Hipoeliticidade global para uma classe de operadores pseudodiferenciais sobre variedades compactas

Orientadores : Prof. Dr. Alexandre Kirilov e Prof. Dr. Todor GramchevTese (doutorado) - Universidade Federal do Paraná, Setor de Ciências Exatas, Programa de Pós-Graduação em Matemática. Defesa: Curitiba, 04/05/2015Inclui referências : f. 65-66Resumo: O objetivo deste trabalho é investigar a hipoeliticidade global para uma classe de operadores do tipo L =Dt +C (t , x ,Dx ), t 2 T = R=(2_Z), x 2M, sendo M uma variedade suave, fechada (compacta e sem bordo) e C (t , x ,Dx ) é um operador pseudodiferencial, de primeira ordem, definido sobreM, o qual depende suavemente da variável periódica t . Palavras-chave: Hipoeliticidade global, operadores pseudodiferenciais, fórmula assintótica deWeyl, variedades compactasAbstract: The main goal on this work is to investigate the global hypoellipticity of the following class of operators L .= Dt +C (t , x ,Dx ), t 2 T = R=(2_Z), x 2M, where M is a closed (compact without boundary) smooth manifold and C (t , x ,Dx ) is a first order pseudodifferential operator onM, smoothly depending on the periodic variable t . Keywords: Global hypoellipticity, pseudo-differential operators, Weyl's asymptotic formula, compact manifold

Folheações transversais à esfera tridimensional

Resumo: O objetivo deste trabalho é investigar a existência, bem como a quantidade, de folhas compactas de uma folheação da esfera tridimensional, no casoemque esta folheação é determinada pela interseção das curvas integrais de um campo vetorial holomorfo definido num aberto de C2. Mais especificamente prova-se que quando a esfera é transversal à folheação gerada pelas curvas integrais do campo holomorfo, então a folheação induzida sobre a esfera deverá possuir uma, duas ou infinitas folhas compactas

Streptococcal bacteraemia in patients submitted to hematopoietic stem cell transplantation : the role of tooth brushing and use of chlorhexidine

A retrospective evaluation of 73 consecutive recipients of hematopoietic stem cell transplantation (HSCT) was conducted to investigated the role of oral care and incidence of streptococcal bacteremia in patients submitted to hematopoietic stem cell transplantation. Patients were retrospectively evaluated and divided into group A (GA=38) and group B (GB=35). During hospitalization patients from GA performed oral hygiene daily with extra soft toothbrush and toothpaste besides performing mouth cleaning with an ethanol-free 0.12% chlorhexidine solution tree times a day. In contrast GB patients performed mouth cleaning with extra soft toothbrush and toothpaste, but no chlorhexidine was used. Using the Chi square test it was observed that all patients from GA presented negative blood culture for alpha-hemolytic Streptococcus viridans and Candida albicans and only 1 patient without oral mucositis from GB presented positive blood cultures for Streptococcus intermedius (p=0.48). The results indicate that methodology used for oral care before the HSCT and the practice of tooth brushing during the period were effective in preventing streptococcal bacteremia. Moreover, our data suggest that the mouth cleaning with chlorhexidine during HSCT may be not mandatory

Oltre il senso comune. Il concetto di pluralit\ue0 in Hannah Arendt, tra estetica e politica

O trabalho foi desenvolvido na fazenda Jordão (município de Araguari, MG), na época do verão (período das águas), com o objetivo de verificar o desempenho agronômico de genótipos de tomateiro tipo Santa Cruz. Utilizou-se o delineamento experimental blocos casualizados, com 16 tratamentos (genótipos) e quatro repetições. A parcela experimental foi constituída por duas fileiras com 12 plantas cada, no espaçamento de 1,00 m entre linhas e 0,55 m entre plantas (1 planta/cova). Efetuaram-se 17 colheitas, sendo a primeira aos 69 dias após o transplante. Vários genótipos apresentaram um bom desempenho agronômico, principalmente Saladinha, Débora Plus, SM-16 e Atlas, podendo ser cultivados no período de verão. Apenas Saladinha e Atlas ultrapassaram 140 g de peso médio, destacando-se também em frutos do tipo extra AA. Observou-se uma correlação significativa e negativa com r = -0,52 e -0,54 na primeira avaliação, e r = -0,55 e -0,45 na segunda avaliação para a produção total e produção comercial, respectivamente, em relação à incidência de geminivírus nos diferentes genótipos. Os híbridos Saladinha e SM-16 apresentaram o menor número de plantas viróticas, enquanto Santa Clara Importada, Santa Clara, Jumbo AG-592 e IAC Santa Clara, apresentaram o maior número.A field experiment was carried out in the Jordão farm in Araguari, MG, Brazil, during the summer season, to evaluate the agronomic potential of genotypes (Santa Cruz type) of tomato. A randomized block design was used with 16 treatments (genotypes) and four replicates. The experimental plot was made up of two lines (1.00 m between lines and 0.55 m between plants) with 12 plants each (1 plant/pit). Seventeen harvests were made, starting 69 days after transplanting. Several genotypes as Saladinha, Débora Plus, SM-16 and Atlas had a good agronomic performance, being recommended to be cultivated in the region, in the summer season. Classified as AA type, the Saladinha and Atlas showed an average of 140 g/fruit. During the experiment a negative correlation, r = -0.52 and -0.54, could be observed, in the first evaluation, and correlation r = -0.55 and -0.45 in the second evaluation between total production, and commercial production in relation to geminivirus infection, respectively, for the different genotypes. The Saladinha e SM-16 hybrids showed the lowest number of infected plants, while Santa Clara Imported, Santa Clara, Jumbo AG-592 and IAC Santa Clara showed the highest number

Subversion of early innate antiviral responses during antibody-dependent enhancement of Dengue virus infection induces severe disease in immunocompetent mice

Dengue is a mosquito-borne disease caused by one of four serotypes of Dengue virus (DENV-1–4). Epidemiologic and observational studies demonstrate that the majority of severe dengue cases, dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS), occurs predominantly in either individuals with cross-reactive immunity following a secondary heterologous infection or in infants with primary DENV infections born from dengue-immune mothers, suggesting that B-cell-mediated and antibody responses impact on disease evolution. We demonstrate here that B cells play a pivotal role in host responses against primary DENV infection in mice. After infection, μMT[superscript −/−] mice showed increased viral loads followed by severe disease manifestation characterized by intense thrombocytopenia, hemoconcentration, cytokine production and massive liver damage that culminated in death. In addition, we show that poly and monoclonal anti-DENV-specific antibodies can sufficiently increase viral replication through a suppression of early innate antiviral responses and enhance disease manifestation, so that a mostly non-lethal illness becomes a fatal disease resembling human DHF/DSS. Finally, treatment with intravenous immunoglobulin containing anti-DENV antibodies confirmed the potential enhancing capacity of subneutralizing antibodies to mediate virus infection and replication and induce severe disease manifestation of DENV-infected mice. Thus, our results show that humoral responses unleashed during DENV infections can exert protective or pathological outcomes and provide insight into the pathogenesis of this important human pathogen