Plan de negocios solución para restaurantes “Da' gusto”

134 páginas y anexos.Da'Gusto is the presentation of a technological solution proposition for restaurants, based on two main concepts that are the digital economy and the change of consumer behavior. Analyzing the restaurants business model and taking knowledge from the personal experience of the authors, it has been identified several consumer dissatisfaction points and the lack of technology in the service provided comes evident. In the document, we present a context analysis of the situation, the description of the problem, a market research and the objectives. The information allows developing the proposal, based on the development of an application for restaurants that allows consumers to perform the interaction through a terminal at their table, whose objective is to create the experience that the client wants and to deliver to the restaurant a value differentiation in their business model.Da' Gusto es la presentación de una propuesta de solución tecnológica para restaurantes, basada en dos pilares que son la economía digital y el cambio de comportamiento de los consumidores. Al realizar el análisis del modelo de negocio de los restaurantes y a partir de la experiencia personal de los autores, se evidencian varios puntos de insatisfacción del consumidor y la falta de tecnología en el servicio prestado. Durante el presente trabajo se hace un análisis de contexto de la situación detectada, la formulación del problema y el planteamiento de objetivos, así como la investigación de mercado, lo cual permite el desarrollo de la propuesta, basada en el desarrollo de una aplicación para restaurantes que permita a los consumidores realizar la interacción a través de una terminal en su mesa, cuyo objetivo es generar la experiencia que el cliente desea y entregar al restaurante un diferenciador en su modelo de negocio.Pregrad

La violencia posacuerdo: un análisis comparado entre Colombia y El Salvador

Through a comparative analysis of violence in the post-accord period in Colombia and El Salvador, it is sought to argue whether it is reasonable to support the hypothesis of salvadorization of Colombia after signing the Peace Accord between the Government and the FARC-EP. The analysis questions the discourse of salvadorization, promoted by political sectors opposing the Agreement, stating that war and peace in both countries present significant differences, so it is not possible to make an analogy between the behavior of post-accord violence, evidencing the contrived nature of this discourse. In addition, the transformation of the violence in Colombia after signing the Peace Accord is analyzed, which is characterized by the geographical rearrangement of illegal armed groups in the former guerrilla territories.Mediante un análisis comparado de la violencia homicida en el periodo posacuerdo en Colombia y El Salvador, se busca argumentar si es razonable sostener la hipótesis de la “salvadorización” de Colombia tras la firma del Acuerdo de Paz entre el Gobierno y LAS FARC-EP. El análisis cuestiona el discurso de la salvadorización sostenido por sectores políticos opositores al Acuerdo, planteando que, tanto la guerra como la paz en ambos países presentan diferencias sustanciales, por lo que no es posible hacer una analogía entre el comportamiento de la violencia posacuerdo salvadoreña y colombiana, lo que evidencia el carácter artificioso de dicho discurso. Asimismo, se analiza la transformación de la violencia en Colombia tras la firma del Acuerdo de Paz, caracterizada por el reacomodo de los grupos armados ilegales en los antiguos territorios de la guerrilla, hecho que refuerza las diferencias con el país centroamericano

Improving the antinutritional profiles of common beans (Phaseolus vulgaris L.) moderately impacts carotenoid bioaccessibility but not mineral solubility

