesso ao atendimento fisioterapêutico em nível secundário para melhoria da resolutividade do sistema. Trata-se de um estudo transversal realizado com a equipe de fisioterapia de atenção secundária e 70 pacientes em lista de espera. A equipe foi entrevistada e os pacientes foram avaliados e encaminhados para os diferentes pontos de atenção segundo suas necessidades. As informações obtidas com as entrevistas dos profissionais e triagem dos pacientes foi utilizada para propor melhorias e maior resolutividade ao serviço. Observou-se que a equipe de fisioterapia de atenção secundária tem alta demanda de atendimento. A origem dos encaminhamentos foi primeiramente de ortopedistas/traumatologistas (88%) e diagnóstico clínico de osteoartrose (36%). Após a avaliação, verificou-se que 72% dos pacientes não necessitavam da complexidade de um atendimento fisioterapêutico secundário. Os problemas encontrados foram relacionados à baixa resolutividade na atenção primária, à ausência de coordenação entre as equipes de fisioterapia, à falta de comunicação com os demais profissionais, e aos critérios de triagem e atendimento em nível secundário de atenção. A falta de compreensão sobre a organização da rede de serviços repercutiu em uma longa lista de espera para atendimento fisioterapêutico secundário. A partir da identificação dos principais problemas, as estratégias indicadas foram a triagem pela equipe de atenção primária e por profissionais médicos de atenção especializada e a instauração de uma coordenadoria para melhora do diálogo entre os pontos de atenção em fisioterapia

Mulheres em situação de prostituição e covid-19: por que excluídas dos grupos vulneráveis?

This study analyzed the exposure of women engaged in prostitution in downtown São Paulo to COVID-19. This cross-sectional study had a convenience sample selected in May 2021. We interviewed 219, mostly black, middle-aged, poor women with comorbidities. Among them, 61 had shown COVID-19 symptoms, 23, tested positive for the disease, seven underwent hospitalization, and four reported post-COVID-19 complications. Only 26 (30.2%) had been vaccinated. In addition to gender, race, and class inequalities, these women suffer both from a higher risk of contracting COVID-19 due to their working conditions and from the subsequent worsening of that disease due to age and lack of vaccination.Esta pesquisa analisou a exposição de mulheres em situação de prostituição no centro de São Paulo à covid-19. Este estudo transversal contou com amostra de conveniência selecionada em maio de 2021. Entrevistou-se 219 mulheres majoritariamente negras, de meia idade, pobres e com comorbidades. Dentre essas mulheres, 61 tiveram sintomas de covid-19, 23 com teste positivo,7 foram internadas e 4 relataram complicações pós-covid-19. Somente 26 (30,2%) haviam sido vacinadas. Além das desigualdades de gênero, raça e classe, essas mulheres são expostas a um maior risco de contraírem covid-19, devido às condições de trabalho e por apresentarem doença grave relacionada à idade e falta de vacinação

Prevalence of environmental fall harzards in elderly commmunity-dwelling in São Paulo - SP

Objetivos: O Objetivo deste estudo foi determinar a prevalencia de fatores ambientais de risco para quedas em idosos vivendo na comunidade e sua associacao com idosos que nunca cairam e com idosos que cairam recorrentemente. Metodo: foi, realizado um estudo transversal com 87 idosos com mais de 65 anos morando na comunidade e participantes de um estudo coorte prospectivo. Uma avaliacao ambiental padronizada foi realizada no domicilio de 53 idosos que cairam recorrentemente e de 34 idosos que nunca haviam caido. Resultados: Riscos ambientais apresentaram uma prevalencia bastante alta nos domicilios desta populacao: piso escorregadio (88,5 por cento), presenca de tapetes na sala (62°/a), armarios inacessiveis na cozinha (87,4 por cento) e ausencia de iluminacao noturna (44,8 por cento). Nao houve nenhum domicilio livre de riscos, sendo a media encontrada de 22 riscos/domicilio de 47 avaliados So houve associacao entre riscos ambientais e idosos que cairam recorrentemente para a presenca de interruptores de luz inacessiveis em todos os comodos. Tapetes nos banheiros, presenca de escadas com riscos e subir em um banco para alcancar objetos apareceram em uma associacao paradoxal, sendo mais prevalentes entre os idosos que nunca cairam. Conclusoes: Os domicilios de idosos apresentam muitos riscos ambientais. Nao foi encontrada uma associacao importante entre a presenca dos riscos e idosos que cairam. Idosos que nunca cairam parecem adotar com mais frequencia comportamentos de risco frente aos atributos ambientaisBV UNIFESP: Teses e dissertaçõe

The impact of environmental factors in the disability in older people: the importance of the public housing policies for aging in place

Introdução: A incapacidade no idoso é multidimensional, envolvendo aspectos de saúde física, emocional, cognitiva, ambiental e social. Os fatores ambientais têm um impacto importante como facilitadores ou barreiras nas atividades e participação social do idoso, especialmente relacionado ao ambiente de moradia e a capacidade de continuar vivendo no próprio domicilio apesar do envelhecimento (Aging in place). Políticas públicas devem ser pensadas levando a questão do Aging in place em consideração. Objetivos: investigar o impacto dos fatores ambientais na incapacidade de idosos que residem em conjuntos habitacionais verticais de interesse social que não contam com quesitos de acessibilidade como o elevador, sob a perspectiva da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF). Método: Para alcance dos objetivos propostos foi necessário a realização da validação de construto e identificação das propriedades psicométricas e de normatização do WHODAS 2.0- 12 itens para avaliação da incapacidade em idosos brasileiros. Após esta etapa, foi realizada a análise dos fatores ambientais sugeridos pela CIF e reconhecidos por moradores dos conjuntos habitacionais e sua associação com a incapacidade funcional. Os estudos transversais aqui apresentados foram realizados com duas amostras distintas: Amostra 1 para o processo de validação de construto e normatização do WHODAS 2.0 contou com 350 idosos assistidos pelo Centro de referência do Idoso na cidade de São Paulo. Com dados desta amostra foi realizada uma análise fatorial exploratória, confirmatória e teoria de resposta ao item e análise de variância para validação de construto e observação da distribuição dos escores na amostra. Amostra 2 contando com 96 idosos residentes em um conjunto habitacional com 26 edifícios verticais com até 4 andares em Bragança Paulista (SP) para análise do impacto dos fatores ambientais na incapacidade dos idosos. Com os dados desta amostra foi realizada análise de regressão linear multivariada para identificação dos fatores ambientais mais associados ao aumento do escore de incapacidade. Resultados: O WHODAS 2.0, 12 itens apresentou boa adequação das cargas fatorais em um modelo unidimensional somente com 10 itens dos 12 avaliados. A retirada do item 6 (concentrar-se) e 10 (lidar com pessoas estranhas) na análise fatorial exploratória melhorou o desempenho do teste com variância explicada de 70 por cento (x2/df = 2,45; p < 0,001, NNFI = 0,98, CFI = 0,99, GFI = 0,99, RMSEA = 0,06; Alpha de Cronbach = 0,95 e Mc Donald = 0,92). Na análise da associação entre barreiras ambientais e incapacidade observou-se que fatores ambientais como escadas, acesso ao transporte público, ruídos, clima e preconceito reconhecidos como barreira foram associados a um aumento no escore do WHODAS 2.0-BO. Conclusão: A presença de barreiras ambientais como dificuldade de acesso ao transporte público, presença de escadas na entrada da casa, ruídos, condições climáticas adversas e preconceito foram associadas a um aumento no escore de incapacidade, o que pode impedir idosos de continuar vivendo no próprio domicílio na presença de tais barreiras. Políticas públicas deveriam considerar o envelhecimento e as barreiras ambientais identificadas neste estudo para a garantia do Aging in place.Introduction: Disability in older people is multidimensional with physical, emotional, cognitive, environmental and social aspects. The environmental factors could have an important impact as facilitators or barriers in their activities and social participation, specially related to the habitation and the aging in place. Public housing policies should be made based on aging in place. Objectives: to investigate the impact of environmental factors in disability of older people living in a multi-storey apartment complex building for low-income families with no elevator, by International Classification of Functioning, Disability and Health (ICF) perspective. Method: As a first step to this study purpose, analyses of the psychometric properties and normative data of the WHODAS 2.0- 12 item were necessary to validate this instrument and assess disability in Brazilian older people. After that, the analysis of the environmental factors (as suggested by ICF) recognized by older people living in apartment complex building and their association with disability was done. The cross-sectional studies here presented were done with two different samples: Sample 1 was used to identify the construct validation and normative data of the WHODAS 2.0 12 item. This sample had 350 individuals attending a community based reference center for older people in São Paulo. The construct validity was tested with Exploratory and Confirmatory Factor Analysis, Parallel Analysis, Item Response Theory. Sample 2 was used to analyse the perceived environmental factors and the disability. It had 96 older people living in a multi-storey apartment complex for low income families in Bragança Paulista. The regression linear analysis was done to identify the environmental barriers associated to disability in the older people. Results: The WHODAS 2.0, 12-item version, is a unidimensional scale, and goodness of fit occurs only with 10 items evaluating disability in older people. Withdrawn items 6 (concentration) and 10 (leading with strangers) established an appropriate adjustment, with high and excellent values for all indicators. The explained variance was 70 per cent and confirmatory analysis showed X2/df = 2,45; p < 0,001, NNFI = 0,98, CFI = 0,99, GFI = 0,99, and RMSEA = 0,06; reliability indexes Cronbachs ( = 0.95) and McDonalds ( = 0,92) were adequate. This new version was named WHODAS 2.0-BO (Brazilian version for older people). At the environmental barriers and disability association study was observed the association between perceived barriers as public transportation, stairs, noise, climate and prejudice and disability with the increased WHODAS 2.0-BO score. Conclusion: older people who recognize environmental barriers such as access to public transportation, stairs, noise, adverse climate and prejudice have an increase in disability score, which can prevent them from aging in place. The public policies should consider the aging and the environmental barriers identified by this study in order to assure aging in place

WHODAS 2.0-BO: normative data for the assessment of disability in older adults

ABSTRACT OBJECTIVE: To examine the normative data of WHODAS 2.0-BO for older Brazilians (World Health Disability Assessment Schedule – Brazilian version for older people) and its distribution according to sex, age, health, subjective health perception, performance in a mobility test and presence of chronic diseases and depression. METHODS: Cross-sectional study, with 350 participants with 60 years of age or older, men and women, patients of a geriatric specialized center for medical consultations or rehabilitation. The older adults were evaluated using a semi-structured questionnaire containing demographic and clinical data (WHODAS 2.0-BO) and the geriatric depression scale (GDS), having been subsequently subjected to a mobility test (Timed Up and Go). The data were analyzed via their distribution in percentiles of the population and via analysis of variance. RESULTS: Two-hundred and sixty-six (76%) participants were women, and the average age was 71.8 (DP = 6.7) years old. The average score in WHODAS 2.0-BO was 4.3 (DP = 5.2) points, the highest value found having corresponded to 33 points. The average time for the Timed Up and Go test was 10.0 (SD = 3.2) seconds. About 30% of the older adults did not report any difficulties in the tasks evaluated by WHODAS 2.0-BO and half of the sample scored up to two points. CONCLUSIONS: A score corresponding to 12 points in the 90 percentile on a scale from zero to 40 was observed, which suggests severe disability. The score in WHODAS 2.0-BO increased with the advance in age, as well as in the presence of comorbidities, negative health perception, depression, high blood pressure, visual and hearing impairment and mobility impairment

7th Drug hypersensitivity meeting: part two

Table of contents Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101) P92 16 years of experience with proton pump inhibitors (PPIs) Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez P93 Allergy evaluation of quinolone induced adverse reactions Jaume Martí Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández Fernández De Rojas P94 Bupropion-induced acute urticaria and angioedema, a case report Emre Ali Acar, Ayse Aktas, Aylin Türel Ermertcan, Peyker Temiz P96 Delayed type hypersensitivity and study of cross-reactivity between proton-pump inhibitors Chien-Yio Lin, Chung-Yee Rosaline Hui, Ya-Ching Chang, Chih-Hsun Yang, Wen-Hung Chung P97 Diagnostic work-up in suspected hypersensitivity to proton-pump inhibitors: looking at cross-reactivity Fabrícia Carolino, Diana Silva, Eunice Dias De Castro, Josefina R. Cernadas P98 Management of infusion-related hypersensitivity reactions to enzyme replacement therapy for lysosomal diseases Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Alex Lacerda, Ana Maria Martins, Ekaterini Goudouris, Marcia Ribeiro, José Francisco Da Silva Franco, Leandra Queiroz, Dirceu Solé P99 Management of insulin allergy with continuous subcutaneous insulin infusion Ceyda Tunakan Dalgiç, Aytül Zerrin Sin, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Ali Kokuludag P100 Off-label use of icatibant for management of serious angioedema associated with angiotensin inhibitors Ana M. Montoro De Francisco, Talía Mª De Vicente Jiménez, Adriana M. Mendoza Parra, Angella M. Burgos Pimentel, Amelia García Luque P101 Thiocolchicoside anaphylaxis: an unusual suspect? Luis Amaral, Fabricia Carolino, Leonor Carneiro Leão, Eunice Castro, Josefina Cernadas Poster walk 12: betalactam hypersensitivity (P102–P111) P102 A curious delayed reading: a case report of a β-lactam allergy in a child Nicole Pinto, Joana Belo, João Marques, Pedro Carreiro-Martins, Paula Leiria-Pinto P103 Betalactam-induced hypersensitivity: a 10-years’ experience Amel Chaabane, Haifa Ben Romdhane, Nadia Ben Fredj, Zohra Chadly, Naceur A. Boughattas, Karim Aouam P104 Cefazolin hypersensitivity: towards optimized diagnosis Astrid P. Uyttebroek, Chris H. Bridts, Antonino Romano, Didier G. Ebo, Vito Sabato P105 Clavulanic acid allergy: two cases report Anabela Lopes, Joana Cosme, Rita Aguiar, Tatiana Lourenço, Maria-João Paes, Amélia Spínola-Santos, Manuel Pereira-Barbosa P106 Diagnosis of betalactam allergy in an allergy department Cíntia Rito Cruz, Rute Pereira Dos Reis, Elza Tomaz, Ana Paula Pires, Filipe Inácio P107 Diagnostic work-up of 410 patients with suspicion of betalactam antibiotic hypersensitivity Filipe Benito-Garcia, Inês Mota, Magna Correia, Ângela Gaspar, Marta Chambel, Susana Piedade, Mário Morais-Almeida P108 Immediate selective hypersensitivity reactions to clavulanic acid Alla Nakonechna, Yurij Antipkin, Tetiana Umanets, Fernando Pineda, Francisca Arribas, Volodymyr Lapshyn P109 Prevalence and incidence of penicillin hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P110 Selective sensitization to amoxicilin and clavulanic acid Jose Julio Laguna Martinez, Aranzazu Jimenez Blanco, Javier Dionicio Elera, Cosmin Boteanu, Rosario Gonzalez-Mendiola, Marta Del Pozo P111 Infliximab-specific T cells are detectable also in treated patients who have not developed anti-drug antibodies Alessandra Vultaggio, Francesca Nencini, Sara Pratesi, Andrea Matucci, Enrico Maggi Poster walk 13: biologicals, local anesthetics, others (P112–P118) P112 A case report of allergic immediate systemic reaction to adalimumab and certolizumab Ceyda Tunakan Dalgiç, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Aytül Zerrin Sin, Ali Kokuludag P113 Allergy to local anesthetics: negative predictive value of skin tests Ivana Cegec, Danica Juricic Nahal, Viktorija Erdeljic Turk, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iva Kraljickovic, Iveta Simic P114 Cutaneous adverse reactions of molecular targeted agents: a retrospective analysis in 150 patients in our department Yukie Yamaguchi, Tomoya Watanabe, Megumi Satoh, Tomohiko Tanegashima, Kayoko Oda, Hidefumi Wada, Michiko Aihara P115 Generalized paralysis induced by local lidocaine injection Jaechun Jason Lee, Jay Chol Choi, Hwa Young Lee P116 Hypersensitivity to local anaesthetics: a 10 year review Rosa-Anita Rodrigues Fernandes, Emília Faria, Joana Pita, Nuno Sousa, Carmelita Ribeiro, Isabel Carrapatoso, Ana Todo Bom P117 Local anaesthetics: a rare culprit in hypersensitivity reactions Ana Rodolfo, Eunice Dias-Castro, Josefina Cernadas P118 Stevens–Johnson syndrome in clinical practice: a variant of clinical course Marina Voronova Poster walk 14: RCM (P119–P128) P119 13 cases of severe anaphylactic reactions due to radiocontrast media Jaume Martí Garrido, Ramon Lopez Salgueiro, Diana Kury Valle, Verónica Pacheco Coronel, Carolina Perales Chordá, Dolores Hernandez Fernandez De Rojas P120 Anaphylactic shock after administration of iodinated contrast medium during cardiac catheterization Roselle Catherine Yu Madamba, Marta Ferrer, Maria Jose Goikoetxea, Carmen D’Amelio, Amalia Bernad, Olga Vega, Gabriel Gastaminza P121 Anaphylactic shock and cardiac arrest induced by gadolinium-based contrast agents Beatriz Pola Bibián, Marina Lluncor Salazar, Gemma Vilà Nadal, Ana María Fiandor Roman, Javier Dominguez Ortega, Miguel Gonzalez Muñoz, Santiago Quirce Gancedo, Maria Rosario Cabañas Moreno P122 Anaphylaxis to gadobenate and cross-reactivity to other gadolinium-based contrast agents in two patients Kathrin Scherer Hofmeier P123 Anaphylaxis to glatiramer acetate in a patient with multiple sclerosis Fabrícia Carolino, Vladyslava Barzylovych, Josefina R. Cernadas P124 Delayed hypersensitivity reaction to radiocontrast media Fabrícia Carolino, Diana Silva, Leonor Leão, Josefina R. Cernadas P125 Drug reaction with eosinophilia and systemic symptoms induced by iodixanol Gemma Vilà-Nadal, Beatriz Pola, Marina Lluncor, Ana Fiandor, Teresa Bellón, Javier Domínguez, Santiago Quirce P126 Electronic consultation support system for radiocontrast media hypersensitivity changes clinician’s behavior Min-Suk Yang, Sun-Sin Kim, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, Sang-Heon Cho, Kyung-Up Min, Yoon-Seok Chang P127 Hypersensitivity reactions to iodinated contrast media: skin testing and follow-up Danica Juricic Nahal, Ivana Cegec, Viktorija Erdeljic Turk, Iva Kraljickovic, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iveta Simic P128 Would iodine allergy exist? Clémence Delahaye, Jenny Flabbee, Julie Waton, Olivia Bauvin, Annick Barbaud Poster walk 15: MPE/type 4 (P129–P137) P129 Delayed hypersensitivity cutaneous reactions: a case/control study from a tunisian database Karim Aouam, Najah Ben Fadhel, Zohra Chadly, Nadia Ben Fredj, Naceur A. Boughattas, Amel Chaabane P130 Delayed hypersensitivity reactions to cephalosporins: a review of seven cases Joana Cosme, Anabela Lopes, Amélia Spínola-Santos, Manuel Pereira-Barbosa P131 Diclofenac induced allergic contact dermatitis: case series of four patients Sandra Jerkovic Gulin, Anca Chiriac P132 Late-onset maculopapular rash to irbesartan Bárbara Kong Cardoso, Elza Tomaz, Regina Viseu, Filipe Inácio P133 Nonimmediate hypersensitivity reactions to betalactams: a retrospective analysis Ana Moreira, Susana Cadinha, Ana Castro Neves, Patricia Barreira, Daniela Malheiro, J. P. Moreira Da Silva P134 Occupational airborne contact dermatitis to omeprazole Ružica Jurakic-Toncic, Suzana Ljubojevic, Petra Turcic P135 Ornidazole-induced fixed drug eruption confirmed by positive patch test on a residual pigmented lesion Liesbeth Gilissen, Sara Huygens, An Goossens P136 Repeated delayed reaction induced by amoxicillin and amoxicillin clavulanate Inmaculada Andreu, Ramon Lopez-Salgueiro, Alicia Martinez Romero, Pau Gomez Cabezas P137 Systemic photosensitivity from fenofibrate in a patient photo-sensitized to ketoprofen Liesbeth Gilissen, An Goossens Poster walk 16: HLA genetics (P138–P146) P138 A copy number variation in ALOX5 and PTGER1 is associated with nonsteroidal anti-inflammatory drugs induced urticaria and/or angioedema Pedro Ayuso Parejo, Maria Del Carmen Plaza-Serón, Inmaculada Doña, Natalia Blanca López, Carlos Flores, Luisa Galindo, Ana Molina, James Richard Perkins, Jose Antonio Cornejo-García, José Augusto García-Agúndez, Elena García-Martín, Paloma Campo, María Gabriela Canto, Miguel Blanca P139 Association of galectin-3 (LGALS3) single nucleotide polymorphisms with non-steroidal anti-inflammatory drugs-induced urticaria/angioedema José Antonio Cornejo-Garcia, Inmaculada Doña, Rosa María Guéant-Rodríguez, Natalia Blanca-López, María Carmen Plaza-Serón, Raquel Jurado-Escobar, Esther Barrionuevo, María Salas, María Luisa Galindo, Gabriela Canto, Miguel Blanca, Jean-Louis Guéant P140 Detection of T cell responses to ticlopidine using peripheral blood mononuclear cells from HLA-A*33:03+ healthy donors Toru Usui, Arun Tailor, Lee Faulkner, John Farrell, Ana Alfirevic, B. Kevin Park, Dean J. Naisbitt P141 Epistasis approaches to identify novel genes potentially involved in NSAIDs hypersensitivity James Richard Perkins, Jose Antonio Cornejo García, Oswaldo Trelles, Inmaculada Doña, Esther Barrionuevo, María Salas, María Auxiliadora Guerrero, Miguel Blanca, Alex Upton P142 Genetic predisposition of cold medicine related SJS/TEN with severe ocular complications Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Katushi Tokunaga, Shigeru Kinoshita P143 HLA-B*13:01 and dapsone induced hypersensitivity in Thai population Chonlaphat Chonlaphat Sukasem, Patompong Satapornpong, Therdpong Tempark, Pawinee Rerknimitr, Kulprapat Pairayayutakul, Jettanong Klaewsongkram P144 HLA-B*15:02 alleles and lamotrigine-induced cutaneous adverse drug reactions in Thai Chonlaphat Sukasem, N. Koomdee, T. Jantararoungtong, S. Santon, A. Puangpetch, U. Intusoma, W. Tassaneeyakul, V. Theeramoke P145 HLA-B*38:01 and HLA-A*24:02 allele frequencies in Spanish patients with lamotrigine-induced SCARs Teresa Bellón, Elena Ramirez, Alberto Manuel Borobia, Hoi Tong, Jose Luis Castañer, Francisco José De Abajo P146 Overrepresentation of a class II HLA haplotype in severe hypersensitivity type I reactions to carboplatin Violeta Régnier Galvao, Rebecca Pavlos, Elizabeth Mckinnon, Kristina Williams, Alicia Beeghly-Fadiel, Alec Redwood, Elizabeth Phillips, Mariana Castells Poster walk 17: in vivo diagnosis + sIgE (P147–P154) P147 Absence of specific Ig-e against beta-lactams 9 months after an allergic reaction to amoxicillin-clavulanic acid Elisa Boni, Marina Russello, Marina Mauro P148 Drug provocation tests in suspected opioid allergy Kok Loong Ue, Krzysztof Rutkowski P149 Improvement to the specific IgE cut-off in the assess of β-lactamic allergy Victor Soriano Gomis, Jorge Frances Ferre, Angel Esteban Rodriguez, Vicente Cantó Reig, Javier Fernandez Sanchez P150 Initial false negative specific IgE to gelatin in a patient with gelatin-induced anaphylaxis Christine Breynaert, Erna Van Hoeyveld, Rik Schrijvers P151 Inmediate reactions to beta-lactam antibiotics: pattern of skin test response over the time Jose Julio Laguna Martinez, Rosario Gonzalez Mendiola, Javier Dionicio Elera, Cosmin Boteanu, Aranzazu Jimenez Blanco, Marta Del Pozo, Raquel Fuentes Irigoyen P152 New fluorescent dendrimeric antigens for the evaluation of dendritic cell maturation as a test to detect allergy reactions to amoxicillin Daniel Collado, Yolanda Vida, Francisco Najera, Ezequiel Perez-Inestrosa, Pablo Mesa-Antunez, Cristobalina Mayorga, María José Torres, Miguel Blanca P153 Positive skin test or positive specific IgE to penicillin does not predict penicillin allergy Line K. Tannert, Charlotte G. Mortz, Per Stahl Skov, Carsten Bindslev-Jensen P154 Significance of skin testing and in vitro-analysis of neuromuscular blocking agents in diagnosis of perioperative drug hypersensitivity: evaluation of a negative control population Wolfgang Pfützner, Hannah Dörnbach, Johanna Visse, Michele Rauber, Christian Möbs Poster walk 18: in vitro/ex vivo (P155–P158, P160–P164) P155 Diagnostic value of the lymphocyte toxicity assay (LTA) and the in vitro platelet toxicity assay (IPTA) for β-lactam allergy Abdelbaset A. Elzagallaai, Lindsey Chow, Awatif M. Abuzgaia, Michael J. Rieder P156 Enzyme linked immunospot assay used in the diagnosis of severe cutaneous adverse reactions to antimicrobials Alec Redwood, Jason Trubiano, Rebecca Pavlos, Emily Woolnough, Kaija Stautins, Christina Cheng, Elizabeth Phillips P157 Evaluation of in vitro diagnostic methods for identifying the culprit drugs in drug hypersensitivity Kenichi Kato, Hiroaki Azukizawa, Takaaki Hanafusa, Ichiro Katayama P158 Ex-vivo expanded skin-infiltrating T cells from severe drug eruptions are reactive with causative drugs: a possible novel method for determination of causative drugs Toshiharu Fujiyama, Hideo Hashizume, Takatsune Umayahara, Taisuke Ito, Yoshiki Tokura P160 In vitro release of IL-2, IL-5 and IL-13 in diagnosis of patients with delayed-type nickel hypersensitivity Mira Silar, Mihaela Zidarn, Helena Rupnik, Peter Korosec P161 Single cell analysis of drug responsive T cells; identification of candidate drug reactive T cell receptors in abacavir and carbamazepine hypersensitivity Alec James Redwood, Kaija Strautins, Katie White, Abha Chopra, Katherine Konvinse, Shay Leary, Rebecca Pavlos, Simon Mallal, Elizabeth Phillips P162 Specificity and sensitivity of LTT in DRESS: analysis of agreement with the Spanish pharmacovigilance system probability algorithm Rosario Cabañas, Elena Ramirez, Ana María Fiandor, Teresa Bellón P163 The role of interleukin-22 in β-lactam hypersensitivity Andrew Sullivan, Paul Whitaker, Daniel Peckham, B. Kevin Park, Dean J. Naisbitt P164 Vancomycin-specific T cell responses and teicoplanin cross-reactivity Wei Yann Haw, Marta E. Polak, Carolann Mcguire, Michael R. Ardern-Jones Poster walk 19: BAT and biomarkers (P165–P173) P165 A combination of early biomarkers useful for the prediction of severe ADRs Yumi Aoyama, Tetsuo Shiohara P166 Basophil activation test in the diagnostic approach of reactions during general anaesthesia Ana Moreira, Susana Cadinha, Patrícia Barreira, Ana Castro Neves, Daniela Malheiro, Sara Correia, J. P. Moreira Da Silva P167 IL-10 can be related to successful desensitization Asli Gelincik, Semra Demir, Fatma Sen, Hamza Ugur Bozbey, Muge Olgac, Derya Unal, Raif Coskun, Bahauddin Colakoglu, Suna Buyuozturk, Esin Çatin-Aktas, Gunnur Deniz P168 Immediate reactions to proton pump inhibitors: value of basophil activation test Maria Salas, Jose Julio Laguna, Esther Barrionuevo, J. Dionicio, Tahia Fernandez, R. Gonzalez-Mendiola, I. Olazabal, Maria Dolores Ruiz, Miguel Blanca, Cristobalina Mayorga, Maria José Torres P169 Improvement of the elevated tryptase criterion to discriminate IgE from non-IgE mediated allergic reactions Gabriel Gastaminza, Alberto Lafuente, Carmen D’Amelio, Amalia Bernad, Olga Vega, Roselle Catherine Madamba, M. Jose Goikoetxea, Marta Ferrer, Jorge Núñez P170 Low expression of Tim-3 could serve as a biomarker for control and diagnose maculopapular exanthema induced by drugs Tahia Diana Fernández, Inmaculada Doña, Francisca Palomares, Rubén Fernández, Maria Salas, Esther Barrionuevo, Maria Isabel Sanchez, Miguel Blanca, Maria José Torres, Cristobalina Mayorga P171 Role of basophil activation test using two different activation markers for the diagnosis of allergy to fluoroquinolones Esther Barrionuevo, Tahía Fernandez, Arturo Ruiz, Adriana Ariza, Maria Salas, Inmaculada Doña, Ana Molina, Miguel Blanca, Maria Jose Torres, Cristobalina Mayorga P172 The importance of basophil activation test in anaphylaxis due to celecoxib Amalia Bernad Alonso, Carmen D’Amelio Garófalo, Olga Vega Matute, Marta Ferrer Puga, María José Goikoetxea Lapresa, Roselle Catherine Yu Madamba, Gabriel Gastaminza Lasarte P173 The role of basophil activation test in the diagnosis of immediate type drug hypersensitivity to betalactam antibiotics Antonia Thinnes, Hans F. Merk, Jens Malte Baron, Martin Leverkus, Galina Balakirski Poster walk 20: TCR recognition, cellular (P174–P183) P174 Characterisation of the effect of co-inhibitory signalling on the activation of drug-derived antigen-specific T-cells Andrew Gibson, Monday Ogese, Lee Faulkner, B. Kevin Park, Dean J. Naisbitt P175 Characterization of drug hapten-specific T cell responses in piperacillin hypersensitive patients Zaid Al-Attar, Fiazia Yaseen, Xiaoli Meng, Rozalind Jenkins, Paul Whitaker, Daniel Peckham, Lee Faulkner, John Farrel, Kevin Park, Dean Naisbitt P176 Characterization of the response of T-cells to telaprevir and its metabolite in normal volunteers Zaid Al-Attar, Khetam Alhilali, Yanni Xue, John Farrell, Lee Faulkner, Kevin Park, Dean Naisbitt P177 Characterization of the T cell receptor signatures of drug-responsive T cells Patricia Illing, Nicole Mifsud, Heidi Fettke, Jeffrey Lai, Rebecca Ho, Patrick Kwan, Anthony Purcell P178 Defining the signals between hepatocytes and immune cells in idiosyncratic drug-induced liver injury (DILI) Monday O. Ogese, Lee Faulkner, B. Kevin Park, Catherine Betts, Dean J. Naisbitt P179 Development of novel chemicals that do not bind to HLA-B*57:01 or activate CD8 + T-cells through modification of the 6-amino cyclopropyl group of abacavir Paul Thomson, John Farrell, Mohammad Alhaidari, Neill Berry, Paul M. O’Neill, B. Kevin Park, Dean J. Naisbitt P180 Generation and characterization of dapsone- and nitroso-dapsone-specific T-cell clones using lymphocytes from healthy volunteers Abdulaziz Alzahrani, Monday O. Ogese, John Farrell, Lee Faulkner, Andrew Gibson, Arun Tailor, B. Kevin Park, Dean J. Naisbitt P181 Identification of benzylpenicillin-hapten peptides responsible for naïve T-cell activation and immunization of allergic patients to penicillin Marie Eliane Azoury, Lucia Fili, Rami Bechara, Noémie Scornet, Cathy Nhim, Richard Weaver, Nancy Claude, Delphine Joseph, Bernard Maillere, Paola Parronchi, Marc Pallardy P182 Massive expansion of clonotypic and polycytotoxic CD8+ T cells in toxic epidermal necrolysis Axel Patrice Villani, Aurore Rozières, Benoît Bensaïd, Mathilde Tardieu, Floriane Albert, Virginie Mutez, Tugba Baysal, Marc Pallardy, Janet Maryanski, Jean-François Nicolas, Osami Kanagawa, Marc Vocanson P183 Pharmaco-immunological synapse of HLA-drug-TCR in SCAR Shuen-Iu Hung Poster walk 21: new in vitro methods, haptens, etc. (P184–P194) P184 Amoxicillin-clavulanate forms distinct multiple haptenic structures on human serum albumin in patients Xiaoli Meng, Arun Tailor, Caroline J. Harrison, Rosalind E. Jenkins, Paul Whitaker, Neil S. French, Dean J. Naisbitt, B. Kevin Park P185 Dendrimeric antigens for studying the influence of penicillin determinants orientation on IgE recognition Maria Isabel Montañez, Cristobalina Mayorga, Francisco Najera, Adriana Ariza, Tahia D. Fernandez, Maria Salas, Angela Martin-Serrano, Miguel Blanca, Ezequiel Perez-Inestrosa, Maria Jose Torres P186 Dendrimeric antigens on solid supports: designed materials for IgE quantification Yolanda Vida, Maria Isabel Montañez, Noemi Molina, Daniel Collado, Francisco Najera, Adriana Ariza, Maria Jose Torres, Cristobalina Mayorga, Ezequiel Perez-Inestrosa P187 Development of a screening assay for drug hypersensitivity using naïve T cells from donors with seven different HLA class I risk alleles Lee Faulkner, Sally Wood, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park P188 Different patterns of recognition of structures derived from amoxicillin by IgE antibodies from patients with immediate hypersensitivity reactions to betalactams Adriana Ariza, Cristobalina Mayorga, María Isabel Montañez, María Salas, Inmaculada Doña, Ángela Martín-Serrano, Ezequiel Pérez-Inestrosa, Dolores Pérez-Sala, Miguel Blanca, Antonio E. Guzmán, María José Torres P189 High-resolution typing of HLA polymorphism and T-cell receptor repertoire for severe adverse drug reactions based on the cost-effective next-generation sequencing approaches Tai-Ming Ko, Yuan-Tsong Chen, Jer-Yuarn Wu P190 Identification and fate of intracellular proteins haptenated by amoxicillin Francisco J. Sánchez-Gómez, Juan M. González-Morena, Yolanda Vida, Ezequiel Pérez-Inestrosa, Miguel Blanca, María J. Torres, Dolores Pérez-Sala P191 In vitro detection of terbinafine protein adducts Arun Tailor, Toru Usui, Yanni Xue, Xiaoli Meng, Dean J. Naisbitt, B. Kevin Park P192 MicroRNAs dysregulation in PBMCs from drug hypersensitivity patients during drug challenge in vitro Alejandra Monroy Arreola, Jesus Agustin Badillo Corona, Silvia Mendez Flores, Judith Dominguez Cherit, Dean J. Naisbitt, Noe Valentin Duran Figueroa, Jose Luis Castrejon Flores P193 NSAIDs-exacerbated cutaneous disease: high throughput gene expression profiling José Antonio Cornejo-García, James Perkins, Natalia Blanca-López, Diana Pérez-Alzate, Raquel Jurado-Escobar, Inmaculada Doña, Gador Bogas, María J. Torres, Gabriela Canto, Miguel Blanca P194 Utility of skin tests in non-immediate reactions to amoxicillin Luis Mario Tubella Marti, Fernando Pineda De La Losa, Francisca Arribas Poves, Jaime Tubella Lopez, Teodora Lopez Santiag