Producción CientíficaCommon beans are a common staple food with valuable nutritional qualities, but their high contents in antinutritional factors (ANFs) can decrease the bioavailability of (i) fat-soluble micronutrients including carotenoids and (ii) minerals. Our objective was to select ANF-poor bean lines that would not interfere with carotenoid and mineral bioavailability. To achieve this objective, seeds of commercial and experimental Phaseolus vulgaris L. bean lines were produced for 2 years and the bean’s content in ANFs (saponins, phytates, tannins, total polyphenols) was assessed. We then measured carotenoid bioaccessibility and mineral solubility (i.e. the fraction of carotenoid and mineral that transfer into the aqueous phase of the digesta and is therefore absorbable) from prepared beans using in vitro digestion. All beans contained at least 200 mg/100 g of saponins and 2.44 mg/100 g tannins. The low phytic acid (lpa) lines, lpa1 and lpa12 exhibited lower phytate levels (≈ − 80%, p = 0.007 and p = 0.02) than their control BAT-93. However, this decrease had no significant impact on mineral solubility. HP5/1 (lpa + phaseolin and lectin PHA-E free) bean line, induced an improvement in carotenoid bioaccessibility (i.e., + 38%, p = 0.02, and + 32%, p = 0.005, for phytofluene bioaccessibility in 2021 and 2022, respectively). We conclude that decrease in the phytate bean content should thus likely be associated to decreases in other ANFs such as tannins or polyphenols to lead to significant improvement of micronutrient bioaccessibility

SARS-CoV-2 Infection in Patients With Waldenström's Macroglobulinemia: A Multicenter International Cohort Study

The coronavirus disease 2019 (COVID-19) pandemic has represented a huge challenge for vulnerable patients affected with hematological malignancies.1,2 So far, heterogeneous series on patients with lymphoma and COVID-19 have been published with mortality rates ranging from 25% to 40%,3–8 with only limited information about specific neoplasms.Peer reviewe

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Post-Accord violence: a comparative analysis between el Salvador and Colombia

Mediante un análisis comparado de la violencia homicida en el periodo posacuerdo en Colombia y El Salvador, se busca argumentar si es razonable sostener la hipótesis de la “salvadorización” de Colombia tras la firma del Acuerdo de Paz entre el Gobierno y LAS FARC-EP. El análisis cuestiona el discurso de la salvadorización sostenido por sectores políticos opositores al Acuerdo, planteando que, tanto la guerra como la paz en ambos países presentan diferencias sustanciales, por lo que no es posible hacer una analogía entre el comportamiento de la violencia posacuerdo salvadoreña y colombiana, lo que evidencia el carácter artificioso de dicho discurso. Asimismo, se analiza la transformación de la violencia en Colombia tras la firma del Acuerdo de Paz, caracterizada por el reacomodo de los grupos armados ilegales en los antiguos territorios de la guerrilla, hecho que refuerza las diferencias con el país centroamericano.Through a comparative analysis of violence in the post-accord period in Colombia and El Salvador, it is sought to argue whether it is reasonable to support the hypothesis of salvadorization of Colombia after signing the Peace Accord between the Government and the FARC-EP. The analysis questions the discourse of salvadorization, promoted by political sectors opposing the Agreement, stating that war and peace in both countries present significant differences, so it is not possible to make an analogy between the behavior of post-accord violence, evidencing the contrived nature of this discourse. In addition, the transformation of the violence in Colombia after signing the Peace Accord is analyzed, which is characterized by the geographical rearrangement of illegal armed groups in the former guerrilla territories

Jornada para el impulso del emprendimiento científico CSIC Dinamiza

Datos técnicos: 79 minutos la primera parte, 58 minutos la segunda parte, color, español. Ficha técnica: Gabinete de Presidencia CSIC y Departamento de ComunicaciónN

En busca del futuro II

Se completa el proyecto del curso 96-97 de incorporación de los medios audiovisuales e informáticos a las aulas de Educación Infantil con la creación de un rincón del ordenador. Se pretende que el alumnado adquiera una serie de conocimientos y actitudes positivas relacionadas con el mundo informático que les rodea, y que estos conocimientos les enriquezcan y les permitan adquirir sus propias posibilidades expresivas y de representación. La metodología empleada es eminentemente práctica, tratando despertar el interés del alumnado. Se evalúa el grado de motivación e interrelación del alumnado y la repercusión en la actividad de las aulas por medio de la observación directa.Madrid (Comunidad Autónoma). Consejería de Educación y CulturaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES